Article
Chemistry, Physical
Swapna M. Gade, Vitthal B. Saptal, Bhalchandra M. Bhanage
Summary: This review discusses the synthesis, properties, and applications of glycerol carbonate (GC). The conversion of glycerol (GLY) to GC via transesterification is considered the most promising route. The effects of catalysts and operating conditions on GC yield are summarized, and future directions for GC production are discussed.
CATALYSIS COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Antonio J. Fernandez-Ropero, Bartosz Zawadzki, Emil Kowalewski, Izabela S. Pieta, Miroslaw Krawczyk, Krzysztof Matus, Dmytro Lisovytskiy, Anna Srebowata
Summary: In this study, the catalytic performance of 1 wt.% Pd/gamma-Al2O3 for the hydrogenation of 2-methyl-3-butyn-2-ol in continuous-flow mode was evaluated under different pretreatment conditions. The high-temperature reduction led to the formation of Pd-Al species in addition to pure Pd, enhancing the catalytic activity for the semi-hydrogenation reaction.
Review
Biochemistry & Molecular Biology
Juliano B. Azeredo, Filipe Penteado, Vanessa Nascimento, Luca Sancineto, Antonio L. Braga, Eder Joao Lenardao, Claudio Santi
Summary: This review highlights the applications of organoselenium compounds in biology, medicine, and material sciences, as well as the potential to synthesize them through environmentally sustainable methods.
Article
Chemistry, Multidisciplinary
Tahani A. C. A. Bayrakdar, Camille Lescot
Summary: A simple Rh-based catalyst has been developed for the carbene transfer reaction of methyl diazoacetate (MDA) and various substrates under heterogeneous flow conditions. Two different methods for heterogenizing the catalyst in a column reactor have been successfully applied. The catalyst exhibited high activity and selectivity for functionalizing different X-H (X=O, S, Si, CH2) bonds and for cyclopropenation under mild continuous flow conditions. Catalyst recycling experiments showed that up to 5 catalytic cycles could be achieved for the carbene O-H insertion reaction, and a sequential transformation of different substrates with up to 10 consecutive runs per reactor was achieved without any loss in catalytic activity, allowing the production of compound families.
Article
Chemistry, Multidisciplinary
Luca Sancineto, Cecilia Scimmi, Ornelio Rosati, Claudio Santi
Summary: The use of flow technologies is increasing among chemists working with organochalcogens compounds, specifically organoselenium and organosulfur compounds. This necessitates a review of recent literature on this topic. The review will focus on the flow synthesis of organosulfur and organo-selenium compounds, with emphasis on the advantages over batch processes. Special attention will be given to the preparation of sulfur-containing drugs and catalytic reports in both organoselenium and organosulfur research fields.
CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Mohamad Reza Khodadadi, Julien Thiel, Rajender S. Varma, Christophe Len
Summary: Solketal is identified as a promising chemical for oleochemicals, particularly for ketalisation of glycerol. Recent advancements in catalytic ketalisation of glycerol in laboratories involve homogeneous, commercial heterogeneous, and specifically designed heterogeneous catalysts.
JOURNAL OF FLOW CHEMISTRY
(2021)
Article
Chemistry, Physical
Christian Heider, Alina Winter, Viktoria Voss, Dieter Vogt, Thomas Seidensticker
Summary: Combining a tubular flow reactor with a robust homogeneous catalyst enabled running the alcohol amination at unique conditions, i.e., very high temperatures at low residence times. Catalytic activities were thus increased to unprecedented values of >900 h(-1) in the synthesis of tertiary dimethylalkylamines directly from alcohols with excellent selectivities exceeding 99%. Furthermore, several alcohols could be converted to the desired tertiary amines.
