Article
Cell Biology
Xiaoxuan Duan, Yihuan Chen, Kai Zhang, Wei Chen, Jun Zhao, Xiaoshuo Dai, Wenbo Cao, Ziming Dong, Saijun Mo, Jing Lu
Summary: This study found that phosphoglycerate dehydrogenase (PHGDH) was highly expressed in esophageal squamous carcinoma (ESCC), and high expression was associated with poor prognosis. In vitro and in vivo experiments demonstrated that PHGDH knockdown inhibited ESCC progression by suppressing Wnt/beta-catenin signaling pathway. These results indicate that PHGDH may be a potential therapeutic target for ESCC.
CELLULAR SIGNALLING
(2023)
Article
Oncology
Yu-Xian Yang, Yu-Zhen Zheng, Tian-Tian Gao, Shi-Liang Liu, Mian Xi, Meng-Zhong Liu, Jun-Ye Wang, Shu-Nan Qi, Yong Yang, Lei Zhao
Summary: This study systematically evaluated 3-year progression-free survival and overall survival in patients with esophageal squamous cell cancer (ESCC). The results showed that patients who experienced progression within 3 years had poor survival outcomes, while those who achieved 3-year progression-free survival had excellent outcomes. 3-year progression-free survival can be used as a reliable primary endpoint for study design and risk stratification in locally advanced ESCC.
Article
Oncology
Hongyu Zhang, Xinzhan Jiang, Qi Yu, Hanyong Yu, Chen Xu
Summary: We developed a deep learning-based staging system for predicting overall survival in patients with esophageal squamous cell carcinoma. The system was validated and visualized using data from multiple cohorts. It included 16 prognostic factors and a deep learning model to derive a total risk score for the novel staging system. Results showed that the system outperformed traditional nomograms in predicting survival outcomes.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Zewei Zhang, Chunxia Xie, Tiantian Gao, Yuxian Yang, Yong Yang, Lei Zhao
Summary: This study examines whether progression-free survival (PFS) can serve as a surrogate endpoint for overall survival (OS) in advanced Esophageal Squamous Cell Carcinoma (ESCC) treated with immunochemotherapy. The results show weak support for PFS as an OS surrogate in these cases. Additionally, continuous immunotherapy beyond progression may decrease the risk of death in qualified patients with advanced ESCC.
Article
Oncology
Miao-Fen Chen, Ming-Shian Lu, Ching-Chuan Hsieh, Wen-Cheng Chen
Summary: Increasing evidence suggests that the microbiome can influence tumor growth and the tumor microenvironment in gastrointestinal cancers. Porphyromonas gingivalis, a periodontal pathogen, is associated with the development and progression of esophageal squamous cell carcinoma. Targeting P. gingivalis or blocking IL-6 signaling may be a potential strategy to prevent and treat EsoSCC associated with this oral bacterium.
Article
Oncology
Yi Huang, Fangfang Liu, Ruiping Xu, Fuyou Zhou, Wenlei Yang, Yu He, Zhen Liu, Bolin Hou, Linlin Liang, Lixin Zhang, Mengfei Liu, Yaqi Pan, Ying Liu, Zhonghu He, Yang Ke
Summary: This study investigated the clinical data of 2769 patients with resected esophageal squamous cell carcinoma (ESCC) from a high-risk area in northern China from 2011 to 2018. The results showed that postoperative serum levels of SCC and CEA could predict the overall survival of ESCC surgical patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Weiming Han, Lan Wang, Chen Li, Junqiang Chen, Wencheng Zhang, Xin Wang, Qingsong Pang, Yidian Zhao, Xinchen Sun, Kaixian Zhang, Gaofeng Li, Ling Li, Xueying Qiao, Miaoling Liu, Yadi Wang, Lei Deng, Wenqing Wang, Nan Bi, Tao Zhang, Wei Deng, Wenjie Ni, Xiao Chang, Zongmei Zhou, Jun Liang, Qinfu Feng, Lvhua Wang, Dongfu Chen, Jima Lv, Shuchai Zhu, Chun Han, Zefen Xiao
Summary: This study aimed to investigate whether PFS can serve as a surrogate endpoint for OS in ESCC patients and characterize the prognostic factors and survival of these patients. The study found that three-year PFS may act as a potential surrogate endpoint for five-year OS, and TNM stage was considered a significant prognostic factor.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)
Article
Mathematical & Computational Biology
Ting Yan, Lili Liu, Zhenpeng Yan, Meilan Peng, Qingyu Wang, Shan Zhang, Lu Wang, Xiaofei Zhuang, Huijuan Liu, Yanchun Ma, Bin Wang, Yongping Cui
Summary: By using radiomics features and traditional TNM staging, we successfully constructed a prognostic model for predicting esophageal squamous cell carcinoma (ESCC), which demonstrated good predictive ability in both the training and validation cohorts.
