Article
Clinical Neurology
Christina L. Cui, Hanaa Dakour-Aridi, Jinny J. Lu, Kevin S. Yei, Marc L. Schermerhorn, Mahmoud B. Malas
Summary: This study compares the in-hospital outcomes of three different carotid artery revascularization procedures performed within different time intervals. The results show that carotid endarterectomy (CEA) remains the safest method during the urgent period. For revascularizations performed outside of 48 hours, transcarotid artery revascularization (TCAR) and CEA have comparable outcomes, while transfemoral carotid stenting (TFCAS) carries a higher risk of stroke or death.
Article
Surgery
Kara A. Rothenberg, Lue-Yen Tucker, Rebecca C. Gologorsky, Andrew L. Avins, Hui C. Kuang, Rishad M. Faruqi, Alexander C. Flint, Mai N. Nguyen-Huynh, Robert W. Chang
Summary: This study reports low rates of adverse events and long-term stroke risk up to 5 years following carotid endarterectomy (CEA) in a large health care system. The outcomes for both asymptomatic and symptomatic indications are within consensus guidelines and published trial outcomes, supporting the optimal use of CEA for severe carotid stenosis.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Multidisciplinary Sciences
Wen-Xin Wang, Ting Wang, Lin Ma, Zheng-Hui Sun, Ge-Sheng Wang, Xin Lou
Summary: This study found a relationship between new-onset DWI lesions and changes in CBF before and after CAS in patients with symptomatic unilateral carotid stenosis. Patients in the micro-embolism group may experience a loss of CBF regulation due to long-term hypoperfusion prior to stenting, rather than direct changes in cerebral hemodynamics.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
John Joseph McCabe, Pol Camps-Renom, Nicola Giannotti, Jonathan P. McNulty, Sarah Coveney, Sean Murphy, Mary Barry, Joseph Harbison, Simon Cronin, David Williams, Gillian Horgan, Eamon Dolan, Tim Cassidy, Ciaran McDonnell, Eoin Kavanagh, Shane Foley, Sean Collins, Martin O'Connell, Alejandro Fernandez-Leon, Raquel Delgado-Mederos, Michael Marnane, Joan Marti-Fabregas, Peter J. Kelly
Summary: The study aimed to determine the association between carotid plaque inflammation detected by F-18-fluorodeoxyglucose (18)FDG-PET and late (5-year) recurrent stroke. Results showed that baseline plaque SUVmax and SCAIL score independently predicted 5-year ipsilateral recurrent stroke. This suggests that plaque inflammation-related (18)FDG uptake could improve identification of recurrent ipsilateral stroke over a 5-year period.
Article
Clinical Neurology
Francesco Squizzato, Jeffrey J. Siracuse, Fahad Shuja, Jill Colglazier, Parvathi Balachandran Wilkins, Philip P. Goodney, Benjamin Sands Brooke, Randall R. DeMartino
Summary: Objective: This study aimed to assess the impact of surgeons' shunting practice and shunt use on the early outcomes of carotid endarterectomy (CEA) in recently symptomatic patients. Results showed that the overall outcomes of CEA were similar between routine and selective shunters. However, routine shunters achieved a lower postoperative stroke rate when CEA was performed within 2 days after an ischemic stroke.
Article
Surgery
Jon S. Matsumura, Bret M. Hanlon, Kenneth Rosenfield, Jenifer H. Voeks, George Howard, Gary S. Roubin, Thomas G. Brott
Summary: This study compares the outcomes of asymptomatic, nonoctogenarian patients treated with CAS and CEA. The results show that CAS achieves comparable short- and long-term results to CEA.
