Article
Immunology
Christelle Kassis, Michelle Durkin, Eric Holbrook, Robert Myers, Lawrence Wheat
Summary: Combining antibody and antigen detection can improve sensitivity and specificity in the diagnosis of coccidioidomycosis, particularly with higher sensitivity in immunocompromised patients. Antigen detection can help prevent missed diagnoses.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Chemistry, Analytical
Miroslav Pohanka
Summary: Point-of-care tests, especially lateral flow immunoassays, have proven to be valuable tools for early diagnosis of COVID-19. Biosensors, composed of selective molecules and sensor platforms, offer an advanced alternative to current diagnostic tests and laboratory methods.
Review
Medicine, General & Internal
Melissa R. Gitman, Maryia Shaban, Alberto E. Paniz-Mondolfi, Emilia M. Sordillo
Summary: The emergence and rapid spread of COVID-19 in the past year has strained global health infrastructure and economy, prompting the development of various rapid and accurate testing strategies. These strategies fall into three categories: NAATs, RATs, and serology-based exams, each with different strengths and weaknesses. These testing measures not only enhance pathogen identification accuracy but also help flatten the statistical curve of viral spread.
Article
Multidisciplinary Sciences
Kosuke Mori, Shohei Imaki, Yutaro Ohyama, Kosuke K. Satoh, Takeru K. Abe, Ichiro K. Takeuchi
Summary: This study evaluated the diagnostic accuracy of combining rapid antigen and antibody test results. The combined test showed improved diagnostic accuracy compared to the reverse transcription-polymerase chain reaction, making it a reliable alternative method.
Article
Chemistry, Multidisciplinary
David S. Kinnamon, Jacob T. Heggestad, Jason Liu, Thu Nguyen, Vo Ly, Angus M. Hucknall, Cassio M. Fontes, Rhett J. Britton, Jian-Piao Cai, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Thuy Le, Ashutosh Chilkoti
Summary: We developed a self-contained immunoassay platform that can be used in field settings with varied temperature, humidity, and blood samples. The platform has high sensitivity and accuracy in detecting analyte concentration, and a portable detection device. We also improved the microfluidic cassette for better usability and faster results. By using this platform, we successfully conducted a rapid diagnostic test for talaromycosis infection in patients, showing comparable sensitivity and specificity to laboratory tests.
Article
Public, Environmental & Occupational Health
Kalliopi Avgoulea, Maria-Ioanna Beredaki, Sophia Vourli, Maria Siopi, Nikolaos Siafakas, Spyros Pournaras
Summary: NG-Test immunoassay was evaluated for SARS-CoV-2 antigen detection. The results showed that NG-Test had high sensitivity in detecting the virus in nasopharyngeal samples, especially in patients with high viral loads.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Oncology
Giulia Pellizzari, Olivier Martinez, Silvia Crescioli, Robert Page, Ashley Di Meo, Silvia Mele, Giulia Chiaruttini, Jan Hoinka, Ihor Batruch, Ioannis Prassas, Melanie Grandits, Jacobo Lopez-Abente, Eva Bugallo-Blanco, Malcolm Ward, Heather J. Bax, Elise French, Anthony Cheung, Sara Lombardi, Mariangela Figini, Katie E. Lacy, Eleftherios P. Diamandis, Debra H. Josephs, James Spicer, Sophie Papa, Sophia N. Karagiannis
Summary: The study identified a novel tumor-specific target, SLC3A2, and successfully developed IgE monoclonal antibodies and SLC3A2-specific CAR T cells, which showed potent cytotoxicity against tumor cells in vitro and in vivo without triggering adverse reactions.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biophysics
Robert Hughes, Aaron Fishman, Kathryn Lamb-Riddell, Valentina Sleigh Mun, Alan Champneys, Janice Kiely, Richard Luxton
Summary: The study describes the development of an end-to-end model of a magneto-immunoassay, simulating the agglutination effect caused by the specific binding of bacteria to paramagnetic particles. Through direct imaging and microfluidic assays, the dose-specific agglutination properties and magnetophoretic transport dynamics of agglutinated clusters were observed. Mathematical modeling was used to predict the physical processes underlying the assay and show agreement with experimental results.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Immunology
