期刊
SEMINARS IN REPRODUCTIVE MEDICINE
卷 35, 期 3, 页码 217-224出版社
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0037-1603095
关键词
infertility; female infertility; genetics; GWAS
资金
- NICHD NIH HHS [R01 HD078641] Funding Source: Medline
- NIMH NIH HHS [R01 MH101810] Funding Source: Medline
Female infertility is a complex disease linked to multiple etiologies including genetic factors. Owing to the multifactorial nature of infertility, it is often difficult to identify single causative genes. Despite this challenge, investigations into the genetic causes of infertility have been performed to shed light on the etiology and for the possibility of developing personalized medical approaches to therapy. Multiple techniques have been utilized to better characterize the genetic origins of this disease, including genome- wide association studies. We present here a review of the genetic causes of female infertility, detailing some of the more recent findings in the genetics of polycystic ovary syndrome, endometriosis, primary ovarian insufficiency, hypothalamic amenorrhea, leiomyomas, and Mullerian anomalies.
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