Article
Chemistry, Multidisciplinary
Qiang Chen, Yujun Wang, Guangsheng Luo
Summary: In this study, an enzyme-rich hydrogel monolithic microreactor was developed to achieve a self-sufficient cofactor system. The flow asymmetric production of chiral alcohols in this gel microreactor showed high selectivity and yield. Additionally, the cofactor utilization was significantly improved, and the catalyst exhibited improved product tolerance and storage stability.
Article
Engineering, Environmental
Chenghao Zhang, Jing Luo, Binqi Xie, Wei Liu, Jisong Zhang
Summary: A continuous micro-packed bed reactor platform is developed to determine the kinetics of aerobic ethylbenzene oxidation in the presence of N-hydroxyphthalimide. The reactor system offers enhanced gas-liquid mass transfer, leading to a significant increase in the space-time yield of ethylbenzene oxidation compared to traditional batch reactors. Furthermore, the organic catalyst NHPI is covalently anchored on commercial activated carbon through an imidization reaction. The synthesized heterogeneous catalysts exhibit excellent performance in terms of acetophenone yield and turnover frequency (TOF).
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Applied
Ailbhe A. Ryan, Sean D. Dempsey, Megan Smyth, Karen Fahey, Thomas S. Moody, Scott Wharry, Paul Dingwall, David W. Rooney, Jillian M. Thompson, Peter C. Knipe, Mark J. Muldoon
Summary: This article describes the design and development of a continuous flow process for epoxidation of alkenes using a homogeneous manganese catalyst at low metal loadings of 0.05 mol%. In this process, peracetic acid is generated in situ and directly telescoped into the epoxidation reaction, reducing risks associated with handling and storage. The success of the reaction relies on controlling the speciation of manganese/2-picolinic acid mixtures by adjusting the ligand:manganese ratio. As a result, this continuous flow process provides a cost-effective, sustainable, and scalable route to epoxides.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2023)
Article
Chemistry, Organic
Wei-Hsin Hsu, Susanne Reischauer, Peter H. Seeberger, Bartholomaus Pieber, Dario Cambie
Summary: Metallaphotoredox catalysis is a versatile synthetic platform that enables mild cross-couplings without the need for noble metals. In this study, a continuous-flow approach using a heterogeneous catalyst that combines both photo- and nickel-catalysts in one material is reported. The catalyst is embedded in a packed-bed reactor, simplifying the translation from batch to continuous flow reactions. The catalyst exhibited stability and effectiveness in the metallaphotoredox cross-coupling reactions.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Lei Cao, Syed Asad Abbas, Seo Hyeon Jeong, Dongho Seo, Ki Min Nam, Jin Kyoon Park
Summary: Selective reduction of nitro-containing arenes and heteroarenes was achieved using inexpensive NaBH4 as a hydrogen source and a newly developed Ni@N-C catalyst. The catalyst was obtained via a simple carbon coating process without the need for an external carbon source. A wide variety of nitro derivatives, including pharmaceutical molecules, were successfully reduced to the corresponding amines in yields ranging from 45% to 99%. The reactivity and selectivity of the nitro reduction were further enhanced by a continuous flow reaction system, resulting in gram-scale production of Osimertinib intermediate without any nickel metal contamination or silica gel chromatography purification.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Energy & Fuels
Anderson Cazumb, Felipe Cunha, Maira Taynara Silva, Thamiris Paiva
Summary: In this study, process intensification using a millichannel reactor was employed to reduce the reaction time and acid usage in glycerol acetylation. The results showed that the microreactors with high area/volume ratio and efficient mixing enabled high glycerol conversions and selectivities to diacetin in a short reaction time (< 5 min).
CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION
(2022)
Article
Chemistry, Physical
Debora Procopio, Maria Luisa Di Gioia
Summary: The development of renewable energy sources as alternatives to traditional fossil fuels has become a major global challenge due to declining fossil fuel reserves and their impact on global warming. Biodiesel has emerged as a popular alternative energy source for reducing gas emissions compared to traditional fuels. However, the production of biodiesel generates a large amount of glycerol as a by-product, posing environmental concerns. This review discusses the synthesis of glycerol carbonate, an important derivative of glycerol, and evaluates various synthetic methods and catalytic systems while forecasting future prospects for its development.
