Article
Immunology
Lily E. Cohen, Chelsea L. Hansen, Melissa K. Andrew, Shelly A. McNeil, Philippe Vanhems, Jan Kyncl, Javier Diez Domingo, Tao Zhang, Ghassan Dbaibo, Victor Alberto Laguna-Torres, Anca Draganescu, Elsa Baumeister, Doris Gomez, Sonia M. Raboni, Heloisa I. G. Giamberardino, Marta C. Nunes, Elena Burtseva, Anna Sominina, Snezana Medic, Daouda Coulibaly, Afif Ben Salah, Nancy A. Otieno, Parvaiz A. Koul, Serhat Unal, Mine Durusu Tanriover, Marie Mazur, Joseph Bresee, Cecile Viboud, Sandra S. Chaves
Summary: This study uses the data set from the Global Influenza Hospital Surveillance Network (GIHSN) to investigate the severity of influenza among patients in different countries. The results show that patients in lower middle-income countries have a higher risk of severe illness and a higher mortality rate. Age and comorbid conditions also contribute to higher mortality rates. Additionally, influenza A/H1N1pdm09 infection is found to be more severe compared to A/H3N2 infection.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Editorial Material
Anesthesiology
David Lockey
Summary: The identification, triage, and extrication of casualties, as well as on-scene management and transport, can be complex and cause significant delays. An effective pre-hospital pathway is crucial for increasing survival chances and improving emergency response effectiveness.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Medicine, General & Internal
Vu Quoc Dat, Bui Thi Khanh Linh, Giang Bao Kim
Summary: This study on the burden of disease and in-hospital mortality in critical care units in Vietnam found that respiratory diseases were the leading causes of death, with infants and elderly people being at higher risk, and sepsis having the highest in-hospital mortality rate.
Article
Virology
Gregory Queromes, Emilie Frobert, Elena Burtseva, Anca Draganescu, Paravaiz A. Koul, Andrey Komissarov, V. Alberto Laguna-Torres, Jason Leblanc, F-Xavier Lopez-Labrador, Snezana Medic, Alla Mironenko, Nancy A. Otieno, Guillermo M. Ruiz-Palacios, M. Tanriover, Laurence Josset, Bruno Lina
Summary: The Global Influenza Hospital Surveillance Network (GIHSN) confirms its ability to provide valuable information on influenza infection dynamics in hospital settings through standardized data collection and analysis.
JOURNAL OF CLINICAL VIROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Peter C. Laussen
Summary: The recent events of the 2019 Coronavirus Disease pandemic have highlighted the importance of global medical collaboration and sharing of knowledge. The Invited Expert Opinion article by Peter C. Laussen emphasizes the significance of collaboration in Critical Care Medicine, particularly in the field of Pediatric Cardiac Critical Care.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Medicine, General & Internal
Tae Hwa Hong, Hyung Seok Lee, Nam-Eun Kim, Kyu Jin Lee, Yong Kyun Kim, Jung Nam An, Joo-Hee Kim, Hyung Won Kim, Sunghoon Park
Summary: This study analyzed data of hospitalized adult patients with influenza in South Korea and found that the rates of hospitalization, critical care resource use, and in-hospital mortality have increased again in recent years. Older adults are particularly vulnerable to influenza-related complications. Strategies are needed to reduce infections, optimize resource use, and prioritize care for older people.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Roland Faigle, Bridget J. Chen, Rachel Krieger, Elisabeth B. Marsh, Ayham Alkhachroum, Wei Xiong, Victor C. Urrutia, Rebecca F. Gottesman
Summary: This study developed an INTRINSIC score to identify patients with ICH at low risk for critical care interventions, based on factors such as SBP, GCS, ICH volume, and IVH. The score demonstrated high sensitivity and specificity in predicting absence of critical care needs in patients with ICH.
Article
Clinical Neurology
Roland Faigle, Bridget J. Chen, Rachel Krieger, Elisabeth B. Marsh, Ayham Alkhachroum, Wei Xiong, Victor C. Urrutia, Rebecca F. Gottesman
Summary: The INTRINSIC score was developed to identify patients with intracerebral hemorrhage (ICH) at low risk for critical care interventions. It includes factors such as systolic blood pressure, Glasgow Coma Scale score, intraventricular hemorrhage, and ICH volume as predictors. The score showed good predictive ability in both the validation cohort and external validation dataset, with high sensitivity and specificity for predicting the absence of critical care needs.