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jiahang Song, Yanhu Liu, Xiang Guan, Xun Zhang, Wenda Yu, Qingguo Li
Summary: This study focused on evaluating the association between ferroptosis-related gene expression profiles and prognosis in ESCC patients, developing a new ferroptosis-related gene signature that accurately classified patients with diverse survival outcomes in GEO and TCGA cohorts. The signature was identified as an independent predictor of ESCC risk and showed potential clinical application for predicting prognosis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Liang Ma, Wenyue Yan, Xingwei Sun, Ping Chen
Summary: The study demonstrates that VPS9D1-AS1 is significantly upregulated in esophageal squamous cell carcinoma (ESCC), correlating with poor prognosis in patients. VPS9D1-AS1 can promote tumor progression and may serve as a potential biomarker for ESCC diagnosis.
Article
Cell Biology
Wenhao Zhang, Junwen Luo, Zhaohua Xiao, Yifeng Zang, Xin Li, Yougjia Zhou, Jie Zhou, Zhongxian Tian, Jian Zhu, Xiaogang Zhao
Summary: Our study revealed a novel deubiquitinase, USP36, in regulating Hippo signaling in ESCC, which could be an encouraging drug target for Hippo-driven ESCC.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Jiongyu Chen, Zhangzhu Zhou, Xueqiong Lin, Jiahui Liao, Yujie Zhang, Bingmeng Xie, Yiteng Huang, Lin Peng
Summary: This study investigates the relationship between cadmium (Cd) exposure and the development, progression, and therapeutic resistance of esophageal squamous cell carcinoma (ESCC). The results show that ESCC patients have higher levels of blood Cd compared to controls, and Cd exposure is associated with increased risk and rapid progression of ESCC. Long-term Cd exposure in ESCC cells leads to enhanced cell proliferation, invasion, and migration, as well as reduced efficacy of chemotherapy and irradiation. Cd also stimulates cancer cell stemness and activates the Wnt/β-catenin signaling pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Ying-Ying Xu, Xi-Lei Zhou, Chang-Hua Yu, Wan-Wei Wang, Fu-Zhi Ji, Dong-Cheng He, Wei-Guo Zhu, Yu-Suo Tong
Summary: The study revealed a high prevalence of sarcopenia in postoperative recurrent esophageal squamous cell carcinoma patients, with those affected experiencing higher rates of treatment-related toxicity and significantly lower survival rates compared to non-sarcopenic patients. Sarcopenia was found to be significantly associated with decreased overall survival and serves as an independent indicator of poor prognosis in this patient population.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Zhuolin Li, Yao Lin, Bizhen Cheng, Qiaoxin Zhang, Yingmu Cai
Summary: This study evaluated prognostic factors for cervical squamous cell carcinoma (CSCC) and developed personalized risk assessment nomograms to predict overall survival (OS) and cancer-specific survival (CSS) in CSCC patients. The nomograms showed good performance in prognostic prediction and could be used as an effective tool for evaluating the prognosis of CSCC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Ying-Hua Xie, Li-Qiang Ran, Zhi-Yong Wu, Chun Sun, Xiu-E Xu, Hai-Ying Zou, Wang-Kai Fang, Jian-Jun Xie
Summary: This study found that Integrin alpha 5 beta 1 is up-regulated in esophageal squamous cell carcinoma (ESCC) and is associated with prognosis. Knockdown of Integrin beta 1 and L1CAM can inhibit the proliferation, migration, and invasion of ESCC cells and reduce cisplatin resistance. These findings suggest that Integrin alpha 5 beta 1 and beta 1 play important roles in the development and chemo-resistance of ESCC.
