Article
Clinical Neurology
Chifaou Abdallah, Helene Brissart, Sophie Colnat-Coulbois, Ludovic Pierson, Olivier Aron, Natacha Forthoffer, Jean-Pierre Vignal, Louise Tyvaert, Jacques Jonas, Louis Maillard
Summary: The study evaluated the decline in visual object naming in drug-resistant temporal lobe epilepsy patients after dominant temporal lobe resection according to the resection status of the basal temporal language area identified by cortical stimulation during stereoelectroencephalography. The results showed that resection of the basal temporal language area was associated with specific and early naming decline, with BTLA+ patients experiencing lower naming scores compared to their baseline even in the long run. Seamless mapping helps predict postoperative language outcomes after dominant temporal lobe resection.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Kathryn M. M. Snyder, Kiefer J. J. Forseth, Cristian Donos, Patrick S. S. Rollo, Simon Fischer-Baum, Joshua Breier, Nitin Tandon
Summary: Researchers found that surgical resections in the ventral temporal cortex were associated with a decline in naming ability, highlighting the important role of this region in postoperative language deficits.
Article
Clinical Neurology
William Louis Gross, Alexander I. Helfand, Sara J. Swanson, Lisa L. Conant, Colin J. Humphries, Manoj Raghavan, Wade M. Mueller, Robyn M. Busch, Linda Allen, Christopher Todd Anderson, Chad E. Carlson, Mark J. Lowe, John T. Langfitt, Madalina E. Tivarus, Daniel L. Drane, David W. Loring, Monica Jacobs, Victoria L. Morgan, Jane B. Allendorfer, Jerzy P. Szaflarski, Leonardo Bonilha, Susan Bookheimer, Thomas Grabowski, Jennifer Vannest, Jeffrey R. Binder
Summary: This study aimed to evaluate the predictive role of preoperative language functional magnetic resonance imaging (fMRI) in naming decline after left temporal lobe epilepsy (TLE) surgery. A large multicenter cohort study was conducted on 81 patients, and the results showed that fMRI was the strongest predictor of naming decline, with a negative correlation. These findings provide evidence supporting the use of preoperative language fMRI in predicting language outcome in TLE surgery patients.
Article
Clinical Neurology
Valeri Borger, Motaz Hamed, Julia Taube, Gulsah Aydin, Inja Ilic, Matthias Schneider, Patrick Schuss, Erdem Guresir, Albert Becker, Christoph Helmstaedter, Christian E. Elger, Hartmut Vatter
Summary: Temporal lobe epilepsy (TLE) is a common form of epilepsy, and about 30% of patients have drug-resistant seizures. This study evaluated the seizure outcomes of patients with drug-refractory TLE who underwent resective temporal lobe surgery (rTLS), finding that the lack of MRI lesions and placement of depth electrodes before surgery were associated with unfavorable postsurgical seizure outcomes.
JOURNAL OF NEUROSURGERY
(2021)
Review
Clinical Neurology
Nadim Jaafar, Amar Bhatt, Alexandra Eid, Mohamad Z. Koubeissi
Summary: Some surgical failures after temporal lobe epilepsy surgery may be caused by the presence of extratemporal epileptogenic zones, particularly in the medial parietal lobe. Seizures originating from this area may not cause obvious symptoms before spreading to the temporal lobe.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Dahye Kim, June Sic Kim, Woorim Jeong, Min-Sup Shin, Chun Kee Chung
Summary: Selective resection in mesial temporal lobe epilepsy surgery has been shown to effectively preserve postoperative memory function, with specific areas of resection correlating with memory decline. This suggests the importance of selective resection to protect memory function in temporal lobe surgery.
JOURNAL OF NEUROSURGERY
(2021)
Article
Medicine, General & Internal
Xi Zhang, Guojun Zhang, Tao Yu, Cuiping Xu, Jin Zhu, Xiaoming Yan, Kai Ma, Runshi Gao
Summary: This study analyzed the surgical outcomes of patients with temporal lobe epilepsy (TLE) who underwent temporal and insular SEEG recordings. The findings suggest that insular involvement may be associated with failed anterior temporal lobectomy (ATL) and poorer seizure outcomes. The study also identified temporal-insular spreading time (TIST) as an independent predictor of postoperative seizure-free outcomes in these patients.
Article
Clinical Neurology
Karin Trimmel, Lorenzo Caciagli, Fenglai Xiao, Louis A. van Graan, Matthias J. Koepp, Pamela J. Thompson, John S. Duncan
Summary: The study found that language networks in left temporal lobe epilepsy patients are particularly susceptible to dysfunction and reorganization. Early onset and long duration of epilepsy, as well as high seizure frequency, are associated with compromised activation and deactivation patterns of task-associated regions, which might explain the impaired naming performance in individuals with temporal lobe epilepsy.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Leonardo Favi Bocca, Thiago Pereira Rodrigues, Thiago Bortholin, Elza Marcia Targas Yacubian, Henrique Carrete Jr, Mirian Guaranha, Ricardo Silva Centeno
Summary: Sotos syndrome is a genetic disorder caused by NSD1 gene haploinsufficiency, with some patients experiencing epilepsy, including drug-resistant seizures. A 47-year-old female patient with Sotos syndrome had focal-onset seizures in the left temporal lobe, left-side hippocampal atrophy, and cognitive impairment. After undergoing left-side temporal lobe resection, the patient achieved complete awake seizure control and significant improvement in quality-of-life during the 3-year follow-up. Resective surgeries may be beneficial for improving seizure control and quality of life in selected patients with Sotos syndrome.
