Article
Chemistry, Analytical
Paulina K. Wells, Artem Melman, Evgeny Katz, Oleh Smutok
Summary: A new nano-structured platform using PQQ-dependent glucose dehydrogenase was developed for fluorescent analysis. The platform immobilized the enzyme on SiO2 nanoparticles and used a smartphone for signal quantification. This platform shows great potential for developing a variety of biosensors for different analytes.
Article
Engineering, Electrical & Electronic
Jinze Li, Xin Liu, Hao Sun, Liming Wang, Jianqi Zhang, Xi Huang, Li Deng, Jiawei Xi, Tianhong Ma
Summary: The immobilization of enzymes is a key factor in biosensor development. This study successfully used the electrospinning method to immobilize enzymes on optical fiber sensors, demonstrating high sensitivity in detecting glucose with promising potential for further development.
IEEE SENSORS JOURNAL
(2021)
Article
Nanoscience & Nanotechnology
Xinshuo Huang, Shantao Zheng, Baoming Liang, Mengyi He, Feifei Wu, Jingbo Yang, Hui-jiuan Chen, Xi Xie
Summary: Monitoring human health is crucial in biomedicine, and blood ion concentrations serve as important reference indicators for many diseases. Microneedle array-based sensors have enabled continuous health monitoring by being minimally invasive. In this study, we developed a microneedle sensing-array integrated system that can continuously detect subcutaneous ions for real-time human health monitoring. The system overcomes limitations in preparing 3D microneedle structures with multiple electrode channels and tackles challenges in modifying closely spaced microneedle tips into different types of electrodes. The system exhibits sufficient sensitivity and good detection performance, as demonstrated by in vivo experiments on rats. By integrating the sensor into a wearable monitoring system, it can potentially provide feedback on diseases related to physiological ion changes.
MICROSYSTEMS & NANOENGINEERING
(2023)
Article
Chemistry, Analytical
Lucie Kostejnova, Jakub Ondracek, Petra Majerova, Martin Kostejn, Gabriela Kuncova, Josef Trogl
Summary: The study demonstrated the control of glucose concentration using feedback regulation with an in situ optical fiber glucose sensor and preimmobilized glucose oxidase in the ORMOCER(R) polymer. The system showed fast response times and low deviation in controlling low glucose concentrations and maintaining desired glucose levels in a laboratory bioreactor. The durable and long-lasting sensitive layer of the sensor indicates potential applications in various biotechnological processes such as production of low glucose content beverages.
Article
Biophysics
Abdullah Reda, Sherif A. El-Safty, Mahmoud M. Selim, Mohamed A. Shenashen
Summary: The development of visual readout, easy-to-use, and wearable biosensors for diabetes management has gained considerable interest. Advances in nano/microscale materials are key to improving the integration of optical biosensors into wearable electronic devices for prolonged periods of clinical diagnostics, both indoors and outdoors.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Environmental Sciences
Tomas Makaras, Julija Razumiene, Vidute Gureviciene, Gintare Sauliute, Milda Stankeviciute
Summary: This study investigates the reliability of glucose measurement as a biomarker for evaluating stress response in fish. The findings suggest that the amount of glucose released in fish-holding water significantly increases under stress, while the circulating levels of glucose in blood and gills decrease over time. The swimming activity of fish is also reduced when exposed to specific stressors.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Hessamaddin Sohrabi, Ehsan Dezhakam, Ehsan Nozohouri, Mir Reza Majidi, Yasin Orooji, Yeojoon Yoon, Alireza Khataee
Summary: This article provides an overview of different types and applications of glucose analysis methods, including traditional chromatography, spectroscopy, and electrochemical analysis. It also discusses the utilization of nanomaterials in sensor design. Additionally, the article highlights the current limitations and future challenges in glucose analysis.
Review
Chemistry, Analytical
Marjan Majdinasab, Marc Lamy de la Chapelle, Jean Louis Marty
Summary: Interleukin 6 (IL-6) is a pleiotropic cytokine that exerts pathological pro-inflammatory effects and plays important roles in various biological processes. The detection of IL-6 in small quantities with high selectivity is crucial in medical and biological fields. Conventional laboratory methods such as ELISAs and CLIAs are complex, expensive, and time-consuming, while biosensors offer a simple, rapid, economical, and user-friendly alternative due to their high sensitivity, quick detection time, ease of use, and miniaturization capability.
