Article
Immunology
Mehdi Mohammadi, Mahmood Jeddi-Tehrani, Forough Golsaz-Shirazi, Mohammad Arjmand, Tannaz Bahadori, Mohammad Ali Judaki, Fariba Shiravi, Hengameh Ahmadi Zare, Farzaneh Notash Haghighat, Maryam Mobini, Mohammad Mehdi Amiri, Fazel Shokri
Summary: Overexpression of HER2 is common in many types of cancer, and the novel bispecific anti-HER2 antibody trasintuzumab, which combines trastuzumab and hersintuzumab, shows promising anti-tumor activity in preclinical studies, suggesting its potential as a therapeutic candidate for HER2-overexpressing cancers.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jie Chen, Zhidi Pan, Lei Han, Yuexian Zhou, Huifang Zong, Lei Wang, Rui Sun, Hua Jiang, Yueqing Xie, Yunsheng Yuan, Mingyuan Wu, Yanling Bian, Baohong Zhang, Jianwei Zhu
Summary: The study constructed a novel T cell-engaging bispecific antibody targeting Lewis Y and CD3, showing high affinity and anti-tumor activity against gastric cancer in vitro and in vivo. It demonstrated stronger T cell recruiting, activation, proliferation, cytokine release, and cytotoxicity compared to the parent monoclonal antibody, indicating potential therapeutic efficacy for gastric cancer.
Article
Oncology
Lisa A. King, Elisa C. Toffoli, Myrthe Veth, Victoria Iglesias-Guimarais, Manon C. Slot, Derk Amsen, Rieneke van de Ven, Sarah Derks, Marieke F. Fransen, Jurriaan B. Tuynman, Thilo Riedl, Rob C. Roovers, Anton E. P. Adang, Jurjen M. Ruben, Paul W. H. I. Parren, Tanja D. de Gruijl, Hans J. van der Vliet
Summary: This study assessed the antitumor activity and safety of a bispecific antibody that activates Vy9V82 T cells. In vitro, in vivo, and ex vivo experiments were conducted, and safety was evaluated in nonhuman primates. The findings demonstrated the potential of the antibody to activate Vy9V82 T cells for antitumor activity and its acceptable safety profile, providing a solid basis for further testing in patients with EGFR-positive malignancies.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Oncology
Lin Yu, Nan Huang, Heng Sun, Xi Yang, Yuna Fu, Qiaoli Lang, Jianhua Wang, Liangpeng Ge
Summary: This study engineered a highly stable and effective tetravalent BsAb h8B-BsAb targeting GPC3 and CD3 antigens as a potential candidate for HCC treatment. The BsAb showed potent T-cell recruitment and activation for HCC cell lysis in vitro, and induced robust regression of tumors in HCC xenograft mouse studies.
JOURNAL OF IMMUNOTHERAPY
(2021)
Article
Cell Biology
Xilin Wu, Lin Cheng, Ming Fu, Bilian Huang, Linjing Zhu, Shijie Xu, Haixia Shi, Doudou Zhang, Huanyun Yuan, Waqas Nawaz, Ping Yang, Qinxue Hu, Yalan Liu, Zhiwei Wu
Summary: Neutralizing nanobodies derived from an alpaca immunized with SARS-CoV-2 spike glycoprotein show potential therapeutic effects against COVID-19. A trimer of Nbs, Nb-15-NbH-Nb-15, exhibits high neutralization potency against SARS-CoV-2 live virus and variants with a long half-life. Intranasal administration of Nb-15-Nb-H-Nb-15 provides effective protection against SARS-CoV-2 infection in transgenic hACE2 mice for both prophylactic and therapeutic purposes.
Article
Medicine, General & Internal
Manley T. F. Huang, Vikram Sharma, Andrew Mendelsohn, Qisheng Wei, Jinjing Li, Bo Yu, James W. Larrick, Lawrence G. Lum
Summary: Bispecific antibody (BiAb)-armed activated T cells (BATs) show promise as a novel adoptive T cell therapy platform for treating various types of cancer.
ANNALS OF MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Ellie A. Mews, Pauline Beckmann, Mahathi Patchava, Yiao Wang, David A. Largaespada, Carston R. Wagner
Summary: This study presents bispecific chemically self-assembling nanorings targeting B7-H3 and CD3ε, which exhibit potent anti-tumor activity against medulloblastoma and reduce non-specific T cell activation. This novel technology holds promise as an alternative or complementary therapy for B7-H3(+) brain tumors.
