Article
Gastroenterology & Hepatology
Ioannis I. Lazaridis, Marko Kraljevic, Julian Susstrunk, Thomas Kostler, Urs Zingg, Tarik Delko
Summary: LAGB may be a salvage option after failed RYGB, but the high rate of revisions after secondary LAGB needs to be taken into consideration.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Surgery
Panagiotis Drakos, Panagiotis Volteas, Alisa Khomutova, Jie Yang, Lizhou Nie, Aurora D. Pryor, Salvatore Docimo, Kinga A. Powers, Konstantinos Spaniolas
Summary: Revisional sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) have better long-term durability compared to primary surgery in terms of revision or conversion.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Michael O'Laughlin, Jorge Cornejo, Alba Zevallos, Alisa Coker, Michael Schweitzer, Gina Adrales, Christina Li, Raul Sebastian
Summary: Background: The rates of secondary bariatric surgery have increased, with sleeve gastrectomy to gastric bypass conversion being the most common. This study evaluates the outcomes of this conversion compared to primary Roux-en-Y gastric bypass (RYGB) surgery using MBSAQIP data. Methods: The study analyzed the data of patients who underwent sleeve gastrectomy to RYGB conversion and primary laparoscopic RYGB, matching them based on preoperative characteristics. Results: The analysis showed that the conversion from sleeve gastrectomy to RYGB was associated with higher readmissions, interventions, conversion to open surgery, longer hospital stay, and longer operative time compared to primary RYGB. However, there were no significant differences in mortality or rates of bariatric complications. Conclusion: The study concludes that conversion from sleeve gastrectomy to RYGB is a safe and feasible procedure with reasonable outcomes compared to primary RYGB.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Medicine, General & Internal
Marita Salame, Noura Jawhar, Amanda Belluzzi, Mohammad Al-Kordi, Andrew C. Storm, Barham K. Abu Dayyeh, Omar M. Ghanem
Summary: Marginal ulcers (MU) are a potential complication following Roux-en-Y gastric bypass (RYGB) surgery, with an average prevalence of 4.6%. Early identification and prompt intervention are crucial to prevent further complications. MU is a complex condition influenced by factors such as smoking, Helicobacter pylori infection, NSAID use, and pouch size. Diagnosis is typically made through endoscopy, and treatment involves modifying risk factors and medical therapy with proton pump inhibitors. Surgical intervention may be necessary for complicated ulcers, while endoscopic procedures and vagotomy may be considered for recurrent or challenging cases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Mohamed Hany, Iman El Sayed, Ahmed Zidan, Mohamed Ibrahim, Ann Samy Shafiq Agayby, Bart Torensma
Summary: This study compared the outcomes of one-stage Roux-en-Y gastric bypass (RRYGB) and primary Roux-en-Y gastric bypass (PRYGB) after Laparoscopic adjustable gastric banding (LAGB). The results showed that one-stage RRYGB after LAGB is safe and effective, with comparable rates of complications, re-interventions, and resolution of associated comorbid conditions compared to PRYGB.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Endocrinology & Metabolism
Maria Jose Luesma, Jose Fernando, Irene Cantarero, Pilar Lucea, Sonia Santander
Summary: The prevalence of obesity has been increasing rapidly in recent decades, making it one of the most impacting diseases on global health. It is a chronic disease associated with various comorbidities that result in a reduced life expectancy and quality of life. The treatment of obesity requires a multidisciplinary approach by a specialized medical team and can be done through conservative or surgical treatments. Vertical gastrectomy, mixed techniques, and gastric bypass are the most commonly used surgical techniques. The choice of technique should consider the characteristics of each patient and the surgical team's experience.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Surgery
Samuel Hunter Dunn, Sanaa Tejani, Jaime P. Almandoz, Sarah E. Messiah, Jeffrey Schellinger, Elisa Morales Marroquin, Matthew Mathew, Jay Horton, Anna Tavakkoli
Summary: Transoral gastric outlet reduction (TORe) is a safe and effective treatment for post-prandial hypoglycemia and weight regain after Roux-en-Y gastric bypass (RYGB) in patients with symptoms refractory to medications and dietary changes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Samuel Hunter Dunn, Sanaa Tejani, Jaime P. Almandoz, Sarah E. Messiah, Jeffrey Schellinger, Elisa Morales Marroquin, Matthew Mathew, Jay Horton, Anna Tavakkoli
Summary: TORe is a safe and effective treatment for patients with refractory symptoms of post-prandial hypoglycemia and weight regain after RYGB.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Brigitte Anderson, Bryan Robins, James A. Fraser, Luke Swaszek, Caroline Sanicola, Neil King, Aurora Pryor, Konstantinos Spaniolas, Renee Tholey, Sami Tannouri, Francesco Palazzo, Alec Beekley, Talar Tatarian
Summary: This study compared the weight loss and clinical outcomes of primary Roux-en-Y Gastric Bypass (P-RYGB), adjustable gastric banding to RYGB (B-RYGB), and sleeve gastrectomy to RYGB (S-RYGB). The results showed that primary RYGB had better short-term weight loss outcomes compared to secondary RYGB, with lower risks.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Mark Dudash, Kashif Saeed, Shengxuan Wang, Alicia Johns, Ryan Colonie, Alexandra Falvo, Ryan Horsley, Jon Gabrielsen, Anthony T. Petrick, David M. Parker