JOURNAL OF VASCULAR SURGERY
(2022)
Review
Surgery
Andreia Coelho, Joao Peixoto, Armando Mansilha, A. Ross Naylor, Gert J. de Borst
Summary: This review analyzed the timing of carotid endarterectomy (CEA) and carotid artery stenting (CAS) after the index event and the outcomes within 30 days. The results suggested that CEA is safer than CAS within 2/7 days of symptom onset, but the ideal timing for performing CAS is not yet defined.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Article
Clinical Neurology
Pol Camps-Renom, John McCabe, Joan Marti-Fabregas, Nicola Giannotti, Alejandro Fernandez-Leon, Jonathan P. McNulty, Jean-Claude Baron, Mary Barry, Shelagh B. Coutts, Simon Cronin, Raquel Delgado-Mederos, Eamon Dolan, Shane Foley, Marina Guasch-Jimenez, Daniel Guisado-Alonso, Joseph A. Harbison, Gillian Horgan, Eoin C. Kavanagh, Michael Marnane, Alejandro Martinez-Domeno, Ciaran McDonnell, Vijay K. Sharma, David Williams, Martin O. Connell, Sean Murphy, Luis Prats-Sanchez, Peter J. Kelly
Summary: The SCAIL score improves the identification of early recurrent stroke in subgroups who did not experience benefit in endarterectomy trials.
Article
Clinical Neurology
Ya Yuan Rachel Leung, Kasia Bera, Daniel Urriza Rodriguez, Alan Dardik, Jean-Louis Mas, Gioele Simonte, Kittipan Rerkasem, Dominic P. J. Howard
Summary: This study conducted a systematic review and meta-analysis of 47 studies and found that elderly patients with symptomatic carotid stenosis have a higher perioperative risk following carotid endarterectomy. The risk of stroke and death after surgery is significantly higher in octogenarians compared to nonoctogenarians. However, the perioperative stroke risk has declined in octogenarians over the past three decades. These findings suggest that selective urgent intervention should be considered for symptomatic elderly patients when medical therapy alone is ineffective.
Article
Multidisciplinary Sciences
Chia-Hung Wu, Shu-Ting Chen, Jung-Hsuan Chen, Chih-Ping Chung, Chao-Bao Luo, Wei-Hsin Yuan, Feng-Chi Chang, Han-Hwa Hu
Summary: This study found that measuring the signal ratio and diameter of intracranial ICAs using TOF-MRA can help in early diagnosis and effective management of SECS, serving as a new method for severe extracranial carotid stenosis.
SCIENTIFIC REPORTS
(2021)
Article
Surgery
Kimberley Hammar, Ann Charlotte Laska, Per Wester, Kevin Mani, Annika Lundstrom, Magnus Jonsson
Summary: This Swedish study investigated the occurrence of ipsilateral ischemic stroke in patients with symptomatic carotid stenosis after surgical treatment, and found that age above 80 years and carotid artery stenting were associated with an increased risk of ipsilateral ischemic stroke.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Article
Clinical Neurology
Stephan C. Knipp, Torulv Holst, Konstantinos Bilbilis, Otgonzul von Velsen, Claudia Ose, Hans-Christoph Diener, Heinz Jakob, Arjang Ruhparwar, Karl-Heinz Joeckel, Christian Weimar
Summary: In patients with coronary artery disease and asymptomatic severe carotid stenosis, the risk of stroke or death is higher following combined CABG+CEA compared with CABG alone. However, there is no significant difference in long-term outcomes after 5 years.
