Article
Biophysics
Mahmoud Amouzadeh Tabrizi, Juan P. Fernandez-Blazquez, Dahiana Mojena Medina, Pablo Acedo
Summary: A novel molecularly imprinted polymer-based electrochemical sensor has been developed for the determination of SARS-CoV-2-RBD. The fabricated sensor showed high selectivity, sensitivity, and stability in detecting SARS-CoV-2-RBD in saliva samples. The sensor exhibited a good response in a concentration range of 2.0 to 40.0 pg mL(-1) with a low detection limit of 0.7 pg mL(-1).
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Physical
Azam Zolfaghari Asl, Amir Abbas Rafati, Sadegh Khazalpour
Summary: Novel screen-printed gold electrodes modified with molecularly imprinted polyphenol were used for the detection of guanine and adenine in the presence of each other. The electrochemical polymerization method was used to synthesize a thin layer of molecularly imprinted polymer on the electrode surface. The fabricated sensors showed high sensitivity, good repeatability, and long-term stability, and were successfully utilized for the measurement of guanine and adenine in human serum samples.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Analytical
H. F. El-Sharif, S. Patel, E. N. Ndunda, S. M. Reddy
Summary: This study reports the use of electropolymerised molecularly imprinted polymers (E-MIPs) for the determination of dioctyl phthalate (DOP). E-MIPs with high affinity for DOP were produced using commercially available screen printed electrodes (SPEs). The E-MIPs showed rapid and accurate detection of DOP in freshwater samples.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Samuel M. Mugo, Scott V. Robertson, Weihao Lu
Summary: This study presents a novel approach using molecularly-imprinted polymers embedded screen printed carbon electrode sensors to detect epinephrine, lactate, and cortisol biomarkers in human sweat. The sensors exhibited rapid and selective response to the target analytes with excellent precision. The method was successfully validated by quantifying epinephrine, lactate, and cortisol in human sweat.
ANALYTICA CHIMICA ACTA
(2023)
Article
Electrochemistry
Henry Setiyanto, Atik Dwi Oktaviani, Robeth Viktoria Manurung, Brian Yuliarto, Ajeng Nega Reni Damayanti, Evyka Setya Aji, Vienna Saraswaty
Summary: A novel electrochemical sensor based on chitosan molecularly imprinted polymer was developed for selective detection of methyl paraben in cosmetic products. The sensor exhibited satisfactory linearity and detection limit, and showed similar performance to UV-visible spectrophotometry analysis.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Marie Elhachem, Elias Bou-Maroun, Maher Abboud, Richard G. Maroun, Philippe Cayot
Summary: Caffeic acid (CA) is an efficient antioxidant found in wine and plants. A specific molecularly imprinted polymer (CA-MIP) with high selectivity and good repeatability towards CA was prepared. Cyclic voltammetry was used to characterize the rebinding activities between the polymer and CA. This fast and simple method is suitable for further applications in wine sample analysis.
Article
Chemistry, Analytical
Patricia Rebelo, Joao G. Pacheco, Iuliia V. Voroshylova, Andre Melo, M. Natalia D. S. Cordeiro, Cristina Delerue-Matos
Summary: In this study, an electrochemical molecularly imprinted polymer (MIP) sensor for the detection of ATV in water samples was developed. Computational studies were conducted to select a suitable functional monomer and investigate the template-monomer interaction. The sensor exhibited high sensitivity and selectivity, and was successfully applied in spiked water samples.
ANALYTICA CHIMICA ACTA
(2022)
Review
Chemistry, Analytical
Elly Septia Yulianti, Siti Fauziyah Rahman, Yudan Whulanza
Summary: Cortisol, a steroid hormone, is closely related to the stress response and can be used as a biomarker for early stress detection. An electrochemical immunosensor, with antibodies as its bioreceptor, is a widely used method for cortisol detection. However, both antibodies and aptamers face issues with short shelf life. Molecularly imprinted polymers (MIPs) provide an alternative to natural antibodies, offering high durability, long shelf life, and the ability to detect cortisol molecules at a low concentration.
