期刊
SMALL
卷 13, 期 15, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201603340
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资金
- National Natural Science Foundation of China [21475066, 81401463]
- Fundamental Research Funds for Central Universities (China)
- Thousand Youth Talents Plan of China
An interference-free surface-enhanced Raman scattering tag is constructed to profile the expression of cancer biomarkers at the single-cell level. The Raman tags present a strong and sharp peak in the cellular Raman-silent region, significantly diminishing the background interference. Moreover, the reporters are embedded in the layered gold nanoparticles, avoiding desorption and enzymatic degradation in physiological conditions.
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