4.6 Review

Ribosomal Chamber Music: Toward an Understanding of IRES Mechanisms

期刊

TRENDS IN BIOCHEMICAL SCIENCES
卷 42, 期 8, 页码 655-668

出版社

ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2017.06.002

关键词

-

向作者/读者索取更多资源

Internal initiation is a 50-end-independent mode of translation initiation engaged by many virus-and putatively some cell-encoded templates. Internal initiation is facilitated by specific RNA tertiary folds, called internal ribosomal entry sites (IRESs), in the 50 untranslated region (UTR) of the respective transcripts. In this review we discuss recent structural insight into how established IRESs first capture and then manipulate the eukaryotic translation machinery through non-canonical interactions and by guiding the intrinsic conformational flexibility of the eukaryotic ribosome. Because IRESs operate with reduced complexity and constitute minimal systems of initiation, comparison with canonical initiation may allow common mechanistic principles of the ribosome to be delineated.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据