期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 67, 期 -, 页码 39-47出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2017.03.001
关键词
Lung cancer; Extracellular vesicle; Exosome; Microenvironment; Biomarker; Therapy
资金
- Basic Science and Platform Technology Program for Innovative Biological Medicine
- Project for Cancer Research and Therapeutic Evolution (P-CREATE)
Lung cancer is the leading cause of cancer-related deaths worldwide. Despite significant advances in lung cancer research and novel therapies, a better understanding of the disease is crucially needed to facilitate early detection and appropriate diagnoses and to improve treatment outcomes. Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are released from all tested cell types and modulate cell-cell communication. EVs transfer a wide variety of molecules, such as proteins, messenger RNAs and microRNAs. Emerging data suggest that EVs play an important role in lung cancer pathogenesis and may have potential as biomarkers and therapeutics. Here, we review current research on EVs in lung cancer. (C) 2017 Elsevier Ltd. All rights reserved.
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