Article
Medicine, General & Internal
Xing Li, Lijiang Gu, Yuhang Chen, Xiaobing Wang, Yibo Mei, Jinlai Zhou, Minghai Ma, Jianbin Ma, Yue Chong, Xinyang Wang, Peng Guo, Dalin He, Jin Zeng
Summary: The study found that the novel 450-nm laser-mediated DVDMS-based photodynamic therapy (PDT) can inhibit and induce apoptosis in gastric cancer cells by producing excessive reactive oxygen species (ROS). Additionally, PDT also promoted apoptosis in gastric cancer cells through the autophagy pathway. Furthermore, the study identified the involvement of the ROS/PI3K/Akt/mTOR pathway in the regulation of PDT-induced autophagy.
Article
Chemistry, Medicinal
Kenji Mishiro, Ryuichi Nishii, Izumi Sawazaki, Tomoki Sofuku, Takeshi Fuchigami, Hitomi Sudo, Nurmaya Effendi, Akira Makino, Yasushi Kiyono, Kazuhiro Shiba, Junichi Taki, Seigo Kinuya, Kazuma Ogawa
Summary: Researchers attempted to develop nuclear imaging probes for detecting EGFR mutations. They designed and synthesized radioactive or nonradioactive osimertinib derivatives and evaluated their activity. The results showed that these derivatives accumulated significantly higher in tumors with mutations compared to normal tissues, but they also showed high accumulation in the lungs. Therefore, further structural modifications of the probes are needed.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Food Science & Technology
Hsin-Ling Yang, Sheng-Teng Huang, Zi-He Lyu, Asif Ali Bhat, Chithravel Vadivalagan, Yu-Lyu Yeh, You-Cheng Hseu
Summary: Coenzyme Q0 (CoQ0) from Antrodia camphorata exhibits therapeutic benefits in cancer treatment by activating apoptotic and autophagic cell death pathways.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Chemistry, Medicinal
Haojie Dong, Xiuquan Ye, Yasheng Zhu, Hao Shen, Hongtao Shen, Weijiao Chen, Minghui Ji, Mingming Zheng, Keren Wang, Zeyu Cai, Haopeng Sun, Yibei Xiao, Peng Yang
Summary: In this study, a series of Osimertinib derivatives were designed as fourth-generation inhibitors targeting Osimertinib-resistant NSCLC. The top candidate D51 showed potent inhibition against EGFR mutants, selectivity against wild-type forms, and favorable in vivo druggability.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Jiali Yuan, Luke Mo, Yiqun Mo, Yuanbao Zhang, Yue Zhang, Qunwei Zhang
Summary: This study evaluated the toxic effects and mechanisms of fine airborne particulate matter (PM2.5) on human glioblastoma LN-229 cells. The results showed that PM2.5 exposure reduced cell viability and increased autophagy, apoptosis, and ROS production. Further experiments revealed that PM2.5-induced autophagy and apoptosis were mainly caused by ROS generation, particularly by mitochondria, and JNK activation.
Article
Biochemistry & Molecular Biology
Yu Chen, Ping Li, Yueting Peng, Xiaoxue Xie, Yixi Zhang, Ying Jiang, Tingting Li, Xiang Qin, Shun Li, Hong Yang, Chunhui Wu, Chuan Zheng, Jie Zhu, Fengming You, Yiyao Liu
Summary: The study demonstrates that the soft substrate-induced ROS/JNK signaling increases cell apoptosis and protective autophagy by promoting the interaction of Bcl-2 and Beclin-1 and suppressing the interaction of Bcl-2 and Beclin-1, respectively, in human breast cancer cells.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Cell Biology
Hiwot Tezera Endale, Winta Tesfaye, Tiget Ayelgn Mengstie
Summary: Reactive oxygen species (ROS) are involved in cell death processes, such as apoptosis, autophagy, and ferroptosis. ROS play a role in lipid oxidation and generate compounds like 4-hydroxynonenal. Lipid peroxidation may facilitate ferroptosis. In order to explore disorders related to these processes, we evaluate the function of ROS in lipid peroxidation leading to ferroptosis and propose crosstalk mechanisms between ferroptosis and other types of programmed cell death.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Environmental Sciences
Jing Chen, Yaxia Yao, Yijia Wang, Xiaotong Wang, Xia Peng, Tianli Li, Ying Liu, Juan Du
Summary: Maternal cigarette smoking during pregnancy is a high-risk factor for cleft lip and/or palate in infants. Nicotine induces autophagy in mouse embryonic palatal cells (MEPCs) through the ROS/ERK1/2 signaling pathway, which may protect the cells from nicotine-induced damage.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Oncology
Xinying Li, Cen Chen, Zimu Wang, Jiaxin Liu, Wei Sun, Kaikai Shen, Yanling Lv, Suhua Zhu, Ping Zhan, Tangfeng Lv, Yong Song
Summary: The study indicated that exosomal miRNAs participate in osimertinib resistance mechanisms through the activation of bypass pathways (RAS-MAPK pathway abnormality and PI3K pathway activation). Increased expression levels of exosome-derived miR-184 and miR-3913-5p may serve as biomarkers for osimertinib resistance in NSCLC patients.