Article
Biochemistry & Molecular Biology
Stefania C. Carrara, Jan P. Bogen, David Fiebig, Julius Grzeschik, Bjoern Hock, Harald Kolmar
Summary: This study focuses on the role of MerTK receptors in the clearance of apoptotic cells and successfully generates bispecific antibodies that can simultaneously bind EGFR and MerTK. These bispecific antibodies exhibit appropriate binding properties in vitro and promote phagocytosis between macrophages and cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Ramesh Duwa, Ram Hari Pokhrel, Asmita Banstola, Mahesh Pandit, Prakash Shrestha, Jee-Heon Jeong, Jae-Hoon Chang, Simmyung Yook
Summary: Bispecific nanoparticles enhance T cell cytotoxicity by targeting tumor-specific proteins and activating T cells to lyse tumor cells. The nanoparticles also activate dendritic cells and enhance T cell activation, leading to the inhibition of PD-L1 expressed cancer cells. In vivo experiments show that the nanoparticles significantly inhibit tumor growth and enhance intratumoral infiltration of CD4+ and CD8+ T cells, as well as tumor-infiltrated cytokines.
Article
Oncology
Aolin Shen, Wenting Liu, Huizhen Wang, Xiaoli Zeng, Mengli Wang, Dayan Zhang, Qun Zhao, Qing Fang, Fengrong Wang, Liansheng Cheng, Guodong Shen, Yongxiang Li
Summary: HK006, an Fc-muted IgG4 HER2/4-1BB bispecific antibody, exhibited synergistic antitumor activity by blocking HER2 signal transduction and stimulating 4-1BB signaling pathway simultaneously and dependent on HER2 expression in vitro and in vivo. Treatment with HK006 enhanced antitumor immunity by increasing and activating tumor-infiltrating T cells without inducing nonspecific production of proinflammatory cytokines and showed no obvious toxicity in mice.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Oncology
Martin Hutchings, Franck Morschhauser, Gloria Iacoboni, Carmelo Carlo-Stella, Fritz C. Offner, Anna Sureda, Gilles Salles, Joaquin Martinez-Lopez, Michael Crump, Denise N. Thomas, Peter N. Morcos, Cristiano Ferlini, Ann-Marie E. Broeske, Anton Belousov, Marina Bacac, Natalie Dimier, David J. Carlile, Linda Lundberg, David Perez-Callejo, Pablo Umana, Tom Moore, Martin Weisser, Michael J. Dickinson
Summary: The study evaluated the use of glofitamab in relapsed or refractory B-cell non-Hodgkin lymphoma (B-NHL) patients. The results showed favorable activity of glofitamab in patients with predominantly refractory, aggressive B-NHL, with frequent and durable complete responses and a predictable and manageable safety profile.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Jie Chen, Zhidi Pan, Lei Han, Junjun Liu, Yali Yue, Xiaodong Xiao, Baohong Zhang, Mingyuan Wu, Yunsheng Yuan, Yanlin Bian, Hua Jiang, Yueqing Xie, Jianwei Zhu
Summary: This study generated CD22-TCBs with different avidity to different domains on CD22 protein, and found that the avidity of CD22-TCBs to protein was not consistent with the avidity to target cells. The cytotoxicity of CD22-TCBs depended on the avidity of antibodies to target cells. The distal binding domain of the antigen contributed to the avidity and biological activity of CD22-TCBs.
Article
Multidisciplinary Sciences
Alex A. Shepherd, Bigitha D. Bennychen, Anne Marcil, Darin Bloemberg, Robert Pon, Risini A. Weeratna, Scott A. McComb
Summary: Bi-specific T-cell engager antibodies (BiTEs) are synthetic fusion molecules that induce active contact between T-cells and antigen expressing cells. The current process for BiTE development is time-consuming and costly. This study aims to establish a cost-efficient method for generating and evaluating novel BiTE sequences without purification.
Article
Oncology
Shiyu Liu, Fan Li, Li Deng, Qiongqiong Ma, Wenyi Lu, Zhuoqian Zhao, Huanzhen Liu, Yixuan Zhou, Manli Hu, Hui Wang, Yingbin Yan, Mingfeng Zhao, Hongkai Zhang, Mingjuan Du
Summary: The combination of bispecific T cell engagers (BiTEs) and oncolytic viruses (OVs) has shown promising results in the treatment of pancreatic cancer, improving the tumor microenvironment, enhancing immune response, and inhibiting tumor growth.