Article
Food Science & Technology
Xin Xiong, Yuqing Tan, Elliot Mubango, Ce Shi, Joe M. Regenstein, Qingfeng Yang, Hui Hong, Yongkang Luo
Summary: This review critically discusses recent advancements in the field of biosensors for evaluating the quality of fish products. Biosensors offer the advantages of simplicity of operation and speed of analysis, improving the efficiency of fish product quality detection. However, there are still limitations of biosensors, including limited lifespan, damage by environmental factors, measurement of only a single freshness marker, and high cost.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Analytical
Jinghan Zhang, Xinming Mai, Xueming Hong, Yuzhi Chen, Xuejin Li
Summary: We propose a portable and user-friendly optical fiber sensing platform for rapid glucose detection based on surface plasmon resonance (SPR) sensing and enzymatic reaction. The platform allows for specific detection of different levels of urine glucose concentrations with high sensitivity. It offers a simple and fast operation, making it suitable for the detection of food additives and medical immunoassays.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Polymer Science
Jorge-A. Ortega-Contreras, Edgar Alvarado-Mendez, Guillermo Almanza-Rodriguez, Maria del Carmen Hernandez, Luis Celaya-Garcia
Summary: In this study, a biocatalytic glucose optical sensor was developed by immobilizing glucose oxidase (GOD) on a polymethylmethacrylate (PMMA) optical fiber. The enzyme encapsulation process was carried out using the sol-gel method, with a TEOS-based coating deposited on the fiber end by immersion. The sensor was characterized using different glucose levels. The optimal enzyme encapsulation process was found to be performed at room temperature, followed by the deposition of the coating on the fiber. The drying process showed optimal results at temperatures below 8°C.
Review
Chemistry, Analytical
Reza Eivazzadeh-Keihan, Zahra Saadatidizaji, Ali Maleki, Miguel de la Guardia, Mohammad Mahdavi, Sajjad Barzegar, Samad Ahadian
Summary: Thrombin is a serine protease that plays a crucial role in blood clotting and homeostasis. Detecting thrombin quickly and accurately is important for biological analysis and clinical diagnosis. Various biosensors have been developed to achieve highly selective and specific detection of thrombin. Aptasensors, which use DNA or RNA aptamers as biological recognition elements, have shown great sensitivity and affinity in identifying thrombin.
Review
Biochemical Research Methods
Linan Zhang, Chunchuan Gu, Jiajun Wen, Guangxian Liu, Hongying Liu, Lihua Li
Summary: Exosomes, actively secreted by eukaryotic cells, are promising biomarkers for cancer diagnosis and therapeutic response evaluation. The incorporation of nanomaterials into sensing systems can enhance sensitivity, selectivity, and stability, improving detection methods for exosomes.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Review
Optics
Pengqi Gong, Xuegang Li, Xue Zhou, Yanan Zhang, Ning Chen, Shankun Wang, Siqi Zhang, Yong Zhao
Summary: The paper provides a brief overview of the current research progress of optical fiber glucose sensor (OFGS), including detection principles and measurement methods, as well as discussing its shortcomings and future prospects.
OPTICS AND LASER TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Shunyao Tian, Meng Wang, Paolo Fornasiero, Xiaoyu Yang, Seeram Ramakrishna, Shih-Hsin Ho, Fanghua Li
Summary: Monitoring blood glucose is crucial for the prevention and treatment of diabetes. However, current materials used in biosensors for glucose monitoring have inherent defects. MXene, a novel two-dimensional material, shows great potential in biosensing due to its remarkable properties. This review focuses on the synthesis of MXenes and their recent advancements as electrode modifiers for glucose detection, as well as the prospects and challenges of glucose sensing technology based on MXenes.
CHINESE CHEMICAL LETTERS
(2023)
Article
Fisheries
Haiyun Wu, Madoka Ogata, Hitoshi Ohnuki, Hideaki Endo
Summary: This study developed a biosensor that can rapidly quantify superoxide concentrations in biological samples by immobilizing cytochrome c on the surface of a gold electrode. The sensor exhibited good correlation with superoxide concentrations in the range of 0.58-9.33 μM and showed acceptable performance in Nile tilapia eyeball interstitial sclera fluid.
