Article
Plant Sciences
Esam E. Elgorashi, Ibrahim M. S. Eldeen, Tshepiso J. Makhafola, Jacobus N. Eloff, Luc Verschaeve
Summary: Smoke from Acacia seyal Delile wood is used for making a smoke bath in Sudan. The study aimed to investigate its anti-inflammatory effects using COX-1 and COX-2 assays, as well as potential genotoxic effects using bacterial and mammalian cell-based assays. Results showed that the smoke condensate induced mutations and DNA damage, highlighting potential health risks associated with the practice.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Borja Quiroga
Summary: BPA, a common component of plastics worldwide, has been shown to act as an endocrine disruptor with some hormonal functions. High levels of BPA are related to cardiovascular events and carcinogenesis pathways, and CKD patients have higher serum concentrations of BPA due to impaired renal function. Efforts to reduce BPA levels in these patients include developing BPA-free dialysis filters and other techniques.
Review
Environmental Sciences
Ivana Durovcova, Stanislav Kyzek, Jana Fabova, Jana Makukova, Eliska Galova, Andrea Sevcovicova
Summary: This review aims to summarize the genotoxic effects of BPA on organisms across all taxa. BPA can induce DNA damage through multiple mechanisms and has adverse effects on organisms in various ecosystems.
ENVIRONMENTAL POLLUTION
(2022)
Article
Food Science & Technology
Archana Molangiri, Saikanth Varma, M. Satyavani, Saikrishna Kambham, Asim K. Duttaroy, Sanjay Basak
Summary: Early exposure to bisphenol may result in adverse reproductive health issues in later life. This study investigated the effects of orally administered bisphenol S (BPS) and bisphenol A (BPA) on testicular development in rats. The results showed that prenatal exposure to BPS can lead to changes in plasma testosterone levels, testis histology, inflammation, oxidative stress, and sperm DNA damage, potentially affecting male reproductive functions.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Review
Cell Biology
Marina Rodriguez-Munoz, Teresa Anglada, Anna Genesca
Summary: The nuclear envelope regulates transport in and out of the nucleus and is essential for nuclear functions. During mitosis, the nuclear envelope disintegrates and reforms, but it is delayed on lagging chromosomes and DNA bridges. Defects in the coordination between nuclear envelope reformation and chromosome segregation impair nuclear functions and result in DNA damage.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Environmental Sciences
Marcelino Benvindo-Souza, Daiany Folador Sotero, Cirley Gomes Araujo dos Santos, Rhayane Alves de Assis, Rinneu Elias Borges, Lia Raquel de Souza Santos, Daniela de Melo e Silva
Summary: Pollution from mining activities can cause genotoxic damage to bats, particularly in species like Carollia perspicillata and Glossophaga soricina. High levels of elements such as Mn, Cr, Pb, and Zn were found in water samples from the mining area. The study suggests that bats in mining areas are susceptible to increased DNA damage, similar to what has been observed in other species.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Carine Al-Ayoubi, Maria Alonso-Jauregui, Amaya Azqueta, Julien Vignard, Gladys Mirey, Ophelie Rocher, Olivier Puel, Isabelle P. Oswald, Ariane Vettorazzi, Laura Soler
Summary: Versicolorin A (VerA), a precursor of Aflatoxin B1 (AFB1), induces genotoxicity by causing DNA damage and activating DNA repair pathways. This study highlights the potential carcinogenicity of VerA exposure, even at low concentrations, and calls for further research on this emerging food contaminant.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
W. A. P. M. De Silva, A. Pathiratne
Summary: This study investigates the potential genotoxic and histopathological effects of nano-TiO2 exposure on Nile tilapia. Results show that nano-TiO2 induces concentration-dependent erythrocytic DNA damage and micronuclei induction. Histopathological alterations, including hepatic parenchyma and intestinal mucosa necrosis, were observed in the fish exposed to nano-TiO2. Bulk TiO2 exposure increased liver damage and erythrocytic DNA damage, suggesting its dissolved form is also biologically active. Further research is needed to assess the environmental risks of nano-TiO2 and bulk TiO2 at realistic levels.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Environmental Sciences
Jonathan Kiwitt-Cardenas, Evdochia Adoamnei, Julian J. Arense-Gonzalo, Laura Sarabia-Cos, Fernando Vela-Soria, Mariana F. Fernandez, Jaime Gosalvez, Jaime Mendiola, Alberto M. Torres-Cantero
Summary: A study conducted with university students in the region of Murcia, Spain, found a significant positive association between urinary BPA concentrations and sperm DNA fragmentation in men with a high SDF index. However, further research is needed to confirm these results and draw conclusions in other male populations.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Aryelle Canedo, Lazaro Wender Oliveira de Jesus, Elisa Flavia Luiz Cardoso Bailao, Thiago Lopes Rocha
Summary: This study summarized the literature on micronucleus (MN) and other nuclear abnormalities (NA) in zebrafish, and their applications in toxicity screening and environmental risk assessment. It was found that MN was the most frequently encountered NA in zebrafish, with 15 other types of nuclear alterations reported. The study also discussed the molecular mechanisms underlying NA in zebrafish, as well as the impact of different pollutants.
