Article
Environmental Sciences
Christine W. Lee, Amber L. Cathey, Deborah J. Watkins, Zaira Y. Rosario-Pabon, Carmen M. Velez-Vega, Akram N. Alshawabkeh, Jose F. Cordero, John D. Meeker
Summary: This study examined the impact of maternal phthalate exposures on inflammatory processes and found that phthalates may play a role in mediating the maternal inflammatory response, with significant sexual dimorphism observed. These findings have implications for adverse pregnancy outcomes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Cell Biology
Jiali You, Wei Wang, Hsun-Ming Chang, Yuyin Yi, Hongjin Zhao, Hua Zhu, Yu Sun, Minyue Tang, Chunyan Wang, Yimiao Sang, Guofang Feng, Shaobing Cheng, Peter C. K. Leung, Yi-Min Zhu
Summary: Embryo implantation and trophoblast invasion are critical for establishing pregnancy, with BMP2 playing a significant role in regulating these processes by influencing gene expression and promoting the development and invasion of embryo and trophoblast cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Developmental Biology
Tomoaki Yoshida, Kazuhide Takada, Shihoko Komine-Aizawa, Yoshimasa Kamei, Osamu Ishihara, Satoshi Hayakawa
Summary: Recent studies indicate that Lactobacillus crispatus can promote trophoblast invasion by increasing the activation of MMP-1 and MMP-2, without affecting migration. This suggests that the dominance of Lactobacillus in the endometrium may be beneficial for implantation, but further research is needed to determine if it is favorable for successful placentation at the early stage of pregnancy.
Review
Nutrition & Dietetics
Yushu Qin, Donalyn Bily, Makayla Aguirre, Ke Zhang, Linglin Xie
Summary: The increasing incidence of pregnancy complications, such as gestational diabetes mellitus and preeclampsia, is a cause for concern. The pathogenesis of these complications involves the pathological placenta, and the transcription factor PPARγ may have a critical role. While PPARγ agonists show potential in treating preeclampsia, their safety during pregnancy is not yet established.
Article
Biochemistry & Molecular Biology
Zhenzhen Liu, Jiangnan Pei, Xiaoyue Zhang, Chengjie Wang, Yao Tang, Haiyan Liu, Yi Yu, Shouling Luo, Weirong Gu
Summary: This study investigated the role of apolipoprotein A1 (APOA1) in the pathophysiology of preeclampsia (PE). The expression of APOA1 was found to be elevated in both plasma and placental tissues of PE patients. Importantly, the concentration of APOA1 was positively associated with systolic blood pressure during late gestation. Additionally, APOA1 was found to promote the proliferation and invasion of trophoblast, possibly through the activation of the transcription factor PPARγ.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Audrey Antoine, Coraline De Sousa Do Outeiro, Coline Charnay, Corinne Belville, Fanny Henrioux, Denis Gallot, Loic Blanchon, Regine Minet-Quinard, Vincent Sapin
Summary: Phthalates, as reprotoxic pollutants, are found everywhere in the environment. They may disrupt the PPAR gamma pathway and lead to premature rupture of fetal membranes.
Article
Biochemistry & Molecular Biology
Lena Neuper, Daniel Kummer, Desiree Forstner, Jacqueline Guettler, Nassim Ghaffari-Tabrizi-Wizsy, Cornelius Fischer, Herbert Juch, Olivia Nonn, Martin Gauster
Summary: This study investigated the effects of candesartan on trophoblastic PPAR gamma and its target genes in early gestation. The results showed that candesartan did not negatively affect PPAR gamma or its target genes in human trophoblasts, but may influence angiogenesis in the placenta.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Hironori Takahashi, Manabu Ogoyama, Shiho Nagayama, Hirotada Suzuki, Akihide Ohkuchi, Shigeki Matsubara, Toshihiro Takizawa
Summary: The study demonstrated that WNT3A, WNT5A, and WNT10B can accelerate invasion in EVT cell lines and isolated primary EVTs, upregulating CD44 and MMP9 expression. WNT10B may act as a novel accelerator of EVT invasion, suggesting that WNT signaling mediated by multiple ligands contributes to EVT invasion.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Shinji Takai, Denan Jin
Summary: Chymase-activated MMP-9 is closely related to the pathogenesis of various diseases, especially inflammation-related diseases. Upregulated chymase and MMP-9 have been observed in tissues from patients and animal models of these diseases. Chymase inhibitors attenuate MMP-9 formation and reduce inflammatory cell numbers, thereby ameliorating the development and progression of these disorders.