Article
Infectious Diseases
Amanda Thurler Palomo, Ana Paula Maia Pires, Marcelo Fernando Matielo, Rafael de Athayde Soares, Christiano Pecego, Roberto Sacilotto, Alexandre Inacio de Paula, Nair Hosino, Cristiano de Melo Gamba, Cibele Lefreve Fonseca, Daniela K. S. Paraskevopoulos, Augusto Yamaguti, Joao Silva de Mendonca, Silvia Figueiredo Costa, Thais Guimaraes
Summary: This retrospective study evaluated the microbiologic profile and susceptibility pattern of diabetic foot infection patients requiring hospitalization. The results showed that Enterococcus and Staphylococcus aureus were the most prevalent pathogens, while Pseudomonas aeruginosa was the most common Gram-negative bacterium. The knowledge of microbial characteristics and susceptibility patterns is essential for guiding empirical therapy for DFI patients.
Article
Medicine, General & Internal
Antonia Gasch-Illescas, Maria Andrade-Arroyo, Antonio J. Vallejo-Vaz, Juan M. Praena-Fernandez, Jose A. Guerrero, Enrique J. Calderon, Marina Pollan, Francisco J. Medrano
Summary: This study evaluates the impact of the COVID-19 pandemic on non-COVID patients in a tertiary hospital in Spain during the second pandemic wave. The results show a decrease in non-COVID admissions, an increase in emergency admissions and mortality, longer hospital stays, and a significant impact on medical and surgical diagnoses. These findings emphasize the need to consider the broader impact of the pandemic on non-COVID patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Melissa K. Andrew, Henrique Pott, Lisa Staadegaard, John Paget, Sandra S. Chaves, Justin R. Ortiz, John McCauley, Joseph Bresee, Marta C. Nunes, Elsa Baumeister, Sonia Mara Raboni, Heloisa I. G. Giamberardino, Shelly A. McNeil, Doris Gomez, Tao Zhang, Philippe Vanhems, Parvaiz A. Koul, Daouda Coulibaly, Nancy A. Otieno, Ghassan Dbaibo, Maria Lourdes Guerrero Almeida, Victor Alberto Laguna-Torres, Anca Cristina Draganescu, Elena Burtseva, Anna Sominina, Daria Danilenko, Snezana Medic, Javier Diez-Domingo, Bruno Lina, GIHSN Investigators
Summary: The Global Influenza Hospital Surveillance Network (GIHSN) conducted a study to analyze the comorbidities, symptoms, and outcomes of patients hospitalized with influenza. The study found that age, diabetes, and chronic obstructive pulmonary disease were associated with higher odds of death and ICU admission, while male sex and influenza vaccination were associated with lower odds.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Critical Care Medicine
Ryan L. DeSanti, Binod Balakrishnan, Tom B. Rice, Jose A. Pineda, Peter A. Ferrazzano
Summary: This study aimed to define the prevalence of neurologic diagnoses and evaluate the utilization of critical care resources among children in the PICU. The findings showed that a diagnosis of acute neurologic disease was associated with greater use of resources and was linked to a decline in functional status and an increase in mortality.
PEDIATRIC CRITICAL CARE MEDICINE
(2022)
Article
Obstetrics & Gynecology
Nicole Krenitsky, Timothy Wen, Stephanie Cham, Kartik K. Venkatesh, Frank Attenello, William J. Mack, Mary D'Alton, Alexander M. Friedman
Summary: The objective of this study was to determine whether obstetric patients are more likely to be admitted for influenza and require critical care interventions. The study found that pregnant women are three times more likely to be admitted for influenza and have a higher risk of intensive care unit interventions compared to nonpregnant women. These findings emphasize the importance of reducing infection risk in pregnant women.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Review
Critical Care Medicine
Jason Phua, Chae-Man Lim, Mohammad Omar Faruq, Khalid Mahmood Khan Nafees, Bin Du, Charles D. Gomersall, Lowell Ling, Jigeeshu Vasishtha Divatia, Seyed Mohammad Reza Hashemian, Moritoki Egi, Aidos Konkayev, Mohd Basri Mat-Nor, Gentle Sunder Shrestha, Madiha Hashmi, Jose Emmanuel M. Palo, Yaseen M. Arabi, Hon Liang Tan, Rohan Dissanayake, Ming-Cheng Chan, Chairat Permpikul, Boonsong Patjanasoontorn, Do Ngoc Son, Masaji Nishimura, Younsuck Koh
Summary: Critical care in Asia has made progress over the years, but challenges such as lack of skilled healthcare workers and resources, as well as cultural differences in end-of-life care, continue to exist. Collaboration across disciplines, societies, and governments is essential to address these challenges and improve critical care in the region.
JOURNAL OF INTENSIVE CARE
(2021)
Article
Multidisciplinary Sciences
Pichanon Mingchay, Leilani Paitoonpong, Kamon Kawkitinarong, Pirapon June Ohata, Gompol Suwanpimolkul
Summary: This study assessed the incidence of tuberculosis (TB) disease among healthcare workers (HCWs) at a hospital in Thailand. The results showed that the incidence of TB among HCWs was similar to the general population. Certain professions that had contact with TB patients and their specimens had a higher incidence of TB. Additionally, a significant proportion of asymptomatic HCWs and those who had worked for less than 5 years were found to have TB disease.
