Review
Chemistry, Organic
Nassima Medjahed, Zahira Kibou, Amina Berrichi, Noureddine Choukchou-Braham
Summary: Pyrazole, an important unit in organic chemistry, has received much attention in organic synthesis due to its significance in therapeutic and biological values. Green synthetic methods have attracted researchers' interest for the preparation of pyrazole derivatives.
CURRENT ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Hanwen Yan, Feng Huo, Ping Li, Chunshan Li
Summary: This study presents a detailed mechanistic investigation on the synthesis of methylacrolein (MAL) through a mild Mannich reaction, catalyzed by sec-amine short-chain aliphatic acid ionic liquids (ILs). The catalyst ILs exhibit excellent activity and significantly reduce the reaction energy barrier, resulting in mild reaction conditions. The study provides a thorough explanation of the synthesis mechanism and may have practical applications.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Review
Chemistry, Multidisciplinary
Brenno A. D. Neto, Rafael O. Rocha, Alexandre A. M. Lapis
Summary: This tutorial review presents the application and importance of ionic liquids (ILs) as catalysts or reaction media in multicomponent reactions (MCRs). It discusses the effect of ion-pairing formation and its influence on the reaction outcomes. ILs not only improve yields and selectivities, but also aid in the formation, stabilization, and reactivity of reagents and intermediates during MCRs.
CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY
(2022)
Review
Agricultural Engineering
Yaoyao Zhang, Shangde Sun
Summary: The scarcity of fossil fuel and increasing environmental concerns have led to a growing need for the development of environmentally friendly and sustainable energy resources. Biodiesel, produced through transesterification of oils or fats with short-chain alcohol, is considered an optimal replacement for fossil-fuel based diesel due to its reproducible and eco-friendly properties. Among various catalysts, ionic liquids have shown potential as viable substitutes for conventional catalysts in biodiesel production. This paper provides a comprehensive review of the classification, synthetic schemes, and catalytic mechanism of basic ionic liquids, which have been less explored compared to acidic ionic liquids. The utilization of basic ionic liquids as catalysts for biodiesel preparation, along with the current challenges and prospects for future use, is also discussed.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Chemistry, Physical
Geeta Durga, Pooja Kalra, Vinay Kumar Verma, Kanjur Wangdi, Anuradha Mishra
Summary: Ionic liquids have established themselves as a preferred solvent in synthetic chemistry, particularly in polymer chemistry. They are versatile solvents used for polymeric reactions and can also be polymerized to enhance their inherent properties, finding applications in various fields such as electrochemical devices, nanocomposites, optoelectronics, and more. This comprehensive review covers both aspects of ILs as a solvent in polymeric reactions and their polymeric form, poly(ionic liquids), presenting their diverse potential applications.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
Amrita Natekar, Ranjan Dey
Summary: In this study, a modification using the volume fraction HU approach was explored and tested on various mixtures at different temperatures. The results showed that the proposed approach outperformed the original HU method and other approaches in terms of agreement with experimental findings.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Review
Biochemistry & Molecular Biology
Justyna Wieclawik, Anna Chrobok
Summary: The chemical industry needs environmentally friendly processes, as acid-catalysed processes may cause environmental problems. The search for sustainable alternatives to conventional acids is urgent. Metal-containing ionic liquids have been of great interest to scientists due to their high Lewis acidity, which depends on the composition of the ionic liquid and the specific content of metal salt. These compounds are widely used as catalysts, co-catalysts, or reaction media in various fields of chemistry, particularly in organic chemistry. Gallium(III)- and indium(III)-containing ionic liquids effectively enhance the activity of metal salts and are easier to handle. This review emphasizes the wide range of applications and the potential of metal-containing ionic liquids, with a focus on Ga(III) and In(III), which can guide further research and synthesis of new compounds in this group.
Article
Chemistry, Organic
Cansu Gulbenek, Muhammet Yildirim, Arzu Yildirim
Summary: In this study, new polysubstituted nitropyridimines were efficiently synthesized through double Mannich cyclizations under microwave irradiation. Some of the nitropyridimines showed moderate to low antioxidant and antibacterial activities.
Article
Chemistry, Organic
Marine Pinaud, Leila Vaitilingom, Gayathiri Gnanalingam, Tania Xavier, Erwan Le Gall, Marc Presset
Summary: The use of N-alkyl imines in decarboxylative Mannich reaction with substituted malonic acids half oxyesters (SMAHOs) has been developed to afford a direct access to secondary beta(2,3)-aminoesters. The transformation occurs under very practical conditions (DABCO as a catalyst in bulk toluene and open to air) and can be performed with a broad range of each substrate in yields of 36 to 97 %. Importantly, the reaction was found to require the use of acidic additives in combination with the organocatalyst to limit the competitive olefination reaction.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Nicolas S. dos Anjos, Luiz S. Longo Jr.