Article
Biochemistry & Molecular Biology
Manabu Ogoyama, Akihide Ohkuchi, Hironori Takahashi, Dongwei Zhao, Shigeki Matsubara, Toshihiro Takizawa
Summary: The study revealed that miR-675-5p promotes EVT cell invasion by inhibiting GATA2 and upregulating matrix metalloproteinases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Reihaneh Alsadat Mahmoudian, Maryam Lotfi Gharaie, Mohammad Reza Abbaszadegan, Ali Alasti, Mohammad Mahdi Forghanifard, Atena Mansouri, Mehran Gholamin
Summary: This study investigated the expression of MMP-13, TWIST1, and CD44 in ESCC and found significant correlations with clinical features, such as tumor progression and invasion. The results suggest that the TWIST1-CD44-MMP-13 axis may be involved in tumor aggressiveness and could serve as diagnostic markers and therapeutic targets in ESCC.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Cell Biology
Eliza Grbac, Teresa So, Swati Varshney, Nicholas Williamson, Evdokia Dimitriadis, Ellen Menkhorst
Summary: Research suggests that prednisolone affects the expression of cytokines and protein production in human endometrial stromal fibroblasts (hESF), altering their regulation of trophoblast cells. Decidualization of hESF in the presence of prednisolone enhances trophoblast cell growth and influences the expression of cell motility genes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Greta Barbaro, Annalisa Inversetti, Martina Cristodoro, Carlo Ticconi, Giovanni Scambia, Nicoletta Di Simone
Summary: Placentation is a process where maternal immune cells and trophoblastic cells interact to achieve immune balance. HLA-G, expressed on trophoblastic cells, plays a crucial role in modulating maternal immune response. Recurrent pregnancy loss (RPL), affecting 5% of pregnant women, with 40-60% cases unexplained, shares immunological similarities with allograft rejection. This review aims to explain how alterations in the HLA-G pathway disrupt immune balance and increase the risk of RPL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Han-Soo Kim, Ha Jeong Kim, Mi Ra Lee, Ilkyu Han
Summary: The study found that the expression level of EMMPRIN in osteosarcoma is associated with metastasis-free survival, and EMMPRIN plays an important role in osteosarcoma metastasis by regulating the production of MMP and VEGF.
Article
Biochemistry & Molecular Biology
Lu Gao, Qian-Han Xu, Li-Na Ma, Jing Luo, Kahindo P. Muyayalo, Li-Ling Wang, Dong-Hui Huang, Xian-Jin Xiao, Shi-Bin Cheng, Gil Mor, Ai-Hua Liao
Summary: This study reveals the important role of lactic acid metabolism in the differentiation of decidual macrophages during early pregnancy, contributing to immune tolerance. Lactic acid can induce the polarization of M2 or M1 macrophages through regulation of oxidative phosphorylation and glycolysis under different oxygen levels. The inhibition of lactic acid metabolism through the HIF-1 alpha/SRC/LDHA pathway is involved in recurrent pregnancy loss. Blocking lactic acid intake rescues pregnancy in an abortion-prone mouse model, suggesting a potential therapeutic target in recurrent pregnancy loss.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Engineering, Environmental
Zhaomin Dong, Tong Li, Yi Wan, Yibin Sun, Jianying Hu
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2020)
Article
Engineering, Environmental
Shixiong Gao, Hang Liu, Hong Chang, Zhaobin Zhang, Jianying Hu, Shu Tao, Yi Wan
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2020)
Article
Engineering, Environmental
Ichiro Yoshida, Keishi Ishida, Hiroshi Yoshikawa, Sho Kitamura, Youhei Hiromori, Yasushi Nishioka, Akiko Ido, Tomoki Kimura, Jun-ichi Nishikawa, Jianying Hu, Hisamitsu Nagase, Tsuyoshi Nakanishi
JOURNAL OF HAZARDOUS MATERIALS
(2020)
Article
Environmental Sciences
Haifeng Zhang, Yingting Jia, Zhuoheng Tang, Lei Wang, Wenxin Hu, Junmin Gao, Jianying Hu, Min Yang
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Article
Environmental Sciences
