期刊
TRENDS IN COGNITIVE SCIENCES
卷 21, 期 3, 页码 195-204出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tics.2017.01.002
关键词
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资金
- Henry Dale Fellowship - Wellcome Trust
- Royal Society [104128/Z/14/Z]
- NINDS [R01 NS095251, NS 095162]
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1150209] Funding Source: National Science Foundation
Textbooks teach us that the removal of sensory input to sensory cortex, for example, following arm amputation, results in massive reorganisation in the adult brain. In this opinion article, we critically examine evidence for functional reorganisation of sensory cortical representations, focusing on the sequelae of arm amputation on somatosensory topographies. Based on literature from human and non-human primates, we conclude that the cortical representation of the limb remains remarkably stable despite the loss of its main peripheral input. Furthermore, the purportedly massive reorganisation results primarily from the formation or potentiation of new pathways in subcortical structures and does not produce novel functional sensory representations. We discuss the implications of the stability of sensory representations on the development of upper-limb neuroprostheses.
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