期刊
TETRAHEDRON
卷 73, 期 44, 页码 6372-6380出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2017.09.034
关键词
A(3)-coupling; Propargylamines; Isocyanates; Reductive Heck reaction; 1,3-Benzodiazepines; Medium-rings
资金
- Soochow University [Q410900714]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- project of scientific and technologic infrastructure of Suzhou [SZS201708]
- Hercules Foundation [AUGE/11/029]
- Research Foundation - Flanders (FWO)
- Ministry of Education and Science of the Russian Federation [02.a03.0008]
A concise assembly of the 1,3-benzodiazepine core from A(3')-coupling-derived propargylamines and ortho-bromophenylisocyanates is described. The developed synthetic sequence involves the addition of propargylamine to isocyanate followed by palladium-catalyzed intramolecular alkyne hydroarylation that could be accomplished in a stepwise or one-pot manner. (C) 2017 Elsevier Ltd. All rights reserved.
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