Review
Pharmacology & Pharmacy
Dan Zhang, Lin Liu, Jian Wang, Hong Zhang, Zhuo Zhang, Gang Xing, Xuan Wang, Minghua Liu
Summary: Nanoparticles based on PLGA and PEG-PLGA have been extensively studied for drug delivery in cancer treatment. These nanoparticles can encapsulate and release various drugs, and their surface can be modified with ligands for active tumor targeting. This review provides an overview of the synthesis, application, and recent advances of PEG-PLGA nanoparticles in cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Isaac H. Caballero-Floran, Hernan Cortes, Fabiola V. Borbolla-Jimenez, Carla D. Floran-Hernandez, Maria L. Del Prado-Audelo, Jonathan J. Magana, Benjamin Floran, Gerardo Leyva-Gomez
Summary: This study proposes the use of polyethylene glycol 400 (PEG) and trehalose as a surface modification technique to improve PLGA-based nanoparticles as drug carriers for neurons. The combination of PEG and trehalose enhances the hydrophilicity of the nanoparticles and promotes their cellular internalization. Through optimization using central composite design, PLGA nanoparticles with diameters smaller than 200 nm were produced, and the coating process did not significantly increase their size. The nanoparticles showed high curcumin entrapment efficiency and a controlled release profile.
Article
Materials Science, Biomaterials
Mark Rutschmann, Natalja Redinger, Ulrich E. Schaible, Claus Feldmann
Summary: AMC@SiO2 core@shell nanocarriers with a high drug load of 0.8 mg mg(-1) are prepared using a solvent-antisolvent approach. The nanocarriers have a mean diameter of 240 nm, with an inner AMC core of 200 nm and an outer silica shell of 20 nm. The size, structure, and composition of the nanocarriers are confirmed by various characterization methods. The AMC@SiO2 core@shell nanocarriers show promising potential for the treatment of multidrug resistant bacterial pathogens.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Biochemistry & Molecular Biology
M. Torres-Ramos, M. F. Martin-Marquez, Maria del Carmen Leal-Moya, Suresh Ghotekar, Jorge Alberto Sanchez-Burgos, Alejandro Perez-Larios
Summary: This paper reports the green synthesis of PLGA-TiO2 nanocomposite using a natural extract and its characterization. The study used UV-visible spectrometry, scanning electron microscopy, infrared spectroscopy, and X-ray diffraction to analyze the properties of the nanoparticles. The results showed that terpenes enhance the synthesis and stabilization of titanium dioxide nanoparticles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Eman Jaradat, Edward Weaver, Adam Meziane, Dimitrios A. Lamprou
Summary: In conventional drug administration, drug molecules may not effectively reach the pathological site, so nanoparticles (NPs) as drug carriers have potential. NPs have a large surface area and quantum properties. Traditional methods for manufacturing NPs have limitations and new methods need to be investigated.
Article
Chemistry, Multidisciplinary
Ayaka Harada, Hiroyasu Tsutsuki, Tianli Zhang, Kinnosuke Yahiro, Tomohiro Sawa, Takuro Niidome
Summary: Advances in drug delivery systems have allowed specific delivery of drugs to target cells. This study demonstrates the selective delivery of SubAB to macrophages and its anti-inflammatory effects by modifying it with PLGA nanoparticles. These findings provide a useful technique for protein delivery to macrophages and support the application of drug delivery systems in the treatment of inflammatory diseases.
Article
Biochemistry & Molecular Biology
Paul Nana Kwame Sagoe, Eduardo Jose Machado Velazquez, Yohely Maria Espiritusanto, Amelia Gilbert, Thalma Orado, Qiu Wang, Era Jain
Summary: In this study, we developed a novel method for synthesizing tunable-sized microparticles with improved monodispersity and batch-to-batch reproducibility. We evaluated the effect of various process parameters on particle size, distribution, and morphology. By adjusting key parameters, we achieved microparticles of comparable sizes across different formulations. The study also demonstrated the influence of polymer concentration, stirring rate, and surfactant concentration on microparticle characteristics.
