期刊
TETRAHEDRON-ASYMMETRY
卷 28, 期 2, 页码 374-380出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2017.01.012
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-
资金
- National Science Centre [2014/15/B/NZ7/00972, 2014/15/D/NZ7/01805]
The enzymatic method was used for the direct resolution of racemic atenolol. The catalytic activities of commercially available lipases from Candida rugosa (MY and OF) immobilized onto new-synthesized chitosan magnetic nanoparticles [Fe3O4-CS-Et(NH2)(2), Fe3O4-CS-Et(NH2)(3)]in the kinetic resolution of racemic atenolol were compared. The best results were obtained by using Candida rugosa lipase OF immobilized onto Fe3O4-CS-Et(NH2)(3). Additionally, the enzyme reusability was investigated. It was established that even after 5 reaction cycles, both lipases from Candida rugosa maintained their high catalytic activities and operational stabilities. This approach is extremely important from an economical point of view, because it allows for a direct cost reduction of the biotransformation. (C) 2017 Elsevier Ltd. All rights reserved.
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