Article
Multidisciplinary Sciences
Uikyu Chae, Jiwan Woo, Yakdol Cho, Jeong- Kyu Han, Soo Hyun Yang, Esther Yang, Hyogeun Shin, Hyun Kim, Hyun- Yong Yu, C. Justin Lee, Il-Joo Cho
Summary: Real-time monitoring of neurochemicals and electrical activity in the brain is essential for investigating neural circuits. We have developed a real-time bimodal neural probe that can simultaneously measure multiple neurochemicals without cross-talk and record electrical activity. Using this probe, we have demonstrated simultaneous measurements of glucose, lactate, choline, and glutamate, as well as functional connectivity between brain regions. This device has the potential to greatly enhance our understanding of neurochemicals in neural circuits and aid in the development of drugs for brain diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Mohammad Sadeq Saleh, Sandra M. Ritchie, Mark A. Nicholas, Hailey L. Gordon, Chunshan Hu, Sanjida Jahan, Bin Yuan, Rriddhiman Bezbaruah, Jay W. Reddy, Zabir Ahmed, Maysamreza Chamanzar, Eric A. Yttri, Rahul P. Panat
Summary: Researchers have developed customizable and physically robust 3D multi-electrode devices using a 3D nanoparticle printing approach, allowing efficient recording and analysis of electrophysiological activity in the brain.
Review
Biochemical Research Methods
Anton Guimera-Brunet, Eduard Masvidal-Codina, Jose Cisneros-Fernajndez, Francesc Serra-Graells, Jose A. Garrido
Summary: Neuroelectronic interfaces play a crucial role in uncovering the working mechanisms of the brain, with multichannel neural probes and acquisition systems enabling recording of brain signals using thousands of channels.
CURRENT OPINION IN BIOTECHNOLOGY
(2021)
Article
Physics, Applied
Hiroki Yasunaga, Toshihiro Takagi, Daisuke Shinko, Yusei Nakayama, Yuichi Takeuchi, Atsushi Nishikawa, Alexander Loesing, Masahiro Ohsawa, Hiroto Sekiguchi
Summary: A neural probe with MicroLEDs and neural electrodes was fabricated for optogenetic application, successfully recording local field potentials. The MicroLEDs showed consistent current-voltage characteristics and sufficient light output for manipulating neural activity. Simulation of light distribution in brain tissue and investigation of LED temperature increase led to valuable insights for improving efficiency.
JAPANESE JOURNAL OF APPLIED PHYSICS
(2021)
Article
Biophysics
Shahrzad Forouzanfar, Nezih Pala, Marc Madou, Chunlei Wang
Summary: The review provides an overview of the progress, fabrication processes, technical challenges, and opportunities of C-MEMS and C-NEMS technologies in biotech applications, as well as outlooks for future developments.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Multidisciplinary
Lei Gao, Jinfen Wang, Yan Zhao, Hongbian Li, Mengcheng Liu, Jianfei Ding, Huihui Tian, Shouliang Guan, Ying Fang
Summary: Flexible neural electrodes integrated on micrometer-thick polymer substrates offer important opportunities for improving neuronal activity recordings. By developing self-assembled nanofilm electrode arrays, high-density, free-standing gold nanofilm electrodes are able to form intimate interfaces with neural tissue, enabling stable recordings across multiple brain regions over several months. The results highlight the potential of free-standing nanoscale materials for interfacing biological systems over long terms.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Analytical
Guizheng Zou, Xuwen Gao, Xiancheng Liu, Ying Zeng, Qingqing Zhang, Bin Zhang
Summary: This study developed a highly monochromatic and bandgap-engineered ECL luminophore and achieved spectrum-resolved multiplexing detection of different targets. The method does not require signal amplification and avoids interference between immunoassays and DNA probe detection.
