期刊
SEMINARS IN IMMUNOLOGY
卷 34, 期 C, 页码 3-24出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2017.09.003
关键词
Nanoparticle; Physicochemical property; Inflammasome; Pattern-recognition receptor; Innate immune cell; Dendritic cell
类别
资金
- Fundacaopara a Ciencia e a Tecnologia, Ministerio da Ciencia, Tecnologia e Ensino Superior (FCT-MCTES), Portugal [SFRH/BD/87591/2012, PD/BD/113959/2015, SFRH/BD/87150/2012, SFRH/BD/87869/2012, SFRH/BPD/94111/2013]
- Israeli Ministry of Health [3-13620]
- FCT-MCTES [ENMed/0003/2015]
- Fonds National de la Recherche Scientifique (FNRS) [ENMed/0051/2016]
- European Research Council (ERC) under the European Union's Seventh Framework Programme/ERC [[617445] - PolyDorm]
- iMed.ULisboa [UTAP-ICDT/DTP-FTO/0016/2014, SAICTPAC/0019/2015, Pest-UID/DTP/04138/2013]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/87150/2012, SFRH/BD/87591/2012, SFRH/BD/87869/2012, SFRH/BPD/94111/2013, PD/BD/113959/2015, ENMed/0003/2015] Funding Source: FCT
Nanotechnology-based strategies can dramatically impact the treatment, prevention and diagnosis of a wide range of diseases. Despite the unprecedented success achieved with the use of nanomaterials to address unmet biomedical needs and their particular suitability for the effective application of a personalized medicine, the clinical translation of those nanoparticulate systems has still been impaired by the limited understanding on their interaction with complex biological systems. As a result, unexpected effects due to unpredicted interactions at biomaterial and biological interfaces have been underlying the biosafety concerns raised by the use of nanomaterials. This review explores the current knowledge on how nanoparticle (NP) physicochemical and surface properties determine their interactions with innate immune cells, with particular attention on the activation of pattern-recognition receptors and inflammasome. A critical perspective will additionally address the impact of biological systems on the effect of NP on immune cell activity at the molecular level. We will discuss how the understanding of the NP-innate immune cell interactions can significantly add into the clinical translation by guiding the design of nanomedicines with particular effect on targeted cells, thus improving their clinical efficacy while minimizing undesired but predictable toxicological effects.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据