Enantioselective Synthesis of anti-β-Hydroxy-α-amino Esters via an Organocatalyzed Decarboxylative Aldol Reaction

The first enantioselective decarboxylative aldol addition with alpha-amido-substituted malonic acid half oxyesters (MAHOs) is described. The combined use of a newly designed bifunctional sulfonamide catalyst with pentafluorobenzoic acid as an additive afforded the beta-hydroxy-alpha-amino acid derivatives in moderate to high yields and with high enantioselectivities.