Article
Surgery
Suk F. Cheng, Toby Richards, John Gregson, Martin M. Brown, Gert J. de Borst, Leo H. Bonati
Summary: After carotid endarterectomy, patch angioplasty is more effective in reducing the risk of restenosis compared to primary closure, with no significant difference between eversion endarterectomy and patch angioplasty. The use of intra-operative shunts has no significant impact on the occurrence of restenosis.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Clinical Neurology
Bin Yang, Yan Ma, Tao Wang, Yanfei Chen, Yinzhou Wang, Zhenwei Zhao, Dong Chen, Jiyue Wang, Xiaolin Xu, Tao Luo, Yang Hua, Feng Ling, Adnan I. Qureshi, Bo Hong, Liqun Jiao
Summary: In Chinese patients with carotid artery stenosis, both carotid endarterectomy (CEA) and carotid artery stenting (CAS) have low rates of recurrent risk, and the occurrence rate of postoperative complications is relatively low.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Clinical Neurology
N. Singh, J. Ospel, A. Mayank, M. Marko, O. O. Zaidat, N. H. Mueller-Kronast, D. S. Liebeskind, M. Goyal
Summary: The study used CTA to assess nonstenotic carotid plaques in patients with cardioembolic and cryptogenic strokes, finding a significant association between these plaques and ipsilateral strokes. In the cryptogenic stroke subgroup, plaque irregularity and hypodense plaque were also associated with ipsilateral stroke, suggesting a potential causative role of these plaques in certain stroke subgroups.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Article
Clinical Neurology
Ghil Schwarz, Gargi Banerjee, Isabel C. Hostettler, Gareth Ambler, David J. Seiffge, Hatice Ozkan, Simone Browning, Robert Simister, Duncan Wilson, Hannah Cohen, Tarek Yousry, Rustam Al-Shahi Salman, Gregory Y. H. Lip, Martin M. Brown, Keith W. Muir, Henry Houlden, Rolf Jager, David J. Werring
Summary: This study found associations between putative biomarkers of parenchymal CAA and putative biomarkers of leptomeningeal CAA, and suggested that CT biomarkers may help in diagnosing CAA, but MRI still plays an important role in ICH survivors with suspected CAA.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Cardiac & Cardiovascular Systems
Marc Girod, Michael Coslovsky, Stefanie Aeschbacher, Christian Sticherling, Tobias Reichlin, Laurent Roten, Nicolas Rodondi, Peter Ammann, Angelo Auricchio, Giorgio Moschovitis, Richard Kobza, Patrick Badertscher, Sven Knecht, Philipp Krisai, Andrea Marugg, Helena Aebersold, Elisa Hennings, Miquel Serra-Burriel, Matthias Schwenkglenks, Christine S. Zuern, Leo H. Bonati, David Conen, Stefan Osswald, Michael Kuehne
Summary: In this study, patients with atrial fibrillation who underwent pulmonary vein isolation (PVI) had a lower incidence of all-cause mortality and hospital admission for acute heart failure compared to those without PVI. However, there was no significant association between PVI and stroke, myocardial infarction, or bleeding.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Clinical Neurology
David J. Seiffge, Alexandros A. Polymeris, Zhe Kang Law, Kailash Krishnan, Annaelle Zietz, Sebastian Thilemann, David Werring, Rustam Al-Shahi Salman, Robert A. Dineen, Stefan T. Engelter, Philip M. Bath, Nikola Sprigg, Philippe Lyrer, Nils Peters
Summary: In this study, the type of intracerebral hemorrhage (ICH) did not show significant differences in terms of hematoma expansion (HE) or favorable outcome. Tranexamic acid was found to significantly reduce the risk of HE, regardless of the type of ICH, but was not associated with a favorable outcome. Patients with lobar CAA-ICH did not independently have an increased risk of HE, suggesting different dynamics compared to other types of ICH.
ANNALS OF NEUROLOGY
(2022)
Article
Clinical Neurology
Marta Kubacka, Annaelle Zietz, Sabine Schaedelin, Alexandros A. Polymeris, Lisa Hert, Johanna Lieb, Benjamin Wagner, David Seiffge, Christopher Traenka, Valerian L. Altersberger, Tolga Dittrich, Joachim Fladt, Urs Fisch, Sebastian Thilemann, Gian Marco De Marchis, Henrik Gensicke, Leo H. Bonati, Philippe Lyrer, Stefan T. Engelter, Nils Peters
Summary: Global cortical atrophy (GCA) is associated with the clinical prognosis of stroke patients with atrial fibrillation (AF) receiving oral anticoagulation.
CEREBROVASCULAR DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Helena Aebersold, Miquel Serra-Burriel, Fabienne Foster-Wittassek, Giorgio Moschovitis, Stefanie Aeschbacher, Angelo Auricchio, Juerg Hans Beer, Eva Blozik, Leo H. Bonati, David Conen, Stefan Felder, Carola A. Huber, Michael Kuehne, Andreas Mueller, Jolanda Oberle, Rebecca E. Paladini, Tobias Reichlin, Nicolas Rodondi, Anne Springer, Annina Stauber, Christian Sticherling, Thomas D. Szucs, Stefan Osswald, Matthias Schwenkglenks
Summary: This study analyzed the long-term costs and associated factors of atrial fibrillation (AF). It identified three patient clusters and determined patient characteristics and cost trajectories related to cost allocation. These findings are important for stratification in clinical and economic studies.