Shao-Juan Wang, Zi-Min Chen, Min Wei, Jia-Qi Liu, Zong-Lin Li, Tian-Shu Shi, Sheng Nian, Rao Fu, Yang-Tao Wu, Ya-Li Zhang, Ying-Bin Wang, Tian-Ying Zhang, Jun Zhang, Jun-Hui Xiong, Shu-Ping Tong, Sheng-Xiang Ge, Quan Yuan, Ning-Shao Xia
Summary: In this study, a novel method for detecting HBeAg was developed with high sensitivity and specificity, able to detect HBeAg from various HBV genotypes without cross-reactivity with HBcAg. This new method could be useful in drug screening and clinical HBeAg detection.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Engineering, Chemical
Cui Zhang, J. Viridiana Garcia Meza, Keqiang Zhou, Jiazhi Liu, Shaoxian Song, Min Zhang, Delong Meng, Jinhui Chen, Ling Xia, Xiheng Hu
Summary: A salt-tolerant superabsorbent polymer (ST-SAP) was developed for use in saline-alkali soil. The ST-SAP exhibited excellent swelling capacity and stability under high salt conditions. Addition of ST-SAP to saline-alkali soil significantly extended the water retention time.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2023)
Article
Immunology
Thai Leong Yap, Shin Yee Hong, Jun Hui Soh, Lekha Ravichandraprabhu, Vanessa W. X. Lim, Hsi-Min Chan, Tommy Z. X. Ong, Ying Ping Chua, Shi En Koh, Huajing Wang, Yee Sin Leo, Jackie Y. Ying, William Sun
Summary: Dengue virus and Zika virus, both transmitted by Aedes mosquitoes, require accurate diagnostic tests for patient management and disease control. Serological tests, particularly using engineered ZIKV NS1 antibodies, can help increase sensitivity in detecting early infections.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Johannes G. M. Koeleman, Henk Brand, Stijn J. de Man, David S. Y. Ong
Summary: RT-qPCR is the gold standard for diagnosing acute COVID-19 infections, but rapid antigen tests can provide quicker results. Different rapid antigen tests have varying levels of sensitivity and specificity, with the Romed test showing good clinical performance in patients with high viral loads.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Review
Microbiology
Mateusz Plucinski, Michael Aidoo, Eric Rogier
Summary: The research discusses the significance of identifying and characterizing proteins produced during human infection with Plasmodium spp. in malaria research, diagnosis, and epidemiology. It highlights the development of laboratory methods for protein detection and the potential implications for malaria control strategies.
CLINICAL MICROBIOLOGY REVIEWS
(2021)
Article
Parasitology
Jennifer N. Lane, Annette Litster, Susan E. Little, Jessica Y. Rodriguez, Kennedy K. Mwacalimba, Kellee D. Sundstrom, E. Susan Amirian, Simone D. Guerios, Maria A. Serrano, Kellie M. Hays, Julie K. Levy
Summary: This study compared different methods for diagnosing HW infection in high-risk dogs, finding that combining POC Ag and Mf detection improved diagnostic performance, but may have missed more than one in four infected dogs.
PARASITES & VECTORS
(2021)
Article
Multidisciplinary Sciences
Mahyumi Fujimori, Ruth Tamara Valencia-Portillo, Jose Angelo Lauletta Lindoso, Beatriz Julieta Celeste, Roque Pacheco de Almeida, Carlos Henrique Nery Costa, Alda Maria da Cruz, Angelita Fernandes Druzian, Malcolm Scott Duthie, Carlos Magno Castelo Branco Fortaleza, Ana Lucia Lyrio de Oliveira, Anamaria Mello C. Miranda Paniago, Igor Thiago Queiroz, Steve Reed, Aarthy Vallur, Hiro Goto, Maria Carmen Arroyo Sanchez
Summary: The performance of recombinant antigens K18 and KR95 in serological diagnosis was evaluated and compared with rK28 and rK39. The results showed that rKR95 had higher sensitivity and specificity in the diagnosis of visceral leishmaniasis, suggesting its use in serological assays.
Article
Multidisciplinary Sciences
Masato Suzuki, Koki Kamiya
Summary: Lipid vesicles are used to study life's origin and artificial cell construction, but micro-sized protein vesicles are difficult to form. This study successfully generated cell-sized asymmetric phospholipid-amphiphilic protein (oleosin) vesicles that can reconstitute membrane proteins and undergo growth and fission. The vesicles consist of a lipid membrane on the outer leaflet and an oleosin membrane on the inner leaflet, and their growth and fission mechanisms were elucidated by feeding phospholipid micelles. These vesicles have the advantages of both lipid and protein layers, potentially advancing our understanding of biochemistry and synthetic biology.
