Mendelian randomization supports causality between maternal hyperglycemia and epigenetic regulation of leptin gene in newborns

Epigenetics as the mediator of fetal programming of adult onset disease: what is the evidence?

(2014) Richard Saffery et al.   ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA

Maternal obesity and gestational diabetes are associated with placental leptin DNA methylation

(2014) Corina Lesseur et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays

(2014) Martin J. Aryee et al.   BIOINFORMATICS

Pregnancy glycaemia and cord-blood levels of insulin and leptin in Pakistani and white British mother–offspring pairs: findings from a prospective pregnancy cohort

(2014) Debbie A. Lawlor et al.   DIABETOLOGIA

Global and gene-specific DNA methylation across multiple tissues in early infancy: implications for children's health research

(2014) David A. Armstrong et al.   FASEB JOURNAL

DNA methylation of leptin and adiponectin promoters in children is reduced by the combined presence of obesity and insulin resistance

(2014) M C García-Cardona et al.   INTERNATIONAL JOURNAL OF OBESITY

20 YEARS OF LEPTIN: What we know and what the future holds

(2014) Steve O'Rahilly   JOURNAL OF ENDOCRINOLOGY

A data-driven approach to preprocessing Illumina 450K methylation array data

(2013) Ruth Pidsley et al.   BMC GENOMICS

Identification of HKDC1 and BACE2 as Genes Influencing Glycemic Traits During Pregnancy Through Genome-Wide Association Studies

(2013) M. Geoffrey Hayes et al.   DIABETES

Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray

(2013) Yi-an Chen et al.   Epigenetics

Major epigenetic development distinguishing neuronal and non-neuronal cells occurs postnatally in the murine hypothalamus

(2013) Ge Li et al.   HUMAN MOLECULAR GENETICS

Neonatal Leptin Exposure Specifies Innervation of Presympathetic Hypothalamic Neurons and Improves the Metabolic Status of Leptin-Deficient Mice

(2013) K. Bouyer et al.   JOURNAL OF NEUROSCIENCE

Tissue-specific Leptin promoter DNA methylation is associated with maternal and infant perinatal factors

(2013) Corina Lesseur et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Maternal and fetal leptin, adiponectin levels and associations with fetal insulin sensitivity

(2013) Zhong-Cheng Luo et al.   Obesity

Duration of breastfeeding and gender are associated with methylation of the LEPTIN gene in very young children

(2013) Sylvia A. Obermann-Borst et al.   PEDIATRIC RESEARCH

Metabolic Programming of MEST DNA Methylation by Intrauterine Exposure to Gestational Diabetes Mellitus

(2012) N. El Hajj et al.   DIABETES

The Hyperglycemia and Adverse Pregnancy Outcome Study: Associations of GDM and obesity with pregnancy outcomes

(2012) P. M. Catalano et al.   DIABETES CARE

Periconceptional maternal micronutrient supplementation is associated with widespread gender related changes in the epigenome: a study of a unique resource in the Gambia

(2012) Batbayar Khulan et al.   HUMAN MOLECULAR GENETICS

Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease

(2012) Caroline L Relton et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

(2012) Benjamin F Voight et al.   LANCET

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

(2012) Robert A Scott et al.   NATURE GENETICS

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

(2012) Alisa K Manning et al.   NATURE GENETICS

Neonatal exposure to leptin reduces glucose tolerance in adult mice

(2011) H. Itoh et al.   Acta Physiologica

Maternal Obesity and Developmental Programming of Metabolic Disorders in Offspring: Evidence from Animal Models

(2011) M. Li et al.   Experimental Diabetes Research

Using multiple genetic variants as instrumental variables for modifiable risk factors

(2011) Tom M Palmer et al.   STATISTICAL METHODS IN MEDICAL RESEARCH

Glucose Intolerance and Cardiometabolic Risk in Adolescents Exposed to Maternal Gestational Diabetes: A 15-year follow-up study

(2010) W. H. Tam et al.   DIABETES CARE

Leptin Gene Epigenetic Adaptation to Impaired Glucose Metabolism During Pregnancy

(2010) L. Bouchard et al.   DIABETES CARE

International Association of Diabetes and Pregnancy Study Groups Recommendations on the Diagnosis and Classification of Hyperglycemia in Pregnancy

(2010)   DIABETES CARE

Epigenetic changes in early life and future risk of obesity

(2010) K A Lillycrop et al.   INTERNATIONAL JOURNAL OF OBESITY

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

(2010) Richa Saxena et al.   NATURE GENETICS

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific

(2009) Elmar W. Tobi et al.   HUMAN MOLECULAR GENETICS

Linking DNA methylation and histone modification: patterns and paradigms

(2009) Howard Cedar et al.   NATURE REVIEWS GENETICS

Cord Blood Leptin and Adiponectin as Predictors of Adiposity in Children at 3 Years of Age: A Prospective Cohort Study

(2009) C. S. Mantzoros et al.   PEDIATRICS

Intrauterine Exposure to Gestational Diabetes, Child Adiposity, and Blood Pressure

(2008) C. S. Wright et al.   AMERICAN JOURNAL OF HYPERTENSION

Association of Intrauterine Exposure to Maternal Diabetes and Obesity With Type 2 Diabetes in Youth: The SEARCH Case-Control Study

(2008) D. Dabelea et al.   DIABETES CARE

Newly identified loci that influence lipid concentrations and risk of coronary artery disease

(2008) Cristen J Willer et al.   NATURE GENETICS

Hyperglycemia and Adverse Pregnancy Outcomes

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

(2007) Debbie A. Lawlor et al.   STATISTICS IN MEDICINE