Review
Microbiology
Yehudis Rosenwasser, Irene Berger, Zvi G. Loewy
Summary: This article discusses the pharmacotherapeutic approaches for COPD exacerbation, including antimicrobials, bronchodilators, and anti-inflammatory drugs, as well as the connection between the oral cavity and the lungs.
Review
Pharmacology & Pharmacy
Z. Lahmar, E. Ahmed, A. Fort, I. Vachier, A. Bourdin, A. Bergougnoux
Summary: COPD is a chronic airway disease that affects millions of people worldwide and is ranked as the third leading cause of death. Genetic susceptibility, environmental factors, and the combined effects of these factors play important roles in the development of COPD. The Hedgehog signaling pathway and its inhibitor HHIP are potential targets for therapeutic interventions in COPD.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Environmental Sciences
Maria Koreny, Ane Arbillaga-Etxarri, Magda Bosch de Basea, Maria Foraster, Anne-Elie Carsin, Marta Cirach, Elena Gimeno-Santos, Anael Barberan-Garcia, Mark Nieuwenhuijsen, Pere Vall-Casas, Robert Rodriguez-Roisin, Judith Garcia-Aymerich
Summary: The study found that population density, pedestrian street length, slope, and NO2 exposure were associated with physical activity and exercise capacity in COPD patients, providing support for considering neighborhood environmental factors in COPD management.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Li-Xiang Wang, Jun Fei, Xin-Ming Wang, Guo-Fang Xie, Peng Cao, Chen Zhang, Hui Zhao, Lin Fu, Wei Cao
Summary: This study found that serum cadmium levels were higher in COPD patients compared to controls, and increased with disease severity. Autophagy and apoptosis markers were elevated in the lungs of COPD patients, and were positively associated with serum cadmium levels. Pulmonary function decline in COPD patients was partially attributed to cadmium-induced autophagy and apoptosis.
ATMOSPHERIC POLLUTION RESEARCH
(2022)
Article
Medicine, General & Internal
Christopher Byron, Christian R. Osadnik
Summary: People with hospitalised acute exacerbations of chronic obstructive pulmonary disease (AECOPD) have low levels of physical activity and high risks of future exacerbations. This study evaluated the amount of physical activity accumulated during hospitalised AECOPDs and the effect on length of stay, physical activity recovery, and readmission risk. The findings suggest that sedentary behavior and light physical activity are the most promising metrics associated with clinically relevant outcomes following AECOPD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Respiratory System
Xinyue Xiang, Lihua Huang, Yong Fang, Shasha Cai, Mingyue Zhang
Summary: Reduced physical activity is a strong predictor of all-cause mortality in patients with chronic obstructive pulmonary disease (COPD). This scoping review identified barriers to physical activity in COPD patients, such as older age, lung function, and lack of motivation. However, physical exercise interventions have shown positive effects on the prognosis of COPD patients.
BMC PULMONARY MEDICINE
(2022)
Article
Multidisciplinary Sciences
Kentaro Hyodo, Hironori Masuko, Hisayuki Oshima, Rie Shigemasa, Haruna Kitazawa, Jun Kanazawa, Hiroaki Iijima, Hiroichi Ishikawa, Takahide Kodama, Akihiro Nomura, Katsunori Kagohashi, Hiroaki Satoh, Takefumi Saito, Tohru Sakamoto, Nobuyuki Hizawa
Summary: This study aimed to investigate the exacerbation-prone phenotypes beyond disease labels in asthma and COPD using shared risk factors and to examine the role of the IL4RA gene polymorphism related to type 2 inflammation. The results showed common exacerbation-prone endotypes in chronic inflammatory airway diseases, supporting the use of a treatable traits approach for prevention.
Article
Respiratory System
Federico Mei, Michela Dalmartello, Martina Bonifazi, Paola Bertuccio, Fabio Levi, Paolo Boffetta, Eva Negri, Carlo La Vecchia, Matteo Malvezzi
Summary: Based on the analysis of data from the World Health Organization (WHO), the global mortality rate from chronic obstructive pulmonary disease (COPD) has been decreasing steadily, but there are several countries where the mortality rate for women is increasing. These trends are mainly attributed to changes in smoking habits, as well as the impact of air pollution and occupational exposures.
Review
Respiratory System
Nancy Gomez, Victoria James, David Onion, Lucy C. Fairclough
Summary: This systematic review examines the role of extracellular vesicles (EVs) in the pathogenesis and diagnosis of Chronic Obstructive Pulmonary Disease (COPD). The research found that EVs are involved in the mechanism of COPD pathogenesis, derived from various cell types and containing modified levels of miRNAs. The findings suggest that EVs could be a potential method for COPD diagnosis and progress monitoring.
