Review
Biochemistry & Molecular Biology
Umur Keles, Jin Rong Ow, Katharina Barbara Kuentzel, Li Na Zhao, Philipp Kaldis
Summary: Excessive fat accumulation in the liver is a major health threat globally, with unresolved deposition leading to various diseases. The interaction between metabolites released from the liver and other organs plays a crucial role in the development of fatty liver disease.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Food Science & Technology
Xiaoguo Ji, Mai Chen, Mengyao Zhao, Yudong Song, Yong Lin, Hao Yin, Liming Zhao
Summary: Chitobiose and chitotriose can modulate the gut microbial community of NAFLD patients, increasing beneficial bacteria and decreasing harmful bacteria. Furthermore, the increase in targeted flora is closely related to the significant increase in total short-chain fatty acids, propionic acid, and butyric acid in the OC and TOC groups.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Environmental Sciences
Hua Zhang, Renwen Zhang, Xujia Zeng, Xiao Wang, Desheng Wang, Hongling Jia, Weiguo Xu, Yunfei Gao
Summary: This study examines the association between exposure to neonicotinoid insecticides (NEOs) and liver disease. The results show that NEOs are frequently detected in the blood samples of individuals, with higher concentrations found in females. Additionally, the concentrations of NEOs and their metabolites are positively correlated with the prevalence of liver cancer. These findings suggest that exposure to NEOs may increase the odds of developing liver cancer.
ENVIRONMENTAL RESEARCH
(2022)
Article
Cell Biology
Saima Ajaz, Mark J. McPhail, Luigi Gnudi, Francesca M. Trovato, Salma Mujib, Salvatore Napoli, Ivana Carey, Kosh Agarwal
Summary: This study demonstrates for the first time the association of NAFLD progression with mitochondrial dysfunction and changes in metabolites related to the urea cycle. A unique panel of mitochondrial-based signatures was identified to differentiate between stages of NAFLD progression.
Review
Biochemistry & Molecular Biology
Maria Del Barrio, Lucia Lavin, Alvaro Santos-Laso, Maria Teresa Arias-Loste, Aitor Odriozola, Juan Carlos Rodriguez-Duque, Coral Rivas, Paula Iruzubieta, Javier Crespo
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease (CLD) currently. Lifestyle change is the only available therapeutic recommendation, but adherence to this approach is often challenging. Manipulation of the microbiota and improving intestinal permeability may offer promising therapeutic strategies for NAFLD. Faecal microbiota transplantation (FMT) is a potential method to achieve this. In this review, we summarize key aspects of FMT, discuss its current indications, and highlight recent advances in NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agricultural Engineering
Xiaobo Guo, Ao Xia, Wuyuan Zhang, Yun Huang, Xianqing Zhu, Xun Zhu, Qiang Liao
Summary: The recently discovered CvFAP provides a new approach for producing carbon-neutral biofuels and fine chemicals. This review presents strategies to improve CvFAP catalysis and explores its potential applications.
BIORESOURCE TECHNOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Aleksandra Dzido, Marcin Wolowicz, Piotr Krawczyk
Summary: The article discusses the use of Liquid Air Energy Storage (LAES) in conjunction with the transcritical carbon dioxide cycle to increase efficiency. The analysis shows that maximizing CO2 pressure and directing residual heat to the CO2 cycle improves storage efficiency, while lowering the air temperature prior to expansion has a negative impact. Implementing a parallel system yields a higher increase in storage efficiency compared to a subsequent system.
