Article
Chemistry, Multidisciplinary
Shubhendu S. Karandikar, Avik Bhattacharjee, Bryan E. Metze, Nicole Javaly, Edward J. Valente, Theresa M. McCormick, David R. Stuart
Summary: Diarylhalonium compounds play important roles as reagents and catalysts in organic synthesis, with the key reactivity of the three center, four electron bond requiring refinement for broader applicability. The combination of Density Functional Theory, Natural Bond Orbital Theory, and X-ray structure data can provide insights into the bonding and structure of these compounds.
Article
Chemistry, Organic
Aleksandra Nilova, Bryan Metze, David R. Stuart
Summary: Controlling reaction pathways selectively leads to a broad scope of arenes and arynophiles, offering efficient access to diverse arene chemical space and biologically active compounds with high yields.
Article
Chemistry, Organic
Kotaro Kikushima, Naoki Miyamoto, Kazuma Watanabe, Daichi Koseki, Yasuyuki Kita, Toshifumi Dohi
Summary: High reactivity of trimethoxyphenyl (TMP)-iodonium(III) acetate was achieved for phenol O-arylation. The cooperation of TMP ligand and acetate anion enhances the electrophilic reactivity towards phenol oxygen atoms. This ligand- and counterion-assisted strategy shows high applicability with tolerance towards various functional groups.
Review
Chemistry, Multidisciplinary
Cheng Pan, Limin Wang, Jianwei Han
Summary: This account summarizes our research interest in synthetic methodology with diaryliodonium salts. In addition to employing a dual activation strategy of C-I and ortho C-H bonds, we have introduced vicinal functional groups at the ortho-positions of diaryliodonium salts and explored their unique reactivities in various processes, including arylation, diarylation, cascade annulation, benzocyclization, arylocyclization, and intramolecular aryl migration. The diverse mechanisms of these reactions involving transition metals, especially palladium in organometallic catalysis, or transition-metal free conditions, are discussed in the context.
Article
Chemistry, Multidisciplinary
Avery J. To, Graham K. Murphy
Summary: In this study, it was discovered that cyclic diaryliodonium salts can act as effective Lewis-acidic halogen-bond donor catalysts in the Nazarov cyclization reaction.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Organic
Yohann Landrain, Gwilherm Evano
Summary: An efficient copper-catalyzed inter/intramolecular oxy/aminoarylation of gamma-hydroxy/aminoalkenes with diaryliodonium triflates is described. Activation of the arylating agents and the alkene with copper(II) triflate in dichloromethane leads to the formation of highly substituted tetrahydrofurans and pyrrolidines, depending on the nature of the internal nucleophile. The cyclization process is stereospecific and can also be extended to oxyalkynylation.
Article
Chemistry, Multidisciplinary
Yun Ye, Jie Zhu, Haijiao Xie, Yinhua Huang
Summary: A ligand-controlled rhodium-catalyzed reaction has been reported, which allows the synthesis of different structures of alkene products in a switchable manner.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Organic
Hend Besrour, Matthieu Hedouin, Lina Truong, Sami Lakhdar, Hassan Oulyadi
Summary: In this study, the interaction between a diphenyliodonium salt and trivalent phosphorus compounds was investigated using {H-1, F-19, P-31} NMR and DFT calculations. The importance of blue light in the reaction was highlighted, and the formation of a phosphonium intermediate was identified. The formation of an EDA complex was characterized, and the significance of acetonitrile for the formation of this complex was demonstrated. The study was further extended to other phosphonium salt formation reactions, and the stability and photoreactivity of the complexes were investigated using DFT calculations.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Multidisciplinary
Zhiyuan Bao, Chao Chen
Summary: An efficient method for the synthesis of multi-substituted cyclic imides was developed using cyanoesters and diaryliodonium salts. This method involves a cascade of N-arylation-acylation and rearrangement reactions, producing the desired heterocycles in high yields. The method has a broad substrate scope, excellent functional group compatibility, and can be extended to fused cyclic imides.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Gabriella Kervefors, Leonard Kersting, Berit Olofsson
Summary: A transition metal-free approach using unsymmetric diaryliodonium salts with anisyl ligands has been developed for the N-arylation of amino acid derivatives, achieving high chemoselectivity and yields. This method is applicable for transferring electron deficient, electron rich, and sterically hindered aryl groups, and a cyclic diaryliodonium salt was successfully employed. The N-arylated products were obtained with retained enantiomeric excess.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Chemistry, Organic
Dan Wang, Qian Li, Mengting Li, Zhengyin Du, Ying Fu
Summary: Hypervalent iodine compounds, in particular diaryliodonium salts, have been widely used in organic synthesis due to their low toxicity, mild conditions, and high selectivity. These compounds serve as efficient alternatives to heavy metal-based oxidants and expensive organometallic catalysts, showing good reactivity and selectivity in various transformations.
