期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 42, 期 3, 页码 219-231出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2016.10.008
关键词
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资金
- MRC core support to the MRC/UCL Laboratory for Molecular Cell Biology University Unit [MC_UU_1201814]
- Medical Research Council [MC_UU_00012/4, MC_UU_12018/4, MC_U122680443] Funding Source: researchfish
- MRC [MC_U122680443, MC_UU_00012/4, MC_UU_12018/4] Funding Source: UKRI
Phosphate, as a cellular energy currency, essentially drives most biochemical reactions defining living organisms, and thus its homeostasis must be tightly regulated. Investigation into the role of inositol pyrophosphates (PP-IPs) has provided a novel perspective on the regulation of phosphate homeostasis. Recent data suggest that metabolic and signaling interplay between PP-IPs, ATP, and inorganic polyphosphate (polyP) influences and is influenced by cellular phosphate homeostasis. Different studies have demonstrated that the SPX protein domain is a key component of proteins involved in phosphate metabolism. How PP-IPs control some aspects of phosphate homeostasis has become clearer with the recently acquired crystal structures of SPX domains. We review here recent studies on eukaryote phosphate homeostasis and provide insights into future research.
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