Article
Biotechnology & Applied Microbiology
Anna Czapka, Christian Grune, Patrick Schaedel, Vivien Bachmann, Karl Scheuer, Michael Dirauf, Christine Weber, Alexios-Leandros Skaltsounis, Klaus D. Jandt, Ulrich S. Schubert, Dagmar Fischer, Oliver Werz
Summary: In this study, we encapsulated 6BIGOE into sustainable solvents-based PLGA nanoparticles, which resulted in efficient drug delivery systems with improved cellular uptake and the ability to mask cytotoxic effects. The anti-inflammatory properties of 6BIGOE were fully retained in these nanoparticles.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Polymer Science
Guangliang Liu, Kathleen McEnnis
Summary: PLGA-based nano- and micro- drug delivery vehicles have rapidly developed in recent decades. Factors influencing PLGA particle properties have been extensively studied. Particle size, PDI, surface morphology, zeta potential, and drug loading efficiency have all been found to be key factors for determining drug release kinetics. Drug release behavior is critical, but still problematic. The glass transition temperature (T-g) is an underreported property that plays a role in drug release behavior.
Review
Pharmacology & Pharmacy
Hashem O. Alsaab, Fatima D. Alharbi, Alanoud S. Alhibs, Nouf B. Alanazi, Bayan Y. Alshehri, Marwa A. Saleh, Fahad S. Alshehri, Majed A. Algarni, Turki Almugaiteeb, Mohammad N. Uddin, Rami M. Alzhrani
Summary: Research on the use of biodegradable polymers for drug delivery, particularly PLGA, has been ongoing for several decades. PLGA, a family of FDA-approved biodegradable polymers, possesses high biocompatibility and tunability. This paper explores the manufacturing processes, characteristics, and applications of PLGA in drug release.
Article
Pharmacology & Pharmacy
Elahe Akbari, Hanieh Mousazadeh, Ziba Sabet, Tannaz Fattahi, Alireza Dehnad, Abolfazl Akbarzadeh, Effat Alizadeh
Summary: The study demonstrated the synergistic anticancer effects of TPX and MTX co-loaded PLGA-PEG nanoparticles against breast cancer cells, showing potential in enhancing the efficiency of breast cancer therapy by altering apoptotic pathways and cell growth inhibition.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Polymer Science
Naz Dilawar, Tofeeq Ur-Rehman, Kifayat Ullah Shah, Humaira Fatima, Aiyeshah Alhodaib
Summary: The study investigates a transdermal delivery approach utilizing PLGA nanoparticles and PLO gel for more efficient drug release and permeation.
Article
Chemistry, Multidisciplinary
Morgan D. McSweeney, Limei Shen, Alexander C. DeWalle, Jordan B. Joiner, Elizabeth C. Ciociola, Dharmendra Raghuwanshi, Matthew S. Macauley, Samuel K. Lai
Summary: This study explored the effectiveness of prophylaxis with free PEG or tolerogenic PEGylated liposomes as a strategy to reduce the amount of APA induced by subsequently administered PEGylated liposomes. The results showed that a single administration of free PEG alone was capable of markedly reducing the APA response to PEG-liposomes for up to 2 months, which was comparable to, and often exceeded, interventions with different tolerogenic PEG-liposomes. These findings support further research on free PEG prophylaxis as a potential strategy to mitigate the APA response to sensitizing PEGylated therapeutics.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biophysics
Ibrahima Youm, Matthew B. West, Xiangping Huang, Wei Li, Richard D. Kopke