ANALYTICAL CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Jiaxin Xu, Hamidreza Shirinkami, Seoyoung Hwang, Hee Soo Jeong, Gijung Kim, Sang Beom Jun, Honggu Chun
Summary: A reconfigurable TiO2 electrode array with an anatase-brookite bicrystalline polymorphous mesoporous layer was fabricated for high-resolution light-addressing. The electrode array showed high stability and enabled highly localized neural stimulation at the single-cell level.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Majid Laleh, Yunze Xu, Mike Y. J. Tan
Summary: This short communication presents a corrosion probe design based on a three-dimensional electro-chemically integrated electrode array. A representative probe was developed for detecting complex localized corrosion in a liquid-containing pipe. The results show that the probe has sufficient temporal and spatial resolutions for in-situ monitoring of various corrosion types and investigating the influencing factors. This work suggests that the three-dimensional electrode array probe is a promising tool for probing multi-phase and multi-mechanism localized corrosion in complex industrial environments.
Article
Chemistry, Physical
Yong Lin, Qingsong Li, Chen Ding, Jiayi Wang, Wei Yuan, Zhiyuan Liu, Wenming Su, Zheng Cui
Summary: This paper proposes a method for preparing large-size stretchable circuit boards with high-resolution electrodes using screen printing and vacuum filtration. The prepared electrodes have smooth edges and controllable conductivity, making them suitable for strain-insensitive stretchable circuits in wearable and health-related electronic applications.
Article
Biophysics
Venkata Suresh Vajrala, Kamil Elkhoury, Sophie Pautot, Christian Bergaud, Ali Maziz
Summary: This paper reports a novel Hollow Ring-like type electrode for sensing and/or stimulating neural activity from three-dimensional neural networks. The ring electrode architecture enables easy access to three-dimensional neural networks with reduced mechanical contact on the biological tissue, and provides improved electrical interface with cells. The hollow ring design shows great potential for developing next-generation microelectrodes for applications in neural interfaces.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Biotechnology & Applied Microbiology
Kevin Woeppel, Christopher Hughes, Angelica J. Herrera, James R. Eles, Elizabeth C. Tyler-Kabara, Robert A. Gaunt, Jennifer L. Collinger, Xinyan Tracy Cui
Summary: In this clinical study, long-term implanted brain-computer interfaces showed more pronounced tissue encapsulation and material degradation, resulting in lower signal amplitude and impedance. Strategies for minimizing fibrotic encapsulation and enhancing material stability are needed for better recording and stimulation in longer implantation periods.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Energy & Fuels
Kugalur Shanmugam Ranjith, Seyed Majid Ghoreishian, Nilesh R. Chodankar, Ganji Seeta Rama Raju, Swati J. Patil, Yun Suk Huh, Young-Kyu Han
Summary: Heterostructured metallic electrode materials fabricated by altering the structurally engineered morphologies are promising in ameliorating electrodes' functionality in energy storage applications. Effective and novel double-shell sandwich-like NiCO3/NiMnO3-rGO-Co3O4 (Ni-NMO-rGO-CoO) nanoflake array (NFA) heterostructures were prepared on highly conducting 3D Ni foam using a two-step hydrothermal process. The fabricated all-solid-state Ni-NMO-rGO-CoO//AC hybrid supercapacitors (HSCs) showed a superior energy density of 57.2 W h kg(-1) at 472.2 W kg(-1) with 97.7% capacitance retention after 10 000 cycles. The Ni-NMO-rGO-CoO NFA ternary layered architecture offers a promising approach for fabricating high-performance hierarchical composite array electrodes for next-generation energy storage devices.
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
(2022)
Article
Engineering, Electrical & Electronic
Dengfei Yang, Lei Yang, Xuying Chen, Mengjiao Qu, Ke Zhu, Hong Ding, Dongsheng Li, Yun Bai, Jian Ling, Jinghui Xu, Jin Xie
Summary: This paper presents a micromachined hydrophone with high sensitivity and low noise density, achieving a wide bandwidth and superior acoustic performance. By analyzing the equivalent noise model and applying a new pouring method, the noise floor is effectively reduced, making the hydrophone perform excellently in low frequency engineering applications.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Materials Science, Multidisciplinary
Vikrant Kumar, Caroline Yu, Christine K. McGinn, Krista E. Perks, Sarah M. Thompson, Nathaniel B. Sawtell, Ioannis Kymissis
Summary: This paper presents an electrode array and system that can stimulate specific regions of an electroreceptor array, providing potential for high spatial resolution stimulation and mapping of electrosensory systems.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Biochemistry & Molecular Biology
Zahra Ghassemi, Gymama Slaughter
Review
Chemistry, Multidisciplinary
Meimei Lai, Gymama Slaughter
Article
Engineering, Electrical & Electronic
J. Shankara Narayanan, Gymama Slaughter
IEEE SENSORS JOURNAL
(2020)
Article
Biochemical Research Methods
Ankit Baingane, Gymama Slaughter
IEEE TRANSACTIONS ON NANOBIOSCIENCE
(2020)
Review
Chemistry, Analytical
Saikat Banerjee, Stephanie McCracken, Md Faruk Hossain, Gymama Slaughter
Article
Engineering, Electrical & Electronic
Ankit Baingane, Gymama Slaughter
Summary: The study introduces a abiotic glucose indicator system developed using a biofuel cell, demonstrating high sensitivity and selectivity, potentially serving as a platform in point-of-care medical applications.
