Article
Environmental Sciences
Fan Hu, Weifeng Liang, Linke Zhang, Huan Wang, Zimu Li, Yifeng Zhou
Summary: The study found that both BPA and BPS exposure in mice can negatively impact emotion and social interaction, and high-dose exposure can lead to abnormal local neuronal activation. Although BPS has less adverse effects on mice at low doses compared to BPA, there are still risks associated with prolonged high-volume exposure.
Article
Biochemistry & Molecular Biology
Yan Wang, Xiaoyu Xiu, Shengzhou Wu
Summary: The study suggests a potential link between Dicer1 and Alzheimer's disease, showing that exposure to A13O can affect Dicer1 protein and mRNA levels in neurons. A13O regulates Dicer1 stability in neurons by influencing its phosphorylation level.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Engineering, Environmental
Bo Wang, Ting Zhao, Xiao-Xi Chen, Yan-Yan Zhu, Xue Lu, Qing-Hua Qian, Hui-Ru Chen, Xiu-Hong Meng, Hua Wang, Wei Wei, De-Xiang Xu
Summary: The study found that gestational exposure to 1-NP caused anxiety-like behavior in male adult offspring and impaired dendritic arborization, dendritic length, and dendritic spine density in the ventral hippocampus. Gephyrin-related genes, Nrg1 and Erbb4, were also decreased in 1-NP-exposed fetuses, along with decreased TET activity and α-KG content in the fetal forebrain. Supplementation with α-KG ameliorated the effects of 1-NP, improving synaptic plasticity and anxiety-like behavior in male adult offspring.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Behavioral Sciences
Kethely L. Marques, Milena L. Moreira, Maria C. Thiele, Marta C. Cunha-Rodrigues, Penha C. Barradas
Summary: Perinatal hypoxia-ischemia (HI) is a major cause of morbidity and mortality in newborns, and infants with HI encephalopathy may suffer from long-term consequences such as depression in adulthood. This study investigated the effects of a prenatal HI model on depressive-like behavior, neuronal population, and markers of monoaminergic and synaptic plasticity in the prefrontal cortex of adolescent rats. The results showed that the HI group exhibited reduced sucrose consumption and increased immobility in behavioral tests, as well as decreased neuronal density and synaptic marker levels. These findings highlight the importance of this model in studying the effects of HI-induced injuries on mood modulation circuits.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
S. Rao Sirasanagandla, Isehaq Al-Huseini, R. G. Sumesh Sofin, Srijit Das
Summary: Bisphenol A (BPA) is a commonly used industrial compound, and evidence suggests that perinatal exposure to BPA increases the risk of cardiovascular diseases. Developmental programming and epigenetic modifications of genes may play a role in this impact.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Nair C. F. Castro, Izabelle S. Silva, Sabrina C. Cartagenes, Luanna M. P. Fernandes, Paula C. Ribera, Mayara A. Barros, Rui D. Prediger, Eneas A. Fontes-Junior, Cristiane S. F. Maia
Summary: This study evaluated the long-lasting neurobehavioral and nociceptive consequences in adult rats and mice exposed to morphine during pregnancy and lactation periods. The results showed that both male and female rats exhibited anxiety- and depressive-like behaviors, while mice displayed alterations in nociceptive responses. These findings suggest that intrauterine and lactation exposure to morphine can have long-lasting effects on psychological and pain responses in adulthood.
Article
Pharmacology & Pharmacy
Maarten C. Bosland, Michael J. Schlicht, Nicole Acevedo, Ana M. Soto, Gail Prins
Summary: This study aimed to determine the effects of perinatal exposure to bisphenol A (BPA) on induction of prostate cancer in rats. The results showed that perinatal BPA exposure did not significantly affect the incidence of prostate carcinomas but significantly reduced the occurrence of malignant tumors at any site in the body in rats.
