Article
Multidisciplinary Sciences
Louise Kiru, Aimen Zlitni, Aidan Michael Tousley, Guillermo Nicolas Dalton, Wei Wu, Famyrah Lafortune, Anna Liu, Kristen May Cunanan, Hossein Nejadnik, Todd Sulchek, Michael Eugene Moseley, Robbie G. Majzner, Heike Elisabeth Daldrup-Link
Summary: The study introduces a new approach to label CAR T cells with iron oxide nanoparticles, enabling noninvasive detection of the CAR T cells in solid tumors. The results show that labeled CAR T cells could locate to osteosarcomas and off-target sites, while unlabeled cells were not visible. This study provides a new method for monitoring the location of CAR T cells in solid tumors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Nanoscience & Nanotechnology
Sheng Wang, Hailin Shen, Qiulian Mao, Qing Tao, Guotao Yuan, Lingli Zeng, Ziying Chen, Yunjiao Zhang, Liang Cheng, Jingzhong Zhang, Hui Dai, Chunhong Hu, Yue Pan, Yonggang Li
Summary: A macrophage loaded with a photothermal nanoprobe was developed to cross the blood-brain barrier and accumulate into deep gliomas for multimodal imaging and guided surgery purposes. This nanoplatform shows promise for achieving accurate diagnosis, imaging-guided surgery, and effective photothermal therapy for gliomas.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hongxi Zhang, Xingwang Yong, Xiaohui Ma, Jianjiang Zhao, Zhipeng Shen, Xinchun Chen, Fengyu Tian, Weibo Chen, Dan Wu, Yi Zhang
Summary: APT imaging can differentiate high-grade and low-grade gliomas in pediatric patients, and provides additional value beyond quantitative relaxation times.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Sandhya Sharma, Mae Woods, Naren U. Mehta, Tim Sauer, Kathan S. Parikh, Michael Schmuck-Henneresse, Huimin Zhang, Birju Mehta, Malcolm K. Brenner, Helen E. Heslop, Cliona M. Rooney
Summary: This study found that depleting naive T cells before extracting antigen-specific T cells from patients can enhance their expansion, antigen specificity, and therapeutic potency. By using CD45RA-depleted PBMCs, EBV-specific T cells were successfully generated and applied in clinical trials for lymphoma and viral infections.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Angela Bernabeu-Sanz, Maria Fuentes-Baile, Cristina Alenda
Summary: The study found that IDH1-wt tumors are more necrotic than IDH1-mut tumors, and that the infiltrative pattern in HGG is associated with loss of p53 expression, Ki-67 index, and Glx levels. Additionally, tumor choline levels could be used as a predictive factor in survival, in addition to IDH1 status, to provide a more accurate prediction of survival in HGG patients.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stefanie Thust, Caroline Micallef, Sachi Okuchi, Sebastian Brandner, Atul Kumar, Kshitij Mankad, Stephen Wastling, Laura Mancini, Hans Rolf Jaeger, Ananth Shankar
Summary: H3 K27M-mutant diffuse midline gliomas in teenagers and adults exhibit heterogeneous signal, contact with midline, and invasive features. Diffusion-weighted MRI demonstrates commonly low ADC values in the solid tumor portion.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Biotechnology & Applied Microbiology
Zhenyu Luo, Lihua Luo, Yichao Lu, Chunqi Zhu, Bing Qin, Mengshi Jiang, Xiang Li, Yingying Shi, Junlei Zhang, Yu Liu, Xinyu Shan, Hang Yin, Guannan Guan, Yongzhong Du, Ningtao Cheng, Jian You
Summary: A dual-binding magnetic nanoparticle platform was developed to enhance the efficacy of adoptive cell therapy (ACT) for solid tumors and reduce toxic side effects.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lei Zhang, Liu-qing Yang, Li Wen, Sheng-qing Lv, Jun-hao Hu, Qing-rui Li, Jian-ping Xu, Ru-fu Xu, Dong Zhang
Summary: The study investigated the performance of multi-parametric magnetic resonance imaging (MRI) for glioma grading, and found that normalized relative cerebral blood flow (rCBV), mean kurtosis (MK), and water molecular diffusion heterogeneity index (alpha) were the most accurate parameters for assessing glioma grading. Multiparametric MRI can increase the accuracy of glioma grading.