RESPIRATORY RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Daniel Stevens, Pantelis Andreou, Daniel Rainham
Summary: The study found a significant negative correlation between PA level and ozone pollution, a significant association between urban form index and sedentary behavior, a significant positive correlation between self-rated health and PA level, and a significant inverse correlation between self-rated health and sedentary behavior among COPD patients.
JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
(2022)
Review
Medicine, General & Internal
Hiroki Tashiro, Koichiro Takahashi
Summary: Recently, there has been increasing attention on physical activity in patients with COPD, as it is a strong predictor of mortality. Sedentary behavior, such as sitting or lying down, also has a clinical impact on COPD patients. This review examines the clinical data on physical activity and sedentary behavior, including their definition, associated factors, beneficial effects, and biological mechanisms in both COPD and overall human health. It also explores interventions to improve physical activity or sedentary behavior in COPD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Alvise Casara, Graziella Turato, Marta Marin-Oto, Umberto Semenzato, Davide Biondini, Mariaenrica Tine, Nicol Bernardinello, Elisabetta Cocconcelli, Pablo Cubero, Elisabetta Balestro, Paolo Spagnolo, Jose M. Marin, Manuel G. Cosio, Marina Saetta, Erica Bazzan
Summary: Chronic bronchitis (CB) significantly affects symptoms, quality of life, and survival in smokers without COPD, with 27% of noCOPD smokers having CB. CB does not impact FEV1 decline in noCOPD but does significantly in COPD patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Respiratory System
David M. MacDonald, Ken M. Kunisaki, Timothy J. Wilt, Arianne K. Baldomero
Summary: A systematic review found that higher serum bilirubin levels may be associated with improved COPD outcomes and lower mortality rates. However, there is insufficient evidence to support the relationship between serum bilirubin levels and respiratory health status/exercise capacity and airflow obstruction.
BMC PULMONARY MEDICINE
(2021)
Review
Dentistry, Oral Surgery & Medicine
Niamh Kelly, Lewis Winning, Christopher Irwin, Fionnuala T. Lundy, Dermot Linden, Lorcan McGarvey, Gerard J. Linden, Ikhlas A. El Karim
Summary: This systematic review explores the association between poor periodontal health and frequency of COPD exacerbations. Research suggests that periodontal treatment can reduce exacerbation frequency in COPD patients, leading to improved quality of life.
Article
Medicine, General & Internal
Kulothungan Gunasekaran, Swetha Murthi, Kalaimani Elango, Mandeep Singh Rahi, Bright Thilagar, Sathishkumar Ramalingam, Dinesh Voruganti, Vijaya Kumar Paramasivam, Krishna Prasad Kolandaivel, Ashish Arora, Arul Chandran
Summary: Investigating the impact of diabetes on COPD patient outcomes during inpatient hospitalization revealed that patients with COPD and diabetes had longer hospital stays and higher risks of complications, but lower odds of mortality during hospitalization compared to COPD patients without diabetes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Geriatrics & Gerontology
Remi Gontie, Judith Garcia-Aymerich, Julia Jubany, Marina Bosque-Prous, Tivy Baron-Garcia, Helena Gonzalez-Casals, Gemma Drou-Roget, Anna Beringues, Albert Espelt
Summary: This study analysed the relationship between physical activity and the incidence of dementia in people aged 50 years or older without dementia in Europe. The results showed that frequent moderate physical activity is independently associated with a lower risk of dementia. The study also found that the risk of dementia is higher in individuals who rarely or never engage in moderate-to-vigorous physical activity.
