期刊
THROMBOSIS AND HAEMOSTASIS
卷 117, 期 7, 页码 1289-1295出版社
GEORG THIEME VERLAG KG
DOI: 10.1160/TH17-05-0325
关键词
Angiogenesis; diabetes; obesity; PI3-kinase; insulin resistance; metabolism; glycolysis
资金
- Telethon [GGP 14106]
- Associazione Italiana Ricerca Cancro (AIRC) [161813]
- Compagnia di San Paolo and World Wide Cancer Research Association [151324]
- Deutsche Forschungsgemeinschaft [CH279/5-1, SFB 655]
Angiogenesis, literally formation of new blood vessels, is the main process through which the vascular system expands during embryonic and postnatal development. Endothelial cells, which constitute the inner lining of all blood vessels, are typically in a quiescent state in the healthy adult organism. However, in vascular and metabolic diseases, the endothelium becomes unstable and dysfunctional. The resulting tissue hypoxia may thereby induce pathological angiogenesis, which is a hallmark of disease conditions like cancer or diabetic retinopathy. However, recent evidence suggests that angiogenesis is also a major player in the context of further metabolic diseases, especially in obesity. In particular, deregulated angiogenesis is linked with adipose tissue dysfunction and insulin resistance. On the other hand, signalling pathways, such as the PI3K pathway, may regulate metabolic activities in the endothelium. Endothelial cell metabolism emerges as an important regulator of angiogenesis. This review summarises the role of angiogenesis in metabolic-vascular disease, with specific focus on the role of angiogenesis in obesity-related metabolic dysfunction and on signaling pathways, especially PI3K, linking cell metabolism to endothelial function.
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