Article
Biochemistry & Molecular Biology
Ming-Kuei Shih, You-Lin Tain, Yu-Wei Chen, Wei-Hsuan Hsu, Yao-Tsung Yeh, Sam K. C. Chang, Jin-Xian Liao, Chih-Yao Hou
Summary: The study showed that Resveratrol butyrate esters (RBE) can suppress obesity and lipid accumulation caused by Bisphenol A (BPA) exposure in female offspring rats, optimize blood lipids, and modulate intestinal microbiota. RBE demonstrated excellent potential for perinatological research due to its regulatory effects on body weight, blood lipids, and gut microbiota in the offspring rats exposed to BPA.
Review
Environmental Sciences
Radia Bousoumah, Veruscka Leso, Ivo Iavicoli, Pasi Huuskonen, Susana Viegas, Simo P. Porras, Tiina Santonen, Nadine Frery, Alain Robert, Sophie Ndaw
Summary: This study found a lack of recent occupational HBM studies on bisphenols, especially on BPS and BPF. Different methodological designs make comparisons between studies difficult. Few studies have been conducted on the industrial applications of bisphenols outside of Asia.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Ran Ji, Mengqiao Cui, Dongyu Zhou, Xiaoyuan Pan, Yuqi Xie, Xiling Wu, Xin Liang, Hongxing Zhang, Weiyi Song
Summary: BPA exposure during adulthood can lead to sex-specific anxiety-like behaviors in mice, particularly in males. The hyperactivity of glutamatergic neurons in the paraventricular thalamus appears to be a key factor contributing to this anxiety. The down-regulation of alpha-1D adrenergic receptor in the PVT may also play a role in BPA-induced anxiety.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Neurosciences
Kohei Takahashi, Kazuhiro Kurokawa, Lihua Hong, Kazuya Miyagawa, Atsumi Mochida-Saito, Hiroshi Takeda, Minoru Tsuji
Summary: This study found that decreased activity of hippocampal SirT2 is associated with the development of depression in olfactory bulbectomized mice, possibly by regulating synaptic plasticity and cell proliferation to modulate psychological state.
NEUROSCIENCE RESEARCH
(2022)
Article
Environmental Sciences
Chao Zhang, Xiao-chang Wu, Sha Li, Lian-jie Dou, Li Zhou, Feng-hui Wang, Kai Ma, Dan Huang, Ying Pan, Ji-jun Gu, Ji-yu Cao, Hua Wang, Jia-hu Hao
Summary: The study found that perinatal exposure to low-dose Bisphenol AF affects the cognitive function of adult mouse offspring, with a more pronounced effect on male offspring. Impairments in dendritic arborization and cognitive function were observed in male offspring, while only high-dose exposure affected female offspring. Additionally, BPAF disrupted the balance of oxidation and antioxidation in the hippocampus of male offspring.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Neurosciences
Suguru Kawato, Mari Ogiue-Ikeda, Mika Soma, Hinako Yoshino, Toshihiro Kominami, Minoru Saito, Shuji Aou, Yasushi Hojo
Summary: Perinatal exposure to BPA at a very low dose affects the development of synapses in the hippocampus, leading to changes in dendritic spine density in adult rats. This exposure also alters the estrous cycle in females and results in different effects on spine density between males and females.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Environmental Sciences
Yi Guo, Yuxin Kang, Wenjie Bai, Qiling Liu, Rongqiang Zhang, Yuxin Wang, Chong Wang
Summary: This study demonstrates that exposure to BPA during prenatal and early postnatal periods affects behavior and memory in male rat offspring, and the alteration in expression of GABA signaling molecules may be one of the molecular mechanisms causing this effect.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Eric Gyimah, Hai Xu, Xing Dong, Xuchun Qiu, Zhen Zhang, Yuanqing Bu, Osei Akoto
Summary: Exposure to low concentrations of BPA and BPS during embryonic development can have deleterious effects on the central nervous system development and induce behavioral abnormalities in zebrafish, potentially by interfering with the normal expression of development-related genes.