AGING & MENTAL HEALTH
(2023)
Article
Critical Care Medicine
Stefano Guerra, Julie G. Ledford, Erik Melen, Iris Lavi, Anne-Elie Carsin, Debra A. Stern, Jing Zhai, Marta Vidal, Mariona Bustamante, Kenneth J. Addison, Renata G. Vallecillo, Dean Billheimer, Gerard H. Koppelman, Judith Garcia-Aymerich, Nathanael Lemonnier, Montserrat Fito, Carlota Dobano, Simon Kebede Merid, Inger Kull, Rosemary R. C. McEachan, John Wright, Leda Chatzi, Manolis Kogevinas, Daniela Porta, Silvia Narduzzi, Ferran Ballester, Ana Esplugues, Carlos Zabaleta, Amaia Irizar, Jordi Sunyer, Marilyn Halonen, Jean Bousquet, Fernando D. Martinez, Josep M. Anto
Summary: A study was conducted to screen circulating proteins in childhood asthma and investigate their association with the disease in a mouse model. It was found that creatine kinase (CK) was consistently associated with asthma, and this association was further supported by gene expression analysis and a mouse model experiment.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Respiratory System
Osama Mahmoud, Raquel Granell, Gabriela P. Peralta, Judith Garcia-Aymerich, Deborah Jarvis, John Henderson, Jonathan Sterne
Summary: This study found that maternal perinatal BMI, birthweight, childhood lean and fat mass, and early-onset asthma were the most important factors influencing lung function in early adulthood.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Letter
Respiratory System
Elisa Martinez-Besteiro, Maria Molina-Molina, Anna Michela Gaeta, Myriam Aburto, Alvaro Casanova, Juan Rigual Bobillo, Sandra Orozco, Raquel Perez Rojo, Radl Godoy, Belen Lopez-Muniz Ballesteros, Erwin Javier Pinillos Robles, Susana Sanchez Fraga, Teresa Pena Miguel, Eva Balcells, Rosalia Laporta, Jose Antonio Rodriguez Portal, Susana Herrera Lara, Eva Cabrera, Orlando Acosta, Adrian Pelaez, Claudia Valenzuela
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Article
Health Care Sciences & Services
Xavier Busquet-Duran, Josep Maria Manresa-Dominguez, Joana Llobera-Estrany, Ana Isabel Lopez-Garcia, Eduard Moreno-Gabriel, Pere Toran-Monserrat
Summary: This study examined the associations between the dimensions of the HexCom care complexity model and the place of death. The results showed that a greater functional impairment, being male, being over 80 years old, and the presence of care complexity in the last days were associated with a higher likelihood of dying at home. On the other hand, having cancer, poor external support, feeling at peace with others, and lack of agreement on the planning of the place of death were associated with a lower likelihood of dying at home.
Article
Environmental Sciences
Mohammad Javad Zare Sakhvidi, Amir Houshang Mehrparvar, Fariba Zare Sakhvidi, Payam Dadvand
Summary: The evidence continues to accumulate on the positive relationship between greenspace exposure and the mental and physical health and wellbeing of children and adolescents. A systematic search was conducted to identify systematic reviews and/or meta-analyses published until August 2022 that examined the health, developmental, and behavioral outcomes associated with greenspace exposure in children and adolescents. Most of the available reviews focus on mental health and behavioral outcomes and are primarily conducted in high-income countries. The main challenges in combining the studies include exposure assessment, outcome assessment, and population characteristics. Overall, the reviews suggest a beneficial association between greenspace and a wide range of outcomes, except for allergic and respiratory outcomes where the evidence is inconclusive.
CURRENT OPINION IN ENVIRONMENTAL SCIENCE & HEALTH
(2023)
Letter
Respiratory System
L. Cobo Sanchez, C. Ruiz Herrero, I. Cobos, J. Bespin, C. Gadea, P. Cerda-Cortes, J. Palma, V. Vicens-Zygmun, G. Bermudo, K. Portillo, A. Boldova, A. Robles, J. Arribas, J. A. Figuerola, R. Blavia, A. Moreno, D. Castillo, A. Villar, Y. Belmonte, D. Badenes-Bonet, D. Zayas, G. Suarez-Cuartin, L. Garcia-Bellmunt, J. Sellares, S. Barril, J. Sans, M. Serra, D. Perich, L. L. Esteban, L. Esteban, E. Balcells, F. Gil, E. Ruiz, C. Fina, Maria Molina-Molina
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Editorial Material
Respiratory System
Jordi Sunyer, Payam Dadvand
Summary: Reducing air pollution is a highly effective method to safeguard our population from the impact of COVID-19.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Editorial Material
Public, Environmental & Occupational Health
Josep M. Anto, Neil Pearce, Jeroen Douwes, Judith Garcia-Aymerich, Lucy Pembrey, Lorenzo Richiardi, Jordi Sunyer
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Multidisciplinary Sciences
Otavio Ranzani, Anna Alari, Sergio Olmos, Carles Mila, Alex Rico, Joan Ballester, Xavier Basagana, Carlos Chaccour, Payam Dadvand, Talita Duarte-Salles, Maria Foraster, Mark Nieuwenhuijsen, Jordi Sunyer, Antonia Valentin, Manolis Kogevinas, Uxue Lazcano, Carla Avellaneda-Gomez, Rosa Vivanco, Cathryn Tonne
Summary: The association between long-term exposure to ambient air pollutants and severe COVID-19 is uncertain. Our study in Catalonia, Spain followed 4,660,502 adults from the general population in 2020 and found that higher exposure to PM2.5, NO2, and BC was associated with an increased risk of COVID-19 hospitalization, ICU admission, death, and hospital length of stay. These findings provide robust evidence for the link between long-term air pollution exposure and severe COVID-19.
