Article
Medicine, General & Internal
Christian Holm Hansen, Daniela Michlmayr, Sophie Madeleine Gubbels, Kare Molbak, Steen Ethelberg
Summary: The study investigated the protection against SARS-CoV-2 reinfection, with results showing an 80.5% protection rate for individuals previously infected. Even in the population aged 65 years and older, the protection rate against reinfection reached 47.1%, with no significant differences observed by gender or time since infection.
Article
Virology
Filippos Filippatos, Elizabeth-Barbara Tatsi, Charilaos Dellis, Vasiliki Efthymiou, Alexandra Margeli, Ioannis Papassotiriou, Vasiliki Syriopoulou, Athanasios Michos
Summary: Limited data on SARS-CoV-2 seropositivity in children during the COVID-19 pandemic were investigated in this prospective study. The seropositivity rates in children were correlated with the number of newly diagnosed cases in the community, with higher rates observed in hospitalized and non-Greek children. School-age children had lower seropositivity rates, emphasizing the need for SARS-CoV-2 immunization.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Immunology
Amanda H. W. Chong, Ruth E. Mitchell, Gibran Hemani, George Davey Smith, Robert H. Yolken, Rebecca C. Richmond, Lavinia Paternoster
Summary: This study analyzed antibody levels in children from the Avon Longitudinal Study of Parents and Children, identifying three genome-wide signals associated with measles virus and Toxoplasma gondii antibodies, as well as 15 HLA alleles associated with five antibodies. These findings contribute to understanding the relationship between host genetics and infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Infectious Diseases
Ole Schmeltz Sogaard, Joanne Reekie, Isik Somuncu Johansen, Henrik Nielsen, Thomas Benfield, Lothar Wiese, Nina Breinholt Staerke, Kasper Iversen, Kamille Fogh, Jacob Bodilsen, Mette Iversen, Lene Surland Knudsen, Vibeke Klastrup, Fredrikke Dam Larsen, Sidsel Dahl Andersen, Astrid Korning Hvidt, Signe Rode Andreasen, Lone Wulff Madsen, Susan Olaf Lindvig, Anne Ovrehus, Sisse Rye Ostrowski, Christiane Abildgaard, Charlotte Matthews, Tomas O. Jensen, Dorthe Raben, Christian Erikstrup, Thea K. Fischer, Martin Tolstrup, Lars Ostergaard, Jens Lundgren
Summary: This study aimed to identify individual characteristics associated with the effectiveness and durability of COVID-19 vaccines. The study found that comorbidity, male sex, vaccine type, and age ≥75 years were associated with a lower response to the vaccine and a lack of durable antibody response. Vaccine-induced antibodies had declined to pre-second-vaccination levels for most individuals after 6 months.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Immunology
Min Z. Levine, Crystal Holiday, Yaohui Bai, Weimin Zhong, Feng Liu, Stacie Jefferson, F. Liaini Gross, Wen-pin Tzeng, Louis Fries, Gale Smith, Philippe Boutet, Damien Friel, Bruce L. Innis, Corey P. Mallett, C. Todd Davis, David E. Wentworth, Ian A. York, James Stevens, Jacqueline M. Katz, Terrence Tumpey
Summary: Influenza A(H7N9) viruses remain a high pandemic threat and pose major challenges in pandemic preparedness strategies through vaccination. The first wave vaccines induce strong antibody responses to the third and fifth wave viruses, but have lower cross-reactivity to the highly pathogenic fifth wave A(H7N9) virus. The US population is largely immunologically naive to A(H7N9) HA.
