Article
Chemistry, Organic
Nilesh B. Patil, Ganesh U. Chaturbhuj
Summary: This study presents a rapid, efficient, and environmentally friendly method for electrophilic thiocyanation of activated arenes. The method utilizes sulfated polyborate as a Bronsted acid catalyst and H2O2 as a green oxidizer. It shows promising results for various activated arenes and allows for recyclability of the aqueous solution, offering easy operation under mild reaction conditions.
TETRAHEDRON LETTERS
(2022)
Article
Chemistry, Analytical
Zhuo Yu, Wenbo Huang, Shengzhen Xu, Shaoyong Ke
Summary: Two novel benzothiazole-naphthol aldehyde conjugates were synthesized and tested for their recognition properties for diverse analytes. One compound showed high selectivity and specificity for recognizing hypochlorite, while another compound did not respond significantly to any analytes. The sensor could sensitively detect hypochlorite with a low detection limit and was successfully applied in test strips.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Organic
Balu Misal, Amey Palav, Prerna Ganwir, Ganesh Chaturbhuj
Summary: A sulfated polyborate catalyst has been developed for efficient iodination of arenes with high regioselectivity and yield. This method is versatile for mono and diiodination of various substrates, including the synthesis of intermediates for thyroid treatment drugs and specialty chemicals.
TETRAHEDRON LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Maryam Mansouri, Davood Habibi, Somayyeh Heydari
Summary: A novel nano-magnetic-supported phenyltetrazolethiol-based Ni complex was synthesized and characterized, then used as a heterogeneous nano-catalyst for the synthesis of two sets of compounds under solvent-free conditions at an appropriate temperature and time.
RESEARCH ON CHEMICAL INTERMEDIATES
(2022)
Article
Chemistry, Organic
Prerna Ganwir, Ganesh Chaturbhuj
Summary: An efficient one-pot reductive amination of aldehydes or ketones catalyzed by sulfated polyborate and further reduced by sodium borohydride is developed. The method offers benefits such as shorter reaction time, excellent yields, and a hassle-free experimental process, making it suitable for a wide range of applications, including secondary amine for reductive amination.
TETRAHEDRON LETTERS
(2021)
Article
Chemistry, Organic
Mohinuddin Khan Imon, Readul Islam, Pran G. Karmaker, Pijush K. Roy, Kee-In Lee, Harendra N. Roy
Summary: A green and efficient method for synthesizing biologically active xanthene derivatives has been developed using a three-component reaction mediated by 2-aminophenol. The method offers advantages such as short reaction time, easy product isolation, non-toxic catalyst, and metal-free process.
SYNTHETIC COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Prerna Ganwir, Priyanka Bandivadekar, Ganesh Chaturbhuj
Summary: We have developed a method using Bronsted acid for Knoevenagel condensation. This method efficiently reacts aromatic, heterocyclic, alpha,beta-unsaturated, and aliphatic aldehydes in an environmentally friendly solvent mixture of ethanol and water at 70 degrees C. The method shows significant benefits in terms of using a Bronsted acid catalyst for the first time, mild reaction conditions, and improved product yields.
RESULTS IN CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Priyanka V. Bandivadekar, Kanchan D. Gavali, Ganesh U. Chaturbhuj
Summary: A method for synthesizing enamines and enaminones through the activation of methyl ketones or active methylenes and N, N-dimethylformamide dimethyl acetal at 110 degrees C by sulfated polyborate under solvent-free conditions has been developed. The use of selected Bronsted acid, optimized reaction conditions, and easy separation method allows for high yields of 82-97%, making this process cost-effective and eco-friendly. This method has been successfully applied to the synthesis of intermediates for Imatinib and Nilotinib, as well as Ocinaplon with high yields.
Article
Chemistry, Multidisciplinary
Prerna Ganwir, Swati Jaydeokar, Ganesh U. Chaturbhuj
Summary: An efficient and fast protocol for the phthaloylation of amines, hydrazines, and hydrazides via transamidation is described. The reaction can be completed in about 30 minutes at 70 degrees C in DMSO as a solvent, resulting in higher yield of products, easy workup, and recyclability of the catalyst. In addition, successful transamidation of cinnamamide and benzamide was also achieved.
RESULTS IN CHEMISTRY
(2022)
Article
Chemistry, Organic
Saiedeh Kamalifar, Hamzeh Kiyani
Summary: In this study, a domino reaction was performed using sulfacetamide as an organocatalyst in refluxing ethanol to synthesize a series of novel oxygen-containing heterocyclic compounds. Clear conclusions were drawn on the catalyst loading and solvent choice, following principles of green chemistry.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Chemistry, Organic
Ashok A. Pise, Ajit P. Ingale, Navnath R. Dalvi
Summary: The developed reaction of amine N-tert-butyloxycarbonylation using sulfated polyborate under ultrasonic irradiation is demonstrated to have a broad substrate scope and excellent yields. The protocol offers advantages such as easy catalyst and product isolation, short reaction time, high selectivity, and recyclability, making it a practical, economical, and environmentally friendly process.
