Article
Public, Environmental & Occupational Health
Susana Cararo Confortin, Liliana Yanet Gomez Aristizabal, Elma Izze da Silva Magalhaes, Aline Rodrigues Barbosa, Cecilia Claudia Costa Ribeiro, Rosangela Fernandes Lucena Batista, Antonio Augusto Moura da Silva
Summary: There is no association between sleep duration and cardiometabolic risk factors in adolescents.
Article
Endocrinology & Metabolism
Mingming Wang, Claudia Flexeder, Carla P. Harris, Elisabeth Thiering, Sibylle Koletzko, Carl-Peter Bauer, Gerd Schulte-Koerne, Andrea von Berg, Dietrich Berdel, Joachim Heinrich, Holger Schulz, Tamara Schikowski, Annette Peters, Marie Standl
Summary: This study used objective sleep characteristics to identify sleep clusters in adolescents and examined their associations with cardiometabolic health. Five sleep clusters were identified, and the study found that the prolonged sleep latency cluster was associated with higher fat mass index (FMI), while the sleep irregularity and variability cluster was specifically linked to elevated triglycerides in male individuals.
Article
Public, Environmental & Occupational Health
Paula R. Pienaar, Laura C. Roden, Cecile R. L. Boot, Willem van Mechelen, Jos W. R. Twisk, Estelle. Lambert, Dale E. Rae
Summary: This study explored the longitudinal associations between self-reported sleep duration and cardiometabolic disease (CMD) risk in corporate executives. The results showed that shorter sleep duration was associated with higher BMI and waist circumference in both women and men. Additionally, shorter sleep duration was also associated with higher CMD risk scores in men.
PREVENTIVE MEDICINE
(2023)
Article
Clinical Neurology
Victoria A. A. Beunders, Elisabeth Koopman-Verhoeff, Marijn J. Vermeulen, Pauline W. Jansen, Annemarie I. Luik, Ivonne P. M. Derks, Irwin K. M. Reiss, Koen F. M. Joosten, Vincent W. V. Jaddoe
Summary: The study found that fragmented 24-hour activity rhythms were associated with increased adiposity in school-age children, while more nightly awakenings were associated with lower body mass index. These findings highlight the importance of sleep and activity patterns in relation to cardiometabolic risk factors in children.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2023)
Article
Clinical Neurology
Lisa Matricciani, Catherine Paquet, Francois Fraysse, Anneke Grobler, Yichao Wang, Louise Baur, Markus Juonala, Minh Thien Nguyen, Sarath Ranganathan, David Burgner, Melissa Wake, Tim Olds
Summary: The study found that different actigraphy-derived sleep profiles are associated with cardiometabolic health, with the overall good sleeper pattern linked to better cardiometabolic health.
Article
Pediatrics
Anna Di Sessa, Giovanni Messina, Ilaria Bitetti, Costanza Falanga, Giovanni Farello, Alberto Verrotti, Marco Carotenuto
Summary: Non-obese children with OSAS have a worse cardiometabolic profile, which is associated with inflammation and metabolic derangements. This study provides therapeutic strategies to improve cardiovascular health in OSAS patients.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Multidisciplinary Sciences
Nazanin Jalali, Parvin Khalili, Zahra Jamali, Zahra Jalali, Amir Moghadam-Ahmadi, Alireza Vakilian, Fatemeh Ayoobi
Summary: This study found that both short and long sleep durations are associated with demographic, medication use, personal habits, and chronic diseases. The impact of hypnotic drug use on sleep duration was also considered. The results showed that short sleep duration was significantly associated with age, BMI, physical activity, and depression, while long sleep duration was associated with female sex, opium consumption, and history of MI. Stratified analysis for hypnotic drug use revealed additional associations with education, physical activity, opium consumption, and thyroid dysfunction.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Yejin Kim, Hye-Ji An, Young-Gyun Seo
Summary: This study aimed to establish the optimal cutoffs of sleep timing and duration to assess various cardiovascular disease risk factors. The findings showed that bedtime between 9:00 PM to 0:30 AM for men and 10:00 PM to 11:00 PM for women is appropriate. The cutoff range was slightly earlier for participants aged 65 years and older. Early MSFsc between 12:00 AM to 3:00 AM and sleep durations around 6 hours were associated with the optimal cutoffs for assessing CVD risk factors.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Stephanie R. Yiallourou, Graeme P. Maguire, Melinda J. Carrington
Summary: The study found that a large proportion of indigenous Australians experience short sleep durations and poor sleep quality, with over one-third of participants obtaining less than 7 hours of sleep per night. Short sleep duration and poor sleep quality are associated with increased cardiometabolic risk in this population.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Psychology, Clinical
Gum-Ryeong Park, Jinho Kim
Summary: This study investigates the association between sleep duration during adolescence and cardiometabolic risk in adulthood, and whether this association differs by sex. The results show that sleep duration during adolescence is associated with higher cardiometabolic risk in adulthood among males, but not females. The association for males is robust even when controlling for unobserved family heterogeneity, and is not explained by sleep duration in adulthood.