Article
Public, Environmental & Occupational Health
Christopher E. Kandel, Andra Banete, Maureen Taylor, Andrea Llanes, Janine McCready, Gloria Crowl, Matthew Young, Angel X. Li, Emily Chien, Winfield Yim, Lily Yip, Robert Kozak, Allison J. McGeer, Samira Mubareka, Jeff E. Powis
Summary: There was no difference in viral shedding between outpatients with coronavirus disease 2019 (COVID-19) due to the severe acute respiratory coronavirus virus 2 (SARS-CoV-2) delta (delta) variant who received 2 vaccine doses at 7 days after symptom onset and those who did not receive the vaccine, with SARS-CoV-2 cultured from 2 (7%) of 28 and 1 (4%) of 26 outpatients, respectively.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Letter
Public, Environmental & Occupational Health
Ahmed Vanker, Lara de Waal, Allison McGeer, Matthew Morgan
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Martha Muller, Kristina A. Bryant, Claudia Espinosa, Jill A. Jones, Caroline Quach, Jessica R. Rindels, Dan L. Stewart, Kenneth M. Zangwill, Pablo J. Sanchez
Summary: This document is part of the SHEA Neonatal Intensive Care Unit (NICU) White Paper Series, providing practical and expert opinions on CLABSI detection and prevention in the NICU. CLABSI is a common and serious infection in the NICU, leading to significant morbidity and mortality. The document highlights the success of bundled central line care practices in reducing CLABSI rates and offers practical approaches.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Letter
Immunology
Matthew P. Muller, Sharmistha Mishra, Allison McGeer, Samir Patel, Jonathan Gubbay, Maan Hasso, Adrienne K. Chan, Robert Kozak, Jerome A. Leis, Darrell S. Tan
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Julie A. Bettinger, Michael A. Irvine, Hennady P. Shulha, Louis Valiquette, Matthew P. Muller, Otto G. Vanderkooi, James D. Kellner, Karina A. Top, Manish Sadarangani, Allison McGeer, Jennifer E. Isenor, Kimberly Marty, Phyumar Soe, Gaston De Serres
Summary: This study examined the short-term safety of COVID-19 vaccines in adults with a previous history of SARS-CoV-2 infection. It found that adults with moderate or severe previous infection were more likely to experience health events after each vaccine dose, while the risk associated with previous infection was attenuated after subsequent doses.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Ana C. Blanchard, Valerie Lamarre, Josee Lamarche, Nathalie Audy, Caroline Quach
Summary: In a pediatric healthcare center in Quebec, Canada, healthcare workers with household exposure to confirmed COVID-19 cases were allowed to work. On repeated testing, 15% tested positive for SARS-CoV-2 by PCR, but there was no nosocomial transmission. Being asymptomatic and receiving a booster dose at least 7 days prior to exposure were protective against becoming PCR-positive for SARS-CoV-2.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Correction
Microbiology
Bradley Pickering, Oliver Lung, Finlay Maguire, Peter Kruczkiewicz, Jonathon D. Kotwa, Tore Buchanan, Marianne Gagnier, Jennifer L. Guthrie, Claire M. Jardine, Alex Marchand-Austin, Ariane Masse, Heather McClinchey, Kuganya Nirmalarajah, Patryk Aftanas, Juliette Blais-Savoie, Hsien-Yao Chee, Emily Chien, Winfield Yim, Andra Banete, Bryan D. Griffin, Lily Yip, Melissa Goolia, Matthew Suderman, Mathieu Pinette, Greg Smith, Daniel Sullivan, Josip Rudar, Oksana Vernygora, Elizabeth Adey, Michelle Nebroski, Guillaume Goyette, Andres Finzi, Genevieve Laroche, Ardeshir Ariana, Brett Vahkal, Marceline Cote, Allison J. McGeer, Larissa Nituch, Samira Mubareka, Jeff Bowman
NATURE MICROBIOLOGY
(2023)
Article
Microbiology
Sheila F. F. O'Brien, Niamh Caffrey, Qi-Long Yi, Shelly Bolotin, Naveed Z. Z. Janjua, Mawuena Binka, Caroline Quach Thanh, Derek R. R. Stein, Amanda Lang, Amy Colquhoun, Chantale Pambrun, Cassandra N. N. Reedman, Steven J. J. Drews
Summary: Canadian blood donors, representing a healthy adult population, demonstrate disparities associated with race and material deprivation, highlighting the impact of socioeconomic gradient on SARS-CoV-2 infections in the country. The study compares the prevalence of SARS-CoV-2 antibodies in blood donors across different regions of Canada in 2021. The highest seroprevalence was observed in Alberta and the Prairies, while Atlantic Canada had significantly lower seroprevalence. Factors such as gender, age, racialization, and material and social deprivation showed varying associations with seroprevalence across different regions.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biotechnology & Applied Microbiology
Thibault Bourdin, Marie-Eve Benoit, Alizee Monnier, Emilie Bedard, Michele Prevost, Dominique Charron, Nathalie Audy, Sophie Gravel, Melanie Sicard, Caroline Quach, Eric Deziel, Philippe Constant
Summary: Compelling evidence suggests that the sink environment is a significant source of transmission of opportunistic pathogens, such as Serratia marcescens, from the hospital environment to patients in the neonatal intensive care units (NICU).