Qiyue Kang, Fumei Gao, Xiaohua Zhang, Lei Wang, Jiaying Liu, Min Fu, Shiyi Zhang, Yi Wan, Huan Shen, Jianying Hu
ENVIRONMENT INTERNATIONAL
(2020)
Article
Environmental Sciences
Yibin Sun, Hongyang Cui, Tong Li, Shu Tao, Jianying Hu, Yi Wan
ENVIRONMENT INTERNATIONAL
(2020)
Article
Engineering, Environmental
Lei Wang, Qiyue Kang, Yingting Jia, Xinjian Li, Jianying Hu
Summary: This study identified a rare chloroalkyl OPTE, DEGBBCPP, as well as DEGBBCEP and EBBCEP in house dust samples. DEGBBCPP had a relatively high detection rate and concentration, indicating a need for further research on its potential health effects.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Engineering, Environmental
Yu Li, Haojia Ma, Ruichao Chen, Hong Zhang, Tsuyoshi Nakanishi, Jianying Hu
Summary: The study shows that EHDPP could potentially affect fish embryo development through maternal transfer, leading to eye deformities and vision disorders, posing a potential risk to wild fish populations.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Editorial Material
Engineering, Environmental
Qiyue Kang, Qiang Li, Lei Wang, Yingting Jia, Xiaohua Zhang, Jianying Hu
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Environmental Sciences
Huizhong Shen, Weiying Hou, Yaqi Zhu, Shuxiu Zheng, Subinuer Ainiwaer, Guofeng Shen, Yilin Chen, Hefa Cheng, Jianying Hu, Yi Wan, Shu Tao
Summary: This study investigated spatiotemporal variations and source contributions of indoor PM2.5 in a typical apartment in Beijing using low-cost sensors. It was found that indoor particulate matter predominantly originates from outdoor infiltration and cooking emissions, with the latter contributing more fine particles. Indoor PM2.5 concentrations were correlated with ambient levels but generally lower, with the predominant indoor source being cooking.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Fumei Gao, Xiangrui Meng, Qiuxiang Zhang, Min Fu, Yumeng Ren, Jianying Hu, Huan Shen, Kun Tang
Summary: The study found that cleaning the house less than twice a week was significantly associated with an elevated risk of miscarriage, which was also linked to cough during day or night. Therefore, it is recommended that pregnant women clean their homes at least twice a week to reduce the risk of miscarriage.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Haojia Ma, Keishi Ishida, Chenke Xu, Kyosuke Takahashi, Yu Li, Chenhao Zhang, Qiyue Kang, Yingting Jia, Wenxin Hu, Daisuke Matsumaru, Tsuyoshi Nakanishi, Jianying Hu
Summary: The study found that TPhP delayed puberty timing in mice and affected ovarian function, possibly by inhibiting estrogen receptor signaling. After 40 days of exposure to TPhP, a significant decrease in the number of follicles was observed in mice, indicating a decline in ovarian reserve.
ENVIRONMENTAL POLLUTION
(2021)
Article
Green & Sustainable Science & Technology
Qirui Zhong, Shu Tao, Jianmin Ma, Junfeng Liu, Huizhong Shen, Guofeng Shen, Dabo Guan, Xiao Yun, Wenjun Meng, Xinyuan Yu, Hefa Cheng, Dongqiang Zhu, Yi Wan, Jianying Hu
Summary: Air pollution is a significant environmental issue in China, and the country has made progress in reducing PM2.5 levels since the introduction of the Air Pollution Prevention and Control Action Plan in 2013. However, there is still some discrepancy between observed reductions and the actual decrease in PM2.5 levels. Research suggests that if current control efforts continue, the long-term air quality target set for 2035 will be met.
Article
Environmental Sciences
Songlin Xiang, Junfeng Liu, Wei Tao, Kan Yi, Jiayu Xu, Xiurong Hu, Huazhen Liu, Yuqing Wang, Yizhou Zhang, Haozhe Yang, Jianying Hu, Yi Wan, Xuejun Wang, Jianmin Ma, Xilong Wang, Shu Tao
ATMOSPHERIC ENVIRONMENT
(2020)
Article
Multidisciplinary Sciences
Xiao Yun, Guofeng Shen, Huizhong Shen, Wenjun Meng, Yilin Chen, Haoran Xu, Yuang Ren, Qirui Zhong, Wei Du, Jianmin Ma, Hefa Cheng, Xilong Wang, Junfeng Liu, Xuejun Wang, Bengang Li, Jianying Hu, Yi Wan, Shu Tao