MOLECULAR THERAPY-ONCOLYTICS
(2023)
Article
Biochemistry & Molecular Biology
Natasa Vukovic, Samer Halabi, Joan Salvador Russo-Cabrera, Bart Blokhuis, Pedro Berraondo, Frank A. M. Redegeld, Dietmar M. W. Zaiss
Summary: Bispecific antibodies (bsAbs) targeting two different antigens offer a higher level of specificity and improved clinical efficacy in cancer therapy compared to monoclonal antibodies (mAbs). We successfully developed dual tumor-associated antigen-targeting bispecific human IgE antibodies to combine the promising potential of IgE molecules with increased target selectivity. These IgE bsAbs demonstrate potent antibody-dependent cell toxicity and have significant clinical application potential.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Obstetrics & Gynecology
Hai-Tao Pan, Xiao-Liang Shi, Min Fang, Xiang-Mei Sun, Pan-Pan Chen, Jin-Long Ding, Gui-Yu Xia, Bin Yu, Tao Zhang, Hong-Dan Zhu
Summary: This study identified differential expression of umbilical serum Exo-miRNAs in patients with preeclampsia compared to normal pregnancies, suggesting that these Exo-miRNAs may be associated with microvascular dysfunction in offspring of mothers with preeclampsia.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Genetics & Heredity
Tao Zhang, Hua Yuan, Hongdan Zhu, Yuyi Ying, Jinlong Ding, Haigang Ding, Xiaoliang Shi, Yao He, Haitao Pan, Yongxing Zhong
Summary: This study reports a case of fetal congenital heart disease (CHD) caused by rare compound heterozygous mutations in the DNAH9 gene in a Chinese patient. The 3D structure and functional changes of the DNAH9 protein were predicted.
FRONTIERS IN GENETICS
(2022)
Article
Psychology, Developmental
Kayla N. LaRosa, Erin MacArthur, Fang Wang, Hui Zhang, Haitao Pan, Jane Brigden, Alberto Pappo, Matthew W. Wilson, Valerie McLaughlin Crabtree
Summary: The study found that bright white light (BWL) has a positive effect on the quality of life and depressive symptoms of adolescents and young adults (AYAs) receiving cancer-directed therapy. These findings will guide future larger randomized controlled trials.
JOURNAL OF PEDIATRIC PSYCHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Guiyu Xia, Yunyi Gao, Canlan Wu, Haitao Pan, Jingyu Hou, Jinfeng Su, Saisai Wei, Xiangwei Gao
Summary: In this study, we identified two alternative translation start codons in Hadh mRNA using QTI-seq. We found that translation from the upstream start codon encodes the mitochondrial isoform of HADH, while translation from the downstream start codon produces a short isoform (HADH-S) with predominant nuclear localization. Additionally, overexpression of HADH-S was shown to inhibit cell proliferation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Chemistry, Medicinal
Xing Chen, Yaoyao Yan, Juncheng Du, Xiaobao Shen, Chuanbiao He, Haitao Pan, Jun Zhu, Xinhua Liu
Summary: In this study, a novel Cat C inhibitor SF38 was identified through structure-based design and modification. SF38 exhibited strong inhibitory activity against Cat C, showed anti-inflammatory effects, and had acceptable PK properties.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Hansong Xue, Song Liu, Wei Xie, Yang Zhou, Jianbo Peng, Haitao Pan, Dingfei Zhang, Fusheng Pan
Summary: The effects of different Dy additions on the microstructure and mechanical properties of Mg-6Zn-1Mn-3Sn (wt%, ZMT613) alloys were investigated. The study found that Dy addition resulted in significant grain refinement and the formation of new MgSnDy phases. A small amount of Dy (≤0.8 wt%) hindered the proportion of dynamic recrystallized grains during the hot-extrusion process and enhanced the basal texture of the alloy. MgSnDy high-temperature phase particles inhibited the recovery process and promoted the precipitation of the second phase. The ZMT613-0.2Dy alloy showed optimum mechanical properties after aging, with yield strength, ultimate tensile strength, and elongation reaching 336 MPa, 399 MPa, and 4.4%, respectively.
