Article
Food Science & Technology
Namhee Kim, Jieun Lee, Hye Seon Song, Young Joon Oh, Min-Sung Kwon, Misun Yun, Seul Ki Lim, Hyo Kyeong Park, Young Seo Jang, Sulhee Lee, Sang-Pil Choi, Seong Woon Roh, Hak-Jong Choi
Summary: This study found that kimchi can suppress obesity-induced inflammation and exert its effects by changing gut microbiota composition and short-chain fatty acids production.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Food Science & Technology
Ce Chen, Han Liang, Jiaoyang Wang, Guoqing Ren, Renshi Li, Zheng-Guo Cui, Chaofeng Zhang
Summary: This study found that Heterophyllin B (HB) improves symptoms of ulcerative colitis (UC) and alleviates intestinal mucosal barrier dysfunction by activating AMPK and reshaping gut microbiota.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Immunology
Tuo Chen, Rong Wang, Zhenglan Duan, Xiaomin Yuan, Yang Ding, Zeyu Feng, Fan Bu, Li Liu, Qiong Wang, Jinyong Zhou, Lei Zhu, Qing Ni, Guoping Shi, Yugen Chen
Summary: Psychological disorders are linked to a greater risk of severe inflammatory bowel disease due to disruptions in gut microbiota balance and colonic mucosal barriers. Chronic restraint stress has been shown to alter microbiota composition and colonic mucus, exacerbating colitis symptoms.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Agriculture, Dairy & Animal Science
Bohan Rong, Qiong Wu, Muhammad Saeed, Chao Sun
Summary: This paper focuses on the interaction between intermittent fasting and gut microbiota, highlighting the potential positive effects on host energy metabolism. It also discusses a potential recommended strain (Akkermansia muciniphila) and a regulatory pathway (circadian rhythm) for gut microbiota in improving host energy metabolism in IF.
Article
Biotechnology & Applied Microbiology
Peishun Li, Boyang Ji, Hao Luo, Daniel Sundh, Mattias Lorentzon, Jens Nielsen
Summary: Recent studies have demonstrated the beneficial effects of probiotic supplementation on bone metabolism, specifically showing that Lactobacillus reuteri ATCC PTA 6475 supplementation can reduce bone loss in older women with low bone mineral density. Secondary analysis of good responders and poor responders in a randomized controlled trial revealed that good responders had higher gene richness of gut microbiota and improved inflammatory state after 12 months of daily supplementation.
NPJ BIOFILMS AND MICROBIOMES
(2022)
Article
Chemistry, Multidisciplinary
Jiang-Hua Liu, Chun-Yuan Chen, Zheng-Zhao Liu, Zhong-Wei Luo, Shan-Shan Rao, Ling Jin, Teng-Fei Wan, Tao Yue, Yi-Juan Tan, Hao Yin, Fei Yang, Fei-Yu Huang, Jian Guo, Yi-Yi Wang, Kun Xia, Jia Cao, Zhen-Xing Wang, Chun-Gu Hong, Ming-Jie Luo, Xiong-Ke Hu, Yi-Wei Liu, Wei Du, Juan Luo, Yin Hu, Yan Zhang, Jie Huang, Hong-Ming Li, Ben Wu, Hao-Ming Liu, Tuan-Hui Chen, Yu-Xuan Qian, You-You Li, Shi-Kai Feng, Yang Chen, Lu-Yue Qi, Ran Xu, Si-Yuan Tang, Hui Xie
Summary: Recent studies have shown that gut microbiota from children can prevent decreases in bone mass and strength in osteoporotic mice induced by ovariectomy. The secretion of extracellular vesicles plays a crucial role in the bone-protective effects induced by gut microbiota and the bacterium Akkermansia muciniphila.
