Article
Immunology
Ryan A. Adams, Catia Fernandes-Cerqueira, Antonella Notarnicola, Elisabeth Mertsching, Zhiwen Xu, Wing-Sze Lo, Kathleen Ogilvie, Kyle P. Chiang, Jeanette Ampudia, Sanna Rosengren, Andrea Cubitt, David J. King, John D. Mendlein, Xiang-Lei Yang, Leslie A. Nangle, Ingrid E. Lundberg, Per-Johan Jakobsson, Paul Schimmel
Summary: Extracellular HARS is homeostatic in normal subjects, and its sequestration contributes to the morbidity of the anti-Jo-1-positive antisynthetase syndrome; HARS is released in increasing amounts during differentiation of human skeletal muscle myoblasts into myotubes; HARS regulates immune cell engagement and inhibits CD4(+) and CD8(+) T-cell activation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Editorial Material
Immunology
Tom D. Bunney, Matilda Katan
Summary: APLAID is a rare autoinflammatory disease caused by PLCG2 mutations. A mouse model of APLAID mimics the disease and reveals the important role of G-CSF, which could be a potential therapeutic target.
Article
Virology
Kristoffer Skaalum Hansen, Sofie Eg Jorgensen, Morten Kelder Skouboe, Jane Agergaard, Berit Schiottz-Christensen, Line Khalidan Vibholm, Martin Tolstrup, Lars Ostergaard, Steffen Leth, Trine H. Mogensen
Summary: Long COVID is an emerging global health concern, and its underlying mechanism and pathophysiology are still unclear. This study found that autoantibodies against type 1 interferons in patients with Long COVID do not contribute to the symptoms.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Immunology
Erin Strachan, Xavier Clemente-Casares, Sue Tsai
Summary: Maternal influences on the immune health and development of an infant begin in utero and continue after birth, shaping and educating the child's immune system. Two important provisions from the mother include early microbial colonizers and the transfer of antibodies. These provisions help educate the developing neonatal immune system, connecting with the microbiota and influencing disease development.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Sean T. Carey, Christopher Bridgeman, Christopher M. Jewell
Summary: Autoimmunity and allergies are widespread diseases with current approaches unable to differentiate between healthy and disease-causing cells. New immunotherapies offer potential cures without immunosuppressive side effects, but translation to patients remains challenging. Biomaterials can maximize tolerance mechanisms through unique capabilities, although their clinical development is still in early stages. This review provides insights into recent advances and the current state of antigen-specific tolerance technologies.
Article
Multidisciplinary Sciences
Tigran Makunts, Keith Burkhart, Ruben Abagyan, Peter Lee
Summary: Biologics targeting immune checkpoint proteins can enhance the immune response against cancer cells, but also have the risk of causing immune related adverse events (irAEs). This study found that patients receiving pembrolizumab treatment had an 80% increased risk of developing irAEs when also having an infection.
Article
Microbiology
Matthew A. Jackson, Claire Pearson, Nicholas E. Ilott, Kelsey E. Huus, Ahmed N. Hegazy, Jonathan Webber, B. Brett Finlay, Andrew J. Macpherson, Fiona Powrie, Lilian H. Lam
Summary: The study presents a detailed IgA-Seq protocol to accurately isolate IgA-bound taxa from intestinal samples and demonstrates the effectiveness of novel probability-based scores in accurately quantifying taxon-level IgA binding using simulated and experimental data. These methods improve the generation and interpretation of IgA-Seq datasets and have the potential to be applied to study other immunoglobulins and sample types.
Article
Oncology
Xingxing Gao, Hechen Huang, Yubo Wang, Caixu Pan, Shengyong Yin, Lin Zhou, Shusen Zheng
Summary: The tumor microenvironment plays a critical role in the pathogenesis of hepatocellular carcinoma. By clustering HCC patients into immune-related subclasses based on TME signatures, significant differences in clinical prognosis and treatment responses were observed. The SVM model based on TME characteristics can help predict clinical outcomes and guide personalized treatment strategies for HCC patients.
FRONTIERS IN ONCOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Frederic Rieux-Laucat, Jean M. Kanellopoulos, David M. Ojcius
Summary: This special issue reviews advances in analyzing mutations responsible for ALPS and ALPS-like syndromes, shedding light on their functional consequences. Genetic diagnoses can help identify specific therapeutic targets and tailor personalized treatment for each patient.