CANCER CELL INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Juliann Chmielecki, Jhanelle E. Gray, Ying Cheng, Yuichiro Ohe, Fumio Imamura, Byoung Chul Cho, Meng-Chih Lin, Margarita Majem, Riyaz Shah, Yuri Rukazenkov, Alexander Todd, Aleksandra Markovets, J. Carl Barrett, Ryan J. Hartmaier, Suresh S. Ramalingam
Summary: By sequencing circulating tumor DNA in patients from the FLAURA trial, this study identifies MET amplification and EGFR C797S mutation as the most frequent acquired resistance mechanisms to first-line osimertinib.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Shiori Mori, Rina Fujiwara-Tani, Momoko Gyoten, Shota Nukaga, Rika Sasaki, Ayaka Ikemoto, Ruiko Ogata, Shingo Kishi, Kiyomu Fujii, Hiroki Kuniyasu
Summary: Berberine (BBR) inhibits the proliferation, invasion, and drug resistance of gastrointestinal cancer cells, and induces cell death by inhibiting mitochondrial complex I and enhancing complex II activities. These effects are associated with autophagy and reactive oxidative species production. BBR shows significant anti-tumor and anti-stemness effects, making it a potential new cell death-inducing agent for the treatment of gastrointestinal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jing-Ru Weng, Balraj Gopula, Po-Chen Chu, Jing-Lan Hu, Chia-Hsien Feng
Summary: This study investigated the anti-tumor activity of a PKM2 inhibitor called MTP in oral squamous cell carcinoma cells. The results showed that MTP inhibited cell growth, induced apoptosis, and modulated the expression of PKM2 and oncogenic biomarkers. In addition, MTP increased reactive oxygen species generation and affected the expression of autophagic genes. These findings suggest that MTP has potential therapeutic use for oral squamous cell carcinoma.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Pharmacology & Pharmacy
Fanfan Liang, Kaina Zhang, Wenzhuo Ma, Heqin Zhan, Qiang Sun, LaiHua Xie, Zhenghang Zhao
Summary: Sorafenib disrupts autophagy and mitochondrial dynamics, leading to oxidative stress and cardiomyocyte apoptosis. Improving autophagy or inhibiting mitochondrial fission can attenuate Sorafenib-induced cardiotoxicity.
Article
Oncology
Kai Lu, Hsin-Chiao Wang, Yi-Chen Tu, Cheng-Chung Chang, Pei-Jen Lou, Ta-Chau Chang, Jing-Jer Lin
Summary: In this study, the G-quadruplex ligand BMVC-8C3O was shown to suppress acquired resistance to osimertinib in non-small cell lung cancer cells. Combination treatment of BMVC-8C3O and osimertinib had a synergistic inhibitory effect on the growth of resistant tumors both in vitro and in vivo.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Cell Biology
Coralie F. Daussy, Mathilde Galais, Baptiste Pradel, Veronique Robert-Hebmann, Sophie Sagnier, Sophie Pattingre, Martine Biard-Piechaczyk, Lucile Espert
Summary: The immunodeficiency observed in HIV-1-infected patients is mainly due to bystander CD4(+)T lymphocyte cell death, triggered by the viral envelope glycoprotein Env-induced autophagy and oxidative stress. Env-mediated autophagy targets peroxisomes, leading to the degradation of these organelles and contributing to immunodeficiency induced by HIV-1.
