Article
Chemistry, Multidisciplinary
Chaolumen Wu, Qingsong Fan, Zhiwei Li, Zuyang Ye, Yadong Yin
Summary: This study demonstrates reversible assembly and active tuning of plasmonic chiral superstructures by introducing a chiral magnetic field. Manipulating the magnetic field controls both the chiral arrangement and spectral properties of the superstructures, enabling fast and reversible tunability.
MATERIALS HORIZONS
(2023)
Article
Chemistry, Multidisciplinary
Renjie Niu, Chunyuan Song, Fei Gao, Weina Fang, Xinyu Jiang, Shaokang Ren, Dan Zhu, Shao Su, Jie Chao, Shufen Chen, Chunhai Fan, Lianhui Wang
Summary: This study introduces a DNA origami based nanoprinting strategy for transferring DNA strands to the surface of gold nanocubes, generating stereo-controlled gold nanostructures with specific geometry and composition for stronger surface enhanced Raman scattering signal amplification.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Renjie Niu, Fei Gao, Dou Wang, Dan Zhu, Shao Su, Shufen Chen, Lihui YuWen, Chunhai Fan, Lianhui Wang, Jie Chao
Summary: A DNA origami-directed pattern recognition strategy is utilized to assemble AuNCs into shape-controllable PGNs, creating localized field enhancement in gaps to generate hot spots for stronger single-molecule SERS signals.
Article
Chemistry, Multidisciplinary
Yuxiang Dong, Jiliang Liu, Xuanzhao Lu, Jialin Duan, Liqi Zhou, Lizhi Dai, Min Ji, Ningning Ma, Yong Wang, Peng Wang, Jun-Jie Zhu, Qianhao Min, Oleg Gang, Ye Tian
Summary: Self-assembly processes are important for fabricating complexly organized nanomaterials, but often limited in creating structures with multiscale order. In this study, a two-stage assembly strategy is introduced to successfully form complexly organized nanoparticle crystals.
Article
Chemistry, Multidisciplinary
Xiaojun Song, Yueliang Wang, Yan Hao, Qingqing Zhu, Yanjuan Li, Lei Song, Zhaoxiang Deng
Summary: This study successfully built a series of homo/heterodimeric plasmonic nanomolecules with prescribed compositions using DNA-guided, solvo-driven Ag ion soldering method. Strong in-solution electric-dipole coupling was achieved for materials with strong (Au, Ag) or damped (Pt, Pd) plasmonic responses.
Article
Chemistry, Multidisciplinary
Joshua A. Johnson, Vasiliki Kolliopoulos, Carlos E. Castro
Summary: Simultaneous self-assembly of two distinct DNA origami nanostructures folded with the same scaffold strand was achieved in a single pot by adjusting concentrations of competing strands. The relative yields were correlated well with folding kinetics of individual structures, facilitating efficient fabrication of multi-structure systems and materials.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Jiahao Pan, Xiaoyao Wang, Jinjin Zhang, Qin Zhang, Qiangbin Wang, Chao Zhou
Summary: By assembling helical plasmonic nanorods with intrinsic chirality, we have created plasmonic metamolecules with both chiral coupling and intrinsic chiroptical responses. These metamolecules offer more dimensions for tailoring chiroptical responses and make it more flexible to design plasmonic nanodevices with custom PCD.
Article
Chemistry, Multidisciplinary
Jue Yin, Mo Xie, Junke Wang, Meirong Cui, Dan Zhu, Shao Su, Chunhai Fan, Jie Chao, Qian Li, Lianhui Wang
Summary: In this work, the authors report a simple and versatile one-pot strategy to fabricate DNA architectures with the assistance of spherical gold nanoparticles modified with thiolated oligonucleotide strands. The desired architectures are formed via the stochastic co-assembly of different modules.
Article
Chemistry, Multidisciplinary
Ruixin Li, Haorong Chen, Jong Hyun Choi
Summary: Deployable geometries are finite auxetic structures that can maintain their overall shape while expanding and contracting. A deployable flight ring made from DNA origami has been demonstrated in this study, showing the feasibility of deployable nanostructures. The flight ring consists of six triangles in two layers that can switch between open and closed states, with a trefoil knot topology and negative Poisson's ratios. This work provides a versatile platform for topological studies and opens up new opportunities for bioengineering.