Article
Multidisciplinary Sciences
Jaime S. Rosa Duque, Xiwei Wang, Daniel Leung, Samuel M. S. Cheng, Carolyn A. Cohen, Xiaofeng Mu, Asmaa Hachim, Yanmei Zhang, Sau Man Chan, Sara Chaothai, Kelvin K. H. Kwan, Karl C. K. Chan, John K. C. Li, Leo L. H. Luk, Leo C. H. Tsang, Wilfred H. S. Wong, Cheuk Hei Cheang, Timothy K. Hung, Jennifer H. Y. Lam, Gilbert T. Chua, Winnie W. Y. Tso, Patrick Ip, Masashi Mori, Niloufar Kavian, Wing Hang Leung, Sophie Valkenburg, Malik Peiris, Wenwei Tu, Yu Lung Lau
Summary: This study compares the immunogenicity and reactogenicity of two widely available SARS-CoV-2 vaccines, BNT162b2 (an mRNA vaccine) and CoronaVac (a whole-virus inactivated vaccine), in healthy adolescents. The results show that the antibody and T cell immune responses in adolescents receiving two doses of either BNT162b2 or CoronaVac are similar to those seen in adults receiving two doses of the same vaccine. However, the immune response to a single dose of BNT162b2 in adolescents is not as robust. Additionally, CoronaVac induces a higher proportion of adolescents to have positive antibody responses compared to adults. Adverse reactions are generally mild for both vaccines, with BNT162b2 having slightly more frequent adverse reactions.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Lara Victoria Donhauser, Julia Veloso de Oliveira, Cordula Schick, Wenzel Manlik, Sabrina Styblova, Sarah Lutzenberger, Michael Aigner, Patrick Philipp, Sebastian Robert, Beate Gandorfer, Dirk Hempel, Louisa Hempel, Dietmar Zehn
Summary: The study analyzed the response to BioNTech/Pfizer's anti-SARS-CoV-2 mRNA vaccine in 237 oncology outpatients and found that patients should wait at least 6 months to 12 months after systemic therapy before receiving mRNA vaccination.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Immunology
Yuki Takemoto, Naoki Tanimine, Hisaaki Yoshinaka, Yuka Tanaka, Toshiro Takafuta, Aya Sugiyama, Junko Tanaka, Hideki Ohdan
Summary: The study found that there is individual variation in antibody production and strength after COVID-19 vaccination. The researchers identified several single nucleotide polymorphisms (SNPs) related to multiple genes that affect antibody production. They also developed a gene model that can predict whether individuals will experience rapid antibody attenuation.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Taylor Matthew Wilcox, Mads Reinholdt Jensen
Summary: Environmental DNA (eDNA) sampling is a powerful tool for monitoring biodiversity by using genetic material in the environment to infer species presence. Previous studies focused on between-species and ecosystem-level biodiversity, but recent research has shown the potential to unlock information about individual and population-level diversity through population genomic analysis of environmental samples. This requires the development of genomic resources for nonmodel organisms and careful study design considerations.
MOLECULAR ECOLOGY RESOURCES
(2022)
Article
Biochemistry & Molecular Biology
Kristen N. Finch, Adam D. Leache
Summary: Rarity, range restriction, and narrow endemism have significant conservation implications for imperilled species. The study shows that human-associated extinction risk factors can also impact widespread species. Comparing newts in the same region, the research highlights the importance of local-scale landscape genetics in understanding population connectivity.
Review
Immunology
Lisa Hirahara, Kaoru Takase-Minegishi, Yohei Kirino, Yuki Iizuka-Iribe, Yutaro Soejima, Ryusuke Yoshimi, Hideaki Nakajima
Summary: Behcet's disease is a systemic inflammatory disease characterized by recurrent oral ulcers, genital ulcers, cutaneous inflammation, and uveitis. The pathogenesis of BD is not fully understood, but it is likely a result of genetic susceptibility and environmental factors. This review discusses the roles of monocytes and macrophages in BD and their potential as therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Carla Bromuro, Brunella Posteraro, Rita Murri, Massimo Fantoni, Mario Tumbarello, Maurizio Sanguinetti, Rosanna Dattilo, Roberto Cauda, Antonio Cassone, Antonella Torosantucci, Floyd L. Wormley
Summary: In this retrospective study, antibody immunity in candidemia patients was evaluated by analyzing sera taken at candidemia diagnosis. The presence of IgG antibodies against Candida antigens Als3, Mp65, Hyr1, and Eno1 were observed in all patients at significantly higher levels compared to non-candidemia controls. Antibodies against Als3 and Mp65 were found to be associated with lower 30-day patient mortality. Multivariable logistic regression analysis showed that the antibody response against Als3 and Mp65, along with other variables, could accurately predict candidemia outcome.