ACADEMIC RADIOLOGY
(2021)
Article
Oncology
Florian Maerkl, Mohamed-Reda Benmebarek, Julius Keyl, Bruno L. Cadilha, Martina Geiger, Clara Karches, Hannah Obeck, Melanie Schwerdtfeger, Stefanos Michaelides, Daria Briukhovetska, Sophia Stock, Jakob Jobst, Philipp Jie Mueller, Lina Majed, Matthias Seifert, Anna-Kristina Kluever, Theo Lorenzini, Ruth Gruenmeier, Moritz Thomas, Adrian Gottschlich, Richard Klaus, Carsten Marr, Michael von Bergwelt-Baildon, Simon Rothenfusser, Mitchell P. Levesque, Markus Vincent Heppt, Stefan Endres, Christian Klein, Sebastian Kobold
Summary: Melanoma is an immune sensitive disease, and immune check point blockade has shown activity. However, TIL therapy after ICB failure has shown promising efficacy, indicating the potential of cellular therapies. To overcome limitations of TIL treatment, a controlled adoptive cell therapy approach using synthetic agonistic receptors and bispecific antibodies targeting melanoma-associated antigens is proposed.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yeo Kyung Nam, Ji Eun Park, Seo Young Park, Minkyoung Lee, Minjae Kim, Soo Jung Nam, Ho Sung Kim
Summary: This study aimed to determine MRI parameters predictive of molecular subtype and risk stratification in glioma and develop a structured reporting system. Reproducible imaging parameters such as presence of necrosis, T2/FLAIR mismatch, internal cyst, and predominant contrast enhancement were identified as significant predictors across readers. The highest diagnostic performance was found in predicting risk type 5 with predominant enhancement, followed by risk types 2 and 1 with specific imaging features.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sirui Li, Yuan Zheng, Wenbo Sun, Samo Lasic, Filip Szczepankiewicz, Qing Wei, Shihong Han, Shuheng Zhang, Xiaoli Zhong, Liang Wang, Huan Li, Yuxiang Cai, Dan Xu, Zhiqiang Li, Qiang He, Danielle van Westen, Karin Bryskhe, Daniel Topgaard, Haibo Xu
Summary: The DIVIDE technique shows promise for characterizing and diagnosing gliomas, with the potential to differentiate between different grades, molecular features, and microstructural characteristics of tumors. The diffusion metrics obtained from DIVIDE imaging are able to accurately distinguish between high-grade and low-grade gliomas, as well as between wild-type and mutated IDH tumors.
EUROPEAN RADIOLOGY
(2021)
Article
Health Care Sciences & Services
David Doig, Lewis Thorne, Jeremy Rees, Naomi Fersht, Michael Kosmin, Sebastian Brandner, Hans Rolf Jager, Stefanie Thust
Summary: This study aimed to characterize patients with gliomatosis cerebri and assess clinical outcomes. Among the 29 patients included, the median age was 64 years, with neuropsychiatric symptoms, seizures, and headaches being the most common presenting symptoms. Most patients had IDH wild-type glioblastoma, and the median survival time from referral to death was 48 weeks. Advanced imaging, including MR perfusion, proved to be valuable in identifying biopsy targets, while negative MR spectroscopy did not rule out the diagnosis of glioma.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Hongyu Chen, Fuhua Lin, Jinming Zhang, Xiaofei Lv, Jian Zhou, Zhi-Cheng Li, Yinsheng Chen
Summary: In this study, a reliable model was built from multi-parametric MRI to predict PTEN mutation status in glioma patients. The CNN model showed better performance compared to the radiomics model, and combining radiomics with CNN further improved predictive accuracy. The integrated model outperformed both the radiomics and CNN models alone.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yiming Li, Dong Wei, Xing Liu, Xing Fan, Kai Wang, Shaowu Li, Zhong Zhang, Kai Ma, Tianyi Qian, Tao Jiang, Yefeng Zheng, Yinyan Wang
Summary: In this study, predictive models based on radiomics and deep convolutional neural network (DCNN) were developed to preoperatively predict the molecular subtypes of diffuse gliomas. The DCNN models outperformed radiomics models in terms of accuracy and area under the curve (AUC) in most tasks, both in the training and validation sets. Therefore, DCNN models demonstrated superior performance in predicting molecular subtypes of diffuse gliomas compared to radiomics models.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tom Finck, Jens Gempt, Claus Zimmer, Jan S. Kirschke, Nico Sollmann
Summary: The study suggests that CE BB imaging can significantly improve the delineation of therapy-naive HGGs compared to traditional TFE imaging, indicating a potential supplementary role for CE BB sequences in MRI protocols for brain tumors.