Article
Chemistry, Physical
Joseph Farah, Edmond Gravel, Eric Doris, Florent Malloggi
Summary: A carbon nanotube-based packed-bed microreactor was developed for on-chip oxidation of silanes. The process is catalyzed by a heterogeneous gold-carbon nanotube hybrid embedded in the device with a micrometric restriction zone. Integration of the nanohybrid enables efficient flow aerobic oxidation of substrates into corresponding silanols with high selectivity and sustainable conditions.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Physical
Yantao Wang, Deyang Zhao, Konstantinos S. Triantafyllidis, Weiyi Ouyang, Rafael Luque, Christophe Len
MOLECULAR CATALYSIS
(2020)
Review
Chemistry, Multidisciplinary
Ting Su, Deyang Zhao, Yantao Wang, Hongying Lu, Rajender S. Varma, Christophe Len
Summary: This Minireview discusses recent advancements in the catalytic oxidation of HMF to 2,5-furandicarboxylic acid (FDCA) and other intermediates using noble, non-noble, and metal-free systems deploying emerging protocols.
Article
Chemistry, Physical
Remi Nguyen, Nicolas Galy, Fatmah Ali Alasmary, Christophe Len
Summary: In this study, glycerol oligomerization for the formation of polyglycerol was successfully carried out under microwave activation using a potassium carbonate catalyst. The effects of temperature, flow rate, and residence time on the reaction were studied, and the main diglycerol and triglycerol regioisomers were quantified. By utilizing successive cyclic mode processes and short distance distillation, the mixture was enriched with glycerol ethers to obtain a mixture consisting of diglycerol, triglycerol, tetraglycerol, and pentaglycerol.
Review
Chemistry, Multidisciplinary
Mohamad Reza Khodadadi, Julien Thiel, Rajender S. Varma, Christophe Len
Summary: Solketal is identified as a promising chemical for oleochemicals, particularly for ketalisation of glycerol. Recent advancements in catalytic ketalisation of glycerol in laboratories involve homogeneous, commercial heterogeneous, and specifically designed heterogeneous catalysts.
JOURNAL OF FLOW CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ajit Kumar, Preeti Kaushik, Sandra Incerpi, Jens Z. Pedersen, Sanjay Goel, Ashok K. Prasad, Vishwajeet Rohil, Virinder S. Parmar, Luciano Saso, Christophe Len
Summary: The study revealed that ellagic acid and its acetylated product have significant ability to scavenge free radicals and exhibit antioxidative properties, as well as potential for inhibiting ROS production.
Article
Chemistry, Physical
Fatemeh Rajabi, Mika Sillanpaa, Christophe Len, Rafael Luque
Summary: The study demonstrates the efficient catalytic performance of an ionic solid nanomaterial PMO-Py-IL for the one-pot Biginelli condensation reaction under solvent-free conditions. The catalyst exhibits remarkable stability and reusability, making it a promising candidate for green synthesis.
Article
Chemistry, Physical
Robbie Radjagobalou, Virgile Rouffeteau, Alexia Deleu, Pierre Nabokoff, Janine Cossy, Christophe Len
Summary: A mild and efficient continuous-flow catalytic reductive alkylation method for methanol has been developed, which can produce high yields of O-methyl ethers and tolyl derivatives using a Pd/C catalyst under certain temperature and pressure conditions, providing an effective synthetic route for organic compounds.
MOLECULAR CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Anitha Muralidhara, Ed De Jong, Hendrikus (Roy) A. Visser, Gert-Jan M. Gruter, Christophe Len, Jean-Pierre Bertrand, Guy Marlair
Summary: This paper focuses on the safety aspects of the YXY process for the production of furandicarboxylic acid (FDCA) and polyethylene furanoate (PEF). The results indicate that FDCA has a better safety margin than other furanic compounds, while PEF exhibits slightly better energy release and combustion completeness compared to bulk polyester PET.