Article
Biochemistry & Molecular Biology
Wangting Zhou, Xuhui Kan, Guijie Chen, Yi Sun, Linwu Ran, Yamei Yan, Jia Mi, Lu Lu, Xiaoxiong Zeng, Youlong Cao
Summary: The purified fraction of polysaccharides from Lycium barbarum fruits (LBPs-4) was found to have therapeutic effects on DSS-induced colitis in mice. LBPs-4 reduced disease activity index score, prevented colon shortening, and reduced plasma levels of pro-inflammatory cytokines. LBPs-4 also improved gut microbiota composition, mitigated intestinal barrier damage, and promoted the growth of beneficial bacteria. These findings suggest that LBPs-4 could be a potential prebiotic for colitis treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Cell Biology
Zaker I. Schwabkey, Diana H. Wiesnoski, Chia-Chi Chang, Wen-Bin Tsai, Dung Pham, Saira S. Ahmed, Tomo Hayase, Miriam R. Ortega Turrubiates, Rawan K. El-Himri, Christopher A. Sanchez, Eiko Hayase, Annette C. Frenk Oquendo, Takahiko Miyama, Taylor M. Halsey, Brooke E. Heckel, Alexandria N. Brown, Yimei Jin, Mathilde Raybaud, Rishika Prasad, Ivonne Flores, Lauren McDaniel, Valerie Chapa, Philip L. Lorenzi, Marc O. Warmoes, Lin Tan, Alton G. Swennes, Stephanie Fowler, Margaret Conner, Kevin McHugh, Tyler Graf, Vanessa B. Jensen, Christine B. Peterson, Kim-Anh Do, Liangliang Zhang, Yushu Shi, Yinghong Wang, Jessica R. Galloway-Pena, Pablo C. Okhuysen, Carrie R. Daniel-MacDougall, Yusuke Shono, Marina Burgos da Silva, Jonathan U. Peled, Marcel R. M. van den Brink, Nadim Ajami, Jennifer A. Wargo, Pavan Reddy, Raphael H. Valdivia, Lauren Davey, Gabriela Rondon, Samer A. Srour, Rohtesh S. Mehta, Amin M. Alousi, Elizabeth J. Shpall, Richard E. Champlin, Samuel A. Shelburne, Jeffrey J. Molldrem, Mohamed A. Jamal, Jennifer L. Karmouch, Robert R. Jeng
Summary: A study suggests that the fecal microbiome may be involved in neutropenic fever, a condition where not all patients with cancer and severe neutropenia develop fever. The study found that patients who developed fever had increased levels of Akkermansia muciniphila, a mucin-degrading bacteria species, in their fecal microbiome. Therapy-induced neutropenia and caloric restriction in mice also led to an expansion of A. muciniphila and a thinning of the colonic mucus layer. Antibiotics targeting A. muciniphila or propionate were found to preserve the mucus layer, reduce inflammation, and improve thermoregulation in irradiated mice. These findings suggest that diet, metabolites, and colonic mucus are important factors linking the microbiome to neutropenic fever and may guide future preventive strategies.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Qihuan Deng, Wenjun Wang, Lieyuan Zhang, Lingli Chen, Qingfeng Zhang, Ying Zhang, Sichen He, Jingen Li
Summary: Gougunao tea polysaccharides (GTP40) alleviate high-fat diet-induced hyperlipidemia and regulate gut microbiota, reducing fat accumulation, inflammation, and restoring normal microbial balance in the gut.
Article
Microbiology
Ruirui He, Jianwen Chen, Ziyan Zhao, Changping Shi, Yanyun Du, Ming Yi, Lingyun Feng, Qianwen Peng, Zhihui Cui, Ru Gao, Heping Wang, Yi Huang, Zhi Liu, Chenhui Wang
Summary: Recent research has found that common variants of the T-cell activation Rho GTPase-activating protein (TAGAP) are associated with susceptibility to inflammatory bowel diseases (IBDs) in humans, but the underlying mechanisms are still unclear. This study showed that TAGAP deficiency or downregulation of TAGAP expression caused by TAGAP gene polymorphism leads to decreased production of antimicrobial peptides (AMPs), such as reg3g, which in turn disrupts the gut microbiota, including Akkermansia muciniphila and Bacteroides acidifaciens strains. These strains can polarize T helper cell differentiation in the gut and exacerbate the phenotype of dextran sodium sulfate-induced disease in mice. Importantly, the study demonstrated that recombinant reg3g protein or anti-p40 monoclonal antibody had therapeutic effects in the treatment of dextran sodium sulfate-induced colitis, suggesting their potential as medicines for human IBD treatment, especially for patients carrying the common variant of TAGAP rs212388.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maria Juarez-Fernandez, David Porras, Petar Petrov, Sara Roman-Sagueillo, Maria Victoria Garcia-Mediavilla, Polina Soluyanova, Susana Martinez-Florez, Javier Gonzalez-Gallego, Esther Nistal, Ramiro Jover, Sonia Sanchez-Campos
Summary: The combination of the antioxidant quercetin and the bacterium Akkermansia muciniphila in an animal model of early obesity and NAFLD can modulate gut microbiota, reduce body fat, improve fatty liver, increase the abundance of beneficial bacteria, decrease the levels of harmful bacteria, raise bile acids levels, and enhance the expression of liver genes related to bile acid metabolism.
Article
Nutrition & Dietetics
Qianqian Yao, Yanan Gao, Linlin Fan, Jiaqi Wang, Nan Zheng
Summary: This study aimed to investigate the alleviating effect of 2'-fucosyllactose (2'-FL) on colitis-induced liver injury and its mechanism of influencing metabolism by regulating gut microbiota. The results showed that 2'-FL could improve liver oxygen stress in colitis mice and regulate gut microbiota and metabolites, especially glycometabolism and lipid-metabolism-related metabolites, thereby alleviating liver oxygen stress.
Article
Biochemistry & Molecular Biology
Cheng Fang, Jinyan Cheng, Wei Jia, Yan Xu
Summary: This study investigated the impact of Akkermansia muciniphila on alcoholic liver disease (ALD) using a mouse model. The results showed that oral administration of A. muciniphila alleviated alcohol-induced liver injury, altered serum metabolomic profiles, and regulated gut microbiota composition. These findings provide a theoretical basis for the development of A. muciniphila as a potential therapeutic approach for preventing and managing ALD.