Article
Pediatrics
Monserrat Solera-Martinez, Angel Herraiz-Adillo, Ismael Manzanares-Dominguez, Lidia Lucas-De La Cruz, Vicente Martinez-Vizcaino, Diana P. Pozuelo-Carrascosa
Summary: The study found that high-intensity interval training (HIIT) in children aged 5 to 12 can significantly improve cardiovascular risk factors and cardiorespiratory fitness levels.
Review
Medicine, General & Internal
Marta Stelmach-Mardas, Beata Brajer-Luftmann, Marta Kusnierczak, Halina Batura-Gabryel, Tomasz Piorunek, Marcin Mardas
Summary: A meta-analysis of multiple studies found that weight reduction significantly influences the apnea-hypopnea index, total cholesterol, triglycerides, fasting insulin, and blood pressure in obstructive sleep apnea patients, highlighting the importance of lifestyle modification in managing cardio-metabolic risk factors.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Ahmad Kamil Nur Zati Iwani, Muhammad Yazid Jalaludin, Farah Aqilah Roslan, Fazliana Mansor, Fuziah Md Zain, Janet Yeow Hua Hong, Ruziana Mona Wan Mohd Zin, Abqariyah Yahya, Zahari Ishak, Rusidah Selamat, Abdul Halim Mokhtar
Summary: This study investigated the prevalence and clinical characteristics of cardiometabolic risk factors among severely obese children in Malaysia. The results showed that severely obese children had a higher prevalence of these risk factors compared to overweight and obese children. This highlights the importance of regular screening and intervention for this group of children.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Paula R. Pienaar, Laura C. Roden, Cecile R. L. Boot, Willem van Mechelen, Jos W. R. Twisk, Estelle Lambert, Dale E. Rae
Summary: This study found that longer work hours and commute time, depression, anxiety, and stress were associated with shorter sleep duration in both men and women. Shorter sleep duration was associated with higher BMI, larger waist circumference, and greater cardiometabolic risk scores. Physical activity, working hours, and stress significantly mediated the relationships between self-reported sleep duration and BMI, waist circumference, diastolic blood pressure, and cardiometabolic risk score in men.
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
(2021)
Article
Pediatrics
Wen Lun Yuan, Michael S. Kramer, Navin Michael, Suresh A. Sadananthan, Mya T. Tint, Ling-Wei Chen, Wei Wei Pang, Sendhil S. Velan, Keith M. Godfrey, Yap-Seng Chong, Mary F. F. Chong, Jonathan T. L. Choo, Lieng Hsi Ling, Johan G. Eriksson, Yung Seng Lee
Summary: The study identified four SBP percentile trajectories in children and found that maternal hypertension during early pregnancy and rapid child weight gain in the first 2 years of life were associated with higher SBP trajectories. Children in the high stable SBP trajectory had greater body fat and metabolic risk factors compared to children in the low stable trajectory.
JOURNAL OF PEDIATRICS
(2021)
Article
Endocrinology & Metabolism
He Liu, Siyu Liang, Yu Li, Junling Fu, Shi Chen, Ming Li, Huijuan Zhu, Hui Pan, Ou Wang, Tao Yuan, Jiangfeng Mao, Yan Qin, Yuxiu Li
Summary: This study presents a case of a novel type of extreme insulin resistance caused by high-affinity insulin autoantibodies, with evaluation of therapeutic effects through the measurement of insulin-free ratio (IFR).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Physiology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: The study reveals that Qishen Yiqi dripping pill exerts renal-protective function by inhibiting the Wnt/beta-catenin and TGF-beta/Smad2 signaling pathways in diabetic rats, as evidenced by reduced levels of serum markers and improved kidney histology and fibrosis.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Mei-ting Chen, Yi-ting Zhao, Li-yuan Zhou, Ming Li, Qian Zhang, Qin Han, Xin-hua Xiao
Summary: This study found that exosomes derived from human umbilical cord mesenchymal stem cells significantly improved insulin sensitivity in insulin-resistant human adipocytes, with effects lasting for at least 48 hours. Additionally, exosome treatment led to a significant decrease in leptin levels and an upregulation of mRNA expression of sirtuin-1 and insulin receptor substrate-1.
CURRENT MEDICAL SCIENCE
(2021)
Article
Endocrinology & Metabolism
Junling Fu, Fan Ping, Tong Wang, Yiwen Liu, Xiaojing Wang, Jie Yu, Mingqun Deng, Jieying Liu, Qian Zhang, Miao Yu, Ming Li, Yuxiu Li, Xinhua Xiao
Summary: The research proposed using numerous and weighted clinical traits as key indicators for genetic testing to predict the probability of MODY in the Chinese population. A prediction model based on data from 306 patients was developed, showing excellent discrimination in distinguishing MODY patients from T1D and T2D patients. Specific biomarkers were identified for different MODY subtypes to improve the identification process.
ENDOCRINE PRACTICE
(2021)
Article
Medicine, General & Internal
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: The study found that vildagliptin effectively improved endothelial function in diabetic rats, and through miRNA regulation, it protected the cardiovascular system by activating anti-inflammatory and anti-apoptosis mechanisms, as well as endothelial moderation.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal overnutrition is a risk factor for metabolic diseases in mothers and offspring. Inulin, a fructan-type plant polysaccharide, has prebiotic functions and is used as a natural antidiabetic supplement. Early maternal inulin intervention improved glucose metabolism in male offspring with hepatic lncRNA and mRNA expression differences compared to offspring from high-fat diet dams.