IEEE SENSORS JOURNAL
(2021)
Article
Chemistry, Analytical
Thakshila Liyanage, Meimei Lai, Gymama Slaughter
Summary: We have developed a novel label-free ultrasensitive tapered optical fiber plasmonic biosensor that can successfully detect a panel of microRNAs with good selectivity. The biosensor showed high refractive index sensitivity and achieved a limit of detection between 103 aM and 261 aM for the microRNA panel. It also demonstrated successful detection of clinically relevant concentrations of microRNAs in human serum with a LOD between 1.097 fM and 1.220 fM. This approach could potentially broaden the applications of biosensors for detecting and quantifying large arrays of microRNAs.
ANALYTICA CHIMICA ACTA
(2021)
Review
Engineering, Electrical & Electronic
Thakshila Liyanage, Ahmad Zaman Qamar, Gymama Slaughter
Summary: Advancements in novel materials, particularly nanomaterials, have revolutionized the field of biological and chemical sensors by serving as building blocks in sensor technologies. These materials offer extraordinary electrical and physical properties that can be tuned through experimentation to achieve desired sensor characteristics and sensing performance. Challenges in the current limitations of nanomaterials as sensing materials are also discussed alongside their prospects.
IEEE SENSORS JOURNAL
(2021)
Article
Materials Science, Multidisciplinary
Johvan O. Hill-Dick, Alexis Harmon, Wei Cao, Kishor K. Sadasivuni, Mehran Elahi, Adetayo Adedeji, Hani E. Elsayed-Ali, Gymama Slaughter, Kapil Kumar, Mohammad Asadi, Bijandra Kumar
Summary: Nonenzymatic glucose sensors based on nanocoral reduced Ag exhibit significantly higher sensitivity and stability, operating at low potentials and detecting glucose concentrations linearly in a wide range from 100 uM to 2.5 mM.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Md Faruk Hossain, Gymama Slaughter
Summary: Fully integrated uric acid and glucose biosensors with excellent electrocatalytic activity and high sensitivity were successfully fabricated. Functionalized laser scribed graphene and platinum nanoparticles loading were utilized to enhance the electrochemical activity of the biosensors, demonstrating wide detection ranges and low detection limits.
BIOELECTROCHEMISTRY
(2021)
Article
Chemistry, Analytical
Saikat Banerjee, Gymama Slaughter
Summary: A glucose abiotic biofuel cell was developed using gold nanoparticles ink printed electrodes on bacterial nanocellulose, with a colloidal platinum anode and silver oxide/multiwalled carbon nanotube nanocomposite cathode. The cell exhibited high open circuit voltage, short circuit current density, and maximum power density at different glucose concentrations, showing good performance in serum with glucose.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Thakshila Liyanage, Bayan Alharbi, Linh Quan, Aurora Esquela-Kerscher, Gymama Slaughter
Summary: A tapered optical fiber plasmonic biosensor was developed for the sensitive detection of a panel of microRNAs in human serum. This biosensor showed high sensitivity and selectivity, enabling cancer diagnosis without the need for RNA extraction or sample amplification. Statistical studies demonstrated its reliable ability to differentiate cancerous and noncancerous samples.
Review
Engineering, Electrical & Electronic
Ajith Mohan Arjun, Megha Shinde, Gymama Slaughter
Summary: Neurotransmitters are crucial small chemical signaling molecules that play a vital role in the proper functioning of the nervous system. Dysregulation of neurotransmitters can lead to various mental disorders, and monitoring their levels is crucial. Electrochemical detection, particularly using MXene composites, holds promise for the early-stage detection of neurological diseases originated from an imbalance in neurotransmitters.