EUROPEAN RADIOLOGY
(2021)
Review
Medicine, General & Internal
Angel Xie, Sumaira Hanif, Jiang Ouyang, Zhongmin Tang, Na Kong, Na Yoon Kim, Baowen Qi, Dylan Patel, Bingyang Shi, Wei Tao
Review
Chemistry, Multidisciplinary
Lude Wang, Duo Xu, Lianfu Jiang, Jie Gao, Zhongmin Tang, Yunjie Xu, Xiang Chen, Han Zhang
Summary: Transition metal dichalcogenides (TMDCs) are increasingly utilized in chemical sensing, biosensing, and tumor therapy due to their diversity, biocompatibility, multifunctionality, adjustable bandgap, and excellent photoelectric characteristics. This review focuses on the effect of the elemental composition and structure of TMDCs on the performance of various biosensors, as well as their applications in tumor therapies. Current challenges and future directions for developing TMDC-based theranostics are also summarized in this review.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Xueqing Sui, Teng Jin, Tonghui Liu, Shiman Wu, Yue Wu, Zhongmin Tang, Yan Ren, Dalong Ni, Zhenwei Yao, Hua Zhang
FRONTIERS IN CHEMISTRY
(2020)
Review
Nanoscience & Nanotechnology
Zhongmin Tang, Na Kong, Xingcai Zhang, Yuan Liu, Ping Hu, Shan Mou, Peter Liljestrom, Jianlin Shi, Weihong Tan, Jong Seung Kim, Yihai Cao, Robert Langer, Kam W. Leong, Omid C. Farokhzad, Wei Tao
NATURE REVIEWS MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Wei Chen, Chuang Liu, Xiaoyuan Ji, John Joseph, Zhongmin Tang, Jiang Ouyang, Yufen Xiao, Na Kong, Nitin Joshi, Omid C. Farokhzad, Wei Tao, Tian Xie
Summary: This study utilized a liquid-phase exfoliation strategy to obtain a new type of two-dimensional stanene-based nanosheets with a narrower band gap, allowing more efficient generation of reactive oxygen species (ROS) through ultrasound-triggered separation of electron-hole pairs. Additionally, these nanosheets showed potential for near-infrared-mediated photothermal therapy (PTT) and as nanocarriers for anticancer drug delivery. This research provides general nanoplatforms for SDT-enhanced combination cancer therapy and highlights the utility of 2D stanene nanosheets in the field of nanomedicine.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Multidisciplinary
Zhongmin Tang, Peiran Zhao, Han Wang, Yanyan Liu, Wenbo Bu
Summary: This review provides a comprehensive overview of the importance and representative applications of Fenton chemistry in the field of biomedicine, as well as future directions for development, which is essential for further advancement in this field.
Article
Chemistry, Multidisciplinary
Peiran Zhao, Yaqin Jiang, Zhongmin Tang, Yanli Li, Bingxia Sun, Yelin Wu, Jiyue Wu, Yanyan Liu, Wenbo Bu
Summary: By regulating the electron density of reaction center atoms, this study has successfully increased the catalytic activity of Fe, reduced the activation energy of the Fenton reaction, and increased the (OH)-O- production rate. This provides a new possibility for highly effective chemodynamic therapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Zhongmin Tang, Xingcai Zhang, Yiqing Shu, Ming Guo, Han Zhang, Wei Tao
Summary: In response to the COVID-19 pandemic, nanotechnology plays a significant role in antiviral research, particularly in drug and vaccine delivery, interference in the virus life cycle, and pneumonia treatment.
