Article
Chemistry, Analytical
Yihui Ma, Nianzu Liu, Zhenying Xu, Jingjing Wang, Xiliang Luo
Summary: A promising electrochemical biosensor based on three-dimensional nanoporous conducting polymer PEDOT decorated with gold nanoparticles was developed for selective and ultrasensitive detection of miRNA24 using methylene blue as redox indicator. The biosensor exhibited significantly enlarged specific surface area and enhanced sensitivity compared to planar PEDOT-based biosensors, achieving a detection range from 1 fM to 10 nM with high stability, selectivity, and low limit of detection. The strategy of using porous conducting polymers decorated with AuNPs proved to be effective in increasing the electroactive surface area of sensing interfaces and enhancing sensitivity.
MICROCHEMICAL JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Heru Agung Saputra, Khatun A. Jannath, Kwang Bok Kim, Deog-Su Park, Yoon-Bo Shim
Summary: This review highlights the importance of electrochemical biosensors in the early detection of lung cancer and discusses in detail the design and development of biosensors using conducting polymer composite materials. The review covers various electrochemical sensing methods for lung cancer markers using composite electrodes, including conducting polyterthiophene, poly(3,4-ethylenedioxythiophene), polyaniline, polypyrrole, molecularly imprinted polymers, and others. The potential of combining electrochemical biosensors with other techniques is emphasized. The outlook for the development of conducting polymer composite-based electrochemical biosensors for point-of-care diagnostic devices is also briefly discussed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Analytical
Zhen Song, Yihui Ma, Aoife Morrin, Caifeng Ding, Xiliang Luo
Summary: Porous conducting polymers (PCPs) are unique materials that integrate excellent electrochemical properties with a porous structure, providing larger surface area and higher electrocatalytic activity. They have received increasing attention as sensing materials and are widely applied in electrochemical sensing applications.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Qingsong Li, Fengjiao Bai, Jing Sun, Xiaomeng Zhou, Wei Yuan, Jin Lin, Ke-Qin Zhang, Guanglin Li, Zhiyuan Liu
Summary: This article presents a dip-coating method for fabricating sub-micron thick silk films and demonstrates their potential in wearable and biomedical applications.
Article
Polymer Science
Yasemin A. Udum, Melek Aktas Gemci, Duygu Cevher, Saniye Soylemez, Ali Cirpan, Levent Toppare
Summary: In this study, a novel D-A-D type monomer containing hexylthiophene as the donor and benzo[c][1,2,5]thiadiazole as the acceptor was successfully electropolymerized to produce P(DTFBT). The electrochromic properties of the polymer and its performance in amperometric biosensors were investigated. The modified electrode surface with laccase immobilization showed potential for catechol sensing. Biosensor optimization values, cycle number, enzyme amount, pH, and interfering compounds were also examined. The results demonstrated that the sensor had satisfactory accuracy and could be used for catechol quantification.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Damilola O. Runsewe, Grace Haya, Tania Betancourt, Jennifer A. Irvin
Summary: Emerging research in conducting polymer-based electrochemical biosensors has highlighted the need for techniques enabling easy functionalization and enhanced stability. This work focused on developing an electrochemical biosensor for adenosine detection using a conducting copolymer as a transducing agent, with promising results in terms of selectivity and performance.
ACS APPLIED POLYMER MATERIALS
(2021)
Review
Polymer Science
Nurul Akmaliah Dzulkurnain, Marliyana Mokhtar, Jahwarhar Izuan Abdul Rashid, Victor Feizal Knight, Wan Md Zin Wan Yunus, Keat Khim Ong, Noor Azilah Mohd Kasim, Siti Aminah Mohd Noor
Summary: This review focuses on the application of conducting polymers, particularly Polypyrrole (PPy), in electrochemical sensors. It discusses the theoretical background and applications of impedance and voltammetric analysis in electrochemical detection, as well as the use of PPy as a sensing material. Researchers, especially those without an electrochemical analysis background, are expected to benefit from this easy-to-understand summary of concepts and technologies used in electrochemical sensor research, particularly with PPy as a sensing material.
