Review
Medicine, General & Internal
Liviu Macovei, Carmen Mirela Macovei, Dragos Cristian Macovei
Summary: The aim of this review is to identify a preventive strategy to minimize the risk of adverse events in coronary syndromes patients exposed to high altitude. Stable coronary artery disease patients can tolerate traveling up to 3500 m, but unstable angina or recent myocardial infarction patients should avoid high-altitude activities. Air-travel is contraindicated for patients with recent myocardial infarction, angioplasty, intracoronary stent placement, unstable angina, or coronary artery bypass grafting.
Review
Chemistry, Multidisciplinary
Wu-Yeh Chang, Kuo-Cheng Wu, Ai-Lun Yang, Yi-Liang Chen
Summary: This article explores different hypoxia training protocols and their effects on sports performance. It discusses the physiological mechanisms of hypoxia training and its impact on cardiorespiratory fitness, muscle oxygen utilization, power performance, hematological adaptations, and specific physiological adaptations. The study finds that hypoxia high-intensity interval training (HHIIT) can increase maximum oxygen intake and improve overall sports performance. Incremental hypoxia training improves aerobic capacity but has fewer effects on hematological variables. Combined training in a hypoxia environment increases oxygen uptake and breathing volume and enhances hemodynamic function. Hypoxia during the recovery state also benefits sports performance. Further research is needed to optimize training protocols and understand their effects on different sports and athlete proficiency.
APPLIED SCIENCES-BASEL
(2023)
Article
Pharmacology & Pharmacy
Jun Hou, Keji Lu, Peiwen Chen, Peng Wang, Jing Li, Jiali Yang, Qing Liu, Qiang Xue, Zhaobing Tang, Haifeng Pei
Summary: This review provides an overview of the relationship between high-altitude hypoxia and heart rate variability (HRV), summarizing the mechanisms of diseases caused by hypoxia and changes in HRV across various systems. The study also discusses pharmaceutical interventions and aims to provide research ideas for in-depth studies on HRV.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Sport Sciences
Manuel Mateo-March, Xabier Muriel, Pedro L. Valenzuela, Alexis Gandia-Soriano, Mikel Zabala, David Barranco-Gil, Jesus G. Pallares, Alejandro Lucia
Summary: Acute altitude exposure affects real-world cycling performance differently in lowlanders and altitude natives, giving altitude natives a competitive advantage in races at altitudes above 1500 meters.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Sport Sciences
Geoffrey Warnier, Estele De Groote, Ophelie Delcorte, Daniel Nicolas Martinez, Joshua P. Nederveen, Mats I. Nilsson, Marc Francaux, Christophe E. Pierreux, Louise Deldicque
Summary: This study investigated the modulation of circulating exosome-like extracellular vesicles (ELVs) after 6 weeks of sprint interval training (SIT) at sea level and different altitudes. The results showed that there were minor differences in the levels of circulating particles, ELV markers, or miRNA between the hypoxic groups. However, the levels of circulating particles increased after training when the hypoxic groups were pooled, and tended to increase at sea level. The miRNA cargo of ELVs seemed to be modulated in hypoxic conditions only.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Multidisciplinary Sciences
Xin-Hua Wu, Yang-Yang He, Zhang-Rong Chen, Ze-Yuan He, Yi Yan, Yangzhige He, Guang-Ming Wang, Yu Dong, Ying Yang, Yi-Min Sun, Yong-Hong Ren, Qiu-Yan Zhao, Xiao-Dan Yang, Li-Ying Wang, Cai-Jun Fu, Miao He, Si-Jin Zhang, Ji-Fen Fu, Hong Liu, Zhi-Cheng Jing
Summary: Single cell transcriptomic sequencing reveals transcriptional differences in monocyte populations in patients with high-altitude pulmonary hypertension (HAPH), indicating the role of immune and inflammatory responses in the pathophysiology of HAPH.