Article
Clinical Neurology
Tolga D. Dittrich, Peter B. Sporns, Lilian F. Kriemler, Salome Rudin, Anh Nguyen, Annaelle Zietz, Alexandros A. Polymeris, Christopher Traenka, Sebastian Thilemann, Benjamin Wagner, Valerian L. Altersberger, Ines Piot, Filip Barinka, Martin Haensel, Henrik Gensicke, Stefan T. Engelter, Philippe A. Lyrer, Raoul Sutter, Christian H. Nickel, Mira Katan, Nils Peters, Lars Michels, Zsolt Kulcsar, Grzegorz M. Karwacki, Marco Pileggi, Carlo Cereda, Susanne Wegener, Leo H. Bonati, Urs Fischer, Marios Psychogios, Gian Marco De Marchis
Summary: This study examined the safety and efficacy outcomes of mechanical thrombectomy (MT) in patients with anterior circulation large vessel occlusions (LVO) who fulfilled or did not fulfill the DEFUSE-3 and DAWN trial inclusion criteria. The results showed that there were no significant differences in outcomes between patients who fulfilled the criteria and those who did not, suggesting the need for randomized trials with broader inclusion criteria for MT.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Tolga D. Dittrich, Peter B. Sporns, Lilian F. Kriemler, Salome Rudin, Anh Nguyen, Annaelle Zietz, Alexandros A. Polymeris, Christopher Tranka, Sebastian Thilemann, Benjamin Wagner, Valerian L. Altersberger, Ines Piot, Filip Barinka, Susanne Mueller, Martin Haensel, Henrik Gensicke, Stefan T. Engelter, Philippe A. Lyrer, Raoul Sutter, Christian H. Nickel, Mira Katan, Nils Peters, Zsolt Kulcsar, Grzegorz M. Karwacki, Marco Pileggi, Carlo Cereda, Susanne Wegener, Leo H. Bonati, Urs Fischer, Marios Psychogios, Gian Marco De Marchis
Summary: This study evaluated the efficacy and safety of mechanical thrombectomy (MT) in adult stroke patients with anterior circulation large vessel occlusion presenting in the late time window not fulfilling the DEFUSE-3 and DAWN inclusion criteria. The study found that MT was associated with higher odds of favorable functional outcomes without an increased risk of symptomatic intracranial hemorrhage. These findings support the use of more permissive inclusion criteria for MT in the late time window.
Article
Health Care Sciences & Services
David Doig, Lewis Thorne, Jeremy Rees, Naomi Fersht, Michael Kosmin, Sebastian Brandner, Hans Rolf Jager, Stefanie Thust
Summary: This study aimed to characterize patients with gliomatosis cerebri and assess clinical outcomes. Among the 29 patients included, the median age was 64 years, with neuropsychiatric symptoms, seizures, and headaches being the most common presenting symptoms. Most patients had IDH wild-type glioblastoma, and the median survival time from referral to death was 48 weeks. Advanced imaging, including MR perfusion, proved to be valuable in identifying biopsy targets, while negative MR spectroscopy did not rule out the diagnosis of glioma.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Tolga D. Dittrich, Mara Aujesky, Salome Rudin, Annaelle Zietz, Benjamin Wagner, Alexandros Polymeris, Valerian L. Altersberger, Tim Sinnecker, Henrik Gensicke, Stefan T. Engelter, Philippe Lyrer, Viviane Hess, Raoul Sutter, Christian H. Nickel, Leo H. Bonati, Urs Fischer, Marios Psychogios, Mira Katan, Gian Marco De Marchis
Summary: This study retrospectively included data from 2715 patients with acute stroke and found that 5.9% (161/2715) of patients had pulmonary lesions on CTA. Approximately one-third of these lesions (58/161) were suspicious for malignancy. Further investigation confirmed primary or secondary pulmonary malignancy in two-thirds of patients (12/16) and they received oncologic therapy.