Article
Neurosciences
Jianqiang Song, Guoliang Du, Haiyun Wu, Xiangliang Gao, Zhen Yang, Bin Liu, Shukun Cui
Summary: The study found that quercetin can protect against TBI-induced neuroinflammation and oxidative stress by activating the cortical Nrf2/HO-1 pathway. Quercetin attenuated brain edema and microgliosis in TBI rats, reduced cortical inflammatory responses and oxidative stress. Furthermore, quercetin treatment activated the cortical Nrf2/HO-1 pathway in TBI rats.
RESTORATIVE NEUROLOGY AND NEUROSCIENCE
(2021)
Article
Spectroscopy
Haiyun Wu, Renjie Yang, Yong Wei, Guimei Dong, Hao Jin, Yanan Zeng, Chenglong Ai
Summary: This study proposes an improved method for identifying milk adulteration using near infrared spectroscopy and discriminant analysis. The results show that the proposed method can effectively reduce the influence of milk brands on the identification models.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Environmental Sciences
Ruixue Sun, Hao Zheng, Shaojing Yin, Xin Zhang, Xiangwei You, Haiyun Wu, Fengyue Suo, Kunxu Han, Yadong Cheng, Chengsheng Zhang, Yiqiang Li
Summary: The study demonstrates the potential of biochar in enhancing peanut growth in coastal salt-affected soil, especially biochars derived from reed straw and cow manure. Biochar can increase fresh shoot weight and salt tolerance of peanuts, improve soil fertility, and promote the growth of beneficial bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Spectroscopy
Ming-Yue Huang, Ren-Jie Yang, Ze-yuan Zheng, Hai-yun Wu, Yan-rong Yang
Summary: A discrimination method for adulterated milk based on temperature-perturbed 2D infrared correlation spectroscopy and NPLS-DA is proposed. The method can accurately classify pure and adulterated milk by calculating 2D correlation spectra and building discrimination models. Compared to the conventional 3D stacked map, this method achieves higher discrimination accuracy.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Spectroscopy
Ming-yue Huang, Jia Long, Hai-yun Wu, Ren-jie Yang, Hao Jin, Yan-rong Yang
Summary: To improve the accuracy of adulterated milk discrimination, a detection method based on temperature-perturbed generalized two-dimensional (2D) correlation characteristic slice spectra was proposed. A total of 240 samples were prepared and the infrared attenuated total reflection spectra were collected at different temperatures. Discrimination models based on 2D correlation characteristics slice spectra were established using N-way partial least squares discriminant analysis (NPLS-DA). The results showed that the proposed method effectively extracted characteristic information and improved the accuracy of discrimination.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Spectroscopy
Haiyun Wu, Renjie Yang, Mingyue Huang, Yong Wei, Guimei Dong, Hao Jin, Yanan Zeng, Yanrong Yang
Summary: The discrimination approach of adulterated milk was proposed using synchronous two-trace two-dimensional (2T2D) correlation slice spectra and multivariate method. The method was demonstrated to be useful for analyzing two common adulterants, melamine and urea. The study showed that the prediction accuracies of the slice spectral models were higher than those of the 1D whole models, indicating that the 2T2D slice spectra improved the discrimination accuracy of adulterants in milk. The complexity of the slice spectra was significantly reduced compared to the whole matrix of synchronous 2T2D correlation spectra, making it a more efficient method for adulterated milk detection.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Cardiac & Cardiovascular Systems
Haiyun Wu, Ruozhu Dai, Min Wang, Chengbo Chen
Summary: Uric acid (UA) induces cardiomyocytes injury by activating NLRP3 inflammasome and ROS/TRPM2 channel/Ca2+ pathway.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Spectroscopy
Hao Jin, Gui -Mei Dong, Hai-Yun Wu, Yan-Rong Yang, Ming-Yue Huang, Meng -Yuan Wang, Ren-Jie Yang
Summary: A qualitative analysis method for melamine-adulterated milk based on two-trace two-dimensional auto-correlation spectra was proposed. Infrared spectroscopy was used to measure the spectral data of pure milk and melamine-adulterated milk. The intensity of auto-correlation peaks at specific wave numbers was selected as independent variables for modeling. The method achieved 100% accuracy for individual brands and 99.05% accuracy for all four brands combined.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Editorial Material