IEEE SENSORS JOURNAL
(2023)
Article
Chemistry, Analytical
Ankit Baingane, J. Shankara Narayanan, Gymama Slaughter
SENSING AND BIO-SENSING RESEARCH
(2018)
Meeting Abstract
Chemistry, Multidisciplinary
Gymama Slaughter
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2018)
Article
Engineering, Electrical & Electronic
Franck Sabatier, Cedric Durand, Dominique Drouin, Michel Pioro-Ladriere, Fabien Ndagijimana, Philippe Galy
Summary: This study investigates the possibility of improving the quality factor and (or) inductance of an inductor integrated into CMOS technology by adding magnetic materials around it. The performance improvement is evaluated through 3D numerical simulations on an SOI substrate made in a 28 nm UTBB FDSOI technology. The choice of materials and their design topologies are the main parameters studied, leading to a solution selection based on the final application. The results show significant improvements in inductance and quality factor by using different design topologies and materials.
SOLID-STATE ELECTRONICS
(2024)
Article
Engineering, Electrical & Electronic
Tobias Reiter, Luiz Felipe Aguinsky, Francio Rodrigues, Josef Weinbub, Andreas Hoessinger, Lado Filipovic
Summary: Atomic layer processing (ALP) is a modern fabrication technique that allows precise control of film thickness, composition, and conformality at a nanometer scale. This article presents a model for surface coverage during ALD in the presence of desorption, leading to incomplete conformality. The model combines diffusion and kinetics methods and has been incorporated into topography simulators for accurate representation of reactor conditions.
SOLID-STATE ELECTRONICS
(2024)
Article
Engineering, Electrical & Electronic
Jingxuan Sun, Yi Han, Yannik Junk, Omar Concepcion, Jin-Hee Bae, Detlev Gruetzmacher, Dan Buca, Qing-Tai Zhao
Summary: This study systematically investigates the formation of NiGeSn and its contact resistivity with GeSn semiconductors. The optimal formation temperature of NiGeSn is found to be 325 degrees C, resulting in a lower contact resistivity on n-GeSn. The study also discusses the elemental diffusion mechanism during the NiGeSn formation. Additionally, GeSn exhibits low contact resistivity at 5 K, making it valuable for optimizing contact technologies for low-power and cryogenic applications.
SOLID-STATE ELECTRONICS
(2024)
Review
Engineering, Electrical & Electronic
Daniela Dragoman, Mircea Dragoman
Summary: Graphene's unique properties have led to the exploration of its analogies in various solid-state structures and systems, enabling the observation of novel phenomena and revealing differences in behavior between different systems. This review highlights the value of using analogies to develop new devices and expand our understanding of physics.
SOLID-STATE ELECTRONICS
(2024)
Article
Engineering, Electrical & Electronic
Sumreti Gupta, Asifa Amin, Reinaldo A. Vega, Abhisek Dixit
Summary: The multifrequency capacitance-voltage characteristics of high-k HfO2-based 10-nm bulk n-channel FinFETs were studied in this work. The dispersion observed in the accumulation region with respect to temperature was found to be influenced by the substrate time constant. Multifrequency conductance measurements and the variation in the surface potential quotient of the accumulation region were used to investigate the effect of direct tunneling current. Modifications to the existing accumulation region compact model equations were proposed.
SOLID-STATE ELECTRONICS
(2024)
Article
Engineering, Electrical & Electronic
N. Vasileiadis, A. Mavropoulis, I. Karafyllidis, G. Ch. Sirakoulis, P. Dimitrakis
Summary: In this work, we fabricate crossbar arrays of silicon nitride resistive memories on silicon-on-insulator substrate and utilize them to realize multi-ratioed logic circuits. The electrical characterization of the memristors shows their ability of multi-state operation with 12 distinct resistance levels. Based on a dedicated modeling and fitting procedure, a reconfigurable logic based on memristor rationed logic scheme is designed and a crossbar integration methodology is proposed. Furthermore, circuitry aspects are simulated with a calibrated model and power optimization prospects are discussed.
SOLID-STATE ELECTRONICS
(2024)