Review
Oncology
Yu-Chi Chen, Wei Shi, Jia-Jie Shi, Jin-Jian Lu
Summary: The development of CD47 targeting agents faces hematotoxicity as a common side effect, but strategies such as changing the mode of administration and using bispecific antibodies can mitigate this issue.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chong Sun, Lin Zhao, Xianzhe Wang, Ying Hou, Xiuli Guo, Jin-Jian Lu, Xiuping Chen
Summary: This study found that Psoralidin (PSO) can induce apoptosis in colon cancer cells through oxidative damage mediated by caspase 3/7 activation and ROS generation.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Cell Biology
Jia Liu, Qing Zhang, Yuanyuan Chen, Lingyu Wang, Ting Tao, Qiang Ren, Xiuping Chen, Yunhui Chen
Summary: This study investigated the protective effect and potential mechanisms of Cinnamomi Ramulus (CR) on rheumatoid arthritis (RA) using multiple approaches. The results showed that CR could ameliorate RA symptoms, inhibit inflammation and oxidative damage, possibly through regulating the TNF and IL-17 signaling pathways.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biochemistry & Molecular Biology
Qing-Xin Ji, Fei-Yan Zeng, Jian Zhou, Wen-Bin Wu, Xu-Jie Wang, Zhen Zhang, Guo-Yan Zhang, Jie Tong, Di-Yang Sun, Jia-Bao Zhang, Wen-Xiang Cao, Fu-Ming Shen, Jin-Jian Lu, Dong-Jie Li, Pei Wang
Summary: This study explores the potential role of ferroptosis in smooth muscle cell (SMC) phenotypic switch and neointimal formation. It found that ferroptotic stress is triggered in dedifferentiated SMCs and arterial neointimal tissue. Inhibition of ferroptosis delays SMC phenotype switch and arterial remodeling, while ferroptosis stress directly triggers SMC dedifferentiation.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Biochemistry & Molecular Biology
Min-Hui Chen, Fong Leong, Si-Jia Gao, Xin Chen, Jin-Jian Lu, Li-Gen Lin, Yitao Wang, Xiao-Jia Chen
Summary: A reliable method was developed for the simultaneous determination of nine chemical components in Chuanmaidong, Zhemaidong, and SMD, and significant differences in their contents were found. The anticancer effects of Chuanmaidong and Zhemaidong extracts were stronger than those of SMD.
Review
Pharmacology & Pharmacy
Zi-Han Ye, Wei-Bang Yu, Mu-Yang Huang, Jun Chen, Jin-Jian Lu
Summary: This review discusses the clinical and preclinical cases of combination therapies targeting CD47, explores their mechanisms of action, and shares ideas for the future.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Oncology
Ziyou Lin, Jingwei Li, Jian Zhang, Weineng Feng, Jiaye Lu, Xiaofan Ma, Wen Ding, Shumin Ouyang, Jinjian Lu, Peibin Yue, Guohui Wan, Peiqing Liu, Xiaolei Zhang
Summary: Acquired resistance is a bottleneck for targeted therapy in lung cancer, and metabolic adaptation may contribute to it. This study discovered a novel mechanism of acquired resistance to EGFR tyrosine kinase inhibitors mediated by IGF2BP3-dependent cross-talk between epigenetic modifications and metabolic reprogramming. IGF2BP3 upregulation is associated with reduced overall survival in TKI-resistant non-small cell lung cancer patients.
Article
Biochemistry & Molecular Biology
Qingwen Xiao, Bingling Zhong, Ying Hou, Miaojuan Wang, Baojian Guo, Ligen Lin, Yinning Zhou, Xiuping Chen
Summary: Isobavachalcone (IBC), a natural chalcone, induces non-apoptotic cell death in lung and breast cancer cells mediated by reactive oxygen species (ROS), triggering non-canonical mitochondrial permeability transition-driven necrosis. This process relies on cyclophilin D (CypD) and could potentially be used as a novel strategy for cancer treatment.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Plant Sciences
Chuanhong Wu, Feipeng Duan, Ruocong Yang, Yaolan Dai, Xiuping Chen, Shaojing Li
Summary: This study found that 15, 16-Dihydrotanshinone I (DHT) can protect against ferroptosis and ischemic stroke by activating the Nrf2 signaling pathway.