Article
Chemistry, Analytical
Ramona Georgescu-State, Jacobus (Koos) Frederick van Staden, Raluca-Ioana Stefan-van Staden, Razvan Nicolae State
Summary: A novel electrochemical platform for amaranth determination has been developed using a molecularly imprinted polymer technique. The platform showed high sensitivity, two linear concentration ranges, and a low limit of detection. Furthermore, it demonstrated excellent selectivity, repeatability, reproducibility, and stability. The platform was successfully applied to determine amaranth in pharmaceutical and water samples.
Article
Multidisciplinary Sciences
Ozgecan Erdem, Ismail Es, Yeseren Saylan, Maryam Atabay, Murat Alp Gungen, Kadriye Olmez, Adil Denizli, Fatih Inci
Summary: The current synthesis methods for molecularly imprinted polymers face challenges such as lengthy process, low productivity, the need for expensive and sophisticated equipment, and inability for in situ synthesis. In this study, a micro-reactor was developed for in situ and continuous production of molecularly imprinted polymer nanoparticles that contain specific molecular fingerprints. The micro-reactor showed significantly improved productivity compared to conventional methods.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Bixuan Wang, Jingyi Hong, Chun Liu, Liying Zhu, Ling Jiang
Summary: The study developed a sensitive electrochemical sensor based on a molecularly imprinted polymer-modified carbon electrode for the detection of beta-lactoglobulin. The sensor exhibited good response to beta-lactoglobulin with a linear detection range between 10(-9) and 10(-4) mg/mL and a detection limit of 10(-9) mg/mL. The sensor showed a high correlation in detecting beta-lactoglobulin in four different milk samples from the market, indicating its potential for practical use.
Article
Chemistry, Analytical
Saad S. M. Hassan, Ayman H. Kamel, Mahmoud Abdelwahab Fathy
Summary: A novel screen-printed electrode (SPE) is developed for the potentiometric determination of nalbuphine, a synthetic narcotic. The electrode utilizes a carboxylated multi-walled carbon nano tubes/polyaniline nanocomposite as an ion-to-electron transducer, covered by a selective polyvinyl chloride membrane incorporated with molecularly imprinted drug polymer beads. The SPE exhibits excellent sensitivity, selectivity, and potential stability, making it suitable for rapid diagnosis of overdose patients in hospitals and quality control/quality assurance in the pharmaceutical industry.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Narges Shaabani, Nora W. C. Chan, Abebaw B. Jemere
Summary: An electrochemical sensor for selective and sensitive detection of the drug naloxone was developed using molecular imprinting and sol-gel techniques. The sensor showed excellent linear response and detection limit for NLX, as well as good selectivity and reproducibility. It demonstrated successful application in measuring NLX in synthetic urine samples with high recoveries.
Article
Polymer Science
Letian Cheng, Zhilong Guo, Yuansheng Lin, Xiujuan Wei, Kongyin Zhao, Zhengchun Yang
Summary: In this study, sodium alginate was used as functional monomers to prepare BSA molecularly imprinted carboxylated multi-wall carbon nanotubes (CMWCNT)/CaAlg hydrogel films (MIPs) and non-imprinted hydrogel films (NIPs) using bovine serum albumin as template molecules and calcium chloride as a cross-linking agent. The MIP film exhibited a high adsorption capacity for BSA and specific recognition for BSA. The loaded MIP film on the electrode surface improved the electrochemical signal.
Article
Chemistry, Analytical
Vu Bao Chau Nguyen, Akinrinade George Ayankojo, Jekaterina Reut, Jorg Rappich, Andreas Furchner, Karsten Hinrichs, Vitali Syritski
Summary: This study presents a method for determining macrolide antibiotics in aqueous environments using a screen-printed electrode combined with a molecularly imprinted polymer. The method achieves broad recognition of macrolides through dual recognition, and demonstrates excellent selectivity and recovery.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Food Science & Technology
Diana Pinto, Manuela M. Moreira, Elsa F. Vieira, Jaroslava Svarc-Gajic, Anna Vallverdu-Queralt, Tanja Brezo-Borjan, Cristina Delerue-Matos, Francisca Rodrigues
Summary: Functional cookies made from Chestnut (Castanea sativa) shells (CSs) extract show good nutritional composition, high phenolic and flavonoid contents, excellent antioxidant and antiradical activities, and great sensory evaluation. This study encourages the sustainable recovery of antioxidants from CSs and their further use as active nutraceutical ingredients in functional cookies.