Article
Endocrinology & Metabolism
Ge Li, Ling Zhong, Lanwen Han, Yonghui Wang, Bo Li, Dongmei Wang, Yanglu Zhao, Yu Li, Qian Zhang, Lu Qi, John R. Speakman, Steven M. Willi, Ming Li, Shan Gao
Summary: This study investigated the effects of adiponectin-related genetic variations and gene-diet interactions on metabolic disorders in children. The results showed significant associations between certain genetic variants and metabolic risks in normal-weight children, as well as a gene-diet interaction effect on metabolic health in this group. These findings suggest a potential long-term impact of gene-diet interactions on cardiometabolic disorders in childhood.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Endocrinology & Metabolism
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Excess maternal energy intake leads to long-term disorders in offspring's brown adipose tissue (BAT), affecting blood lipid panel and BAT structure. It also influences the methylation levels and expression of genes involved in thermogenesis and fatty acid oxidation in BAT.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Dongmei Wang, Dan Feng, Yuhan Wang, Peiyu Dong, Yonghui Wang, Ling Zhong, Bo Li, Junling Fu, Xinhua Xiao, John R. Speakman, Ming Li, Shan Gao
Summary: This study aimed to investigate the relationship between ANGPTL8 and other adipokines with cardiac structure in youths, and to explore the role of lipids in mediating this relationship. The findings showed a significant inverse association between ANGPTL8 and leptin with left ventricular mass index (LVMI), independent of risk factors. Total cholesterol and low-density lipoprotein cholesterol mediated the ANGPTL8-LVMI association, while triglyceride mediation was moderated by leptin levels. Other adipokines showed no significant association with LVMI.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Microbiology
Jieying Liu, Lu Ding, Xiao Zhai, Dongmei Wang, Cheng Xiao, Xiangyi Hui, Tianshu Sun, Miao Yu, Qian Zhang, Ming Li, Xinhua Xiao
Summary: Maternal betaine supplementation improves glucose and lipid metabolism disorders in both dams and offspring and regulates gut microbiota. The persistent alterations in gut microbiota may play a critical role in uncovering the intergenerational metabolic benefits of maternal betaine.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Endocrinology & Metabolism
Yiwen Liu, Fan Ping, Jie Yu, Lu Lv, Yuan Zhao, Mengya Qi, Wei Li, Lingling Xu, Miao Yu, Ming Li, Huabing Zhang, Yuxiu Li
Summary: This study aims to better define autoimmune hypoglycemia caused by exogenous insulin antibody syndrome (EIAS) and improve the identification and intervention for this condition. By summarizing the clinical characteristics of 23 patients with diabetes, we identified certain features of this condition, including autoimmune comorbidities, allergies, and high frequency of insulin autoantibodies and insulin/C-peptide molar ratio. The study also found a high rate of spontaneous remission for this condition.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Pharmacology & Pharmacy
Dongmei Wang, Jieying Liu, Ling Zhong, Lu Ding, Qian Zhang, Miao Yu, Ming Li, Xinhua Xiao
Summary: The combined administration of metformin and pioglitazone has been shown to have protective effects on obese mice fed a high-fat diet. The study found that this combination therapy alters the gut microbiota and its metabolites, leading to improved glucolipid metabolism. The results provide novel evidence and potential targets for metformin and pioglitazone combination therapy in type 2 diabetes.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Bo Li, Shan Gao, Wei Bao, Ming Li
Summary: This systematic review summarizes the efficacy of lifestyle interventions in reducing BMI and metabolic risk factors for overweight/obese Chinese children. The findings suggest that lifestyle interventions are effective, especially when they include multiple components, last longer than one year, and are conducted among teenagers.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Peripheral Vascular Disease
Bo Li, Cong Hou, Lianxia Li, Ming Li, Shan Gao
Summary: This study aimed to assess the associations between hypertension and four adipokine levels in Chinese youth, and to examine the extent to which these associations are mediated by insulin resistance (IR). The results showed that youth with hypertension had lower adiponectin and higher leptin, FGF21, and RBP4 levels. The coexistence of multiple abnormal adipokine levels increased the risk of hypertension, and the associations between adipokines and hypertension were mediated by IR.
HYPERTENSION RESEARCH
(2023)
Review
Endocrinology & Metabolism
Shi Chen, Jiaqi Qiang, Yuelun Zhang, Bin Zhao, Ran Tian, Tao Yuan, Ming Li, Mei Li, Yuxiu Li, Huijuan Zhu, Hui Pan
Summary: Clopidogrel, a commonly used antiplatelet drug, may be a modifiable and causal risk factor of hypoglycemia. Substituting clopidogrel with ticagrelor has been shown to be an effective treatment. The Asian population may be more susceptible to clopidogrel-associated hypoglycemia and require additional care.
FRONTIERS IN ENDOCRINOLOGY
(2023)