期刊
SEMINARS IN IMMUNOLOGY
卷 29, 期 -, 页码 41-48出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2017.01.001
关键词
Immunomodulation; innate immunity; biomaterials; extracellular matrix; dendritic cell; macrophage
类别
资金
- National Institutes of Health [R21AI111081-01A1]
- NIH Collaborative Trans-institutional Pilot Award
- Cornell Center for Vertebrate Genomics
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI111081] Funding Source: NIH RePORTER
Tissue regeneration and repair require a highly complex and orchestrated series of events that require inflammation, but can be compromised when inflammation is excessive or becomes chronic. Macrophages are one of the first cells to contact and respond to implanted materials, and mediate the inflammatory response. The series of events following macrophage association with biomaterials has been well-studied. Dendritic cells (DCs) also directly interact with biomaterials, are critical for specific immune responses, and can be activated in response to interactions with biomaterials. Yet, much less is known about the responses by DCs. This review discusses what we know about DC response to biomaterials, the underlying mechanisms involved, and how DCs can be influenced by the macrophage response to biomaterials. Lastly, I will discuss how biomaterials can be manipulated to enhance or suppress DC function to promote a specific desirable immune response - a major goal for implantable biologically active therapeutics. (C) 2017 Elsevier Ltd. All rights reserved.
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