Article
Chemistry, Multidisciplinary
Andreas Peil, Pengfei Zhan, Xiaoyang Duan, Roman Krahne, Denis Garoli, Luis M. Liz-Marzan, Na Liu
Summary: In this study, a transformable plasmonic helix system is demonstrated, where multiple gold nanoparticles (AuNPs) can be directly transported to target positions using DNA swingarms, resulting in tailored optical responses.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Michael Erkelenz, Richard Kosinski, Helene Giesler, Oliver Sritharan, Jesil Jose, Barbara Sacca, Sebastian Schluecker
Summary: We introduce a reconfigurable DNA/plasmonic nanodevice that allows for precise tuning of the interparticle gap without the use of DNA. The nanodevice consists of two DNA boxes for selectively incorporating nanoparticles in a face-to-face configuration, as well as a switchable DNA platform for controlled and reversible adjustment of the interparticle distance.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Jingwen Wang, Junjie Yuan, Jiajia Liu, Haixia Zou, Lin Yang, Hong Chen, Xiangmeng Qu
Summary: DNA self-assembly is a promising method for constructing complex nanostructures. However, the current approach requires separate design and professional operation, limiting its development and application. In this study, a novel point-and-shoot strategy based on enzyme-assisted DNA paper-cutting was proposed to construct planar DNA nanostructures using the same DNA origami as a template. By annealing the long scaffold strand and selected staple strands, planar DNA nanostructures were successfully constructed. This strategy overcomes the complexity limitation of planar DNA nanostructures and simplifies the design and operation process. Overall, this strategy shows great potential for manufacturing DNA nanostructures.
Article
Chemistry, Multidisciplinary
Qin Zhang, Xiaoyao Wang, Huiying Wu, Jinjin Zhang, Xingyue Lin, Jiaoyang Sa, Hao Li, Chao Zhou, Weihai Ni
Summary: This paper demonstrates the individual switching of chiral plasmonic metamolecules assembled with DNA origami through microscopic observation. The plasmonic metamolecules can maintain their activities upon certain local stimuli and display opposite spectral signals in circular differential scattering, representing successful enantiomeric switching of chirality.
Article
Chemistry, Multidisciplinary
Jiajia Zou, Ashley C. Stammers, Andrea Taladriz-Sender, Jamie M. Withers, Iain Christie, Marina Santana Vega, Badri L. Aekbote, William J. Peveler, David A. Rusling, Glenn A. Burley, Alasdair W. Clark
Summary: An orthogonal, noncovalent approach is presented for the assembly of higher-order DNA origami nanostructures. By incorporating perfluorinated tags into DNA origami tiles, their hierarchical assembly is controlled via fluorous-directed recognition. This integrated catch-and-latch approach combining fluorous effect with base-pairing specificity enables increased assembly efficiency and requires fewer DNA sequences, providing a cheap and efficient means for producing discrete superstructures in DNA nanotechnology.
Article
Chemistry, Multidisciplinary
Yihao Zhou, Jinyi Dong, Chao Zhou, Qiangbin Wang
Summary: Using three-dimensional DNA origami as the building block, it is practical to construct finite hierarchical nanostructures with complicated conformations through orthogonal and directional bonding.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Nanoscience & Nanotechnology
Renqiang Yuan, Ning Yang, Yueru Huang, Weikun Li, Yi Zeng, Zonghao Liu, Xin Tan, Fang Feng, Qianli Zhang, Shao Su, Cuilin Chu, Ling Liu, Liqin Ge
Summary: This study developed a simple and effective layer-by-layer self-assembly transdermal delivery patch, with microneedles coated with recombinant human epidermal growth factor, for sustained release to wound bed driven by electrostatic force. The patch significantly promoted cell proliferation and accelerated wound healing in mechanically injured rats compared to traditional dressings.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Dan Zhu, Xiaojian Li, Yu Zhu, Qingyun Wei, Yang Hu, Shao Su, Jie Chao, Lianhui Wang, Lixing Weng
Summary: Monitoring and tracking multiple low-abundance messenger RNAs (mRNAs) simultaneously in situ at subcellular level is crucial for the diagnosis and pathologic analysis of cancer. This study presents polyA-mediated dual-color sticky flares for simultaneous imaging of two types of intracellular mRNA biomarkers. The sticky flares greatly improve the uniformity, detection sensitivity, and response kinetics compared to traditional nanoprobes, enabling enhanced efficiency in live-cell imaging of mRNAs. The proposed polyA-mediated dual-color sticky flares are a pivotal tool for multiple targets imaging in living cells with excellent cell entry efficiency and low cytotoxicity.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Lulu Huang, Xiuhai Mao, Jie Li, Qian Li, Jianlei Shen, Mengmeng Liu, Chunhai Fan, Yang Tian
Summary: By designing dual-emissive gold nanoparticles with varying spikiness, the interactions between spiky nanoparticles and cells were investigated. It was found that the nanospikes regulated myosin IIA recruitment at the cell membrane, enhancing cellular uptake efficiency. Moreover, the spiky nanoparticles facilitated endocytosis dynamics. These findings provide insights into the intracellular fate of nanoparticles and the development of theranostic nanocarriers.