FRONTIERS IN NEUROLOGY
(2023)
Article
Behavioral Sciences
Karoline Leiberg, Jane de Tisi, John S. Duncan, Bethany Little, Peter N. Taylor, Sjoerd B. Vos, Gavin P. Winston, Bruno Mota, Yujiang Wang
Summary: Neuroimaging captures brain restructuring after anterior temporal lobe resection (ATLR), a surgical procedure for drug-resistant temporal lobe epilepsy (TLE). This study examines the effects of ATLR on brain morphology, showing significant changes mainly in regions near the resection and structurally connected to the anterior temporal lobe.
Review
Biochemistry & Molecular Biology
Alexey M. Yakimov, Elena E. Timechko, Irina G. Areshkina, Anna A. Usoltseva, Kristina D. Yakovleva, Elena A. Kantimirova, Nikita Utyashev, Nikita Ivin, Diana V. Dmitrenko
Summary: Mesial temporal lobe epilepsy is the most common type of epilepsy and surgery is often the only treatment option. This study focuses on miR-654-3p as a potential biomarker for surgical outcome, while also considering other miRNAs as indicators of relapse. The research on miRNAs as predictive biomarkers of surgical outcome is urgent, but several factors need to be taken into account.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Danni Guo, Li Feng, Zhiquan Yang, Rong Li, Bo Xiao, Shirui Wen, Yangsa Du, Chijun Deng, Xuyang Wang, Dingyang Liu, Fangfang Xie
Summary: This study found that dynamic functional network connectivity (DFNC) analysis can help us understand the neural impairment mechanisms and brain network reorganization in drug-resistant temporal lobe epilepsy (TLE), and provide additional preoperative evaluation support for surgical treatment.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Giorgi Kuchukhidze, Iris Unterberger, Elisabeth Schmid, Laura Zamarian, Christian Michael Siedentopf, Florian Koppelstaetter, Elke Gizewski, Martin Kronbichler, Gerhard Luef, Hennric Jokeit, Eugen Trinka
Summary: In this study, we found that unilateral mesial TLE and ipsilateral AE could lead to dysfunction in emotion recognition. Patients with right-side mTLE had more impaired perception and recognition of emotions compared to those with left-side mTLE. Patients also showed deficits in emotion recognition compared to healthy controls.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Olivia Foesleitner, Benjamin Sigl, Victor Schmidbauer, Karl-Heinz Nenning, Ekaterina Pataraia, Lisa Bartha-Doering, Christoph Baumgartner, Susanne Pirker, Doris Moser, Michelle Schwarz, Johannes A. Hainfellner, Thomas Czech, Christian Dorfer, Georg Langs, Daniela Prayer, Silvia Bonelli, Gregor Kasprian
Summary: Epilepsy surgery is a recommended treatment for drug-resistant temporal lobe epilepsy, but can lead to postoperative language impairment. This study found widespread bilateral remodeling of language networks after surgery, with specific patterns in left and right TLE. Contralateral language recruitment before surgery is associated with better language outcomes post-surgery in both left and right TLE.
JOURNAL OF NEUROSURGERY
(2021)
Review
Clinical Neurology
Carmen Barba, Sabrina Giometto, Ersilia Lucenteforte, Simona Pellacani, Giulia Matta, Alessandra Bettiol, Sara Minghetti, Lavinia Falorni, Federico Melani, Gianpiero Di Giacomo, Flavio Giordano, Salvatore De Masi, Renzo Guerrini
Summary: The efficacy of temporal lobe epilepsy (TLE) surgery varies between children and adults, with higher seizure freedom rates observed in children. Histopathology and surgical approach have an impact on seizure outcome, with age being an important variable.
Article
Behavioral Sciences
Thomas Johnstone, Maria Isabel Barros Guinle, Gerald A. Grant, Brenda E. Porter
Summary: The study aimed to evaluate the safety and impact of Dexmedetomidine Hydrochloride (DH) administration during pediatric invasive intracranial electroencephalography (IEEG). The results showed that DH administration was not associated with adverse events and did not significantly affect the frequency of seizures captured on the IEEG and the duration of hospitalization.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Sabra Zaraa, H. Steve White, Andy Stergachis, Edward Novotny Jr, Chris Protos, Grant Simic, Jennifer L. Bacci
Summary: This study used design thinking to develop a community pharmacist-led intervention for people living with epilepsy. Four features - pharmacist-patient consultations, care plan development, regular check-ins, and care coordination with other health care providers - were identified as desirable, feasible, and viable for the intervention. The study highlights the importance of involving pharmacists in epilepsy care and provides evidence-based features for such interventions.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Bofei Tan, Qiang Liu, Yameng Qin, Qiuyan Chen, Rong Chen, Yanzi Jin, Mengyun Li, Xiaodan Jia, Xianrui Xu, Qing Zhang
Summary: The purpose of this study was to identify factors associated with insomnia in patients with epilepsy. The results showed that nocturnal seizures and anxiety were independently associated with insomnia in these patients. Patients with epilepsy and insomnia were more likely to experience depression and excessive daytime sleepiness.
EPILEPSY & BEHAVIOR
(2024)