Summary: The effects of sucrose on the physical stability, cellular entry pathways, and functional efficacy of PLGA-NPs were investigated in this study. The results showed that the addition of 10% sucrose significantly improved the physical stability and cellular uptake of HEI-101-NPs.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Alma Lucia Villela Zumaya, Silvie Rimpelova, Marketa Stejdirova, Pavel Ulbrich, Jarmila Vilcakova, Fatima Hassouna
Summary: In this study, anti-CD133 monoclonal antibody-conjugated PLGA nanocarriers were designed and synthesized for targeted delivery of oxaliplatin and superparamagnetic nanoparticles to colorectal cancer cells. The results showed that non-PEGylated PLGA nanoparticles were more convenient for controlled drug release, while PEGylated PLGA nanoparticles had faster release kinetics. Additionally, the nanoparticles exhibited superparamagnetic behavior without magnetic hysteresis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Multidisciplinary
Sandrine S. Ferreira, Pedro Silva, Amelia M. Silva, Fernando M. Nunes
Summary: The chemical composition and enzymatic activity of the main Portuguese elderberry cultivars were determined for the first time, revealing the decisive influence of climatic conditions on the maturation and quality of elderberries.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Correction
Polymer Science
Sajan Jose, Thomas A. A. Cinu, Rosmy Sebastian, M. H. Shoja, N. A. Aleykutty, Alessandra Durazzo, Massimo Lucarini, Antonello Santini, Eliana B. B. Souto
Review
Oncology
Vaikunthavasan Thiruchenthooran, Elena Sanchez-Lopez, Anna Gliszczynska
Summary: The application of non-steroidal anti-inflammatory drugs (NSAIDs) in cancer therapy has been widely studied. This review summarizes the role of chronic inflammation in carcinogenesis and the anti-cancer activity of NSAIDs. However, the practical application of NSAIDs is hindered by individual side effects, particularly gastrointestinal toxicity. Strategies to reduce toxicity and improve efficacy are being investigated, including combinations with chemotherapeutic drugs and molecular hybridization with other active molecules.
Review
Pharmacology & Pharmacy
Amanda Cano, Alvaro Munoz-Morales, Elena Sanchez-Lopez, Miren Ettcheto, Eliana B. Souto, Antonio Camins, Merce Boada, Agustin Ruiz
Summary: Neurodegenerative diseases have unknown etiology in many cases and lack effective treatments. The blood-brain barrier poses a challenge for drug delivery. Exosomes, secreted vesicles, have emerged as promising therapeutic tools due to their natural origin and molecular similarities. They are particularly promising for targeting neurodegenerative diseases due to the difficulty of accessing the brain and the complexity of the diseases.
Article
Pharmacology & Pharmacy
Gerard Esteruelas, Eliana B. Souto, Marta Espina, Maria Luisa Garcia, Marta Switalska, Joanna Wietrzyk, Anna Gliszczynska, Elena Sanchez-Lopez
Summary: Cancer is a leading cause of death worldwide, but there is still a need for an effective treatment with minimal adverse effects. Diclofenac, a non-steroidal anti-inflammatory drug, has shown promise as an antitumoral agent, but its prolonged use can lead to adverse effects. In this study, biodegradable polymeric nanoparticles were used to deliver diclofenac in a controlled manner, resulting in prolonged release and demonstrating antitumoral effects without cytotoxicity to non-tumoral cells.
