Article
Critical Care Medicine
Thomaz Fleury Curado, Huy Pho, Carla Freire, Mateus R. Amorim, Jordi Bonaventura, Lenise J. Kim, Rachel Lee, Meaghan E. Cabassa, Stone R. Streeter, Luiz G. Branco, Luiz U. Sennes, Kenneth Fishbein, Richard G. Spencer, Alan R. Schwartz, Michael J. Brennick, Michael Michaelides, David D. Fuller, Vsevolod Y. Polotsky
Summary: The study showed that administration of AAV9-DREADD combined with the use of the novel DREADD ligand J60 can activate the genioglossus muscle, improve pharyngeal patency, and enhance breathing during sleep. This treatment strategy offers a new therapeutic approach for obstructive sleep apnea.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Clinical Neurology
Laura Perez-Carbonell, Amaia Munoz-Lopetegi, Raquel Sanchez-Valle, Ellen Gelpi, Ramon Farre, Carles Gaig, Alex Iranzo, Joan Santamaria
Summary: The study revealed that FI patients exhibit frequent breathing alterations, including various breathing disturbances, distorted NREM sleep, and severely impaired REM sleep. Brainstem impairment plays a crucial role in FI.
Review
Clinical Neurology
Janna R. Raphelson, Kimberly Y. Kreitinger, Atul Malhotra
Summary: Obstructive sleep apnea (OSA) is a common condition with significant neurocognitive and cardiovascular effects. Positive airway pressure (PAP) therapy can help prevent airway collapse and improve oxygen levels, carbon dioxide levels, and sleep quality. While adherence to PAP therapy was once seen as a barrier, in reality, adherence rates are likely higher than commonly believed, with various strategies available to help improve patient adherence.
Article
Pediatrics
Rosemary S. C. Horne, Ashwini Sakthiakumaran, Ahmad Bassam, Julie Thacker, Lisa M. Walter, Margot J. Davey, Gillian M. Nixon
Summary: Children with Down syndrome experiencing sleep disordered breathing exhibit reduced parasympathetic activity and increased exposure to hypoxia, which may lead to adverse cardiovascular outcomes compared to typically developing children. Early screening and treatment for sleep disordered breathing in children with Down syndrome is recommended.
PEDIATRIC RESEARCH
(2021)
Article
Respiratory System
Kimihiko Murase, Takeshi Matsumoto, Yasuharu Tabara, Adrienne Ohler, David Gozal, Takuma Minami, Osamu Kanai, Hirofumi Takeyama, Naomi Takahashi, Satoshi Hamada, Kiminobu Tanizawa, Tomoko Wakamura, Naoko Komenami, Kazuya Setoh, Takahisa Kawaguchi, Takanobu Tsutsumi, Satoshi Morita, Yoshimitsu Takahashi, Takeo Nakayama, Motoko Yanagita, Toyohiro Hirai, Fumihiko Matsuda, Kazuo Chin
Summary: Sleep-disordered breathing and office blood pressure are independently and synergistically associated with urinary albumin excretion, which is a risk factor for chronic kidney disease and cardiovascular events.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Multidisciplinary Sciences
Kristina Kairaitis, Terence C. C. Amis, Rita Perri, Sharon Lee, Anne Drury, Christopher Lambeth, Paul Mitchell, Richard I. I. Lindley, John R. R. Wheatley
Summary: This study examined the relationship between obstructive sleep apnea (OSA) and retinal arteriolar and venular widening. The results showed no significant association between OSA and retinal arteriolar and venular measures.
Article
Genetics & Heredity
Anna Bulian, Vincent Couloigner, Kahina Belhous, Romain Luscan, Sonia Khirani, Brigitte Fauroux
Summary: This study analyzed the sleep-disordered breathing in children with neurofibromatosis type 1 (NF1) and found a high prevalence of obstructive sleep apnea (OSA) regardless of the nature of airway obstruction and the clinical and MRI findings. The study highlights the value of systematic respiratory polygraphy and suggests that CPAP may reduce the need for tracheostomy.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2022)
Article
Critical Care Medicine
Sunil Sharma, Robert Stansbury
Summary: Sleep disorders, particularly sleep apnea, have become a significant health issue in the United States. Screening and identifying SDB in hospitalized patients can have a positive impact on the disease outcomes and treatment of patients.