ENVIRONMENTAL POLLUTION
(2021)
Review
Biochemistry & Molecular Biology
Marcelino Perez-Bermejo, Irene Mas-Perez, Maria Teresa Murillo-Llorente
Summary: Bisphenol A, a common endocrine disruptor found in daily products, is linked to obesity and diabetes due to its ability to mimic natural estrogen. This compound can stimulate adipocyte hypertrophy and alter the endocrine system. Despite some countries implementing policies, there is a lack of international agreement on the regulation of Bisphenol A exposure.
Article
Endocrinology & Metabolism
Giada Frenzilli, Joan Martorell-Ribera, Margherita Bernardeschi, Vittoria Scarcelli, Elisabeth Jonsson, Nadia Diano, Martina Moggio, Patrizia Guidi, Joachim Sturve, Noomi Asker
Summary: The study shows that both bisphenol A and its alternative bisphenol S can cause endocrine disrupting and genotoxic effects in brown trout, indicating two different mechanisms of damage underlying the activities of bisphenol A and bisphenol S. Bisphenol A primarily increases micronuclei frequency in fish erythrocytes, while bisphenol S may cause damage through other mechanisms.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Marcelino Benvindo-Souza, Akemi Vieira Hosokawa, Cirley Gomes Araujo dos Santos, Rhayane Alves de Assis, Thays Millena Alves Pedroso, Rinneu Elias Borges, Susi Missel Pacheco, Lia Raquel de Souza Santos, Daniela de Melo e Silva
Summary: Habitat loss and fragmentation pose significant threats to biodiversity. The use of bioindicators can provide insight into the health of the environment. A study conducted in agricultural areas found higher genotoxic damage in bats compared to a control area.
ENVIRONMENTAL POLLUTION
(2022)
Review
Toxicology
Henrique Eloi Costa, Elisa Cairrao
Summary: Bisphenol A (BPA) is a widely produced synthetic compound that can disrupt the endocrine system and have detrimental effects on the neurological system. Exposure to BPA can lead to oxidative stress, changes in gene and protein expression, neuronal damage, and increased risk of neurologic diseases such as stroke, Alzheimer's, and Parkinson's. Epidemiological studies have also shown that BPA exposure during neurodevelopment can contribute to the emergence of disorders such as ADHD, ASD, depression, and cognitive disorders.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Vladimir Baran, Jozef Pisko
Summary: The preimplantation period of embryogenesis plays a crucial role in mammalian development, and cellular abnormalities during this period are the main cause of fetal developmental disorders. Research has found that DNA damage induced before DNA synthesis can significantly affect the preimplantation development of the embryo, and the extent of DNA damage is related to this developmental ability. Although one-cell embryos can correct the first cleavage cycle, a segregation disorder of condensed chromatin after the first cleavage can result in the formation of micronuclei.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