Chemistry, Multidisciplinary
Chuang Pan, Haiyun Wu, Yongqiang Zhao
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Applied
Kangting Sun, Chuang Pan, Shengjun Chen, Haiyun Wu, Shucheng Liu, Shuxian Hao, Hui Huang, Huan Xiang
Summary: This study evaluated the correlation between water changes and quality deterioration of Litopenaeus vannamei during partial freezing storage. The results showed significant increases in cross-sectional area and equivalent diameter, but irregular growth in roundness and longiness of the ice crystals. Bound water and immobilized water decreased significantly, while free water increased significantly during storage. Quality determination revealed a significant decrease in total sulfhydryl and Ca2+-ATPase, but a significant increase in disulfide bonds. Correlation analysis showed significant correlations between cross-sectional area and total sulfhydryl, Ca2+-ATPase, and disulfide bonds, respectively. Additionally, significant correlations were found between water distribution index and Ca2+-ATPase, disulfide bonds. Predictive models for ice crystal growth were developed based on cross-sectional area and equivalent diameter using the Arrhenius model.
Article
Agricultural Engineering
Yongcheng Jiang, Jianjun Li, Yang Li, Shide Li, Xin Song, Haiyun Wu, Shiwei Zhu
Summary: A smart control system for the precision cultivation of black fungus was designed, which utilized intelligent detection and control technology. The system included four independent environments and a remote control system, allowing for the adjustment of key parameters such as temperature, humidity, and light according to the precision cultivation stages. The test results showed that the system had high precision in temperature, humidity, and illuminance control.
INTERNATIONAL JOURNAL OF AGRICULTURAL AND BIOLOGICAL ENGINEERING
(2023)
Article
Chemistry, Analytical
Haiyun Wu, Yusuke Saito, Goro Yoshizaki, Yasutoshi Yoshiura, Hitoshi Ohnuki, Hideaki Endo
Summary: Efficient production of seedlings in aquaculture farms requires control of male and female ratios through sex distinguishing. This study aims to develop a highly sensitive biosensor system utilizing single-walled carbon nanotubes (SWCNTs) to improve the efficiency and accuracy of fish gender determination. The concentration of 11-ketotestosterone (11-KT) in plasma is utilized as an indicator. The biosensor was fabricated by immobilizing an anti-11-KT antibody onto a disk-type gold electrode surface modified with a self-assembled monolayer (SAM) and SWCNTs.
SENSING AND BIO-SENSING RESEARCH
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Shengyao Xiao, Xiaoyu Cui, Yuanqin Fan, Boyuan Lu, Haiyun Wu, Michael Christel, Shirley Saldamarco, Geoff Kaufman
Summary: The game "Blindspot" tells the story of a Chinese student facing microaggressions at an American university, with puzzle games that emphasize this topic. Players' choices in dealing with microaggressions affect the gameplay, leading to different outcomes but ultimately presenting a hopeful ending for all. The narrative and mechanics of the game aim to foster empathy with the protagonist, benefiting players in various groups.
2021 IEEE CONFERENCE ON GAMES (COG)
(2021)
Proceedings Paper
Engineering, Manufacturing
Haiyun Wu, Yanan Zeng, Yong Wei, Renjie Yang, Yaping Yu, Huiyong Shan, Xuemei Sun
Summary: An immunochromatographic test strip for quantitative detection of E.coli O157:H7 was developed using electrochemical impedance technology and the support vector regression (SVR) model, with modified antibodies and a sandwich immune complex formed to change the conductivity of the capture pad. The SVR model showed high correlation coefficients for predicting E.coli O157:H7, demonstrating the feasibility of using impedance electrical parameters and SVR technology for quantitative prediction.
2021 IEEE INTERNATIONAL CONFERENCE ON MANIPULATION, MANUFACTURING AND MEASUREMENT ON THE NANOSCALE (3M-NANO)
(2021)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