Article
Multidisciplinary Sciences
Xiaoyuan Ji, Lanlan Ge, Chuang Liu, Zhongmin Tang, Yufen Xiao, Wei Chen, Zhouyue Lei, Wei Gao, Sara Blake, Diba De, Bingyang Shi, Xiaobing Zeng, Na Kong, Xingcai Zhang, Wei Tao
Summary: Clay-based nanomaterials hold great potential, but challenges in extracting 2D functional core layers have constrained their applications. Wet exfoliation of vermiculite by alkali etching to obtain the core layers is explored, with potential applications in cancer theranostics highlighted.
NATURE COMMUNICATIONS
(2021)
Article
Nanoscience & Nanotechnology
Jiang Ouyang, Ling Zhang, Leijiao Li, Wei Chen, Zhongmin Tang, Xiaoyuan Ji, Chan Feng, Na Tao, Na Kong, Tianfeng Chen, You-Nian Liu, Wei Tao
Summary: This study successfully fabricated two-dimensional tin nanosheets using a new approach, which exhibited good stability and superior biocompatibility after PEGylation, making them promising photothermal agents for cancer treatment. The research paves the way for the development of tin-based biological materials for biomedical applications.
NANO-MICRO LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Han Wang, Hongbo Gao, Xingwu Jiang, Peiran Zhao, Dalong Ni, Zhongmin Tang, Yanyan Liu, Xiangpeng Zheng, Wenbo Bu
Summary: Researchers have developed nanocatalysts with abundant superficial vacancies for water confinement, demonstrating the potential application in cancer radiotherapy. Confined water with enhanced reactivity boosts water radiolysis efficiency and increases the yield of hydroxyl radicals from radiation exposure.
Article
Chemistry, Multidisciplinary
Xinyu Zhang, Xiao Duan, Yueying Hu, Zhongmin Tang, Congxiu Miao, Wei Tao, Jun Wu
Summary: The study developed a peptide-like polydrug for cancer chemotherapy using a simple one-step synthesis strategy, showing high drug loading and stability, and good therapeutic effects on tumors in vivo.
Article
Nanoscience & Nanotechnology
Zulmari Silva Pedraza, Yizhan Wang, Corey Carlos, Zhongmin Tang, Jun Li, Weibo Cai, Xudong Wang
Summary: This study explores the use of piezoelectric microparticles as a method for inducing irreversible electroporation of breast cancer cells. The results show a reduction in cell viability, suggesting that this approach may offer a more benign cancer treatment option.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Yufen Xiao, Zhongmin Tang, Xiangang Huang, John Joseph, Wei Chen, Chuang Liu, Jun Zhou, Na Kong, Nitin Joshi, Jianzhong Du, Wei Tao
Summary: An intelligent oral insulin platform has been developed using glucose-responsive polymeric nanoparticles to protect insulin integrity, overcome intestinal barriers, and release insulin based on blood glucose levels. This platform provides extended therapeutic effects and may reduce insulin administration frequency.
Review
Chemistry, Multidisciplinary
Chuang Liu, Jinwoo Shin, Subin Son, Youmi Choe, Nika Farokhzad, Zhongmin Tang, Yufen Xiao, Na Kong, Tian Xie, Jong Seung Kim, Wei Tao
Summary: Pnictogens, including phosphorus, arsenic, antimony, and bismuth, have diverse chemical characteristics that support extended molecular structures and have a long history in medicinal use. The development of modern technologies has allowed for the functional binding of pnictogen-based drugs to proteins/enzymes in biological systems, paving the way for drug repurposing. Layered pnictogens, such as phosphorene, arsenene, antimonene, and bismuthine, have shown dramatic superiority as emerging photonic nanomedicines due to their favorable optoelectronic properties.
CHEMICAL SOCIETY REVIEWS
(2021)