期刊
TALANTA
卷 165, 期 -, 页码 677-684出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2017.01.022
关键词
Carbon dots; Inner filter effect; Ascorbic acid; Fluorimetric detection
资金
- National Natural Science Foundation of China [21677085, 21537001, 81472986, 21305076, 21475074, 21475075]
- China Postdoctoral Science Foundation [2016M590071]
- The Natural Science Foundation of Shandong Province [ZR2013BQ019, ZFt2016EMB04]
- Project of Shandong Province Higher Educational Science and Technology Program [J16LA03]
A rapid, facile and ultrasensitive fluorescence sensing system based on nitrogen-doped carbon dots (N-doped CDs) for the detection of ascorbic acid (AA) was developed. The highly photoluminescent N-doped CDs with excellent solubility in water and good biocompatibility were prepared by a one-step hydrothermal synthesis and gave the fluorescence quantum yield of 47%. The addition of AA can intensively suppress the fluorescence of the N-doped CDs through the synergistic effect of the inner filter effect (IFE) and the static quenching effect (SQE). Benefited from the remarkable synergistic effect of IFE and SQE, a facile and ultrasensitive sensor was constructed successfully for AA sensing. The detection procedure was achieved within 2 min. The linear response range of AA was obtained from 10(-3) to 10(-8) M with a detection limit of 5 nM. This developed method enjoyed many merits including more simplicity, lost cost, high sensitivity, good selectivity, rapid response and excellent biocompatibility. Notably, the proposed fluorescent sensor exhibits excellent performance and applicability for AA determination in human serum and rat brain microdialysate, and may provide a fast yet facile route for AA detection in physiological and pathological fields.
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