Article
Chemistry, Analytical
Yachana Gupta, Chandra Mouli Pandey, Aditya Sharma Ghrera
Summary: An electrochemical paper-based sensor was developed for the detection of bacterial infection (BI)-specific biomarker procalcitonin (PCT). The sensor utilized reduced graphene oxide-gold nanoparticles and poly(3,4-ethylene dioxythiophene):poly(styrene sulfonate) as modifiers on a cellulose fiber paper substrate. The sensor showed a linear range of 1 x 10(3) to 6 x 10(7) fg mL(-1) for PCT detection and exhibited good reproducibility.
Article
Biophysics
Vinh Van Tran, Nhu Hoa Thi Tran, Hye Suk Hwang, Mincheol Chang
Summary: CP-based electrochemical biosensors are considered as potential alternatives for COVID-19 detection due to their advantages such as rapid detection, low cost, and flexibility, but they still face challenges in application. The study provides scientific evidence for the potential applications of CP-based electrochemical biosensors in COVID-19 detection, proposing strategies to overcome existing problems.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Biochemistry & Molecular Biology
Ancuta Dinu, Constantin Apetrei
Summary: In recent years, the development of sensors and biosensors has become a hot topic in interdisciplinary research, attracting researchers from various fields. This paper synthesizes the most relevant studies on the construction and functioning of versatile devices, as well as electrochemical sensors and biosensors. It focuses on the role and importance of the amino acids phenylalanine, tyrosine, and tryptophan in the central nervous system, and the application of conductor polymers and molecularly imprinted polymers in achieving electrochemical sensors and biosensors. The paper also analyzes the performance of sensors and biosensors developed so far for amino acid detection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Environmental
Sheying Dong, Jie Zhang, Guiqi Huang, Wenbo Wei, Tinglin Huang
Summary: A unique phloroglucinol-based MOP material with abundant -OH functional groups was synthesized and applied for constructing an organophosphate pesticides biosensor. The interaction among OH-POF, AChE, and NF benefited the immobilization of enzymes on the electrode surface, leading to improved catalysis ability for the detection of paraoxon and methyl parathion with wide linear range and low limit of detection. This study highlights the potential value of OH-POF material for electrochemical biosensors and provides a fresh research idea for further exploring MOPs in environmental analysis.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Chemistry, Multidisciplinary
Sam Davies, Yubing Hu, Nan Jiang, Jeff Blyth, Monika Kaminska, Yunzheng Liu, Ali K. Yetisen
Summary: As global populations increase, medical care needs to diversify data collection techniques to provide adequate healthcare for the global population. Holographic sensors, as a new type of biosensor, enable cost-effective and real-time point-of-care analysis of biomarkers. These sensors play a crucial role in applications such as pH, alcohol, ion, glucose, drug detection, and antibiotic monitoring.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Jung Woo Leem, Hee-Jae Jeon, Yuhyun Ji, Sang Mok Park, Yunsang Kwak, Jongwoo Park, Kee-Young Kim, Seong-Wan Kim, Young L. Kim
Summary: Counterfeit medicines pose a threat to patient safety and public health, as well as causing economic losses. A new edible code using silk fibroin genetically encoded with fluorescent proteins is introduced, which can be read by smartphones. This code can serve as a dosage-level anticounterfeit measure and authentication feature, empowering patients to combat illicit pharmaceuticals.
ACS CENTRAL SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Adrian Fontana-Escartin, Anna Puiggali-Jou, Sonia Lanzalaco, Oscar Bertran, Carlos Aleman
Summary: Flexible electrochemical sensors based on electroactive materials have been developed as powerful tools for detecting bioanalytes in biomedical applications. 3D printing technology enables the fabrication of electrochemical devices with no design constraints, waste minimization and high reproducibility. The presented approach for preparing electrochemical dopamine biosensors demonstrates the feasibility of rapid and cost-effective production of sensors without the need for conductive filaments.
ADVANCED ENGINEERING MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Zan Lamberger, Karolina Kocourkova, Antonin Minarik, Martin Humenik
Summary: A combination of self-assembly and photolithography is used to produce functionalized micropatterns. Spider silk proteins are covalently coupled to modified substrates and serve as seeds for the self-assembly of nanofibrils, resulting in immobilized networks. The micropatterns can be further functionalized with modified spider silk variants or nucleic acids.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Engineering, Biomedical
Zahra Khosrowpour, Seyed Mahmoud Hashemi, Samira Mohammadi-Yeganeh, Mehdi Moghtadaei, Peiman Brouki Milan, Lorenzo Moroni, Subhas C. Kundu, Mazaher Gholipourmalekabadi
Summary: The decellularized placental sponge shows potential as a bone substitute and provides a platform for communication between macrophages and mesenchymal stem cells, guiding the differentiation of stem cells towards bone cells.