BIOMEDICAL JOURNAL
(2021)
Article
Medicine, General & Internal
Cesar Picado, Adriana P. Garcia-Herrera, Jose Hernandez-Rodriguez, Alexandru Vlagea, Mariona Pascal, Joan Bartra, Jose Manuel Mascaro
Summary: Selective immunoglobulin E deficiency (SIgED) is an unrecognized primary immunodeficiency that is associated with various skin manifestations and autoimmune diseases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Cecilia Napodano, MariaPaola Marino, Annunziata Stefanile, Krizia Pocino, Roberto Scatena, Francesca Gulli, Gian Lodovico Rapaccini, Stefano Delli Noci, Giovanna Capozio, Donato Rigante, Umberto Basile
Summary: The loss of tolerance to self-antigens is a key factor in the development of autoimmune diseases, with different IgG subclasses in the serum potentially being specific to different underlying driving autoantigens. Understanding the role of IgG subsets may help clarify their pathological function and provide insights for diagnosis, personalized patient management, and prognosis assessment.
IMMUNOLOGICAL INVESTIGATIONS
(2021)
Review
Clinical Neurology
Hugues Lamothe, Ryad Tamouza, Andreas Hartmann, Luc Mallet
Summary: Through a systematic review and meta-analysis of immunological data, discrepancies in immune dysfunctions were found in GTS patients, and specific cytokines' involvement in GTS neurobiology could not be concluded. Evidence of possible infectious involvement was found in a limited number of studies related to pediatric autoimmune neuropsychiatric disorder associated with streptococcus/pediatric acute onset neuropsychiatric syndrome.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Environmental Sciences
Daniele Piovani, Enrico Brunetta, Stefanos Bonovas
Summary: Autoimmune diseases are characterized by disruptive immune responses against self-antigens, chronic morbidity and increased mortality. This study focuses on major autoimmune conditions and suggests a protective role of sunlight exposure, mediated by vitamin D and nitric oxide, on their etiology. Air pollutants have detrimental effects on the human body and contribute to the burden of autoimmune conditions through direct and indirect mechanisms.
ENVIRONMENTAL RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Caroline von Achenbach, Giselle Hevia Hernandez, Stephan von Gunten
Summary: IVIG and SCIG are used to treat various immunodeficiencies and inflammatory conditions, with treatment decisions influenced by patient conditions, preferences, and economic factors. Understanding and comparing the two treatment modalities are crucial for optimal therapeutic options.
Review
Immunology
Anne C. S. Ramos, Luciana M. Oliveira, Yvanna L. D. C. O. Santos, Marlon C. S. Dantas, Cristiani I. B. Walker, Ana M. C. Faria, Lilian L. Bueno, Silvio S. Dolabella, Ricardo T. Fujiwara
Summary: This systematic review aimed to investigate the role of Immunoglobulin-A (IgA) as a mediator of protective immunity against gastrointestinal helminths. The results showed consistent associations between higher IgA levels and lower parasitological parameters in mice, rats, and sheep. However, the role of IgA in other host species remained uncertain, highlighting the need for further research.
IMMUNOLOGY LETTERS
(2022)
Article
Rheumatology
Walter P. Maksymowych, Nele Herregods, Nisha Varma, Arthur B. Meyers, Jennifer Stimec, Andrea S. Doria, Nikolay Tzaribachev, Tarimobo M. Otobo, Marion A. van Rossum, Joel Paschke, Stephanie Wichuk, Robert G. Lambert
Summary: This study aimed to investigate whether systematic calibration improves the scoring proficiency of JAMRIS-SIJ and whether contrast-enhancement enhances its performance. The results showed that calibrated readers achieved greater reliability in scoring specific inflammatory and structural lesions. Sensitivity and reliability for scoring inflammatory lesions were higher on fluid-sensitive sequences compared to contrast-enhanced sequences. Therefore, systematic calibration should be implemented before using JAMRIS-SIJ in clinical trials, and it is unlikely that contrast-enhanced MRI will improve the performance of this method.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)
Article
Rheumatology
L. van Ouwerkerk, S. A. Bergstra, T. D. Maarseveen, T. W. J. Huizinga, R. Knevel, C. F. Allaart
Summary: This study evaluated whether the initial use of glucocorticoid (GC) bridging in RA patients leads to a higher probability of long-term GC and bDMARD use. The results showed that patients who initially started GC had a higher risk of later GC use, but the risk of bDMARD use was not significantly increased.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)
Article
Rheumatology
ShuangHua Liu, YiMei Tan, WeiDong Huang, HongSheng Luo, BingCheng Pan, Shuan Wu
Summary: This study assessed the cardiovascular safety of zoledronic acid in the treatment of primary osteoporosis. The results showed that in women with primary osteoporosis, zoledronic acid may increase the risk of atrial fibrillation and arrhythmias, but the cardiovascular risk in men with osteoporosis is uncertain.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)