Article
Nanoscience & Nanotechnology
Kosuke Komaki, Soichiro Kasuya, Yusei Toda, Toshiyuki Tosaka, Koki Kamiya, Tomomi Koshiyama
Summary: In this study, the researchers modified Amphotericin B (AmB) by introducing a 2,2'-bipyridine ligand (bpy-AmB), and found that the coordination of Cu2+ ions can induce the formation of bpy-AmB channels in liposomes and facilitate efficient permeation of various cations. The results indicate that metal coordination can enhance the stability and pore size of the channels, enabling efficient ion transport.
ACS APPLIED BIO MATERIALS
(2023)
Article
Chemistry, Analytical
Aoi Mameuda, Masahiro Takinoue, Koki Kamiya
Summary: The majority of biological reactions in cells occur via enzymatic cascade reactions. Researchers have recently investigated the proximity of enzymes in the cytoplasm to achieve efficient enzyme cascade reactions. They have used synthetic polymer molecules, proteins, and nucleic acids to create a high local concentration of enzymes. This study reports the reversible formation and dispersion of enzyme-DNA complex networks, controlled by the proximity of each enzyme, which provides a novel platform for controlling production, diagnosis, and biological or environmental sensing.
ANALYTICAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Toshiyuki Tosaka, Koki Kamiya
Summary: Membrane proteins are crucial for various cellular functions, and their structural and functional studies are important in fields like biology, medicine, pharmacology, biotechnology, and bioengineering. However, observing their precise reactions and structures is challenging. This paper introduces methods for creating liposomes or lipid vesicles and techniques for reconstituting membrane proteins into artificial membranes. It also discusses different types of artificial membranes used to observe the functions of reconstituted membrane proteins, and the reconstitution and function of multiple membrane proteins using a cell-free synthesis system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Satoshi Inagaki, Yuya Morimoto, Ikuo K. Suzuki, Kazuo Emoto, Shoji Takeuchi
Summary: This study presents a co-culture system of human skin equivalents (HSEs) and dorsal root ganglion (DRG) neurons. Spheroids of mouse DRG neurons with or without Schwann cells (SCs) were prepared. Spheroids with DRG neurons and SCs exhibited longer neurite extensions compared to those with DRG neurons alone. Neurite extension of more than 1 mm was observed from spheroids cultured inside HSEs, while neurite extension was primarily observed on the surface of HSEs from spheroids cultured on HSEs. This model may be a useful tool for studying neurite extension in human skin.
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
(2023)
Article
Biophysics
Kazuto Ogishi, Toshihisa Osaki, Hisatoshi Mimura, Izumi Hashimoto, Yuya Morimoto, Norihisa Miki, Shoji Takeuchi
Summary: This paper presents a novel signal processing method for real-time and quantitative characterization of ion channel activities on a lipid bilayer system. The characterization of ion channel activities has traditionally relied on time-consuming analyses after recording, posing a challenge in incorporating the system into practical applications. The proposed system divides the ion channel signal into short segments for processing during the recording, allowing for real-time characterization and response.
BIOSENSORS & BIOELECTRONICS
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Sho Takamori, Hisatoshi Mimura, Toshihisa Osaki, Shoji Takeuchi
Summary: This paper presents a microfluidic device that allows for the selective pairing and electrofusion of cell-sized liposomes. The device consists of two dynamic microarray systems arranged in a symmetric orientation, connected at trapping sites for capturing liposomes. The installation of low melting point alloy electrodes enables the electrofusion of trapped liposomes. The authors demonstrate the selective pairing and electrofusion of two species of liposomes, highlighting the potential usefulness of their device in selectively fusing specific liposomes/cells in polydisperse bulk samples.
2023 IEEE 36TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS, MEMS
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Izumi Hashimoto, Toshihisa Osaki, Hisatoshi Mimura, Sho Takamori, Norihisa Miki, Shoji Takeuchi
Summary: This paper describes a method using air bubbles in arrayed devices to selectively reform ruptured bilayer lipid membranes (BLMs). BLMs are important in membrane protein studies, biosensor applications, and drug screening. The proposed bubble-assisted method allows for selective BLM reformation in multi-channel devices, addressing the challenge of easily ruptured BLMs in high-throughput applications.