MATERIALS CHARACTERIZATION
(2022)
Article
Materials Science, Multidisciplinary
Hansong Xue, Wei Xie, Song Liu, Yang Zhou, Jianbo Peng, Haitao Pan, Dingfei Zhang, Fusheng Pan
Summary: This paper investigates the effect of La addition on the Al-RE phase in Mg-Al-Zn-Ce magnesium alloy. The results show that adding La can change the morphology of the Al11RE3 phase and a transformation mechanism is proposed. La replaces part of Ce in the Al11Ce3 phase, resulting in the formation of Al11RE3 phase. In the Al11RE3 phase, La doping leads to lattice distortion and accelerates the growth rate in a specific direction, forming a tubular structure.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)
Article
Mathematical & Computational Biology
Jianrong Wu, Haitao Pan, Chia-Wei Hsu
Summary: Phase II exploratory multiarm studies that randomize among new treatments are valuable in both scientific and logistical aspects, especially in unmet needs. This design allows for faster recruitment and more treatment choices compared to traditional two-arm randomized controlled trials. The screened selection design (SSD) ranks treatment arms based on effect size, requiring smaller sample sizes compared to other multistage designs.
BIOMETRICAL JOURNAL
(2022)
Article
Materials Science, Multidisciplinary
Yang Zhou, Hansong Xue, Jianbo Peng, Haitao Pan, Wei Xie, Song Liu, Dingfei Zhang, Bin Jiang, Fusheng Pan
Summary: In this work, an Mg-8Zn-1Mn-3Sn-1.2Gd-0.2Dy alloy with excellent combination of tensile strength and ductility is successfully prepared. The formation mechanism of Dy-modified MgSnGd phase and its effect on the microstructure and mechanical properties of the alloy are systematically investigated. The addition of Dy promotes dynamic recrystallization and inhibits the growth of MgSnGd phase, resulting in the alloy exhibiting high strength and ductility.
MATERIALS & DESIGN
(2022)
Article
Pharmacology & Pharmacy
Xiao Su, Yisheng Li, Peter Mueller, Chia-Wei Hsu, Haitao Pan, Kim-Anh Do
Summary: This paper proposes a new framework for modeling the dose-response relationship in oncology phase I dose-finding designs by incorporating pharmacokinetic data and the hypothesized mechanisms of drug effects. The resulting design improves upon common designs and considers the impact of dose, schedule, and method of administration on toxicity. The performance of this design is comparable to other designs when there is significant departure from the underlying drug effect mechanism.
PHARMACEUTICAL STATISTICS
(2022)
Article
Hematology
Andrew M. Heitzer, Jane E. Schreiber, Xiaomeng Yuan, Fang Wang, Haitao Pan, J. Carolyn Graff, Laura Murphy, Rebecca Rupff, Kathryn Russell, Winfred Wang, Jeremie H. Estepp, Jane S. Hankins, Jerlym S. Porter, Lisa M. Jacola
Summary: Children with sickle cell disease are at risk of neurobehavioural problems. This study found that preschool children with sickle cell disease had worse performance in executive function, working memory, and school readiness compared to healthy controls. The study also showed that the primary caregiver's college education was positively associated with school readiness in sickle cell disease patients.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Oncology
Thomas E. Merchant, Sonal Dangda, Mary Ellen Hoehn, Shengjie Wu, Yimei Li, Fang Wang, Haitao Pan, Frederick A. Boop, Niki Jurbergs, Heather M. Conklin
Summary: This study investigated the cognitive outcomes of pediatric patients with craniopharyngioma after conformal photon radiation therapy and the effects of visual deficits and hormone deficiencies. The results showed that younger age and higher doses to the temporal lobes and hippocampi were associated with lower intellectual functioning. Black race and cerebrospinal fluid shunting were linked to lower baseline intelligence quotient. Patients treated for growth hormone deficiency within 12 months of radiation therapy had better intelligence and attention outcomes. It is recommended to improve treatment selection, minimize damage to normal tissues, and manage endocrinopathy in pediatric craniopharyngioma patients.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Plant Sciences
Zhenhao Li, Haitao Pan, Jihong Yang, Dongjie Chen, Yu Wang, Han Zhang, Yiyu Cheng
Summary: This study demonstrates that Xuanfei Baidu Formula (XBF) exhibits anti-acute lung injury (ALI) and anti-inflammatory effects by restoring mitochondrial dynamics and suppressing inflammasome activation, providing a biological explanation for the clinical efficacy of XBF in treating COVID-19 patients.
