Article
Environmental Sciences
Cristian Gomez-Canela, Ferran Esquius, Carlos Barata
Summary: The role of serotonin in the phototactic and locomotor behavior of Daphnia magna was examined through genetic and pharmacological approaches. The study found that animals lacking serotonin exhibited increased negative phototaxis and locomotor activity, as well as reduced responses to fish kairomones. Exogenous serotonin restored the phototactic and locomotor behavior of individuals lacking serotonin, but had no effect on the response to fish kairomones. Surprisingly, fluoxetine altered locomotor activity and phototactic behavior in serotonin-deficient individuals, and also increased acethylcholine and GABA concentrations.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Cell Biology
Colby E. Witt, Sergio Mena, Lauren E. Honan, Lauren Batey, Victoria Salem, Yangguang Ou, Parastoo Hashemi
Summary: This study used fast-scan controlled-adsorption voltammetry (FSCAV) to measure low-periodicity fluctuations in serotonin levels in mouse hippocampi. Correlation analyses revealed that these oscillations were present in vivo but not in vitro, and were not significantly different under different conditions (sex and stress paradigm). The administration of a selective serotonin reuptake inhibitor resulted in a shift in the frequency of the oscillations, suggesting regulation by transporter proteins. Additionally, the experimental parameters of FSCAV were optimized for higher temporal resolution, leading to more pronounced shifts in oscillation frequency and decreased amplitude.
Review
Psychology, Clinical
Susannah E. Murphy, Angharad N. de Cates, Amy L. Gillespie, Beata R. Godlewska, Jessica C. Scaife, Lucy C. Wright, Philip J. Cowen, Catherine J. Harmer
Summary: Animal experimental studies suggest that activation of 5-HT4 receptors may be a promising new approach for treating depression and cognitive disorders, with rapid antidepressant and pro-cognitive effects. These effects are accompanied by molecular changes similar to clinically useful antidepressant drugs.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Min-Kyung Joo, Yoon-Jung Shin, Dong-Hyun Kim
Summary: Antibiotics, particularly cefaclor, may cause anxiety and depression through gut dysbiosis and altered central serotonin expression. Targeting antibiotics-resistant pathogenic bacteria could be a promising therapeutic strategy for anxiety and depression.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Daniela Correia, Ines Domingues, Melissa Faria, Miguel Oliveira
Summary: Fluoxetine, a selective serotonin reuptake inhibitor, is commonly detected in aquatic environments at concentrations ranging from ng/L to μg/L. It can have adverse effects on fish, including neurotoxicity, genetic and biochemical changes, and behavioral dysfunction. However, contradictory results have been found. A comprehensive review is needed to understand the effects of fluoxetine on fish at different biological levels, identify patterns, and discuss potential causes for contradictory results. This review also highlights the need for standardized testing with representative aquatic models to assess the actual environmental risk of fluoxetine to aquatic ecosystems.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Clinical Neurology
Nam-Ju Ji, Seung-Yeon Jeon, Kyung-Joon Min, Myung Ki, Weon-Young Lee
Summary: This study investigated the relationship between the type of initial antidepressants and treatment adherence in outpatients with new onset depression. The results showed a significant association between initial antidepressant type and treatment adherence during the first three- and six-month treatment periods for employed and self-employed patients newly diagnosed with major depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Pharmacology & Pharmacy
Hana Horackova, Rona Karahoda, Lukas Cerveny, Veronika Vachalova, Ronja Ebner, Cilia Abad, Frantisek Staud
Summary: Depression is common during pregnancy and many women are prescribed antidepressants. These drugs may disrupt serotonin homeostasis in the placenta or fetus, potentially leading to adverse effects of antidepressant use during pregnancy.