Summary: This study found no benefit for postoperative pain or opioid requirements in patients undergoing robotic-assisted Roux-en-Y gastric bypass (RA-RYGB) compared to laparoscopic Roux-en-Y gastric bypass (L-RYGB), and the RA-RYGB group was more likely to report pain at the two-week follow-up.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Brigitte Anderson, Tingting Zhan, Luke Swaszek, Caroline Sanicola, Neil King, Aurora Pryor, Konstantinos Spaniolas, Renee Tholey, Francesco Palazzo, Alec Beekley, Talar Tatarian
Summary: This study evaluated the incidence of marginal ulcers (MUs) after primary and secondary Roux-en-Y Gastric Bypass (RYGB). The results showed that patients who underwent conversion of Sleeve Gastrectomy to RYGB had a higher incidence of MUs compared to those who had primary RYGB or Gastric Banding to RYGB. Furthermore, the time to MU development was significantly shorter in patients who underwent conversion surgery.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Hugo Santos-Sousa, Jorge Nogueiro, Luis Lindeza, Maria Neves Carmona, Filipe Amorim-Cruz, Fernando Resende, Andre Costa-Pinho, John Preto, Bernardo Sousa-Pinto, Silvestre Carneiro, Eduardo Lima-da-Costa
Summary: This study compared the short-term outcomes of primary and revisional bariatric surgeries. The results showed that primary surgeries were associated with better weight loss outcomes and resolution of obesity-related comorbidities compared to revisional surgeries. Revisional RYGB resulted in more weight loss than revisional SG. Revisional surgeries were effective and safe in treating obesity and related comorbidities after a failed AGB.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Endocrinology & Metabolism
Jorunn Sandvik, Kirsti Kverndokk Bjerkan, Hallvard Graeslie, Dag Arne Lihaug Hoff, Gjermund Johnsen, Christian Klockner, Ronald Marvik, Siren Nymo, Asne Ask Hyldmo, Bard Eirik Kulseng
Summary: Iron deficiency is a common long-term complication after Roux-en-Y gastric bypass (RYGB), with two-thirds of patients experiencing deficiency or insufficiency even after taking oral iron supplements.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Paolo Gentileschi, Leandro Siragusa, Federica Alicata, Michela Campanelli, Chiara Bellantone, Tania Musca, Emanuela Bianciardi, Claudio Arcudi, Domenico Benavoli, Bruno Sensi
Summary: The study found no significant difference in nutritional status at the 6-month follow-up between patients undergoing RYGB and OAGB surgery. Both procedures may lead to malnutrition, with OAGB potentially more effective in inducing remission of type II diabetes and hypertension. More large prospective studies are needed to confirm the impact of different bypass procedures on nutritional status.
Review
Surgery
Salvatore Docimo, Jie Yang, Xiaoyue Zhang, Aurora Pryor, Konstantinos Spaniolas
Summary: The study findings suggest that One Anastomosis Gastric Bypass (OAGB) has a similar early safety profile compared to Roux-en-Y Gastric Bypass (RYGB) and that concerns about perioperative risks should not deter its adoption. However, OAGB does not appear to have a significantly improved safety profile over RYGB.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Wendy C. King, Gretchen E. White, Steven H. Belle, Susan Z. Yanovski, Alfons Pomp, Walter J. Pories, Bruce M. Wolfe, Bestoun Ahmed, Anita P. Courcoulas
Summary: The study evaluated smoking history and behavior changes in patients undergoing RYGB surgery over a 7-year period. The results showed that although most adults who smoked before surgery quit pre-surgery, smoking prevalence rebounded over 7 years primarily due to relapse. Risk factors for post-surgery smoking included smoking history, younger age, low household income, marital status, and illicit drug use.
Article
Gastroenterology & Hepatology
William M. Lee, Wendy C. King, Kathleen B. Schwarz, Jody Rule, Anna S. F. Lok
JOURNAL OF VIRAL HEPATITIS
(2020)
Article
Surgery
Susan K. Raatz, LuAnn K. Johnson, Alicia Caliquary, Wendy C. King, Melissa A. Kalarchian, Michael J. Devlin, Marsha D. Marcus, James E. Mitchell
SURGERY FOR OBESITY AND RELATED DISEASES
(2020)
Review
Surgery
Wendy C. King, Amanda S. Hinerman, Anita P. Courcoulas
SURGERY FOR OBESITY AND RELATED DISEASES
(2020)
Article
Immunology
Mandana Khalili, Wendy C. King, David E. Kleiner, Mamta K. Jain, Raymond T. Chung, Mark Sulkowski, Mauricio Lisker-Melman, David K. Wong, Marc Ghany, Arun Sanyal, Richard K. Sterling
Summary: The study found that about 30% of HIV-HBV coinfected individuals had FLD, with 10% having steatohepatitis. FLD was associated with non-black race, metabolic risks, an atherogenic lipid profile, and elevated ALT over time. Identifying FLD and managing adverse metabolic profiles is crucial in HIV-HBV coinfection.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Surgery
Amanda S. Hinerman, Samar R. El Khoudary, Abdus S. Wahed, Anita P. Courcoulas, Emma J. M. Barinas-Mitchell, Wendy C. King
Summary: This study identified multiple preoperative factors associated with changes in cardiovascular risk and events following Roux-en-Y gastric bypass surgery, providing insights into patients who may benefit more from the procedure and those who may require additional support for cardiovascular health improvement.