2023 IEEE 36TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS, MEMS
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Aoi Kato, Haruka Oda, Sho Takamori, Hisatoshi Mimura, Toshihisa Osaki, Norihisa Miki, Shoji Takeuchi
Summary: In this paper, a three-layered device is introduced for the preparation of heterologous core layers linearly aligned in a hydrogel sheet without using pumps. The device allows for the detection of various odorant molecules by arraying multiple types of sensor cells expressing different olfactory receptors. Unlike previous methods, this device enables the production of hydrogel sheets with a small amount of samples and with a single manual pipette.
2023 IEEE 36TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS, MEMS
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Hisatoshi Mimura, Toshihisa Osaki, Sho Takamori, Kenji Nakao, Shoji Takeuchi
Summary: This paper presents a device that can simultaneously form planar lipid bilayers and repetitively measure ion channel activities on an arrayed double-well chip. Artificial membrane systems provide excellent platforms for studying single-molecule ion channels. However, since single-molecule measurements can detect differences in individual ion channel activity, a large amount of data is required to converge measurement results. The device developed in this study uses small teeth to trace micro holes for membrane formation and repetitive ion channel detection.
2023 IEEE 36TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS, MEMS
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Takuma Nakane, Toshihisa Osaki, Hisatoshi Mimura, Sho Takamori, Norihisa Miki, Shoji Takeuchi
Summary: This study introduces a gas-flow device that increases the solubility of gas-phase odorants into aqueous solution for cell-based sensors. Olfactory receptor-based cell sensors are popular for their sensitivity and selectivity. However, previous studies mainly focused on liquid-phase odorants due to their low solubility in gas-phase, despite the need for gas-phase odorant detection. Therefore, this research aims to enhance gas-phase odorant detection using the gas-flow device. Computational simulations were used to analyze the impact of convection velocity on solubility enhancement, and experiments were conducted to verify the efficiency of odorant dissolution compared to a negative control sample odorant.
2023 IEEE 36TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS, MEMS
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Kazuto Ogishi, Toshihisa Osaki, Yuya Morimoto, Shoji Takeuchi
Summary: This paper presents an automated platform for lipid bilayer studies, which effectively reduces manual labor. The platform integrates several functions, including real-time acquisition of transmembrane current, digital filters for current analysis, and a bilayer reformation system. It enables automated monitoring of bilayer status and automatic generation of data reports, greatly saving time and effort in the experimental process. The system was successfully applied to gather data on alpha-hemolysin, achieving accurate estimations and reducing manual labor time to just 1 minute, compared to the conventional procedure of over 2 hours.
2023 IEEE 36TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS, MEMS
(2023)
Article
Chemistry, Analytical
Hisatoshi Mimura, Toshihisa Osaki, Sho Takamori, Kenji Nakao, Shoji Takeuchi
Summary: This study proposes a device for repeated measurements of ion channels incorporated into individually arrayed lipid bilayers, overcoming the limitations of existing parallelized approaches. By optimizing the surface properties and clearance of a wiping blade module, the device achieves repeated bilayer formation and a 5-fold improvement in data throughput during ion channel activity measurements. The practical utility of the device is validated by evaluating the effects of an ion channel inhibitor. This device opens new avenues for high-throughput analysis and screening of ion channels, leading to significant advancements in drug discovery and functional studies of membrane proteins.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Koji Sakai, Shigenori Miura, Tetsuhiko F. Teshima, Toichiro Goto, Shoji Takeuchi, Masumi Yamaguchi
Summary: Researchers have developed a 3D culture model of small vascular tissue using a self-folding graphene-based porous film. This model replicates the structural features of a small artery and can help in understanding intercellular communications in physiological and pathological conditions.
NANOSCALE HORIZONS
(2023)
Article
Chemistry, Physical
Koji Sakai, Shigenori Miura, Tetsuhiko F. Teshima, Toichiro Goto, Shoji Takeuchi, Masumi Yamaguchi
Summary: In this study, we developed a three-dimensional culture model of small vascular tissue using a self-folding graphene-based porous film. This model successfully recapitulates the structural features of a small artery and provides insights into intercellular communications at the artery wall under physiological and pathological conditions.
NANOSCALE HORIZONS
(2023)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