Article
Clinical Neurology
Ya-Mei Tzeng, I-Hsun Li, Hui-Han Kao, Jui-Hu Shih, Chin-Bin Yeh, Yi-Hsien Chen, Li-Ting Kao
Summary: This study found that antidepressants can reduce the subsequent risk of psoriasis in patients with major depressive disorder, particularly selective serotonin reuptake inhibitors and low-dose antidepressants have significant protective effects.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Geriatrics & Gerontology
Kyoung-Eun Kwon, Bo Ram Yang, Mi-Sook Kim, Joongyub Lee, Sun-Young Jung
Summary: The effects of serotonin reuptake inhibition induced by antidepressants on ischemic stroke and its pathophysiology remain unclear. This study found that the use of strong and intermediate serotonin reuptake inhibitors (SRIs) in older adult patients is associated with an increased risk of ischemic stroke.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Engineering, Environmental
Yanbin Zhao, Jiahui Liang, Haoyu Meng, Yue Yin, Huajun Zhen, Xuehan Zheng, Haochun Shi, Xiuzhi Wu, Yao Zu, Bin Wang, Liuyin Fan, Kun Zhang
Summary: This study revealed significant developmental effects of rare earth elements (REEs), particularly lanthanum (La) and praseodymium (Pr), on zebrafish embryos, impacting swimming behavior and cardiac physiology. Transcriptomic analysis showed uniform effects of La and Pr at molecular levels, affecting neural signaling and cardiac pathways. High concentrations led to increased DNA damage and apoptotic activity, potentially explaining adverse morphological and physiological outcomes observed, such as pericardial edema.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Clinical Neurology
Mert Karakaya, Andrea Scaramuzzi, Simone Macri, Maurizio Porfiri
Summary: Anxiety is a major health challenge in Western countries, commonly treated with selective serotonin reuptake inhibitors like Citalopram, which may have incomplete efficacy and side effects. Zebrafish, a rapidly emerging model species, was used in a study utilizing robotics and three-dimensional tracking to show the effects of Citalopram on behavior, suggesting potential sex differences in response to the drug.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Pharmacology & Pharmacy
Carolina Ramos Mendonca, Raul Manhaes-de-Castro, Barbara Juacy Rodrigues Costa de Santana, Luana Olegario da Silva, Ana Elisa Toscano, Omar Guzman-Quevedo, Ligia Cristina Monteiro Galindo
Summary: This systematic review investigated the effects of flavonols on the serotonergic system. The results showed that flavonols can modify physiological aspects of the system, increasing serotonin levels, decreasing its metabolite levels, and promoting antioxidant effects. Additionally, flavonols were found to modulate the serotonergic system, associated with antidepressant and anxiolytic activities.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Melinda D. Karth, Brittany J. Baugher, Sophia A. Pellechia, Shama N. Huq, Allison K. Warner, Michelle M. Karth, Benjamin D. Sachs
Summary: This study found significant sex differences in the effects of fluoxetine and brain serotonin deficiency on binge-like food intake, and suggests that low brain serotonin could impact eating disorders both by promoting binge eating and by limiting the efficacy of fluoxetine to reduce binge eating.
PSYCHOPHARMACOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Abeer Essam Hakam, Gabriela Vila, Poliana Mendes Duarte, Marcia Phemba Mbadu, Dannia Sulaiman Ai Angary, Ikramuddin Aukhil, Rodrigo Neiva, Helio Doyle Pereira da Silva, Jia Chang
Summary: This study found that patients taking antidepressants are at higher risk of dental implant failure, with users of SNRI and TCA having the highest risk of implant loss. However, conclusions about TCA are based on a limited number of cases.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Psychiatry
Rene Zeiss, Bernhard J. Connemann, Carlos Schoenfeldt-Lecuona, Maximilian Gahr
Summary: The study found that the categorization of the type of association between drug and event affects the results of quantitative signal detection. Causality assessment seems to play a major role in signal detection, particularly concerning rare, unknown, or clinically insignificant adverse drug reactions. Antidepressants appear to significantly increase the bleeding risk, even independent of antithrombotic comedication.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Environmental Sciences
Erica N. Linard, Peter van den Hurk, Tanju Karanfil, Onur G. Apul, Stephen J. Klaine
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2015)
Article
Environmental Sciences
Peter van den Hurk, Dennis C. Haney
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2017)
Article
Engineering, Environmental
Erica N. Linard, Onur G. Apul, Tanju Karanfil, Peter van den Hurk, Stephen J. Klaine
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2017)
Article
Environmental Sciences
Sarah Y. Au, Cindy M. Lee, John E. Weinstein, Peter van den Hurk, Stephen J. Klaine
INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT
(2017)
Article
Marine & Freshwater Biology
Phenny Mwaanga, Elizabeth R. Carraway, Peter van den Hurk
AQUATIC TOXICOLOGY
(2014)
Article
Environmental Sciences
Jessica Mierzejewski, Dennis C. Haney, Peter van den Hurk
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2014)
Article
Environmental Sciences
Ryan R. Otter, Erika A. Schreiber, Peter van den Hurk, Stephen J. Klaine
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2012)
Article
Multidisciplinary Sciences
Peter B. Marko, Holly A. Nance, Peter van den Hurk
Article
Biochemistry & Molecular Biology
Peter van den Hurk, Harald M. Kerkkamp
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2019)
Article
Ecology
Stephanie B. LaPlaca, Peter van den Hurk
Article
Environmental Sciences
Peter van den Hurk, Ian Edhlund, Ryan Davis, Jacob J. Hahn, Michel J. McComb, Elizabeth L. Rogers, Emily Pisarski, Katy Chung, Marie DeLorenzo
MARINE ENVIRONMENTAL RESEARCH
(2020)
Article
Environmental Sciences
Erica N. Linard, Cindy M. Lee, Tanju Karanfil, Peter van den Hurk
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2020)
Article
Marine & Freshwater Biology
Lauren Stoczynski, Peter van den Hurk
AQUATIC TOXICOLOGY
(2020)
Article
Marine & Freshwater Biology
Peter van den Hurk, Lindsay E. Gerzel, Peter Calomiris, Dennis C. Haney
AQUATIC TOXICOLOGY
(2017)