CURRENT ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Imran Kazi, Anuradha Nandy, Raji Selvam, Govindasamy Sekar
Summary: An efficient method for transition metal-free halogen bond-assisted regioselective C-H arylation of 2-phenylimidazo-[1,2-a]pyridines under visible-light condition has been developed. The halogen bond between an aryl halide and base (KOBu)-Bu-t initiates an electron transfer process and generates an aryl radical, which catalyzes its coupling with 2-phenylimidazo-[1,2-a]pyridines to give arylated products in good yield. This methodology has been successfully utilized to synthesize antileishmanial agents.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yaxing Wu, Chao Wu, Fei Wang, Chao Chen
Summary: A [2 + 2 + 1] annulation protocol has been developed for the modular synthesis of 2,4-disubstituted thiophenes/selenophenes, showing excellent regioselectivity. Catalyzed by copper salt, the reactions utilize elemental sulfur and selenium as the chalcogen source. Mechanistic studies indicate that the process is initiated by a trisulfur radical anion detected using EPR.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Allan J. Canty, Alireza Ariafard, Helena C. Matinakova
Summary: The study uses Density Functional Theory to examine the synthesis of benzofurans through the reaction of a palladium complex with hypervalent iodine(III) reagents. It reveals the key role of oxidative alkenylation, initial adduct formation, and 'chain-walking' at Pd-II centers in the annulation process. Computational analysis helps to reinterpret NMR data and determine barriers in the reaction pathway for key intermediates.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Physical
Alexandra Pacheco-Benichou, Eugenie Ivendengani, Ioannis K. Kostakis, Thierry Besson, Corinne Fruit
Summary: The copper-catalyzed Csp2-Csp2 bond forming reactions through C-H activation offer a useful strategy for the diversification of heterocyclic moieties. Specific phenylation of fused-pyrimidinones, including quinazolinone, has been achieved using this method, leading to the rapid access of various arylated N-containing polyheteroaromatics as potential bioactive compounds.
Article
Chemistry, Multidisciplinary
Jinfei Yang, Dengfeng Lin, Weiwei Yao, Damin Yun, Liwei Zhou, Sheng Gao, Fei Sun
Summary: The study discovers that the Oct4-targeted drug molecule NBMA can promote spermatogenesis and the differentiation of spermatogonial stem cells through activating the Oct4 pathway. This research provides a valuable candidate molecule for the development of therapeutic drugs for azoospermia.
Article
Urology & Nephrology
Song-Tao Feng, Yang Yang, Jin-Fei Yang, Yue-Ming Gao, Jing-Yuan Cao, Zuo-Lin Li, Tao-Tao Tang, Lin-Li Lv, Bin Wang, Yi Wen, Lin Sun, Guo-Lan Xing, Bi-Cheng Liu
Summary: Using bioinformatics analysis and clinical validation, it was found that urinary sediment CCL5 and CXCL1 mRNAs were upregulated in patients with diabetic nephropathy (DN) and were associated with a decline in renal function and degree of renal interstitial fibrosis. Urinary sediment CCL5 mRNA could potentially serve as a prognostic biomarker for DN.
CLINICAL KIDNEY JOURNAL
(2022)
Review
Physiology
Chongbin Liu, Ming Yang, Li Li, Shilu Luo, Jinfei Yang, Chenrui Li, Huafeng Liu, Lin Sun
Summary: Diabetic kidney disease (DKD) is a complex complication of diabetes mellitus. Inflammation is found to play a key role in the development of DKD. Anti-inflammatory agents may have beneficial effects in delaying the progression of DKD.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Weiwei Yao, Peirong Wang, Huihui Yang, Xiaohui Pu, Jinfei Yang
Summary: Breast cancer is the most prevalent cancer among women worldwide. However, currently approved clinical drugs for breast cancer have significant side effects, some of which are even carcinogenic. Lonidamine has been studied due to its potent inhibitory effect with fewer side effects, but its low bioavailability limits its clinical application. In this study, researchers aimed to enhance lonidamine's inhibitory effect on cancer cell proliferation and improve its bioavailability by modifying its structure. Through structure-based drug design strategy, two new drug molecules (18a and 18b) with higher inhibitory activity than lonidamine were synthesized. Subsequent molecular docking experiments suggested that these molecules target the estrogen receptor alpha (ER alpha). These findings are believed to provide valuable guidance for the design and development of innovative drugs against breast cancer in the future.
