期刊
SMALL
卷 13, 期 34, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201700983
关键词
Alzheimer's disease; -amyloid; carbon nanodots; disassembly; self-assembly
类别
资金
- National Research Foundation via the Creative Research Initiative Center, Republic of Korea [NRF-2015R1A3A2066191]
- National Research Foundation of Korea [2015R1A3A2066191] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The self-assembly of amyloidogenic peptides into -sheet-rich aggregates is a general feature of many neurodegenerative diseases, including Alzheimer's disease, which signifies the need for the effective attenuation of amyloid aggregation toward alleviating amyloid-associated neurotoxicity. This study reports that photoluminescent carbon nanodots (CDs) can effectively suppress Alzheimer's -amyloid (A) self-assembly and function as a -sheet breaker disintegrating preformed A aggregates. This study synthesizes CDs using ammonium citrate through one-pot hydrothermal treatment and passivates their surface with branched polyethylenimine (bPEI). The bPEI-coated CDs (bPEI@CDs) exhibit hydrophilic and cationic surface characteristics, which interact with the negatively charged residues of A peptides, suppressing the aggregation of A peptides. Under light illumination, bPEI@CDs display a more pronounced effect on A aggregation and on the dissociation of -sheet-rich assemblies through the generation of reactive oxygen species from photoactivated bPEI@CDs. The light-triggered attenuation effect of A aggregation using a series of experiments, including photochemical and microscopic analysis, is verified. Furthermore, the cell viability test confirms the ability of photoactivated bPEI@CDs for the suppression of A-mediated cytotoxicity, indicating bPEI@CDs' potency as an effective anti-A neurotoxin agent.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据