Article
Chemistry, Multidisciplinary
Daoxia Guo, Xiaoyuan Ji, Hui Xie, Jia Ma, Chunchen Xu, Yanfeng Zhou, Nan Chen, Hui Wang, Chunhai Fan, Haiyun Song
Summary: Cancer-associated fibroblasts (CAFs) play a role in chemoresistance and immunosuppression, but direct depletion may lead to increased invasiveness and metastasis. Gemini-like targeting nanoparticles (NPs) have been designed to transform CAFs and eliminate cancer cells, enhancing drug susceptibility and immune cell infiltration. In mouse models of various resistant cancers, a single dose of these NPs resulted in improved chemosensitivity, immune activation, tumor regression, and long-term protection against tumor rechallenge.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Chunchen Xu, Xiaoyuan Ji, Yanfeng Zhou, Yuchun Cheng, Daoxia Guo, Qian Li, Nan Chen, Chunhai Fan, Haiyun Song
Summary: A study introduces a novel approach to revitalize tumor-associated dendritic cells (TADCs) and enhance their anti-tumor response. This is achieved by using multilevel lipid rewiring nanoparticles to promote TADC maturation and restore their inflammatory cytokine production, cytotoxic T cell recruitment, and tumor inhibition.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Haipei Zhao, Xuehao Xiu, Mingqiang Li, Shaobo Dai, Mingyang Gou, Leyang Tao, Xiaolei Zuo, Chunhai Fan, Zhongqun Tian, Ping Song
Summary: Dynamic interactions of enzymes are important in regulating cellular metabolism. A super DNA-enzymes molecule was constructed for controlling and detecting metabolism. The programmable SDEM shows improved detection limit and reaction rate compared to free enzymes. The SDEM can be assembled and disassembled using a hairpin structure and a displacement DNA strand for multiple cycles. An entropically driven catalytic assembly enables quick switching between different SDEMs for detecting different metabolisms on demand.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
News Item
Chemistry, Multidisciplinary
Ping Song, Chunhai Fan
Summary: A new high-dimensional microfluidic approach allows for the quantitative isolation of aptamers with customizable binding affinities, presenting a challenging yet promising method for constructing aptamers with desired target-binding affinities.
Article
Nanoscience & Nanotechnology
Fangfei Yin, Haipei Zhao, Shasha Lu, Juwen Shen, Min Li, Xiuhai Mao, Fan Li, Jiye Shi, Jiang Li, Baijun Dong, Wei Xue, Xiaolei Zuo, Xiurong Yang, Chunhai Fan
Summary: The article introduces a DNA-encoded molecular classifier that can classify multidimensional molecular clinical data and has been tested in prostate cancer patients.
NATURE NANOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Hui Lv, Nuli Xie, Mingqiang Li, Mingkai Dong, Chenyun Sun, Qian Zhang, Lei Zhao, Jiang Li, Xiaolei Zuo, Haibo Chen, Fei Wang, Chunhai Fan
Summary: We demonstrate a general-purpose DNA integrated circuit (DIC) system by integrating multilayer DNA-based programmable gate arrays (DPGAs), which can be reconfigured and programmed to implement a wide range of circuits. We also show that DNA origami registers can control the asynchronous execution of cascaded DPGAs, and the integration of a DPGA with an analog-to-digital converter can be used for disease classification.