NATURE COMMUNICATIONS
(2023)
Article
Health Care Sciences & Services
Merce Iruela Sanchez, Rosa Garcia-Sierra, Rafael Medrano-Jimenez, Diana Bonachela-Mompart, Natalia Maella-Rius, Esther Soria-Martin, Mar Isnard-Blanchar, Pere Toran-Monserrat
Summary: We aim to investigate the relationship between temperature differences between the wound bed and perilesional skin and the healing process in primary care patients with wounds. This study is a multisite prospective cohort study with one-year follow-up, conducted from January 2023 to September 2023 in the Metropolitan North area of Barcelona. Variables such as percentage reduction of wound area over time, thermal index, Kundin Wound Gauge, and Resvech 2.0 Scale will be measured. Weekly temperature checks will be done using a handheld thermometer and mesh grid. Healing trajectory will be monitored through photographic imaging, the Resvech Scale, calculation of wound size, percentage reduction of wound area over time, and thermal index for one year or until the wound is cured. This study has the potential to improve the management of chronic wounds in primary care by facilitating early diagnosis of wound complications.
Review
Environmental Sciences
Angel M. Dzhambov, Peter Lercher, Natalia Vincens, Kerstin Persson Waye, Maria Klatte, Larisa Leist, Thomas Lachmann, Dirk Schreckenberg, Christin Belke, Gordana Ristovska, Katja M. Kanninen, Dick Botteldooren, Timothy Van Renterghem, Sonja Jeram, Jenny Selander, Arzu Arat, Kim White, Jordi Julvez, Charlotte Clark, Maria Foraster, Irene van Kamp
Summary: The EU-funded project Equal-Life conducted a scoping review and conceptual model to explore the potential mediators linking the exposome to mental health and cognition in children/adolescents. The scarcity of empirical evidence in this research area was found, with only a few cross-sectional studies indicating a tentative association between perceived restorative quality and mental health. Physical activity emerged as a mediator leading to better psychological outcomes in restorative environments.
ENVIRONMENTAL RESEARCH
(2023)
Review
Environmental Sciences
Fatai A. Adewuyi, Pablo Knobel, Priyanka Gogna, Payam Dadvand
Summary: This systematic review found that green prescriptions can have positive effects on psychological health and wellbeing, cardiometabolic health, physical activity, and inflammation. However, there is a lack of studies on the effects of green prescriptions on orthopedic conditions, pain, and recovery from exhaustion disorder. More research with larger sample sizes and objective measures is needed.
ENVIRONMENTAL RESEARCH
(2023)
Article
Health Care Sciences & Services
Joren Buekers, Ane Arbillaga-Etxarri, Elena Gimeno-Santos, David Donaire-Gonzalez, Guillaume Chevance, Jean-Marie Aerts, Judith Garcia-Aymerich
Summary: This study aimed to determine if wearable devices could provide valid heart rate (HR) and oxygen uptake (V?O-2) kinetics during outdoor walks in patients with chronic obstructive pulmonary disease (COPD). The results showed that continuous measurements with wearable devices provided valid HR and V?O-2 kinetics, which were comparable to laboratory-based tests.
Review
Environmental Sciences
M. H. E. M. Browning, D. H. Locke, C. Konijnendijk, S. M. Labib, A. Rigolon, R. Yeager, M. Bardhan, A. Berland, P. Dadvand, M. Helbich, F. Li, H. Li, P. James, J. Klompmaker, A. Reuben, L. A. Roman, W. -L. Tsai, M. Patwary, J. O'Neil-Dunne, A. Ossola, R. Wang, B. Yang, L. Yi, J. Zhang, M. Nieuwenhuijsen
Summary: The 3-30-300 rule provides benchmarks for cities to promote equitable nature access, requiring individuals to have visibility of three trees, a 30% tree canopy in their neighborhood, and proximity to high-quality green spaces within 300 meters. However, there is currently a lack of guidance on how to measure and implement these requirements. This study used an expert-based consensus approach to review measurement methods of 3-30-300 and presented a suitability matrix linking recommended measures with each component of the rule. These methods can not only implement the rule but also foster broader dialogue on local desires and requirements.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