Review
Engineering, Biomedical
Carlos F. Guimaraes, Daniela Cruz-Moreira, David Caballero, Rogerio P. Pirraco, Luca Gasperini, Subhas C. Kundu, Rui L. Reis
Summary: Microfluidic platforms provide a powerful approach to miniaturize important characteristics of cancers and enhance physiological relevance in vitro testing. Photonics plays a crucial role in microfluidic 3D cancer modeling and biosensing, enabling precise manipulation of biomaterials and living cells and offering a broad toolbox for quantifying critical biological phenomena.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Sanaz Alizadeh, Paniz Farshi, Navid Farahmandian, Zahra Aliakbar Ahovan, Ali Hashemi, Mohammad Majidi, Abdolnaser Azadbakht, Mahsa Darestanifarahani, Koushan Sineh Sepehr, Subhas C. Kundu, Mazaher Gholipourmalekabadi
Summary: A nanofibrous chitosan/poly (vinyl alcohol) (CS/PVA) mat was designed for controlled delivery of antibiotics to treat wound infections. The material showed excellent antibacterial activity against resistant strains and demonstrated good biocompatibility in vitro and in vivo.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Nanoscience & Nanotechnology
Prithwish Kola, Prasanth Kumar Bhusetty Nagesh, Pritam Kumar Roy, K. Deepak, Rui Luis Reis, Subhas C. Kundu, Mahitosh Mandal
Summary: The increasing number of breast cancer cases globally and the rising death rate indicate the inadequacy of traditional and current treatments. Nanoparticle-based therapies such as photothermal therapy, photodynamic therapy, chemodynamic therapy, and sonodynamic therapy show promise in combating breast cancer through accurate drug delivery and elimination of cancer stem cells. These innovative therapies have fewer side effects compared to standard chemotherapy and address the stability issues associated with cancer immunotherapy. This review discusses various nanotheranostic systems and smart nanoparticles, their mechanisms of action, and their relevance in the current era.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Zhenzhen Qi, Zheng Yan, Guohongfang Tan, Tianshuo Jia, Yiyu Geng, Huiyan Shao, Subhas C. C. Kundu, Shenzhou Lu
Summary: Silk fibroin microneedles have advantages in terms of biocompatibility, mechanical properties, thermal stability, and control via genetic engineering. This review summarizes the research progress, structure, properties, applications, and clinical trials of silk fibroin microneedles, and discusses the future development trends.
Article
Engineering, Biomedical
Anita Akbarzadeh Solbu, David Caballero, Spyridon Damigos, Subhas C. Kundu, Rui L. Reis, Oyvind Halaas, Aman S. Chahal, Berit L. Strand
Summary: Cell migration plays a crucial role in various biological processes, and recent advancements in materials science have allowed for the development of biomimetic in vitro assays to study cell migration. Three-dimensional hydrogels have been particularly useful in mimicking the extracellular environment and studying cell migration in a more physiologically relevant manner. This article provides an overview of the different types of hydrogels and their characteristics, as well as established methods for cell migration assays and tracking in three-dimensional environments.
MATERIALS TODAY BIO
(2023)
Article
Biotechnology & Applied Microbiology
Ilenia Iaia, Virginia Brancato, David Caballero, Rui L. Reis, Massimo Aglietta, Dario Sangiolo, Subhas C. Kundu
Summary: Little is known about the role of fibroblasts in solid tumors such as melanoma and the mechanism behind it due to the lack of relevant pre-clinical models. In this report, a melanoma-on-a-chip model was proposed to evaluate the essential role of fibroblasts in the antitumor activity of lymphocytes. The presence of fibroblasts was observed to inhibit immune effector recruitment in a 3D pre-clinical tumor model.