Article
Chemistry, Analytical
Alvaro Torrinha, Miguel Tavares, Vitoria Dibo, Cristina Delerue-Matos, Simone Morais
Summary: The increase in anthropogenic pollution raises concerns about water and aquatic species contamination, which could have implications for human health. Pharmaceutical compounds, a type of emerging contaminant, are increasingly consumed and found in the aquatic environment. In this study, a simple electrochemical sensor based on untreated carbon fiber paper was used for the analysis of trimethoprim antibiotic in fish samples. The sensor showed comparable performance to commonly used sensors, with a linear range of 0.05 to 2 mu M, sensitivity of 48.8 mu A mu M-1 cm(-2), and LOD of 0.065 mu M. It was successfully applied to trimethoprim determination in fish samples.
Article
Green & Sustainable Science & Technology
Elena Surra, Alvaro Torrinha, Cristina Delerue-Matos, Simone Morais
Summary: Life cycle assessment (LCA) was used to compare the environmental impacts of using a simple electrochemical carbon paper sensor (CPS) and traditional liquid high-performance chromatography (HPLC) for ketoprofen detection in fish. The results showed that CPS had significant advantages over HPLC in 16 out of 18 impact categories, with average CPS values 26% lower than HPLC. CPS saved significant amounts of non-carcinogenic and carcinogenic human toxicities, fossil resources, and greenhouse gas emissions compared to HPLC.
Article
Chemistry, Multidisciplinary
Elena Surra, Joao Sousa, Manuela Correia, Joao Carvalheiras, Joao A. Labrincha, Jose C. Marques, Nuno Lapa, Cristina Delerue-Matos
Summary: This study provides important information on the feasibility of using granite sludge as a substitute for feldspar in ceramics and as a substitute for inert filler in structural concrete. The results show that while granite sludge can be used as a substitute for feldspar, its tinting effect may limit its applications in certain ceramic products. Similarly, using granite sludge as a substitute for inert filler in concrete reduces strength and increases water:cement ratio. However, the environmental impacts of using granite sludge as an inert filler are lower than as a substitute for feldspar in most impact categories.
APPLIED SCIENCES-BASEL
(2023)
Article
Engineering, Chemical
Cristina Soares, Manuela M. Moreira, Sandra Ramos, M. J. Ramalhosa, Manuela Correia, Jaroslava Svarc-Gajic, Cristina Delerue-Matos, M. Fatima Barroso
Summary: Different extraction techniques were compared to extract phenolic compounds from fruit processing residues. Microwave-assisted extraction (MAE) showed the highest recovery of polyphenolic compounds. Pomegranate peels extracted by M60C and MAE had the highest phenolic content and antioxidant activity. The study highlights the potential of agricultural by-products as a source of phenolic compounds, providing a feasible solution to enhance nutrition and reduce environmental waste.
Review
Chemistry, Analytical
Patricia Rebelo, Isabel Seguro, Henri P. A. Nouws, Cristina Delerue-Matos, Joao G. Pacheco
Summary: The scarcity of clean water leads to the exploration of using treated wastewater. Monitoring campaigns have found emerging contaminants present in trace amounts, including pharmaceuticals, pesticides, and personal care products. Plasmonic sensors with molecularly imprinted polymers (MIPs) offer a potential solution for monitoring analytes in water samples, providing higher sensitivity and fast response through miniaturization. This work provides an overview of MIP-based plasmonic sensors, focusing on the fabrication/recognition procedure and the use of metals and nanomaterials to enhance sensor performance.
Review
Chemistry, Analytical
Mariana Lamas, Francisca Rodrigues, Maria Helena Amaral, Cristina Delerue-Matos, Virginia Cruz Fernandes
Summary: Environmental pollution is a significant issue in our society, and it is important to understand its consequences, including increased contaminant cocktails in the environment. The contamination of honeybees can lead to contamination of their products, such as honey. Controlling the quality and safety of honey, including evaluating contaminants and following legislation, is crucial.