Article
Chemistry, Multidisciplinary
Johann Michael Koehler
Summary: This paper illustrates the importance of quantitative individual effects for disease risk through a simple kinetic model, discussing individual risks, immunity breakthrough, and the impact of different individual reactions to vaccines and infective agents.
APPLIED SCIENCES-BASEL
(2022)
Article
Virology
Zenglei Hu, Jiangyan Zhao, Lei Shi, Jiao Hu, Shunlin Hu, Xiufan Liu
Summary: This study identified two novel non-neutralizing epitopes in the H7N9 HA protein, with one epitope in the head identified as an immunodominant epitope underlying the induction of non-neutralizing H7N9 antibodies. These findings add new knowledge to the molecular basis for antibody immunity against H7N9 vaccines and have implications for vaccine design and modification.
Article
Multidisciplinary Sciences
Jeffrey P. Townsend, Hayley B. Hassler, Pratha Sah, Alison P. Galvani, Alex Dornburg
Summary: This study utilized comparative evolutionary analysis to estimate the durability and breakthrough infection likelihood of different COVID-19 vaccines, showing that mRNA vaccines may offer more long-lasting protection compared to viral vector vaccines.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Mafalda Barbosa, Ricky S. Joshi, Paras Garg, Alejandro Martin-Trujillo, Nihir Patel, Bharati Jadhav, Corey T. Watson, William Gibson, Kelsey Chetnik, Chloe Tessereau, Hui Mei, Silvia De Rubeis, Jennifer Reichert, Fatima Lopes, Lisenka E. L. M. Vissers, Tjitske Kleefstra, Dorothy E. Grice, Lisa Edelmann, Gabriela Soares, Patricia Maciel, Han G. Brunner, Joseph D. Buxbaum, Bruce D. Gelb, Andrew J. Sharp
NATURE COMMUNICATIONS
(2018)
Article
Cell Biology
Josiah E. Hardesty, Banrida Wahlang, K. Cameron Falkner, Hongxue Shi, Jian Jin, Daniel Wilkey, Michael Merchant, Corey Watson, Russell A. Prough, Matthew C. Cave
CELLULAR SIGNALLING
(2019)
Article
Genetics & Heredity
Paras Garg, Ricky S. Joshi, Corey Watson, Andrew J. Sharp
Review
Immunology
Andrew M. Collins, Corey T. Watson
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Cell Biology
Corey T. Watson, Justin T. Kos, William S. Gibson, Leah Newman, Gintaras Deikus, Christian E. Busse, Melissa L. Smith, Katherine J. L. Jackson, Andrew M. Collins
IMMUNOLOGY AND CELL BIOLOGY
(2019)
Article
Immunology
Mingqian Zhou, Paul Dascani, Chuanlin Ding, Justin T. Kos, David Tieri, Xiaoying Lin, Dawn Caster, David Powell, Chengping Wen, Corey T. Watson, Jun Yan
Summary: This study reveals a novel role for CD11b in regulating the healthy humoral response and autoimmune diseases, with CD11b deficiency leading to an enhanced specific humoral response in mice. Defects in BCR signaling were observed in CD11b-deficient mice, with CD11b expression playing a crucial role in B cells.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Jeong Hyun Lee, Laura Toy, Justin T. Kos, Yana Safonova, William R. Schief, Colin Havenar-Daughton, Corey T. Watson, Shane Crotty
Summary: The study demonstrates that a successful HIV vaccine must activate naive precursor B cells encoding broadly neutralizing antibodies, and the use of germline-targeting immunogens and high-throughput single-cell BCR sequencing can efficiently screen large numbers of BCR sequences to elucidate precursor frequencies. Furthermore, analysis of IGHV1-2 allelic usage across different cohorts reveals common alleles previously thought incompatible with VRC01-class responses, and germline variation within IGHV1-2 associates with gene usage frequencies in the naive BCR repertoire.