Article
Pharmacology & Pharmacy
Ming Yang, Shilu Luo, Jinfei Yang, Wei Chen, Liyu He, Di Liu, Li Zhao, Xi Wang
Summary: This review discusses the roles of hepatokines in diabetic nephropathy (DN) and their relationship with the liver-renal axis, proposing the potential therapeutic target of the liver-renal axis in DN.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Shilu Luo, Ming Yang, Yachun Han, Hao Zhao, Na Jiang, Li Li, Wei Chen, Chenrui Li, Jinfei Yang, Yan Liu, Chongbin Liu, Chanyue Zhao, Lin Sun
Summary: This study investigates the role of BHB in cisplatin-induced AKI and finds that BHB can protect against renal damage by inhibiting oxidative stress and reducing inflammatory responses.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Retraction
Computer Science, Information Systems
Jinfei Yang, Jiajia Li, Shouqiang Liu
MULTIMEDIA TOOLS AND APPLICATIONS
(2023)
Article
Polymer Science
Junrui Chi, Yu Zhang, Fanbin Tu, Junchen Sun, Huizhen Zhi, Jinfei Yang
Summary: Vegetable oils have potential as raw materials for polyurethane foam due to their non-toxic, biodegradable, and renewable properties. However, polyurethane foam is highly flammable and the use of vegetable oil grafted phosphorus/silicon flame retardant polyols alone is not sufficient. In this study, a new bio-based flame retardant, Polyol-P, was synthesized and combined with microencapsulated ammonium polyphosphate to modify polyurethane foam, resulting in improved flame retardancy.
JOURNAL OF POLYMER RESEARCH
(2023)
Article
Chemistry, Applied
Junrui Chi, Yu Zhang, Shutong Yu, Aoyu Ju, Yanghao Li, Huizhen Zhi, Jinfei Yang
Summary: A phosphorus-containing soybean oil-based polyol (PSOP) was synthesized from epoxidized soybean oil, and a phosphorous polyol (HEDP-PO) was synthesized from 1-hydroxyethylidene-1,1-diphosphonic acid ( HEDP) and propylene oxide (PO). The combination of these two polyols resulted in flame-retardant polyurethane foams (FRPUF) with improved thermal stability and flame retardancy. The addition of PSOP/HEDP-PO polyols reduced cell size, increased cell numbers, and increased the apparent density of PUF composites.
REACTIVE & FUNCTIONAL POLYMERS
(2023)
Article
Engineering, Biomedical
Chun Wang, Jian Xiao, Xinyue Hu, Qi Liu, Yadan Zheng, Ziyao Kang, Dongsheng Guo, Linqi Shi, Yang Liu
Summary: Biological barriers are a significant limitation in drug delivery systems, reducing their efficiency and causing undesired therapeutic effects. This study introduces a liquid core nanoparticle (LCN) composed of a polymer-encapsulated edible oil droplet. The LCN exhibits high mechanical softness and deformability, allowing it to effectively penetrate through biological barriers and deliver drugs, presenting a potential platform for disease treatments.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Ruoheng Chai, Qi Liu, Wenwei Liu, Zhancheng Li, Hua Cheng, Jianguo Tian, Shuqi Chen
Summary: In this Perspective, recent advancements in planar nanophotonics involving localized resonances, nonlocal modes, and their couplings are reviewed. The intriguing physical effects and applications related to local and/or nonlocal modes are discussed, along with large-area optimization strategies for directly simulating optical responses. Several current challenges and future directions in this attractive field are summarized as well.
Article
Chemistry, Multidisciplinary
Jin-Juan Duan, Ping-Sheng Luo, Qi Liu, Feng-Ao Sun, Li-Ming Zhu
Summary: The proposed CP-KEDL system is a method for complex product modeling design based on Long Short-Term Memory (LSTM) neural network and Kansei Engineering (KE). It transforms product modeling features into feature codes with sequence characteristics using an improved MA method and establishes a mapping model between perceptual images and modeling features based on the LSTM neural network. The experimental results show that the proposed method effectively addresses the modeling design problem of complex products, improves design satisfaction, and shortens the R&D cycle of CP industrial design.
APPLIED SCIENCES-BASEL
(2023)
Review
Chemistry, Medicinal
Huihui Yang, Weiwei Yao, Jinfei Yang
Summary: Like tuberculosis and AIDS, hepatitis B is a globally recognized major public health threat. There are currently no approved drugs that can eradicate the pathogenic DNA in patients, leading to the need for long-term medication to control HBV amplification. This review summarizes the pathogenesis of hepatitis B virus, the development of anti-HBV small molecule drugs, and highlights the role of Chinese herbal medicine in the treatment of chronic hepatitis B. It also proposes potential strategies for cccDNA eradication in the future, providing meaningful guidance for achieving a functional cure for viral hepatitis B.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Materials Science, Biomaterials
Yajing Shen, Meng Wang, Shutang Li, Jinfei Yang
Summary: Alzheimer's disease is the most common neurodegenerative disease among the elderly, causing cognitive impairment and memory loss. Current drugs only improve symptoms and do not prevent disease progression. There is an urgent need for new therapeutic strategies.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Materials Science, Biomaterials
Yajing Shen, Meng Wang, Shutang Li, Jinfei Yang
Summary: This review introduces the latest treatment techniques for Alzheimer's disease (AD) from three aspects: drug therapy, biological therapy, and physical therapy. The nanoparticle-mediated therapeutic approaches and magneto-regulated strategies using magnetic nanoparticles are highlighted. The potential application of magneto-mechanical force regulated technology for remote and precise AD therapy is also discussed.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.