SURGERY FOR OBESITY AND RELATED DISEASES
(2021)
Article
Immunology
Ghady Haidar, Ashley Ayres, Wendy C. King, Mackenzie McDonald, Alan Wells, Stephanie L. Mitchell, Andrew L. Bilderback, Tami Minnier, John W. Mellors
Summary: The study implemented a preprocedural screening initiative for SARS-CoV-2, revealing low infection rates (0.24% overall) that increased during COVID-19 surges. Additional studies are required to define the epidemiological threshold for universal preprocedural screening.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Gastroenterology & Hepatology
Richard K. Sterling, Wendy C. King, Mandana Khalili, David E. Kleiner, Amanda S. Hinerman, Mark Sulkowski, Raymond T. Chung, Mamta K. Jain, Mauricio Lisker-Melman, David K. Wong, Marc G. Ghany
Summary: This study evaluated the diagnostic performance of four noninvasive serum-based scores for detecting hepatic steatosis in chronic HBV cohorts, showing moderate diagnostic efficacy. The relative utility of these scores differed by co-infection/anti-HBV medication status, with population-specific cutoffs providing only moderate utility.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Mandana Khalili, David E. Kleiner, Wendy C. King, Richard K. Sterling, Marc G. Ghany, Raymond T. Chung, Atul K. Bhan, Philip Rosenthal, Mauricio Lisker-Melman, Rageshree Ramachandran, Anna S. Lok
Summary: In a large North American cohort of chronic hepatitis B patients, nearly a third had fatty liver disease, with 13% having steatohepatitis. Steatohepatitis was associated with advanced fibrosis and increased hepatic inflammation markers over time, highlighting the importance of screening and managing metabolic abnormalities to prevent disease progression in HBV patients.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Richard K. Sterling, Wendy C. King, Mandana Khalili, Raymond T. Chung, Mark Sulkowski, Mamta K. Jain, Mauricio Lisker-Melman, Marc G. Ghany, David K. Wong, Amanda S. Hinerman, Atul K. Bhan, Abdus S. Wahed, David E. Kleiner
Summary: In a North American cohort of adults with HBV-HIV on cART with virological suppression, clinical outcomes and worsening histological disease were uncommon.
Article
Gastroenterology & Hepatology
Stewart L. Cooper, Wendy C. King, Douglas B. Mogul, Marc G. Ghany, Kathleen B. Schwarz
Summary: The study found that the level of circulating HBeAg is associated with the degree of liver injury in HBeAg-positive CHB patients, as well as with race and age. In Asians, qHBeAg was inversely related to age, with a less clear relationship in Blacks and Whites. Additionally, regardless of sex, age, race, and HBV genotype, qHBeAg was higher in participants with predominant wild-type viral variants.
JOURNAL OF VIRAL HEPATITIS
(2021)
Editorial Material
Surgery
Wendy C. King
SURGERY FOR OBESITY AND RELATED DISEASES
(2021)
Article
Gastroenterology & Hepatology
Marc G. Ghany, Wendy C. King, Mauricio Lisker-Melman, Anna S. F. Lok, Norah Terrault, Harry L. A. Janssen, Mandana Khalili, Raymond T. Chung, William M. Lee, Daryl T. Y. Lau, Gavin A. Cloherty, Richard K. Sterling
Summary: The study found that HBV RNA and HBcrAg are moderately strongly correlated with HBV DNA levels, and the levels of these two markers also have certain correlations with clinical disease indicators for both HBeAg+ and HBeAg- phases of chronic hepatitis B patients.
Article
Gastroenterology & Hepatology
William M. Lee, Wendy C. King, Harry L. A. Janssen, Marc G. Ghany, Robert J. Fontana, Michael Fried, Richard K. Sterling, Jordan J. Feld, Junyao Wang, Douglas B. Mogul, Stewart L. Cooper, Adrian M. Di Bisceglie
Summary: This study investigated the rate and predictors of HBeAg loss in patients with chronic hepatitis B viral infection. The findings suggest that specific demographic, clinical, and viral characteristics can impact the rate of HBeAg loss, which may be valuable for future therapeutic studies.
JOURNAL OF VIRAL HEPATITIS
(2021)
Letter
Gastroenterology & Hepatology
Marc G. Ghany, Wendy C. King, Mauricio Lisker-Melman, Anna S. F. Lok, Norah Terrault, Harry L. A. Janssen, Mandana Khalili, Raymond T. Chung, William M. Lee, Daryl T. Y. Lau, Gavin A. Cloherty, Richard K. Sterling