NATURE COMMUNICATIONS
(2023)
Article
Physiology
Filipa Almeida, Paulino Padial, Juan Bonitch-Gongora, Blanca de la Fuente, Brad J. Schoenfeld, Antonio J. Morales-Artacho, Cristina Benavente, Belen Feriche
Summary: The study found that a 3-week power-oriented resistance training program conducted at moderate altitude can significantly improve explosive leg capacity, particularly in terms of jump height. The hypoxia group showed additional benefits in peak velocity and jump height compared to training at sea level, but had detrimental effects on execution time and acceleration in the judo technique tested.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mostafa A. Aboouf, Markus Thiersch, Jorge Soliz, Max Gassmann, Edith Schneider M. Gasser
Summary: The brain needs over one-fifth of the body's total oxygen demand to function normally. At high altitudes, the lower atmospheric oxygen pressure poses a challenge to the brain, impacting voluntary spatial attention, cognitive processing, and attention speed after short-term, long-term, or lifelong exposure. Molecular responses to high altitude are primarily controlled by hypoxia-inducible factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Yingda Lin, Fuming He, Ling Wu, Yuan Xu, Qiu Du
Summary: As the main effective monomer of Sophora flavescens Ait, matrine exhibits a wide range of pharmacological activities and has therapeutic effects in various diseases. The pharmacological actions of matrine may involve the activation or inhibition of key molecules in cellular signaling pathways.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Kiichi Hirota
Summary: Oxygen is essential for the body, with the hypoxia-inducible factor playing a key role in hypoxic environments. HIF-prolyl hydroxylases serve as oxygen sensors, detecting decreases in oxygen partial pressure. Inhibiting HIF-PH can activate HIF artificially for medical intervention purposes.
Review
Integrative & Complementary Medicine
Dorota Olex-Zarychta
Summary: Psychomotor performance is the coordination of a sensory or ideational (cognitive) process and a motor activity. This paper reviews the effects of hyperbaric oxygen therapy on different aspects of human psychomotor function, including musculoskeletal properties, motor abilities, cognitive function, and myocardial and pulmonary functions.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2023)
Article
Biochemistry & Molecular Biology
Richa Rathor, Geetha Suryakumar, Som Nath Singh
Summary: Exposure to high altitude leads to compromised physical performance and weight loss, with hypobaric hypoxia being a major stressor that disrupts redox homeostasis. Altered redox balance is considered the main culprit of high altitude-related skeletal muscle atrophy.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Sport Sciences
Franck Brocherie, Sebastien Racinais, Scott Cocking, Nathan Townsend, Anthony Couderc, Julien Piscione, Olivier Girard
Summary: In world-class female rugby sevens players, four additional repeated-sprint sessions before competition can improve repeated-sprint ability and brachial endothelial function. However, adding severe hypoxic stress during sets of repeated sprints does not provide supplementary benefits.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Review
Computer Science, Information Systems
Samman Fatima, Sikandar Ali, Hee-Cheol Kim
Summary: Multiple-instance learning is a popular type of weakly supervised learning that has been widely used in various domains. It has been applied in object detection, image retrieval, medical image analysis, and other areas. Numerous algorithms based on MIL have been developed over the years.
Review
Computer Science, Information Systems
Muhannad J. Alshareef
Summary: This paper provides a comprehensive review of the impact of dust on Photovoltaic (PV) systems and effective cleaning methods. It analyzes previous research and model development, highlighting the negative effects of dust accumulation on PV system efficiency and identifying research gaps for further exploration.
Article
Engineering, Biomedical
Olivier Girard, Sebastien Racinais, Anthony Couderc, Jean-Benoit Morin, Joong Hyun Ryu, Julien Piscione, Franck Brocherie
Summary: This study describes the asymmetry in main running mechanical variables during repeated treadmill sprints in elite female athletes and examines the influence of fatigue on inter-limb differences in sprinting mechanics. The results showed that there was no noticeable difference in asymmetries for the majority of stride mechanical variables during repeated treadmill sprints in elite female Rugby Sevens players.
SPORTS BIOMECHANICS
(2023)
Article
Sport Sciences
Franck Brocherie, Quentin De Larochelambert, Gregoire P. Millet
Summary: This study found that teams with basecamps near match venues had better match outcomes. However, travel distance did not significantly affect match outcomes. FIFA ranking had a positive impact on match outcomes and progression in competition. No significant associations were found between bio-meteorological conditions and match outcomes.
SCIENCE AND MEDICINE IN FOOTBALL
(2023)
Article
Physiology
Francisco Fernandez, Manuel Vazquez-Munoz, Andrea Canals, Alexis Arce-Alvarez, Camila Salazar-Ardiles, Cristian Alvarez, Rodrigo Ramirez-Campillo, Gregoire P. Millet, Mikel Izquierdo, David C. Andrade
Summary: Exercise training has been found to improve the survival rate of hypertensive patients with COVID-19 during their hospitalization period, providing strong evidence for its therapeutic efficacy in improving outcomes for these patients.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Johannes Burtscher, Erik R. Swenson, Peter Hackett, Gregoire P. Millet, Martin Burtscher
Summary: Background altitude sojourns attract individuals of all ages and different health statuses, but the risk of acute mountain sickness (AMS) when flying to high altitude destinations is often overlooked. This mini-review evaluates the altitude-dependent AMS incidence depending on the mode of ascending, such as air travel or terrestrial travel.