BIOENGINEERING-BASEL
(2023)
Article
Engineering, Multidisciplinary
Guohongfang Tan, Fujian Jiang, Tianshuo Jia, Zhenzhen Qi, Tieling Xing, Subhas C. Kundu, Shenzhou Lu
Summary: This study reports the use of polylysine-modified cationized silk fibroin (SF) to prepare microneedles (MNs) for responsive transdermal insulin delivery. The MNs were well arranged and formed an array with 0.5 mm pitch, and had a length of approximately 430 μm. They exhibited pH and glucose-responsive properties, rapidly releasing insulin as pH decreased and glucose concentration increased. In vivo experiments showed that the insulin release from cationized SF MNs was significantly lower in diabetic rats compared to normal rats. Therefore, cationized SF MNs hold promise as a new modality for diabetes treatment, replacing subcutaneous injections of insulin.
Article
Materials Science, Biomaterials
Lara Pierantoni, Virginia Brancato, Joao B. Costa, Subhas C. Kundu, Rui L. Reis, Joana Silva-Correia, Joaquim M. Oliveira
Summary: A 3D breast cancer model based on collagen protein has opened up new avenues for studying cancer progression.
Article
Multidisciplinary Sciences
Wenjing Yang, Ya Ma, Haiting Xu, Zhenhua Zhu, Jiaxue Wu, Cheng Xu, Wei Sun, Erhu Zhao, Min Wang, Rui L. Reis, Subhas C. Kundu, Xiaoxiao Shi, Bo Xiao
Summary: A fluorinated nanoparticle has been developed to improve the therapeutic outcomes of ulcerative colitis (UC). The results showed that the nanoparticles efficiently delivered drugs to the colon, promoted mucosal penetration, and had anti-oxidative and anti-inflammatory effects. In animal models, the nanoparticles significantly improved the therapeutic efficacy, reduced inflammation, and restored intestinal microbiota balance.
Article
Chemistry, Physical
Juan Du, Yue You, Rui L. Reis, Subhas C. Kundu, Jingliang Li
Summary: Gels are self-supporting soft materials widely used in various fields. The design of gels for specific applications requires fast, controllable gelation, desired micro/nano structure, and suitable rheological properties. Surfactants, although widely used in controlling material formation, are less understood in their effects on gelation. This review summarizes the studies on using different surfactants to control the formation, structure, and properties of molecular and silk fibroin gels. The mechanisms of surfactants, interfacial and non-interfacial effects, are classified and discussed. This review is expected to inspire further research on using surfactants for designing and fabricating gels with desired kinetics, structure, properties, and functionalities.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Rui R. Costa, David Caballero, Diana Soares da Costa, Romen Rodriguez-Trujillo, Subhas C. Kundu, Rui L. Reis, Iva Pashkuleva
Summary: Anisotropy plays a crucial role in the organization and healing of neural tissues, and holds great potential for developing regeneration strategies. The study demonstrates the fabrication of microfibers from charged ECM components using interfacial polyelectrolyte complexation, which can mimic the mechanical properties of neural tissues. These fibers are biocompatible and promote the formation of neural processes, enabling the development of neural cells.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Materials Science, Biomaterials
Zhanghong Gu, Suna Fan, Subhas C. Kundu, Xiang Yao, Yaopeng Zhang
Summary: Due to the innate extracellular matrix mimicking features, fibrous materials have great potential in biomedicine. A unique material platform with a non-fouling background and parallel-arranged polycaprolactone fibers is designed to eliminate interference cell adhesions and investigate the effects of fiber diameter on stem cell behaviors. The results show that the fiber diameter can significantly affect cell proliferation and osteogenesis, and the dense fiber arrangement may play a role in inducing different cell behavior trends.
REGENERATIVE BIOMATERIALS
(2023)
Meeting Abstract
Cell & Tissue Engineering
Mariana Carvalho, Cristiana Carvalho, Raquel Maia, David Caballero, Subhas Kundu, Rui Reis, Joaquim Oliveira
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Subhas C. Kundu, Virginia Brancato, Banani Kundu, David Caballero, Sara Amorim, Catarina Abreu, Ricardo A. Pires, Vitor M. Correlo, Joaquim M. Oliveira, Rui L. Reis
TISSUE ENGINEERING PART A
(2022)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
