Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease

Untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses

(2016) Karpagam Srinivasan et al.   Nature Communications

Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement

(2016) Seung-Hye Lee et al.   Cell Reports

c-JunN-terminal kinase inhibitors: a patent review (2010 – 2014)

(2015) Matthias Gehringer et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12)

(2015) Snahel Patel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Dual Leucine Zipper Kinase (DLK, MAP3K12) Inhibitors with Activity in Neurodegeneration Models

(2014) Snahel Patel et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Death Receptor 6-Amyloid Precursor Protein Pathway Regulates Synapse Density in the Mature CNS But Does Not Contribute to Alzheimer's Disease-Related Pathophysiology in Murine Models

(2014) D. Y. Kallop et al.   JOURNAL OF NEUROSCIENCE

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Chronic GluN2B Antagonism Disrupts Behavior in Wild-Type Mice Without Protecting Against Synapse Loss or Memory Impairment in Alzheimer's Disease Mouse Models

(2014) J. E. Hanson et al.   JOURNAL OF NEUROSCIENCE

Advances in treating amyotrophic lateral sclerosis: insights from pathophysiological studies

(2014) Steve Vucic et al.   TRENDS IN NEUROSCIENCES

JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis

(2013) Sarah Huntwork-Rodriguez et al.   JOURNAL OF CELL BIOLOGY

Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration

(2013) Christine D. Pozniak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

EGFR Inhibitor Erlotinib Delays Disease Progression but Does Not Extend Survival in the SOD1 Mouse Model of ALS

(2013) Claire E. Le Pichon et al.   PLoS One

DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury

(2013) T. A. Watkins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death

(2013) D. S. Welsbie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual Leucine Zipper Kinase Is Required for Retrograde Injury Signaling and Axonal Regeneration

(2012) Jung Eun Shin et al.   NEURON

DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity

(2011) Arundhati Sengupta Ghosh et al.   JOURNAL OF CELL BIOLOGY

Alzheimer's Disease: The Challenge of the Second Century

(2011) D. M. Holtzman et al.   Science Translational Medicine

Motor Neuron Diversity in Development and Disease

(2010) Kevin C. Kanning et al.   Annual Review of Neuroscience

Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury

(2010) Xin Xiong et al.   JOURNAL OF CELL BIOLOGY

Multiple Events Lead to Dendritic Spine Loss in Triple Transgenic Alzheimer's Disease Mice

(2010) Tobias Bittner et al.   PLoS One

The DLK-1 Kinase Promotes mRNA Stability and Local Translation in C. elegans Synapses and Axon Regeneration

(2009) Dong Yan et al.   CELL

A dual leucine kinase–dependent axon self-destruction program promotes Wallerian degeneration

(2009) Bradley R Miller et al.   NATURE NEUROSCIENCE

No Benefit from Chronic Lithium Dosing in a Sibling-Matched, Gender Balanced, Investigator-Blinded Trial Using a Standard Mouse Model of Familial ALS

(2009) Alan Gill et al.   PLoS One

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

(2009) I. Wegorzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Axon Regeneration Requires a Conserved MAP Kinase Pathway

(2009) M. Hammarlund et al.   SCIENCE

Design, power, and interpretation of studies in the standard murine model of ALS

(2008) Sean Scott et al.   Amyotrophic Lateral Sclerosis

Antiapoptotic and Trophic Effects of Dominant-Negative Forms of Dual Leucine Zipper Kinase in Dopamine Neurons of the Substantia Nigra In Vivo

(2008) X. Chen et al.   JOURNAL OF NEUROSCIENCE

Expression of Transgenic APP mRNA Is the Key Determinant for Beta-Amyloid Deposition in PS2APP Transgenic Mice

(2008) Laurence Ozmen et al.   Neurodegenerative Diseases