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Immunology
Hannah Chung, Michael A. Campitelli, Sarah A. Buchan, Aaron Campigotto, Branson Chen, Natasha S. Crowcroft, Vinita Dubey, Jonathan B. Gubbay, Timothy Karnauchow, Kevin Katz, Allison J. McGeer, J. Dayre McNally, Samira Mubareka, Michelle Murti, David C. Richardson, Laura C. Rosella, Kevin L. Schwartz, Marek Smieja, George Zahariadis, Jeffrey C. Kwong
Summary: The effectiveness of influenza vaccine against laboratory-confirmed influenza was similar between statin users and nonusers. However, statin users had a higher risk of influenza infection compared to nonusers, regardless of vaccination status. This study suggests that statin use may affect the effectiveness of influenza vaccine and increase the risk of influenza infection.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Dylan C. Kain, Sandra Isabel, Mariana Abdulnoor, Karel Boissinot, Richard De Borja, Amanda Filkin, Bernard Lam, Jason Li, Ilinca Lungu, Liz McCreight, Allison McGeer, Tony Mazzulli, Aimee Paterson, Philip Zuzarte, Felicia Vincelli, Cassandra Bergwerff, Ramzi Fattouh, Jared T. Simpson, Jennie Johnstone
Summary: During the COVID-19 pandemic, a severe SARS-CoV-2 outbreak occurred in a hospital in Toronto, Canada, from November 2020 to January 2021. The outbreak involved 8 patients and 10 staff and resulted in 3 patient deaths. Investigation revealed that patients cared for in geriatric chairs at the nursing station were at high risk for both acquiring and transmitting SARS-CoV-2. Therefore, it is important to consider the risk of informal patient care settings and prioritize room-based care during high-risk periods or outbreaks.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Lucila Baldassarre, Caroline Quach-Thanh, Verinsa Mouajou Feujio, Fazia Tadount, Claudia Deyirmendjian, Marie-Astrid Lefebvre, Nisha Thampi, Oliver Schneider, Isabela Fabri-Karam, Shauna O'Donnell, James Okeny-Owere, N. Audy, Nadia Desmarais
Summary: This study aimed to determine the incidence and risk factors for recurrent Clostridioides difficile infection (rCDI) in pediatric patients. A retrospective cohort study of pediatric patients with laboratory-confirmed CDI was conducted, and it was found that the incidence proportion for rCDI was 12.9%. Immunocompromised patients had a higher risk of rCDI (17.5%) and treatment with vancomycin monotherapy did not show significant protection.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Infectious Diseases
Kuganya Nirmalarajah, Winfield Yim, Patryk Aftanas, Angel X. Li, Altynay Shigayeva, Lily Yip, Zoe Zhong, Allison J. Mcgeer, Finlay Maguire, Samira Mubareka, Robert Kozak
Summary: This study investigated the effects of Remdesivir (RDV) treatment on intra-host SARS-CoV-2 diversity and low-frequency mutations in moderately ill hospitalized COVID-19 patients. The results showed minimal intra-host variability and few low-frequency variants in patients receiving short courses of RDV, suggesting little selective pressure.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2023)
Article
Geriatrics & Gerontology
Pamela Leece, Michael Whelan, Andrew P. Costa, Nick Daneman, Jennie Johnstone, Allison McGeer, Paula Rochon, Kevin L. Schwartz, Kevin A. Brown
Summary: Studies conducted before the COVID-19 pandemic have found that crowding in nursing homes is associated with higher incidence of respiratory infections and mortality. This association is consistent across various respiratory pathogens. Decreasing crowding is important for resident wellbeing and reducing the transmission of respiratory pathogens.
LANCET HEALTHY LONGEVITY
(2023)
Letter
Immunology
Sharon Sukhdeo, Matthew Muller, Allison McGeer, Jerome A. Leis, Adrienne Chan, Jonathan B. Gubbay, Samir Patel, Saman Khan, Stephen Perusini, Xinliu Angel Li, Robert Kozak, Sharmistha Mishra, Darrell H. S. Tan, Christopher Kandel
OPEN FORUM INFECTIOUS DISEASES
(2023)