SYNTHETIC COMMUNICATIONS
(2021)
Article
Biochemical Research Methods
Zhiping Che, Song Zhang, Jiaxuan He, Di Sun, Xiaolong Guo, Yuanhao Li, Lina Zhu, Yihao Guo, Yibo Liu, Yuee Tian, Xiaobo Huang, Shengming Liu, Genqiang Chen
Summary: By synthesizing and evaluating a series of sulfonate derivatives of alpha/beta-naphthol, two compounds 4a and 5a were found to have good antimicrobial activity against P. capsici. It was observed that the aliphatic substituent R is crucial for maintaining the anti-oomycete activity of these derivatives.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2022)
Article
Chemistry, Physical
Jiaxin Gao, Lingchao Zhu, Matthew P. Conley
Summary: Ta-H+ sites supported on sulfated aluminum oxide catalyze the hydrogenolysis of isotactic polypropylene to form low-molecular-weight branched alkanes in good yields. The alkanes lose stereochemical information from the polypropylene, but the remaining polymer maintains high isotacticity. When deuterium is present, similar mixtures of alkanes are formed. The reaction of 1 with pinacolborane forms 2, which can activate C-H bonds in the polymer.
Article
Chemistry, Organic
Abdolharaid Bamonir, Reza Delqavi Khalifa Lou, Nahid Yaghmaeiyan
Summary: 9,9-Dimethyl-12-(aryl)-8,9,10,12-tetrahydrobenzo[a]xanthene-11-one derivatives have been synthesized via a green three-component reaction using nano-kaolin-SO3H as a recoverable solid catalyst. The solid acid catalyst, which possesses the properties of both Lewis and Bronsted acids, has been characterized by various techniques. Compared to conventional methods, this protocol offers advantages such as simple experimental procedure, easy work-up, shorter reaction times, and high yields of pure products.
INDIAN JOURNAL OF CHEMISTRY
(2022)
Article
Engineering, Environmental
Haiyang Fan, Guiyun Yi, Zhengting Zhang, Xiuxiu Zhang, Peng Li, Chuanxiang Zhang, Lunjian Chen, Yulong Zhang, Qi Sun
Summary: In this study, an Ag deposited BiVO4 (ABVO) electrode was successfully fabricated via a combination of electrodeposition and photodeposition for efficient photoelectrocatalytic degradation of 13-naphthol under visible-light illumination. The ABVO photoanode exhibited a 1.6 times higher photocurrent density than BiVO4 (BVO) due to reduced recombination rate of photoinduced electron-hole pairs. The enhanced performance of ABVO can be attributed to the synergy of photocatalysis, electrocatalysis, and the localized surface plasmon resonance effect of deposited Ag particles.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Chemistry, Organic
Krishna Indalkar, Sanjay S. Malge, Anil S. Mali, Ganesh U. Chaturbhuj
ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL
(2021)
Article
Chemistry, Organic
Anil S. Mali, Krishna Indalkar, Ganesh U. Chaturbhuj
ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL
(2021)
Article
Chemistry, Medicinal
Yasanandana S. Wijayasinghe, Meenakshi P. Bhansali, Maheshkumar R. Borkar, Ganesh U. Chaturbhuj, Brian S. Muntean, Ronald E. Viola, Pravin R. Bhansali
Summary: This article introduces a synthetic glucose analogue called 2-DG, which can interfere with energy-dependent processes by inhibiting key enzymes in the glycolytic pathway. 2-DG has been shown to have therapeutic potential in various diseases and disorders.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Organic
Anil S. Mali, Prerna Ganwir, Ganesh U. Chaturbhuj
ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL
(2022)
Article
Chemistry, Organic
Anil S. Mali, Priyanka Bandivadekar, Ganesh U. Chaturbhuj
ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL
(2022)
Article
Chemistry, Organic
Prerna Ganwir, Kanchan Gavali, Ganesh U. Chaturbhuj
Summary: This report presents an efficient method for the synthesis of 3,4-dihydropyrimidine-2(1H)-ones/thiones via Biginelli condensation. The method features a novel catalyst, high yields, quick reaction time, solvent-free environment, simple workup, and the ability to tolerate a variety of functional groups. Additionally, the method is applied to the synthesis of the active pharmaceutical ingredient Piperasterol.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Chemistry, Organic
Nilesh B. Patil, Ganesh U. Chaturbhuj
Summary: This study presents a rapid, efficient, and environmentally friendly method for electrophilic thiocyanation of activated arenes. The method utilizes sulfated polyborate as a Bronsted acid catalyst and H2O2 as a green oxidizer. It shows promising results for various activated arenes and allows for recyclability of the aqueous solution, offering easy operation under mild reaction conditions.