Summary: Improvements in sustainable organic synthesis are achieved through the investigation of greener materials and methods. The application of multicomponent reactions and task-specific ionic liquid catalysts is crucial for the synthesis of organic molecules, contributing to process sustainability and green metrics.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2022)
Article
Biotechnology & Applied Microbiology
Fabiane O. Farias, Ariel A. C. Toledo Hijo, Cassamo U. Mussagy, Ramon S. B. Ferreira, Valeria C. Santos-Ebinuma, Eduardo A. C. Batista, Antonio J. A. Meirelles
Summary: This study investigates two different approaches for vegetable oil deacidification using an ionic liquid as a solvent. The oligomeric IL approach removes oleic acid from soybean oil, and the multicomponent IL approach achieves a FFA removal rate of 85%. Both methods result in lower oil loss compared to conventional chemical processes.
FOOD AND BIOPRODUCTS PROCESSING
(2023)
Article
Chemistry, Multidisciplinary
Sara Gracia-Barberan, Alejandro Leal-Duaso, Elisabet Pires
Summary: This microreview explores the potential of Deep Eutectic Solvents (DES) as alternatives to Ionic Liquids (ILs) in metal-catalysed reactions. The results show that DES have shown promising results in various reactions, but further research is needed to explore their applicability in other reactions and understand the influence of the nature of the DES. The study also introduces bio-based ionic liquids as a complementary solvent to DES for fully replacing traditional ILs.
CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY
(2022)
Review
Chemistry, Inorganic & Nuclear
Anandhu Mohan, Augustine Jaison, Young-Chul Lee
Summary: The regulation of a large amount of CO2 in the environment is crucial to prevent environmental catastrophes, and this can be achieved through efficient carbon capture and conversion into useful chemicals. Mesoporous silica nanoparticles (MSNs) are ideal support materials for heterogeneous catalysis due to their unique characteristics. This review discusses the functionalization of MSNs, the synthesis of MSN-based catalysts, and their potential applications in CO2 fixation reactions. It highlights the design of an ideal CO2 fixation catalyst, the addition of various functionalities to MSNs, and the effects of controlling particle size distribution, active species dispersion, and interactions between active species and supports. Furthermore, this review provides an overview of the key issues, current developments, and barriers in the field of MSN-based catalysts for CO2 fixation, along with proposed research goals and viable solutions for their implementation.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Energy & Fuels
Xiaotong Lu, Shengnan Li, Limin Wang, Sujuan Huang, Zhongqiu Liu, Yujing Liu, Anguo Ying
Summary: The study aims to prepare novel Pickering interfacial solid catalysts for efficient and environmentally benign biodiesel production. The P[3SPA-2DABCO]@SiO2@Fe3O4 catalyst shows excellent catalytic performance, stabilizing soybean oil-in-methanol Pickering emulsion and achieving a biodiesel yield of 98.2% at 60 degrees C. The double responsive solid catalyst can be easily separated and retains superior catalytic activity after 6 cycles.
Article
Chemistry, Multidisciplinary
Tian Yang, Juntao Yang, Xin Deng, Evanie Franz, Lukas Fromm, Nicola Taccardi, Zhi Liu, Andreas Goerling, Peter Wasserscheid, Olaf Brummel, Joerg Libuda
Summary: The solid catalyst with ionic liquid layer (SCILL) is a successful concept in heterogeneous catalysis and electrocatalysis for selective transformation of organic compounds.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Organic
Carolina G. S. Lima, Fernanda P. Pauli, Dora C. S. Costa, Acacio S. de Souza, Luana S. M. Forezi, Vitor F. Ferreira, Fernando de Silva da Silva
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Biochemical Research Methods
Joao Francisco Filho Allochio, Nayara A. dos Santos, Keyller Bastos Borges, Valdemar Lacerda, Fabricio Souza Pelicao, Wanderson Romao
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2020)
Review
Chemistry, Medicinal
Sergio Pinheiro, Erick M. C. Pinheiro, Estela M. F. Muri, Jaqueline C. Pessoa, Mayara A. Cadorini, Sandro J. Greco
MEDICINAL CHEMISTRY RESEARCH
(2020)
Article
Chemistry, Medicinal
Sergio Pinheiro, Jaqueline C. Pessoa, Erick M. C. Pinheiro, Estela M. F. Muri, Eclair Venturini Filho, Laiza B. Loureiro, Maria Clara R. Freitas, Carlos M. D. Silva Junior, Rodolfo G. Fiorot, Jose Walkimar M. Carneiro, Karina M. Rotamiro, Anderson R. A. Guimaraes, Karin J. P. Rocha-Brito, Sandro J. Greco
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2020)
Review
Biochemical Research Methods
Juliana Barreto Ferreira, Clebson de Jesus Macrino, Laise Aparecida Fonseca Dinali, Joao Francisco Allochio Filho, Camilla Fonseca Silva, Keyller Bastos Borges, Wanderson Romao
Summary: Molecularly imprinted polymers (MIP) are a molecular recognition technology with applicability in various fields, including forensic chemistry. In the forensic context, MIP has been increasingly used in the analysis of biological fluids, particularly in the preparation of samples for the analysis of stimulant drugs.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Energy & Fuels
Nata C. L. Madeira, Polianna da S. Ferreira, Joao F. Allochio Filho, Luiz S. Chinelatto Jr, Margareth C. C. Cravo, Adriana T. Martins, Valdemar Lacerda Jr, Wanderson Romao
Summary: The study investigates the chemical variations in petroleum asphalt cement aging, using 15 standards of model compounds to represent different fractions. Results show an increase in degradation as temperature rises, including oxidation, polymerization, and formation of double bonds as observed reactions.