JOURNAL OF TRAVEL MEDICINE
(2023)
Article
Engineering, Biomedical
Elisabetta De Giovanni, Tomas Teijeiro, Gregoire P. P. Millet, David Atienza
Summary: The study proposes a method called BayeSlope, which utilizes unsupervised learning, Bayesian filtering, and non-linear normalization to improve and accurately detect the R peaks in the ECG. By combining BayeSlope with a lightweight algorithm executed in cores with different capabilities, energy consumption is reduced while maintaining accuracy. Experimental results show that BayeSlope achieves an F1 score of 99.3% during high-intensity exercise.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Jessica Lavier, Karima Bouzourene, Gregoire P. Millet, Lucia Mazzolai, Maxime Pellegrin
Summary: Exercise training is an important therapeutic strategy for treating lower extremity peripheral artery disease (PAD). This study aimed to compare the effects of exercising three or five times per week on skeletal muscle gene expression and physical performance in mice with PAD. The results showed that both exercise frequencies improved physical performance to the same extent, and there were no significant differences in gene expression patterns between the two groups. These findings suggest that exercising three to five times per week can have similar beneficial effects on performance in PAD mice.
Article
Physiology
Olivier Girard, Sebastien Racinais
Summary: The purpose of this study was to compare the effects of graded hypoxia on subsequent rapid and maximal torque-production capacity during exhaustive intermittent cycling. The results showed that both normoxia and moderate to severe hypoxia significantly reduced the rate of torque development of the knee extensors during intense intermittent cycling. Rating: 7 out of 10.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2023)
Article
Physiology
Gregoire P. Millet, Johannes Burtscher, Nicolas Bourdillon, Giorgio Manferdelli, Martin Burtscher, Oyvind Sandbakk
Summary: This article provides a brief overview of the research on VO(2)max, the principal progenitor of sports physiology. It discusses the evolution of understanding, current debates, and applications of VO(2)max in elite endurance sports and clinical settings. The accurate determination of the convective and diffusive components of VO(2)max using wearable sensors is seen as an important future application. VO(2)max is not only an indicator of endurance performance and fitness but also a vital sign of cardiovascular function and health in clinical practice.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2023)
Editorial Material
Physiology
Oyvind Sandbakk
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2023)
Article
Physiology
Julien D. Periard, Oliver Girard, Nathan Townsend, Pitre Bourdon, Scott Cocking, Mohammed Ihsan, Mathieu Lacome, David Nichols, Gavin Travers, Mathew G. Wilson, Julien Piscione, Sebastien Racinais
Summary: The purpose of this study was to investigate the effects of a training camp with heat and/or hypoxia sessions on hematological and thermoregulatory adaptations. The results showed that blood and plasma volume increased following the camp. However, sleeping at altitude impeded the increase in hemoglobin mass and only marginally increased it when training in the heat.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2023)
Article
Multidisciplinary Sciences
Chris Chow Li Tee, Mee Chee Chong, Viswanath Sundar, Chuen Leang Chok, Wee Kian Yeo, Olivier Girard
Summary: This study aimed to investigate the effects of manipulating running velocity and hypoxic exposure on gait asymmetry during treadmill running. The results showed that trained runners exhibited low-to-moderate mechanical asymmetries across a range of submaximal running velocities and varying levels of hypoxia severity.
Article
Sport Sciences
Marie-Florine Michel, Olivier Girard, Vincent Guillard, Cyril Brechbuhl
Summary: This article discusses the importance of utilizing tools to effectively manage the well-being of tennis players. These tools include monitoring relevant metrics and carefully planning training to balance health and performance considerations.
FRONTIERS IN SPORTS AND ACTIVE LIVING
(2023)
Article
Engineering, Biomedical
Clint Hansen, Caroline Teulier, Jean-Paul Micallef, Gregoire P. Millet, Olivier Girard
Summary: This study assessed the muscle activity in lower limbs during tennis serves and explored the influence of different normalization methods on the extent of differences. The results showed significant differences in EMG amplitude between different normalization techniques for certain muscles. However, the selected normalization method may provide similar information when comparing the first and second serve.
SPORTS BIOMECHANICS
(2023)
Article
Physiology
Franck Brocherie, Sebastien Racinais, Anthony Couderc, Julien Piscione, Olivier Girard
Summary: This study investigated the effects of cycling-based repeated-sprint training in hypoxia versus in normoxia on single overground running sprint performance and associated force-velocity profile in world-class female rugby sevens players. The results showed that four sessions of repeated-sprint training performed in either hypoxia or normoxia had no influence on the sprint performance and force-velocity profile of the players.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2023)