Review
Pharmacology & Pharmacy
Jie Yu, Bingling Zhong, Lin Zhao, Ying Hou, Nana Ai, Jin-Jian Lu, Wei Ge, Xiuping Chen
Summary: Drug resistance is a significant challenge in cancer treatment, and a natural NQO1 substrate called MAM has been found to have a potent anticancer effect. This study aimed to investigate the efficacy of MAM against drug-resistant non-small cell lung cancer. The results showed that MAM induces ferroptosis by targeting NQO1, leading to ROS generation, LIP increase, and lipid peroxidation. Furthermore, MAM significantly suppressed tumor growth in a zebrafish model. These findings provide a novel therapeutic strategy for overcoming drug resistance in NSCLC by inducing NQO1-mediated ferroptosis.
DRUG RESISTANCE UPDATES
(2023)
Review
Biochemistry & Molecular Biology
Zeyang Shao, Heng Wang, Haiyan Ren, Yinxiang Sun, Xiuping Chen
Summary: Napabucasin, a natural naphthoquinone, has been identified as a cancer cell stemness inhibitor. It has demonstrated significant anticancer effects in various types of cancers by inhibiting cancer stemness through targeting STAT3 and its related gene inhibition. It also inhibits cancer cell proliferation, induces apoptosis and cell cycle arrest, and suppresses metastasis and relapse.
Article
Pathology
Xin-Yuan Li, Xin-Yu He, Hong Zhao, Lu Qi, Jin-Jian Lu
Summary: This study identified MRPL9 as an upregulated gene in lung cancer tissues, which was associated with poor prognosis. Knockdown of MRPL9 inhibited lung cancer cell proliferation, sphere formation, and migration ability. MRPL9 was associated with the c-MYC signaling pathway and its co-expression with MYC correlated with a worse prognosis in lung cancer patients. Bioinformatics analysis revealed the association between c-MYC and the EMT regulator ZEB1. Interfering with c-MYC expression confirmed the relationship between ZEB1 and c-MYC. Thus, MRPL9 may serve as a potential therapeutic target for lung cancer by affecting c-MYC and regulating ZEB1.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Cell Biology
Xianzhe Wang, Wei Shi, Xumei Wang, Jin-Jian Lu, Ping He, Hongjie Zhang, Xiuping Chen
Summary: In this study, it was found that combining nifuroxazide with palbociclib uncouples senescence-associated secretory phenotype (SASP) production from cell cycle exit and promotes growth arrest and senescence in triple-negative breast cancer (TNBC) cells. Nifuroxazide acts as a dual inhibitor of STAT3 and CDK2. The combination of nifuroxazide with palbociclib also inhibits TNBC cell proliferation and blocks SASP-dependent cancer cell migration. In animal models, the combination treatment suppresses tumor growth and metastasis.
CELL DEATH DISCOVERY
(2023)
Article
Oncology
Xin-Ling He, Wen-Yu Lyu, Xin-Yuan Li, Hong Zhao, Lu Qi, Jin-Jian Lu
Summary: Traditional Chinese medicine (TCM) has been used widely in cancer treatment. This study identifies glycogen phosphorylase L (PYGL) as a targeted protein for TCMs in various cancer types, with its expression level correlated with lung cancer stage and poor prognosis. Knockdown of PYGL inhibits proliferation and migration in lung cancer cells. PYGL is also associated with cellular components related to mitosis in lung cancer and is susceptible to upregulation by mutated genes. Therefore, PYGL is a potential target for lung cancer treatment, influencing cellular mitotic function through energy metabolism regulation.
Article
Engineering, Biomedical
Yue Quan, Ziyu Huang, Yuxin Wang, Yu Liu, Sen Ding, Qian Zhao, Xiuping Chen, Haifeng Li, Zikang Tang, Bingpu Zhou, Yinning Zhou
Summary: This study investigated the responses of H9c2 cells to ultramicromagnetic micropillar arrays and found that these micropillars significantly enhanced cell proliferation, cytoskeletal rearrangements, and contractility. Additionally, they were able to decrease reactive oxygen species (ROS) levels, preventing F-actin degeneration. These findings have important implications for the regulation and detection of cell behaviors.
MATERIALS TODAY BIO
(2023)