Article
Chemistry, Organic
Eclair Venturini Filho, Erick M. C. Pinheiro, Sergio Pinheiro, Sandro J. Greco
Summary: This review discusses the strategies and methods for developing aminopyrimidine derivatives, including optimization of synthetic protocols and implementation of multicomponent reactions. It also covers the use of these derivatives as anticancer agents and their main activities in cancer treatment.
Article
Chemistry, Medicinal
Barbara C. Lemos, Regina Westphal, Eclair Venturini Filho, Rodolfo G. Fiorot, Jose Walkimar M. Carneiro, Anne Caroline C. Gomes, Celina J. Guimaraes, Fatima C. E. de Oliveira, Pedro Mikael S. Costa, Claudia Pessoa, Sandro J. Greco
Summary: Ten enamine naphthoquinones were synthesized with yields ranging from 43 to 76%, and were screened for antiproliferative activities against human cancer cell lines. Compounds bearing picolylamine and quinoline moieties showed the highest activities, potentially acting as anticancer molecules by inhibiting topoisomerase-II and thymidylate synthase, as suggested by in silico evaluations and Molecular Docking simulations.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Review
Chemistry, Organic
Barbara C. Lemos, Eclair Venturini Filho, Rodolfo G. Fiorot, Fabrizio Medici, Sandro J. Greco, Maurizio Benaglia
Summary: This MiniReview compiles the most significant successful examples of highly efficient enantioselective catalytic protocols for the Povarov reaction since 2014, and provides a comprehensive discussion of different catalytic strategies employed in recent years. It also critically discusses the controversial dispute regarding the mechanistic pathways of this well-known reaction.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Physics, Atomic, Molecular & Chemical
Maira Kerpel dos Santos, Nayara Araujo dos Santos, Joao Francisco Allochio Filho, Layla Paixao Santos, Wanderson Romao, Rafael Scorsatto Ortiz
Summary: The study utilized Paper Spray Ionization (PSI) coupled to Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR MS) to chemically profile 92 samples of counterfeit medicines and ecstasy tablets. Different strategies for medicine counterfeiting and cross contamination with other substances were identified, providing important evidence for police intelligence.
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
(2021)
Article
Chemistry, Multidisciplinary
Mariana F. C. Cardoso, Luana S. M. Forezi, Acacio S. de Souza, Ana F. M. Faria, Raissa M. S. Galvao, Murilo L. Bello, Fernando C. da Silva, Robson X. Faria, Vitor F. Ferreira
Summary: Furanaphthoquinones are synthesized through a tandem reaction between lawsone and cyclic ketones, providing a method for synthesizing compounds with activity against T. cruzi. Compound 9b shows high potency in killing the parasite, reduced toxicity towards mammalian cells, and acts on CYP51. Candidate 9b demonstrates the best profile when bound to CYP51.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Organic
Eclair Venturini Filho, Mariana K. Antoniazi, Rafael Q. Ferreira, Gabriel F. S. dos Santos, Claudia Pessoa, Celina J. Guimaraes, Jose B. Vieira Neto, Artur M. S. Silva, Sandro J. Greco
Summary: This study presents a new green synthesis method for naphthoquinone-polyphenols and successfully synthesizes twelve novel compounds with good antiproliferative activity and antioxidant capacity under optimized conditions.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Regina Westphal, Eclair Venturini Filho, Laiza Bruzadelle Loureiro, Claudio Francisco Tormena, Claudia Pessoa, Celina de Jesus Guimaraes, Mariana Palmeira Manso, Rodolfo Goetze Fiorot, Vinicius Rangel Campos, Jackson Antonio Lamounier Camargos Resende, Fabrizio Medici, Sandro Jose Greco
Summary: In this study, a microwave-assisted Knoevenagel/Michael/cyclization multicomponent domino methodology was developed for the synthesis of spiro compounds. Twelve spiro compounds were synthesized and one of them exhibited anti-cancer activity.
Article
Chemistry, Inorganic & Nuclear
Catiucia R. M. O. Matos, Henrique C. S. Junior, Dayenny L. D'Amato, Acacio S. de Souza, Sergio Pinheiro, Guilherme P. Guedes, Glaucio B. Ferreira, Odivaldo C. Alves, Filipe B. de Almeida, Flavio Garcia, Celia M. Ronconi
DALTON TRANSACTIONS
(2020)
Article
Chemistry, Analytical
Travon Cooman, Heloa Santos, Joseph Cox, Joao Francisco Allochio Filho, Keyller Bastos Borges, Wanderson Romao, Luis E. Arroyo-Mora
FORENSIC CHEMISTRY
(2020)
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.