Article
Cell Biology
Bin Wang, Yu-xiao Jin, Jia-li Dong, Hui-wen Xiao, Shu-qin Zhang, Yuan Li, Zhi-yuan Chen, Xiao-dong Yang, Sai-jun Fan, Ming Cui
Summary: The study demonstrates that walking can alleviate radiation-induced gastrointestinal toxicity, showing protective effects in mice by helping to rebuild gut microbiota structure and reshape gut metabolome. Importantly, walking does not alter tumor growth after radiotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qiang-Ming Li, Xue-Qiang Zha, Wei-Nan Zhang, Jian Liu, Li-Hua Pan, Jian-Ping Luo
Summary: The study demonstrates that Laminaria japonica polysaccharide has a significant effect on inhibiting atherosclerosis and improving insulin resistance induced by high-fat diet in mice, along with reducing obesity, inflammation, metabolic endotoxemia, and gut permeability. Additionally, it can regulate gut microbiota, especially Akkermansia, to achieve these effects.
Article
Biochemistry & Molecular Biology
Jia Li, Feifei Gu, Chao Cai, Minghua Hu, Luodi Fan, Jiejie Hao, Guangli Yu
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Biochemistry & Molecular Biology
Chao Li, Qingfeng Niu, Shijie Li, Xin Zhang, Chanjuan Liu, Chao Cai, Guoyun Li, Guangli Yu
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Immunology
Fei Liu, Jianxin Fu, Kirk Bergstrom, Xindi Shan, J. Michael McDaniel, Samuel McGee, Xia Bai, Weichang Chen, Lijun Xia
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Article
Chemistry, Applied
Xueliang Wang, Hao Jiang, Ning Zhang, Chao Cai, Guoyun Li, Jiejie Hao, Guangli Yu
CARBOHYDRATE POLYMERS
(2020)
Article
Chemistry, Applied
Qingfeng Niu, Guoyun Li, Chao Li, Qinying Li, Jia Li, Chanjuan Liu, Lin Pan, Shijie Li, Chao Cai, JieJie Hao, Guangli Yu
CARBOHYDRATE POLYMERS
(2020)
Article
Medicine, Research & Experimental
Yan Liu, Haiyan Lin, Lin Jiang, Qingsen Shang, Lei Yin, Jiandie D. Lin, Wen-Shu Wu, Liangyou Rui
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Chemistry, Applied
Xueliang Wang, Zimei Yang, Xu Xu, Hao Jiang, Chao Cai, Guangli Yu
CARBOHYDRATE POLYMERS
(2020)
Article
Multidisciplinary Sciences
Qiong Li, Depeng Wang, Donghui Bai, Chao Cai, Jia Li, Chengxiu Yan, Shuai Zhang, Zhijun Wu, Jiejie Hao, Guangli Yu
Article
Chemistry, Medicinal
Xindi Shan, Xueliang Wang, Hao Jiang, Chao Cai, Jiejie Hao, Guangli Yu
Article
Multidisciplinary Sciences
Kirk Bergstrom, Xindi Shan, David Casero, Albert Batushansky, Venu Lagishetty, Jonathan P. Jacobs, Christopher Hoover, Yuji Kondo, Bojing Shao, Liang Gao, Wesley Zandberg, Benjamin Noyovitz, J. Michael McDaniel, Deanna L. Gibson, Sepideh Pakpour, Negin Kazemian, Samuel McGee, Courtney W. Houchen, Chinthalapally V. Rao, Timothy M. Griffin, Justin L. Sonnenburg, Rodger P. McEver, Jonathan Braun, Lijun Xia
Review
Chemistry, Organic
Xinru Li, Depeng Wang, Ping Zhang, Guangli Yu, Chao Cai
Summary: The ocean is a rich source of active compounds, including small organic molecules, proteins, lipids, and carbohydrates with diverse biological functions. Chemical synthesis is a powerful approach to obtaining marine carbohydrates, with a focus on marine acidic carbohydrates such as alginate and glycosaminoglycans. Recent advances in the synthesis of marine acidic carbohydrates have laid a foundation for the development of novel marine carbohydrate-based drugs and functional reagents.
CURRENT ORGANIC CHEMISTRY
(2021)
Review
Biochemical Research Methods
Lin Pan, Chao Cai, Chanjuan Liu, Di Liu, Guoyun Li, Robert J. Linhardt, Guangli Yu
Summary: Carbohydrates, ubiquitous in nature, are essential biomolecules with untapped potential in pharmaceutical applications. Advanced techniques in carbohydrate-based drug development, such as enzymatic synthesis and carbohydrate libraries, have accelerated the pace of drug discovery, offering new opportunities for novel carbohydrate drugs.
CURRENT OPINION IN BIOTECHNOLOGY
(2021)
Article
Polymer Science
Chendong Yang, Lei Gao, Meng Shao, Chao Cai, Lihao Wang, Yifan Chen, Jianghua Li, Fei Fan, Yubing Han, Ming Liu, Robert J. Linhardt, Guangli Yu
Article
Materials Science, Biomaterials
Jianghua Li, Yang Zhang, Chao Cai, Xiaozhi Rong, Meng Shao, Jiarui Li, Chendong Yang, Guangli Yu
BIOMATERIALS SCIENCE
(2020)