Article
Chemistry, Multidisciplinary
Qinqin Hu, Zongxuan Tong, Ayimukedisi Yalikong, Li-Ping Ge, Qiang Shi, Xinyu Du, Pu Wang, Xi-Yu Liu, Wuqiang Zhan, Xia Gao, Di Sun, Tong Fu, Dan Ye, Chunhai Fan, Jie Liu, Yun-Shi Zhong, Yi-Zhou Jiang, Hongzhou Gu
Summary: Biomarker discovery is crucial for understanding and diagnosing malignant diseases, but the lack of sensitive methods to identify rare disease-specific molecules remains a challenge. This study presents MORAC, a method that utilizes DNAzymes to identify candidate biomarkers with low abundance. By exploiting the catalysis and affinity of DNAzymes, previously unknown biomarkers with clear clinical value can be identified.
Article
Chemistry, Analytical
Shengbiao Zheng, Nini Zhang, Liang Li, Tianna Liu, Yuyang Zhang, Jing Tang, Jiahao Guo, Shao Su
Summary: In this study, a three-dimensional flower-like cobalt-nickel bimetallic metal-organic framework coupled with graphene oxide nanocomposites was synthesized for the selective and simultaneous electrochemical determination of catechol and hydroquinone. The flower-like structure of the nanocomposite enhances its electrocatalytic activity, allowing for the selective and simultaneous detection of catechol and hydroquinone.
Article
Computer Science, Artificial Intelligence
Yan Zhao, Shuting Cao, Yue Wang, Fan Li, Lixuan Lin, Linjie Guo, Fei Wang, Jie Chao, Xiaolei Zuo, Ying Zhu, Lihua Wang, Jiang Li, Chunhai Fan
Summary: The environments in living cells are highly heterogeneous and compartmentalized, posing a grand challenge for the deployment of theranostic agents with spatiotemporal precision. Despite rapid advancements in creating nanodevices responsive to various cues in cellular environments, it remains difficult to control their operations based on the temporal sequence of these cues.
NATURE MACHINE INTELLIGENCE
(2023)
Article
Chemistry, Multidisciplinary
Jingjing Zhang, Jingfeng Zhu, Fenglian Guo, Jinke Jiang, Mo Xie, Lin Hao, Jie Chao
Summary: A novel and reusable electrochemiluminescence biosensor was developed using tetrahedral DNA (TDN) signal amplification for ultrasensitive detection of miRNA-27a. The flowered nickel-iron layered double hydroxide@AuNPs (NiFe-LDH@AuNPs) composites increase the amount of hairpin DNA fixed on the electrode. When miRNA is present, TDN-Ru(bpy)(3)(2+) acts as an ECL probe, forming a stable sandwich structure with miRNA-27a and hairpin DNA through base complementation pairing, thus achieving miRNA detection. This biosensor has the characteristics of high sensitivity, excellent selectivity, and good reproducibility.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Hongyu Wu, Chengwen Zhang, Fulin Zhu, Yu Zhu, Xinhui Lu, Ying Wan, Shao Su, Jie Chao, Lianhui Wang, Dan Zhu
Summary: Here, a poly-adenine (polyA)-mediated programmable FRET-nanoflare is presented for ratiometric intracellular ATP imaging with anti-interference capability. The programmable polyA attachment enhances the signal response for ATP, and the FRET-based nanoflare avoids false-positive signals due to probe degradation in complex environments, showing great potential for clinical diagnosis.
CHEMICAL COMMUNICATIONS
(2023)
Article
Engineering, Biomedical
Wenxin Zhang, Xiaodie Li, Jialin Zeng, Xin Wen, Chao Zhang, Yinan Zhang, Jian He, Lihua Yang
Summary: This study demonstrated a dual-channel parallel free radicals-amplifying radiation therapy strategy for neuroblastoma. By releasing atovaquone (ATO) and Fe3+ in response to the tumor microenvironment, this strategy improved the effectiveness of radiation therapy by inhibiting tumor cell respiration and consuming tumor-overexpressed GSH.
MATERIALS TODAY BIO
(2023)