Article
Polymer Science
Silvia D. Martinho, Virginia Cruz Fernandes, Sonia A. Figueiredo, Rui Vilarinho, J. Agostinho Moreira, Cristina Delerue-Matos
Summary: This study simulated the aging process of six types of microplastics in freshwater and seawater ecosystems and evaluated the effects using various analysis methods. The results showed that aging caused changes in the surface characteristics of microplastics and their interaction with other pollutants.
Review
Polymer Science
Diana Rede, Cristina Delerue-Matos, Virginia Cruz Fernandes
Summary: Plastic, a crucial material in modern society, has caused significant ecological stress due to high production rates and inadequate waste management. Microplastics (MPs) have emerged as a major environmental problem globally, affecting both terrestrial and aquatic ecosystems. This review emphasizes the need for interdisciplinary collaboration to address the issue of MP pollution and highlights gaps in the existing literature for future research.
Article
Biology
Isabella Bracchi, Juliana Guimaraes, Catarina Rodrigues, Rui Azevedo, Claudia Matta Coelho, Catia Pinheiro, Juliana Morais, Ines Barreiros-Mota, Virginia Cruz Fernandes, Cristina Delerue-Matos, Edgar Pinto, Andre Moreira-Rosario, Luis Filipe Ribeiro de Azevedo, Claudia Camila Dias, Jorge Lima, Ines Sapinho, Carla Ramalho, Conceicao Calhau, Joao Costa Leite, Agostinho Almeida, Diogo Pestana, Elisa Keating
Summary: This study aimed to evaluate the role of essential trace elements in pregnancy health. The findings suggest that high urinary zinc levels increase the risk of pre-eclampsia, but decrease the risk of small head circumference at birth.
Article
Environmental Sciences
Luisa Correia-Sa, Virginia C. Fernandes, Maria Luz Maia, Edgar Pinto, Sonia Norberto, Agostinho Almeida, Cristina Santos, Cristina Delerue-Matos, Conceicao Calhau, Valentina F. Domingues
Summary: This study evaluated the exposure of Portuguese children to environmental chemicals through urine analysis and identified predictors of exposure. The results showed that region, age, diet, and weight group were significant predictors of urinary concentrations of certain elements.
Article
Chemistry, Analytical
Diana Pinto, Ana Sofia Ferreira, Julian Lozano-Castellon, Emily P. Laveriano-Santos, Rosa M. Lamuela-Raventos, Anna Vallverdu-Queralt, Cristina Delerue-Matos, Francisca Rodrigues
Summary: This study evaluated the bioaccessibility and bioactivity of chestnut shells during in vitro simulated gastrointestinal digestion. The results showed that the total phenolic and flavonoid contents of chestnut shells increased during digestion, with enhanced antioxidant, radical scavenging, and acetylcholinesterase inhibitory activities. Metabolomic profiling revealed changes in compounds during digestion, with phenolic acids and flavonoids being the major identified polyphenolic classes. The bioactivity of chestnut shells was closely related to the phenolic compounds and their bioaccessibility.
Article
Chemistry, Analytical
Sara Sousa, Paula Paiga, Diogo Pestana, Gil Faria, Cristina Delerue-Matos, Maria Joao Ramalhosa, Conceicao Calhau, Valentina Fernandes Domingues
Summary: This article introduces a method for extracting polycyclic aromatic hydrocarbons (PAHs) from adipose tissue samples using ultrasound-assisted extraction (UAE). The method has been improved to achieve lower detection and quantification limits, and does not require post-cleanup. Additionally, it can be used for the analysis of other lipophilic compounds.
ANALYTICAL METHODS
(2023)
Review
Biochemistry & Molecular Biology
Catia Ferreira, Manuela M. Moreira, Cristina Delerue-Matos, Mafalda Sarraguca
Summary: As the world population increases, the overexploitation of natural resources has become a global concern. Changing the way we produce and consume is crucial for protecting the planet and our way of living. Agriculture activities contribute significantly to greenhouse gas emissions, and valorizing food waste is important for reducing the environmental impact of these activities. Among various extraction techniques, subcritical water extraction (SWE) is a green method that allows high yields using only water as the solvent. This review provides an overview of the SWE process for extracting bioactive compounds from grape biomass, with a focus on circular economy and green extraction.
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