Letter
Genetics & Heredity
Andrew M. Collins, Ayelet Peres, Martin M. Corcoran, Corey T. Watson, Gur Yaari, William D. Lees, Mats Ohlin
GENES AND IMMUNITY
(2021)
Article
Multidisciplinary Sciences
Oscar L. Rodriguez, Andrew J. Sharp, Corey T. Watson
Summary: Lymphoblastoid cell lines (LCLs) are crucial for genetic research, but V(D)J recombination has shown impacts on short read sequencing data from LCLs.
Article
Cell Biology
Andrew M. Collins, Corey T. Watson, Felix Breden
Summary: Reproductive isolation and gene divergence contribute to the formation of new species through Dobzhansky-Muller incompatibilities (DMIs). The nature of vertebrate immunoglobulin (IG) genes makes them prone to DMIs. The coordination of evolution between IG genes and the rest of the genome is critical for avoiding autoimmune disease.
IMMUNOLOGY AND CELL BIOLOGY
(2022)
Article
Immunology
Kevin M. Nickerson, Shuchi Smita, Kenneth B. Hoehn, Anthony D. Marinov, Kayla B. Thomas, Justin T. Kos, Yi Yang, Sheldon I. Bastacky, Corey T. Watson, Steven H. Kleinstein, Mark J. Shlomchik
Summary: Age-associated B cells (ABCs) are a type of memory B cell expressing the transcription factor T-bet, formed under inflammatory conditions. In systemic lupus erythematosus (SLE), ABC frequency is correlated with disease and they are considered the source of autoantibody-secreting cells. The heterogeneity of ABCs and their relationship to other B cell subsets such as plasmablasts is unclear. The study shows that ABCs are dynamic and can be plasmablast precursors or undergo cycles of reactivation. Deletion of CD11c-expressing B cells reveals a direct role for ABC-like B cells in lupus pathogenesis.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ayelet Peres, William D. Lees, Oscar L. Rodriguez, Noah Y. Lee, Pazit Polak, Ronen Hope, Meirav Kedmi, Andrew M. Collins, Mats Ohlin, Steven H. Kleinstein, Corey T. Watson, Gur Yaari
Summary: In adaptive immune receptor repertoire analysis, determining the germline variable (V) allele associated with each T- and B-cell receptor sequence is challenging. In this study, we propose an alternative naming scheme for V alleles and a novel method to infer individual genotypes. We validate the effectiveness of our approach and implement it in a freely available R package (PIgLET).
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Andrew M. Collins, Gur Yaari, Adrian J. Shepherd, William Lees, Corey T. Watson
CURRENT OPINION IN SYSTEMS BIOLOGY
(2020)
Article
Education & Educational Research
Kate E. Snyder, Caroline M. Pittard, Allison Fowler, Corey T. Watson
TEACHING & LEARNING INQUIRY-THE ISSOTL JOURNAL
(2020)
Article
Immunology
Florian Rubelt, Christian E. Busse, Syed Ahmad Chan Bukhari, Jean-Philippe Buerckert, Encarnita Mariotti-Ferrandiz, Lindsay G. Cowell, Corey T. Watson, Nishanth Marthandan, William J. Faison, Uri Hershberg, Uri Laserson, Brian D. Corrie, Mark M. Davis, Bjoern Peters, Marie-Paule Lefranc, Jamie K. Scott, Felix Breden, Eline T. Luning Prak, Steven H. Kleinstein