Article
Engineering, Environmental
Xiaomei Huang, Kaihang Xu, Lina Lyu, Chenhong Ding, Yarong Zhao, Xu Wang
Summary: This study found that the yield of monohydroxylated metabolites of chlorinated paraffins (CPs) decreased with increasing carbon chain length and chlorine content, while the monohydroxylated metabolites of short-chain CPs (SCCPs) reached a yield of 21%. These findings are important for improving the ecological/health risk assessment of CPs.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Biology
Yuanhe Yang, Yue Shi, Wenjuan Sun, Jinfeng Chang, Jianxiao Zhu, Leiyi Chen, Xin Wang, Yanpei Guo, Hongtu Zhang, Lingfei Yu, Shuqing Zhao, Kang Xu, Jiangling Zhu, Haihua Shen, Yuanyuan Wang, Yunfeng Peng, Xia Zhao, Xiangping Wang, Huifeng Hu, Shiping Chen, Mei Huang, Xuefa Wen, Shaopeng Wang, Biao Zhu, Shuli Niu, Zhiyao Tang, Lingli Liu, Jingyun Fang
Summary: Enhancing the terrestrial ecosystem carbon sink is crucial for slowing down the increase in atmospheric CO2 concentration and achieving carbon neutrality. This review summarizes the progress in terrestrial C budget researches, clarifies spatial patterns and drivers of terrestrial C sources and sinks, and examines the role of terrestrial C sinks in achieving carbon neutrality.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Review
Chemistry, Medicinal
Seol Hee Park, Young-Sun Lee, Jaemin Sim, Seonkyung Seo, Wonhyo Seo
Summary: Excessive alcohol consumption contributes significantly to liver diseases, and the liver is the primary organ for alcohol metabolism. The importance of non-oxidative alcohol metabolites in cellular damage has also been discovered. Furthermore, the impact of extrahepatic alcohol effects is crucial for the progression of alcoholic liver disease.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Review
Agriculture, Multidisciplinary
Zhenyu Wang, Maomao Zeng, Zhaojun Wang, Fang Qin, Jie Chen, Zhiyong He
Summary: This review discusses the role of dietary polyphenols in improving NAFLD by regulating the intestinal microecology. Polyphenols can control NAFLD through gut-brain-liver cross-talk, affecting microbial community structure, gut metabolites, and gut-derived hormones. Understanding the communication among the intestine, brain, and liver provides new insights into the mechanisms of dietary polyphenols in NAFLD pathology.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Microbiology
Lidan Yang, Yuzhao Dai, He He, Zhi Liu, Shenling Liao, Yu Zhang, Ga Liao, Zhenmei An
Summary: This study characterized the gut microbiome and overall changes in the fecal and serum metabolomes in patients with metabolic associated fatty liver disease (MAFLD). The results showed decreased species richness and diversity in the gut microbiome of MAFLD patients, as well as alterations in fecal and serum metabolites, particularly lipid molecules. The association analysis provided potential gut microbiota-metabolite combinations that could be important for further research and the development of diagnostic markers and treatments for MAFLD.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Chemistry, Medicinal
Djenisa H. A. Rocha, Diana C. G. A. Pinto, Artur M. S. Silva
Summary: Inflammation is the organism's response to injury and a major cause of death worldwide. Chronic inflammatory diseases pose the greatest threat to human health, and seaweeds offer potential as a source of anti-inflammatory compounds for drug development.
Review
Food Science & Technology
Min Kyo Jeong, Byeong Hyun Min, Ye Rin Choi, Ji Ye Hyun, Hee Jin Park, Jung A. Eom, Sung Min Won, Jin Ju Jeong, Ki Kwang Oh, Haripriya Gupta, Raja Ganesan, Satya Priya Sharma, Sang Jun Yoon, Mi Ran Choi, Dong Joon Kim, Ki Tae Suk
Summary: Diet and lifestyle are crucial factors that affect the occurrence of NAFLD. Personalized diet patterns can influence the composition and activity of gut microbiota, exacerbating NAFLD via the gut-liver axis. Advances in diagnostic technology have improved the diagnosis, treatment, and prognosis of NAFLD. Microbiota-derived metabolites play a significant role in the pathogenesis of NAFLD.
Article
Endocrinology & Metabolism
Ferrol Rome, Curtis C. Hughey
Summary: Loss of GNMT impairs liver oxidative metabolism and leads to nonalcoholic fatty liver disease. Higher SAM levels are associated with decreased gluconeogenesis and oxidative phosphorylation, but not with lower citric acid cycle flux. Methionine-restricted diet can prevent the increase in SAM and lipid accumulation caused by GNMT deficiency.
MOLECULAR METABOLISM
(2022)