期刊
SLEEP MEDICINE REVIEWS
卷 32, 期 -, 页码 123-131出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.smrv.2016.04.002
关键词
Sleep; Slow wave sleep; Rapid eye movement sleep; Targeted memory reactivation; Memory consolidation; Neuronal replay; Cueing; Synaptic homeostasis hypothesis; Active system consolidation hypothesis; Electroencephalography
资金
- CAPES
- Consolidator Grant of the European Research Council [ERC-2011-StG_20101124]
Targeted memory reactivation is a fairly simple technique that has the potential to influence the course of memory formation through application of cues during sleep. Studies have shown that cueing memory during sleep can lead to either an enhanced or decreased representation of the information encoded in the targeted networks, depending on experimental variations. The effects have been associated with sleep parameters and accompanied by activation of memory related brain areas. The findings suggest a causal role of neuronal replay in memory consolidation and provide evidence for the active system consolidation hypothesis. However, the observed inconsistencies across studies suggest that further research is warranted regarding the underlying neural mechanisms and optimal conditions for the application of targeted memory reactivation. The goal of the present review is to integrate the currently available experimental data and to provide an overview of this technique's limitations and pitfalls, as well as its potential applications in everyday use and clinical treatment. Exploring the open questions herein identified should lead to insight into safer and more effective ways of adjusting memory representations to better suit individual needs. (C) 2016 Elsevier Ltd. All rights reserved.
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