Article
Pharmacology & Pharmacy
Jingjing Ye, Vickie Zhang, Foteini Strimenopoulou, Yihua Zhao, Haitao Pan, Mayadah Shabbout, Margaret Gamalo
Summary: The regulatory standards of the FDA require substantial evidence of effectiveness for drugs developed in both adults and children, but extrapolation may still be acceptable. This study reviewed pediatric labeling changes published by the FDA between 1/1/2015 and 7/31/2021, and found that 63.8% of the drugs identified used extrapolation. Extrapolation was most commonly used in neuroscience and infectious disease, and its use increased the rates of new and expanded pediatric indications.
JOURNAL OF BIOPHARMACEUTICAL STATISTICS
(2023)
Article
Statistics & Probability
Chengxue Zhong, Hongyu Miao, Haitao Pan
Summary: Ordinal endpoints are commonly used in clinical studies, such as COVID-19 infection therapies evaluation. However, design methods for ordinal endpoints are limited, and a dichotomized approach is often used for simplicity. This study introduces a Bayesian group sequential scheme to assess ordinal endpoints, considering various scenarios and providing desirable performance through extensive simulations. The R package BayesOrdDesign is publicly available.
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES C-APPLIED STATISTICS
(2023)
Article
Oncology
Xiaofan Pu, Chaolei Zhang, Guoping Ding, Hongpeng Gu, Yang Lv, Tao Shen, Tianshu Pang, Liping Cao, Shengnan Jia
Summary: This study demonstrated the potential utility of the sEV-miRNA d-signature in the diagnosis of PDAC via machine learning methods. A novel sEV biomarker, miR-664a-3p, was identified for the diagnosis of PDAC. It can also potentially promote angiogenesis and metastasis, provide insight into PDAC pathogenesis, and reveal novel regulators of this disease.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Jiaping Wang, Zhijuan Xu, Yanli Lai, Yanli Zhang, Ping Zhang, Qitian Mu, Shujun Yang, Yongcheng Sun, Lixia Sheng, Guifang Ouyang
Summary: This study demonstrates the significance of PD-1 in EBV-infected lymphoma cells. Silencing PD-1 enhances the tumor targeting effect of EBV-specific killer T cells on B lymphocytes and attenuates the immune escape effect.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Qiliang Peng, Jialong Tao, Yingjie Xu, Yi Shen, Yong Wang, Yang Jiao, Yiheng Mao, Yaqun Zhu, Yulong Liu, Ye Tian
Summary: This study investigates the potential role of lipid metabolism-associated genes (LMAGs) in neoadjuvant chemoradiotherapy (nCRT) and immunotherapy for rectal cancer. The results suggest that the SREBF2 gene is a highly predictive factor for nCRT in rectal cancer and is associated with favorable prognosis. SREBF2 is also closely associated with immune cell infiltration and immunotherapy-related genes.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Shiquan Li, Nan Zhang, Yongping Yang, Tongjun Liu
Summary: This study investigated the potential molecular mechanism of SPDEF in immune evasion of colorectal cancer (CRC) and found that it suppresses immune evasion by activating CCL28 through the modulation of M2 polarization of macrophages. These findings provide a new research direction and potential therapeutic target for immunotherapy in CRC.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Manas Sehgal, Soundharya Ramu, Joel Markus Vaz, Yogheshwer Raja Ganapathy, Srinath Muralidharan, Sankalpa Venkatraghavan, Mohit Kumar Jolly
Summary: This study investigates the relationship between gene expression patterns and phenotypic plasticity and heterogeneity in colorectal cancer (CRC). The results demonstrate the interconnectedness between different Consensus Molecular Subtypes (CMS) of CRC and specific phenotypes such as epithelial and mesenchymal characteristics. Additionally, the study reveals correlations between metabolic pathways and phenotypic scores, as well as between PD-L1 activity and mesenchymal phenotype. Single-cell RNA sequencing analysis further confirms the heterogeneity of different CMS subtypes. These findings have important implications for understanding CRC heterogeneity and developing targeted therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yutong Zou, Siyao Guo, Yan Liao, Weidong Chen, Ziyun Chen, Junkai Chen, Lili Wen, Xianbiao Xie
Summary: This study found that ceramide metabolism is associated with the progression and clinical outcome of osteosarcoma by analyzing data from osteosarcoma patients. The gene ST3GAL1 plays an important role in osteosarcoma, regulating the tumor immune microenvironment and affecting T cell function. It may become a new target for the treatment of osteosarcoma.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Chuanhui Chen, Mengzhi Wan, Xiong Peng, Qing Zhang, Yu Liu