TETRAHEDRON LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Prerna Ganwir, Ishwari Kale, Ganesh Chaturbhuj
Summary: This work presents the first use of Wet copper-slag as a catalyst for efficient Knoevenagel condensation. By immersing natural Copper-slag in water, it was converted to Wet copper-slag with improved hydroxyl group and basicity. Various aldehydes and ketones reacted well with active methylenes in a shorter reaction time using environmentally-friendly ethanol:water as solvent. The method offers mild reaction conditions, wide availability, recyclability, and magnetic separability of the catalyst with higher product yields. It was also successfully applied to synthesize the intermediate of AMG 837, a novel GPR40 agonist.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2022)
Article
Chemistry, Multidisciplinary
Prerna Ganwir, Priyanka Bandivadekar, Pawan Kudale, Ganesh U. Chaturbhuj
Summary: This study presents a rapid and efficient method for synthesizing polyhydroquinolines using the Hantzsch reaction and 2-amino-4H-chromene derivatives. The method is catalyst-free and uses ethanol: water (1:1) at room temperature and 90 degrees Celsius. It demonstrates the ability to handle diverse substrates with different functional groups, including ketones. Furthermore, this method offers economical and environmentally friendly advantages with shorter reaction time, simple workup procedure, no catalyst, and excellent yields.
RESEARCH ON CHEMICAL INTERMEDIATES
(2022)
Article
Chemistry, Multidisciplinary
Priyanka V. Bandivadekar, Kanchan D. Gavali, Ganesh U. Chaturbhuj
Summary: A method for synthesizing enamines and enaminones through the activation of methyl ketones or active methylenes and N, N-dimethylformamide dimethyl acetal at 110 degrees C by sulfated polyborate under solvent-free conditions has been developed. The use of selected Bronsted acid, optimized reaction conditions, and easy separation method allows for high yields of 82-97%, making this process cost-effective and eco-friendly. This method has been successfully applied to the synthesis of intermediates for Imatinib and Nilotinib, as well as Ocinaplon with high yields.
Article
Chemistry, Multidisciplinary
Pawan Kudale, Kanchan Gavali, Dipak Pinjari, Ganesh Chaturbhuj
Summary: This work demonstrates the use of carbonic acid from sparkling water and dry ice for efficient Knoevenagel condensation. The reaction showed good results with shorter reaction time using environmentally-friendly ethanol: water mixture as solvent. Carbonic acid is a non-toxic and inexpensive catalyst that is readily available and leaves no traces in the product. The method was also successfully applied to intermediates of a novel GPR40 agonist.
RESULTS IN CHEMISTRY
(2023)
Article
Chemistry, Organic
Kanchan D. Gavali, Pawan R. Kudale, Ganesh U. Chaturbhuj
Summary: A piperidinium borate, an organic conjugate base, is found to be an effective catalyst for promoting Knoevenagel condensation between aromatic, heterocyclic, a, b unsaturated aldehydes and aliphatic, cyclic ketones with active methylenes under mild conditions. The catalyst can be easily prepared from boric acid and piperidine. The method offers advantages of mild reaction conditions, wide availability of starting materials, higher product yields, and simple separation of products by filtering and washing with water. It has been successfully used for the synthesis of AMG 837, a new GPR40 agonist intermediate, with excellent catalyst recyclability and reusability.
TETRAHEDRON LETTERS
(2023)
Article
Chemistry, Analytical
Sutar Purushottam, Ajay Kumar, Chaturbhuj Ganesh
Summary: Recent studies have reported the mono-iodination of 2-chloroaniline in the presence of iodine monochloride. A new HPLC method has been developed for the assay of iodine monochloride using a reversed-phase C18 column and gradient elution with water and acetonitrile as mobile phase. The method showed good linearity and accuracy, with precision within 1%, and was successfully applied to determine the assay of commercially available iodine monochloride and in-situ generated samples.
SEPARATION SCIENCE PLUS
(2023)
Article
Chemistry, Multidisciplinary
Prerna Ganwir, Priyanka Bandivadekar, Ganesh Chaturbhuj
Summary: We have developed a method using Bronsted acid for Knoevenagel condensation. This method efficiently reacts aromatic, heterocyclic, alpha,beta-unsaturated, and aliphatic aldehydes in an environmentally friendly solvent mixture of ethanol and water at 70 degrees C. The method shows significant benefits in terms of using a Bronsted acid catalyst for the first time, mild reaction conditions, and improved product yields.
RESULTS IN CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Prerna Ganwir, Swati Jaydeokar, Ganesh U. Chaturbhuj
Summary: An efficient and fast protocol for the phthaloylation of amines, hydrazines, and hydrazides via transamidation is described. The reaction can be completed in about 30 minutes at 70 degrees C in DMSO as a solvent, resulting in higher yield of products, easy workup, and recyclability of the catalyst. In addition, successful transamidation of cinnamamide and benzamide was also achieved.
RESULTS IN CHEMISTRY
(2022)
Article
Chemistry, Organic
Geeta Devi Yadav, Pooja Chaudhary, Balaram Pani, Surendra Singh
Summary: Chiral transition metal complexes with privileged ligands are efficient catalysts for various asymmetric organic transformations. Transition metal complexes of C1-symmetric pyrrolidine-based ligands have been widely used in asymmetric organic reactions. However, a comprehensive review article on the transition metal complexes of chiral C1-symmetric pyrrolidine-based ligands derived from (L)-proline has not been published.
TETRAHEDRON LETTERS
(2024)
