Review
Cell Biology
Fatma Rashed, Shingo Kamijyo, Yuri Shimizu, Yuna Hirohashi, Masud Khan, Yasutaka Sugamori, Ramachandran Murali, Kazuhiro Aoki
Summary: RANKL-binding peptides can stimulate osteoblast differentiation through RANKL-reverse signaling, while OPG cannot achieve the same effect. This may be due to the ability of RANKL-binding peptides to promote the accumulation and membrane clustering of RANKL molecules on the surface of osteoblasts, thus activating osteoblast differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Lin Song, Lijuan Cao, Rui Liu, Hui Ma, Yanan Li, Qianwen Shang, Zhiyuan Zheng, Liying Zhang, Wen Zhang, Yuyi Han, Xiaoren Zhang, Huilin Yang, Ying Wang, Gerry Melino, Changshun Shao, Yufang Shi
Summary: Despite the widespread clinical use of glucocorticoids (GC), their detailed molecular mechanism in inducing osteoporosis is not fully understood. Research shows that lymphocytes play a critical role in regulating GC-induced osteoporosis.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Karim Sahbani, Laura C. Shultz, Christopher P. Cardozo, William A. Bauman, Hesham A. Tawfeek
Summary: In mice with T cell deficiency, immobilization following spinal cord injury led to marked reduction in bone volume and more severe deterioration of bone structure compared to wild-type mice.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Kridtapat Sirisereephap, Tomoki Maekawa, Hikaru Tamura, Takumi Hiyoshi, Hisanori Domon, Toshihito Isono, Yutaka Terao, Takeyasu Maeda, Koichi Tabeta
Summary: Periodontitis is a common oral disease resulting from dysbiosis of the oral microbiome, leading to interference with the host immune system and bone destruction. Immune cells activate periodontal ligament cells to express RANKL and promote osteoclast activity, with osteocytes playing an active role in periodontitis progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Betsabel Chicana, Nastaran Abbasizadeh, Christian Burns, Hanna Taglinao, Joel A. Spencer, Jennifer O. Manilay
Summary: This study investigates the mechanisms of B cell defects in bone marrow caused by the loss of von-Hippel Lindau protein (VHL). The result shows that there is an increase in the frequency and number of B cell progenitors in VhlcKO bone marrow, while Fransctions B-F are decreased. VhlcKO B cells exhibit increased apoptosis and quiescence. Reciprocal BM chimeras confirm that the B cell defects in VhlcKO are derived from extrinsic sources.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Michael Frech, Gregor Schuster, Fabian T. Andes, Georg Schett, Mario M. Zaiss, Kerstin Sarter
Summary: The study revealed the involvement of the immunomodulatory molecule Btn2a2 in osteoclast differentiation and function, with potential implications in bone homeostasis. Btn2a2 deficiency led to abnormal osteoclast function and numbers, affecting bone architecture.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Nurgul Imangali, Viktoriya Sokolova, Kathrin Kostka, Matthias Epple, Christoph Winkler
Summary: Calcium phosphate (CaP) is the inorganic part of hard tissues and has a high biocompatibility and good biodegradability. In this study, CaP nanoparticles functionalized with DNA encoding bone anabolic factors were used to modulate osteoclast activity in a genetically modified medaka fish model. The results showed that the functionalized CaP nanoparticles efficiently delivered the inhibitory factor Opgb to osteoclasts and delayed or reduced the occurrence of osteoporosis-like phenotypes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Cell Biology
Anqi Zhou, Bingfeng Wu, Hui Yu, Yufei Tang, Jiayi Liu, Yinan Jia, Xiaoyu Yang, Lin Xiang
Summary: This review summarizes the interactions between the skeletal and immune systems, including their co-development and connections at the cellular and molecular levels. Research in osteoimmunology may help uncover the mechanisms of related diseases and provide innovative ideas and solutions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Orthopedics
Guanghao Chi, Longshun Qiu, Jian Ma, Wei Wu, Yuxin Zhang
Summary: Our meta-analysis study supports that OPG and RANKL are important modulatory factors in bone formation and resorption during bone turnover. Although the serum levels of OPG and RANKL are not associated with osteoporosis, the OPG/RANKL ratio is associated with osteoporosis. Standardizing the test method and unit would be beneficial for clinical application.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Ramsha Shams, Kelsey P. Drasites, Vandana Zaman, Denise Matzelle, Donald C. Shields, Dena P. Garner, Christopher J. Sole, Azizul Haque, Narendra L. Banik
Summary: Spinal cord injury (SCI) can lead to osteoporosis, possibly due to neuronal impairment and upregulation of RANKL causing bone resorption, while estrogen may protect bones by decreasing the upregulation of RANKL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Mineon Park, Yong Jin Cho, Bora Kim, Young Jong Ko, Yuria Jang, Yeon Hee Moon, Hoon Hyun, Wonbong Lim
Summary: The study suggests that RANKL promotes migration and invasion of PCa cells through EMT, and inhibiting RANKL signaling may help prevent the metastasis of prostate cancer.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Nagesha Guthalu Kondegowda, Joanna Filipowska, Jeong-su Do, Nancy Leon-Rivera, Rosemary Li, Rollie Hampton, Selassie Ogyaadu, Camilla Levister, Josef M. Penninger, Helena Reijonen, Carol J. Levy, Rupangi C. Vasavada
Summary: Inhibition of the RANKL/RANK pathway promotes beta cell regeneration and survival, offering potential therapeutic benefits for type 1 diabetes. Osteoprotegerin and denosumab provide protection against cytokine-induced beta cell death, and have shown promising results in reversing recent-onset type 1 diabetes in mice and reducing inflammation.
Article
Immunology
Hailin Huang, Fangze Guo, Xuyang Deng, Mingzhe Yan, Danyang Wang, Zhanyi Sun, Changqing Yuan, Qihui Zhou
Summary: Fucoidan has immunomodulatory effects on macrophages, neutrophils, and natural killer cells. It also promotes T cell proliferation and affects osteogenesis. This research provides new insights into the interplay between fucoidan, T cells, and osteoblasts.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Verena Fischer, Jasmin Maria Buelow, Benjamin Thilo Krueger, Deniz Ragipoglu, Anna Vikman, Melanie Haffner-Luntzer, Konstantinos Katsoulis-Dimitriou, Anne Dudeck, Anita Ignatius
Summary: Previous studies have shown that an increase in mast cells in the bone marrow is associated with age-related and post-menopausal osteoporosis. However, this study found that mast cell-derived RANKL does not contribute to the development of post-menopausal osteoporosis, suggesting that other factors may be responsible for this condition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Fangze Guo, Changqing Yuan, Hailin Huang, Xuyang Deng, Zirui Bian, Danyang Wang, Keke Dou, Li Mei, Qihui Zhou
Summary: In this study, the effects of nano-hydroxyapatite (nHA) on T cells and its regulatory interplay on osteogenic differentiation were investigated. It was found that increasing nHA concentration promoted T cell proliferation and reduced the proportion of apoptotic T cells. Furthermore, CD4(+) T cells were more affected by nHA compared to CD8(+) T cells, and the supernatant of T cells co-cultured with nHA significantly inhibited osteogenic differentiation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)