期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 40, 期 1, 页码 199-205出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2015.06.010
关键词
Methylmercury; Neurotoxicity; Nerve growth factor; Brain-derived neurotrophic factor; Astrocyte
资金
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Study (Group) of the Health Effects of Heavy Metals
- Grants-in-Aid for Scientific Research [26740024] Funding Source: KAKEN
The protective roles of astrocytes in neurotoxicity induced by environmental chemicals, such as methylmercury (MeHg), are largely unknown.We found that conditioned medium of MeHg-treated astrocytes (MCM) attenuated neuronal cell death induced by MeHg, suggesting that astrocytes-released factors can protect neuronal cells. The increased expression of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) was observed in MeHg-treated astrocytes. NGF and BDNF were detected in culture media as homodimers, which are able to bind specific tyrosine kinase receptors, tropomyosin related kinase (Trk) A and TrkB, respectively. The TrkA antagonist and TrkB antagonist abolished the protective effects of MCM in neuronal cell death induced by MeHg. Taken together, astrocytes synthesize and release NGF and BDNF in response to MeHg to protect neurons from MeHg toxicity. This study is considered to show a novel defense mechanism against MeHg-induced neurotoxicity. (C) 2015 Elsevier B.V. All rights reserved.
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