Summary: This study examines the function and mechanism of the ceRNA network centered around GPR37 in LUAD. The findings show that high expression of GPR37 in LUAD tissue samples is associated with poor prognosis, and it may regulate the expression of downstream target genes by competitively binding to lncRNA DLEU1 and miR-4458.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Junping Li, Hong Hu, Jinping He, Yuling Hu, Manting Liu, Bihui Cao, Dongni Chen, Xiaodie Ye, Jian Zhang, Zhiru Zhang, Wen Long, Hui Lian, Deji Chen, Likun Chen, Lili Yang, Zhenfeng Zhang
Summary: Sequential administration of CDC7 inhibitor XL413 after carboplatin enhances the chemotherapeutic effect of carboplatin on ovarian cancer cells, possibly by inhibiting homologous recombination repair activity and increasing the accumulation of chemotherapy-induced DNA damage.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Madison Catalanotto, Joel Markus Vaz, Camille Abshire, Reneau Youngblood, Min Chu, Herbert Levine, Mohit Kumar Jolly, Ana -Maria Dragoi
Summary: The study demonstrates that loss of FLASH in cancer cells leads to a hybrid E/M phenotype with high epithelial scores, suggesting FLASH acts as a repressor of the epithelial phenotype. Additionally, FLASH expression is inversely correlated with the epithelial score and subsets of mesenchymal markers are distinctly up-regulated in FLASH, NPAT, or SLBP-depleted cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Xiaorui Wang, Na Li, Minying Zheng, Yongjun Yu, Shiwu Zhang
Summary: Adipocytes are derived from pluripotent mesenchymal stem cells and histone modifications play a key role in their differentiation. Recent studies have shown that cancer stem cells can differentiate into adipocytes, reducing the malignancy of cancer cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Hana Q. Sadida, Alanoud Abdulla, Sara Al Marzooqi, Sheema Hashem, Muzafar A. Macha, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat
Summary: Cancer heterogeneity and drug resistance are major obstacles to effective cancer treatment, and epigenetic modifications play a pivotal role in these processes. This review explores essential epigenetic modifications, including DNA methylation, histone modifications, and chromatin remodeling, and discusses their complex contributions to cancer biology. However, the interplay of epigenetic and genetic changes in cancer cells presents unique challenges that must be addressed to fully exploit the potential of epigenetic modifications.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Pedro De Marchi, Leticia Ferro Leal, Luciane Sussuchi da Silva, Rodrigo de Oliveira Cavagna, Flavio Augusto Ferreira da Silva, Vinicius Duval da Silva, Eduardo C. A. da Silva, Augusto O. Saito, Vladmir C. Cordeiro de Lima, Rui Manuel Reis
Summary: The TIS and IFN-gamma signatures are predictive biomarkers for identifying NSCLC patients who could potentially benefit from immune checkpoint inhibitor therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Giovanni Marchi, Anna Rajavuori, Mai T. N. Nguyen, Kaisa Huhtinen, Sinikka Oksa, Sakari Hietanen, Sampsa Hautaniemi, Johanna Hynninen, Jaana Oikkonen
Summary: The study shows that ctDNA can adequately represent high-grade serous ovarian carcinoma (HGSC), and the mutations observed at relapse suggest personalized therapy options.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yuncang Yuan, Jiawei Fan, Dandan Liang, Shijie Wang, Xu Luo, Yongjie Zhu, Nan Liu, Tingxiu Xiang, Xudong Zhao
Summary: This study demonstrates that csGRP78-directed CAR-T cells can selectively kill pancreatic cancer cells, and the combination with chemotherapy enhances cytotoxicity.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Niyati Piplani, Tanusri Roy, Neha Saxena, Shamik Sen
Summary: The glycocalyx, a protective barrier surrounding cells, has been found to play a role in cancer cell proliferation, survival, and metastasis. However, its function in maintaining DNA/nuclear integrity during migration through dense matrices has not been explored. This study shows that the bulkiness of the glycocalyx is inversely associated with nuclear stresses, and highlights its mechanical role in shielding migration-associated stresses.
TRANSLATIONAL ONCOLOGY
(2024)