Article
Neurosciences
Richard Lim, Ludovico Messineo, Ronald R. Grunstein, Jayne C. Carberry, Danny J. Eckert
Summary: The combination of noradrenergic agent reboxetine and anti-muscarinic hyoscine butylbromide has been shown to improve upper airway function during sleep in healthy individuals and reduce obstructive sleep apnoea (OSA) severity by increasing pharyngeal muscle responsiveness, improving respiratory control, and airway collapsibility without changing the respiratory arousal threshold. This highlights the potential for pharmacotherapy to target these mechanisms to treat OSA.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Respiratory System
Sebastien Baillieul, Sebastien Bailly, Olivier Detante, Sarah Alexandre, Marie Destors, Rita Clin, Marjorie Dole, Jean-Louis Pepin, Renaud Tamisier
Summary: This study investigated the clinical and ventilatory chemosensitivity characteristics of sleep-disordered breathing (SDB) in patients at least 3 months after a first ischemic stroke. The findings revealed that patients with obstructive sleep apnea and coexisting or central sleep apnea differed in their clinical presentation and ventilatory chemosensitivity characteristics, with implications for specific ventilatory support.
Review
Critical Care Medicine
Salam Zeineddine, James A. Rowley, Susmita Chowdhuri
Summary: Sleep-disordered breathing (SDB) has significant cardiovascular and neurological effects, with supplemental oxygen therapy showing mixed results in improving oxygen saturation and apnea severity compared to positive airway pressure therapy. Further research is needed to clarify the optimal dose and duration of nocturnal supplemental oxygen (NSO) and its combination with PAP in improving cardiovascular, sleep, and cognitive outcomes in SDB patients.
Article
Obstetrics & Gynecology
D'Angela S. Pitts, Marjorie C. Treadwell, Louise M. O'Brien
Summary: Emerging literature suggests that women with sleep-disordered breathing are at increased risk for gestational hypertension/preeclampsia and gestational diabetes. Initial data in this study indicate a significant association between maternal respiratory events and fetal heart rate decelerations, potentially impacting fetal well-being.
REPRODUCTIVE SCIENCES
(2021)
Article
Clinical Neurology
Leon S. Siriwardhana, Gillian M. Nixon, Margot J. Davey, Dwayne L. Mann, Shane A. Landry, Bradley A. Edwards, Rosemary S. C. Horne
Summary: The study found that children with Down syndrome and sleep disordered breathing have higher loop gain, indicating more unstable ventilatory control compared to typically developing children. This may be due to an inherent impairment in ventilatory control in children with Down syndrome contributing to their increased risk of sleep disordered breathing, and may inform alternative treatment options for this population.
Article
Multidisciplinary Sciences
Antonio Martinez-Nicolas, Marc Guaita, Joan Santamaria, Josep M. Montserrat, Juan Antonio Madrid, Maria Angeles Rol
Summary: The study found that circadian rhythms were altered in SDB patients, directly related to the severity of SDB, and that CPAP treatment improved the motor activity pattern. This suggests that circadian ambulatory monitoring, including the integrated variable TAP, can be used to assess circadian alterations caused by SDB and monitor CPAP treatment effects.
SCIENTIFIC REPORTS
(2021)
Article
Pediatrics
Alice Baker, Anneke Grobler, Karen Davies, Amanda Griffiths, Harriet Hiscock, Haytham Kubba, Rachel L. Peters, Sarath Ranganathan, Joanne Rimmer, Elizabeth Rose, Katherine Rowe, Catherine M. Simpson, Andrew Davidson, Gillian Nixon, Kirsten P. Perrett
Summary: Obstructive sleep-disordered breathing (SDB) in children can be improved by intranasal corticosteroids, but the effect on symptoms and quality of life is unclear.
Article
Endocrinology & Metabolism
Francois Marcouiller, Alexandra Jochmans-Lemoine, Gauthier Ganouna-Cohen, Mathilde Mouchiroud, Mathieu Laplante, Andre Marette, Aida Bairam, Vincent Joseph
Summary: The metabolic effects of intermittent hypoxia on mice differ between males and females, and are influenced by estradiol in females. Estradiol supplementation can reverse the effects of intermittent hypoxia in ovariectomized females. Intermittent hypoxia improves glucose tolerance in males but impairs it in females, especially after ovariectomy.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Alexandra Ribon-Demars, Alexandra Jochmans-Lemoine, Gauthier Ganouna-Cohen, Anaelle Boreau, Francois Marcouiller, Aida Bairam, Vincent Pialoux, Vincent Joseph
Summary: The study revealed that E-2 has antioxidant effects under CIH, impacting oxidative stress and gene expression in the lungs. Important interactions were found between ovarian hormones and CIH, which may contribute to a better understanding of the consequences of sleep apnea on the occurrence of lung pathologies in women.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Physiology
Christian Arias-Reyes, Jorge Soliz, Vincent Joseph
Summary: Phylogeographic studies suggest that house mice originated in the Himalayan region, while common rats come from lowlands of China and India. It is proposed that the ability for house mice to colonize high-altitude habitats may be due to their enhanced ventilatory, metabolic, and mitochondrial responses. On the other hand, common rats show quicker and higher hematological response but only minor ventilatory and metabolic adjustments, which may explain why they are less able to thrive in high-altitude environments.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Physiology
Y. Voituron, D. Roussel, L. Teulier, M. Vagner, Q. Ternon, C. Romestaing, E. Dubillot, C. Lefrancois
Summary: High-temperature acclimation improves mitochondrial efficiency in sea bass juveniles, allowing for more economical management of oxygen consumption and adaptation to energy constraints associated with warming water.
PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Melanie Boel, Frederic Veyrunes, Anne-Cecile Durieux, Damien Freyssenet, Yann Voituron, Damien Roussel
Summary: The skeletal muscle mitochondria of the African pygmy mouse Mus mattheyi exhibit lower oxidative activity and higher electron leak, but a higher mitochondrial efficiency than expected based on allometric trends.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2022)
Article
Biology
Elisa Thoral, Elie Farhat, Damien Roussel, Hang Cheng, Ludovic Guillard, Matthew E. Pamenter, Jean-Michel Weber, Loic Teulier
Summary: In goldfish, chronic exposure to constant hypoxia leads to metabolic suppression, increased anaerobic capacity, and improved swimming performance, with no changes at the mitochondrial level. On the other hand, swimming performance enhancement is reduced in intermittent hypoxia, with decreased aerobic scope despite an increase in oxidative metabolism.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Mary Rosana Nalzala Thomas, Vincent Joseph Kanniyambatti Lourdusamy
Summary: Dye sensitized solar cells (DSCs) are low-cost and easy to fabricate, and have the potential to convert indoor/low-intensity sunlight into electricity. In this study, MY-101 dye showed better photovoltaic properties compared to the reference dye, and DFT-TD-DFT theoretical study revealed the easy electron transfer from MY-101 to TiO2. The conversion efficiency of solar cells fabricated with MY-101 showed improvement compared to the reference dye, especially in Co(phen)(3)(2+) electrolyte.
APPLIED NANOSCIENCE
(2022)
Article
Physiology
Yann Voituron, Damien Roussel, Jean-Francois Le Galliard, Andreaz Dupoue, Caroline Romestaing, Sandrine Meylan
Summary: This study examines the effects of stress on metabolism and mitochondrial functionality in lizards using the application of corticosterone. The results show that while skeletal muscle is not impacted, there is a time-dependent regulation of liver mitochondrial functionality under stress. The study also reveals the response mechanism of mitochondria to energy demands.
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2022)
Article
Biology
Pawel Brzek, Damien Roussel, Marek Konarzewski
Summary: Intra-specific variation in both basal metabolic rate (BMR) and mitochondrial efficiency can have significant evolutionary and ecological consequences. The relationship between mitochondrial efficiency and BMR differs at different levels, with negative correlation at interspecific level and positive correlation at intraspecific level. However, the mechanisms responsible for this variation are not fully understood.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Environmental Sciences
Vincent Joseph Kanniyambatti Lourdusamy, Mary Rosana Nalzala Thomas, Sekar Subramani
Summary: The purpose of this research is to synthesize near-infrared dye-sensitized nanocomposites for effluent degradation and hydrogen generation under visible light irradiation. The nanocomposites were made using a self-assembled core/shell structure and were found to have a large surface area and prevent dye aggregation, leading to improved photocatalytic efficiency.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Elisa Thoral, Damien Roussel, Laura Quispe, Yann Voituron, Loic Teulier
Summary: Heat waves are expected to increase with global warming, but zebrafish show high tolerance to temperature fluctuations. However, the efficiency of mitochondrial energy production decreases at high temperatures. There is also individual variability in temperature adaptation.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2022)
Article
Cell Biology
Satomi Hirose, Julie Hesnard, Nasser Ghazi, Damien Roussel, Yann Voituron, Oliver Cochet-Escartin, Jean-Paul Rieu, Christophe Anjard, Kenichi Funamoto
Summary: Spatial and temporal variations of oxygen environments affect cell behaviors, and the aerotaxis of Dictyostelium discoideum seems to be an effective strategy for survival. Flavohemoglobins, potential oxygen sensors and oxidative stress modulators, play a role in this phenomenon.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Damien Roussel, Sonia Janillon, Loic Teulier, Nicolas Pichaud
Summary: Decreased NADH-induced and increased reduced FADH(2)-induced respiration rates at high temperatures are associated with thermal tolerance in Drosophila. The study investigated whether these changes were related to ATP production rate and coupling efficiency in Drosophila melanogaster. The results showed that decreased pyruvate + malate oxidation at high temperature resulted in a collapse of ATP synthesis and a drop in ATP/O ratio, but addition of succinate compensated for both oxygen consumption and ATP synthesis rates.
Article
Biology
Jessica Barbe, Damien Roussel, Yann Voituron
Summary: Both birds and mammals have important thermogenic capacities allowing them to maintain high body temperatures. The present study found that birds and mammals have different substrate preferences during hyperthermia.
JOURNAL OF THERMAL BIOLOGY
(2023)