Article
Pharmacology & Pharmacy
Audrey R. S. T. Silva, Amanda M. B. Costa, Sona Jain, Patricia Severino, Ricardo Scher, Rogeria S. Nunes, Eliana B. Souto, Silvio S. Dolabella
Summary: Leishmaniases are parasitic diseases that need cheaper, safer, and more effective treatment options. The anti-fungal compound 3carene (3CR) has potential as a treatment for Leishmania, but its hydrophobicity limits therapeutic uses. In this study, micellar systems made from poloxamers were developed to carry 3CR and enhance its activity against Leishmania braziliensis.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Food Science & Technology
Beatriz N. Guedes, Faezeh Fathi, Amelia M. Silva, Antonello Santini, M. Beatriz P. P. Oliveira, Eliana B. Souto
Summary: Prickly pear, also known as Opuntia ficus-indica (OFI), is a beneficial plant with dietary fibers, vitamins and various bioactive compounds. This article reviews its nutritional composition, biological activities, and extraction techniques commonly used for different parts of the plant.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Aleksandra Zielinska, Jacek Karczewski, Piotr Eder, Tomasz Kolanowski, Milena Szalata, Karolina Wielgus, Marlena Szalata, Dohun Kim, Su Ryon Shin, Ryszard Slomski, Eliana B. Souto
Summary: Scaffolds are commonly used implants for delivering cells, drugs, and genes, with their porous structure providing support for cell attachment, proliferation, differentiation, and migration. Various techniques are used to fabricate scaffolds, and they have applications in tissue engineering and multiple medical fields.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Venancio A. Amaral, Juliana Ferreira de Souza, Thais F. R. Alves, Fernando Batain, Denicezar A. Baldo, Patricia Severino, Norberto Aranha, Eliana B. Souto, Marco V. Chaud
Summary: The aim of this study was to develop a dense lamellar scaffolding composed of collagen, silk fibroin, and polyethylene glycol 400, and to evaluate the influence of freezing parameters on its structure. The results showed that freezing rate could modulate the pore size, connectivity, and anisotropy of the scaffolds. This study provides important insights for potential tissue engineering applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Faezeh Fathi, Reza M. Kouchaksaraee, Samad N. Ebrahimi, Anabela S. G. Costa, Eliana B. Souto, Joao A. Prior, M. Beatriz P. P. Oliveira, Rita C. Alves
Summary: This study aimed to develop an antioxidant-rich grape seed (GS) fraction and formulate appropriate delivery systems for oral administration. Phenolic compounds were enriched in a hydroethanolic extract of GS using adsorbent resin column chromatography, resulting in a 4-fold increase in phenolic content compared to the crude extract. The enriched fraction was loaded into cholesterol-incorporated phytosomes to improve stability, gut absorption, and oral bioavailability. Different polysaccharide-based polymers were tested as natural-based coatings to improve stability and protection against gastrointestinal degradation, while providing a modified-release profile. The phytosomes showed potential as smart nutraceuticals for dietary supplements.
SUSTAINABLE MATERIALS AND TECHNOLOGIES
(2023)
Article
Multidisciplinary Sciences
Saghar Rabieipoor, Meysam Zare, Miren Ettcheto, Antoni Camins, Mohammad Javan
Summary: This study evaluated the therapeutic effects of metformin in a mouse model of Alzheimer's disease. The results showed that metformin reduced inflammatory cells and reactive astrocytes as well as the dying neurons in the hippocampus region and the cortex, and improved cognitive performance.
Review
Toxicology
Carlos Martins-Gomes, Amelia M. Silva
Summary: The role of intestinal barrier homeostasis in an individual's general well-being has been widely addressed. Colorectal cancer poses a challenge due to multidrug resistance (MDR), with ABC transporters playing a major role. Natural products, particularly phytochemicals, have shown potential in reversing MDR and sensitizing cancer cells to chemotherapy drugs. However, a balance must be achieved between xenobiotic efflux and drug accumulation in cancer cells, where ABC transporters play a vital role that requires further analysis. This review summarizes the knowledge on ABC transporters' function in intestinal barrier cells and highlights the potential of natural products as nutraceutical molecules to overcome MDR.
JOURNAL OF XENOBIOTICS
(2023)
Review
Biochemistry & Molecular Biology
Carlos Martins-Gomes, Fernando M. Nunes, Amelia M. Silva
Summary: This review summarizes studies on Thymus spp. and their extracts in terms of their health-promoting effects involving the modulation of cell death or survival signaling pathways. Thymus spp. can be used for wound healing and protection against chemicals-induced toxicity, and also exhibit anti-tumoral activity. Therefore, Thymus spp. is a rich source of compounds with nutraceutical and pharmaceutical value.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)