EUROPEAN STROKE JOURNAL
(2023)
Article
Clinical Neurology
Flurina Lyrer, Annaelle J. Zietz, David J. Seiffge, Masatoshi Koga, Bastian Volbers, Duncan Wilson, Bruno Bonetti, Sabine Schaedelin, Henrik Gensicke, Sohei Yoshimura, Kosmas Macha, Gareth Ambler, Sebastian Thilemann, Tolga Dittrich, Manabu Inoue, Kaori Miwa, Ruihao Wang, Gabriela Siedler, Luise M. Biburger, Martin M. H. Brown, Rolf H. Jager, Keith Muir, Christopher Traenka, Kanta Tanaka, Masayuki H. Shiozawa, Leo H. Bonati, Nils Peters, Gregory Y. H. A. Lip, Philippe A. Lyrer, Manuel Cappellari, Kazunori Toyoda, Bernd Kallmunzer, Stefan J. Schwab, David J. T. Werring, Stefan T. Engelter, Gian Marco A. De Marchis, Alexandros A. Polymeris
Summary: This study aimed to compare the risk of stroke recurrence between known atrial fibrillation before stroke (KAF) and atrial fibrillation detected after stroke (AFDAS) in patients with anticoagulation, and to investigate the impact of pre-existing anticoagulation on this risk difference. The study found that only pre-existing anticoagulation, not KAF, was independently associated with a higher risk of stroke recurrence. Therefore, future research should focus on the causes of stroke despite anticoagulation to develop improved preventive treatments.
ANNALS OF NEUROLOGY
(2023)
Article
Neurosciences
Edgar Chan, Ana-Marija Gal, Natasja Van Harskamp, Matthew E. Adams, Martin M. Brown, David J. Werring, Lisa Cipolotti, Robert Simister
Summary: Moyamoya Disease (MMD) is a rare cerebrovascular disorder that commonly affects the executive functions in adult patients. This study found that cognitive impairment was common in MMD patients, with executive functions being the most frequently affected. Long-term follow-up showed that the neuropsychological profile of MMD patients remained relatively stable, with no significant improvement or decline. Age of onset, history of stroke, or revascularization surgery did not affect the pattern of cognitive impairment.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mohamed Kassem, Soraya S. de Kam, Twan J. van Velzen, Rob van der Geest, Benjamin Wagner, Magdalena Sokolska, Francesca B. Pizzini, Paul J. Nederkoorn, H. Rolf Jager, Martin M. Brown, Robert J. van Oostenbrugge, Leo H. Bonati, M. Eline Kooi
Summary: This study investigated the diagnostic accuracy of detecting intraplaque hemorrhage (IPH) by using mask images from CE-MRA and TOF. The mask images from CE-MRA showed high specificity, while the TOF images had lower sensitivity.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Clinical Neurology
Simone J. A. Donners, Marjolijn L. Rots, Raechel J. Toorop, Aad van der Lugt, Leo H. Bonati, Gert J. de Borst
Summary: This study investigated the relationship between diffusion-weighted imaging (DWI) lesions after carotid artery revascularization and long-term cerebrovascular events. The results showed that DWI lesions following carotid revascularization did not seem to have a relationship with long-term stroke risk.
Article
Cardiac & Cardiovascular Systems
Fabienne Foster-Witassek, Helena Aebersold, Stefanie Aeschbacher, Peter Ammann, Juerg H. Beer, Eva Blozik, Leo H. Bonati, Mattia Cattaneo, Michael Coslovsky, Stefan Felder, Giorgio Moschovitis, Andreas Mueller, Seraina Netzer, Rebecca E. Paladini, Tobias Reichlin, Nicolas Rodondi, Annina Stauber, Christian Sticherling, Thomas Szucs, David Conen, Michael Kuehne, Stefan Osswald, Miquel Serra-Burriel, Matthias Schwenkglenks
Summary: In patients with atrial fibrillation (AF), health-related quality of life (HRQoL) remained stable over time, regardless of baseline patient characteristics. Clinical events such as hospitalization for heart failure, stroke, and bleeding had only a temporary effect on HRQoL.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)