Article
Chemistry, Multidisciplinary
Aurore Richel, Pedro Maireles-Torres, Christophe Len
Summary: This report outlines recent advances in reducing furfural to high-value chemicals, with a focus on biobased chemicals such as furfuryl alcohol, tetrahydrofurfuryl alcohol, 2-methylfuran, and 2-methyltetrahydrofuran.
CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY
(2022)
Article
Chemistry, Organic
Xinxin Han, Xin Liu, Christophe Len, Le Liu, Dongdong Wang, Yinbin Zhang, Xin-Hua Duan, Mingyou Hu
Summary: A switchable synthesis method for the preparation of alcohols and ketones containing a CF2-OR scaffold using visible-light promotion is reported. The PDI catalysis method is characterized by its easy operation, broad substrate scopes, and the ability to switch between desired products without the need for transition metal catalysts. The addition or absence of a base plays a key role in controlling the synthesis of the major desired products.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Pouya Ghamari Kargar, Mohammad Mehdi Sadughi, Ashkan Bahadoran, Rahman S. Zabibah, Christophe Len
Summary: Recently, the green synthesis of metal nanoparticles using plant constituents and extracts has gained attention. In this study, Ag NP colloids were synthesized using Stevia plant leaf extracts and their performance as a catalyst was evaluated. The catalytic oxidation reaction carried out in deep eutectic mixtures showed high efficiency and selectivity in synthesizing the target molecule.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Review
Chemistry, Physical
Wissal Adhami, Aurore Richel, Christophe Len
Summary: The production of biobased furfural has been well-studied for a long time. Recently, the concepts of bioeconomy and circular economy have driven research towards improving production methods and exploring diverse applications. This review focuses on the recent advancements in furfural production from organic feedstocks rich in free sugars and/or polysaccharides.
MOLECULAR CATALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Sabikeh Azimi, Muna S. Merza, Fatemeh Ghasemi, Hasan Ali Dhahi, Farid Baradarbarjastehbaf, Mehdi Moosavi, Pouya Ghamari Kargar, Christophe Len
Summary: In this study, small non-peptide molecules were synthesized to inhibit the major proteinase (Mpro) of SARS-CoV-2. The antiviral potential of imidazoline derivatives as inhibitors of (SARS-CoV-2) Mpro was evaluated using in-silico techniques. The results confirmed that these compounds interacted satisfactorily with the active site of the coronavirus and showed strong interactions with specific residues.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Article
Chemistry, Organic
Xinxin Han, Xin Liu, Christophe Len, Le Liu, Dongdong Wang, Yinbin Zhang, Xin-Hua Duan, Mingyou Hu
Summary: A switchable synthesis method is developed for the production of alcohols and ketones with a CF2-OR scaffold using visible-light promotion. The PDI catalysis method is characterized by its simplicity, broad substrate scopes, and the ability to switch between desired products without the need for transition metal catalysts. The presence or absence of a base is crucial in controlling the synthesis of the major desired products.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Deyang Zhao, Ting Su, Christophe Len, Rafael Luque, Zhenglong Yang
Summary: This article provides a comprehensive review on the oxidative esterification of 5-Hydroxymethylfurfural (HMF) to furan-2,5-dimethylcarboxylate (FDMC), which is considered as a potential replacement for 2,5-furan dicarboxylic acid (FDCA) in bioplastics synthesis. The recent progress in various catalytic approaches, including the use of noble or non-noble metal catalysts in different reaction environments, is discussed. The continuous flow regime for FDMC preparation is also summarized. Furthermore, the perspective towards industrialization of HMF oxidative esterification to FDMC in a more sustainable, efficient, and economical way is proposed.
